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DK2994528T3 - Organoider, der omfatter isolerede renale celler og anvendelser deraf - Google Patents

Organoider, der omfatter isolerede renale celler og anvendelser deraf Download PDF

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Publication number
DK2994528T3
DK2994528T3 DK14730323.4T DK14730323T DK2994528T3 DK 2994528 T3 DK2994528 T3 DK 2994528T3 DK 14730323 T DK14730323 T DK 14730323T DK 2994528 T3 DK2994528 T3 DK 2994528T3
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DK
Denmark
Prior art keywords
organoids
renal cells
isolated renal
isolated
cells
Prior art date
Application number
DK14730323.4T
Other languages
English (en)
Inventor
Joydeep Basu
Andrew Bruce
Rusty Kelley
Kelly Guthrie
Original Assignee
Prokidney
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prokidney filed Critical Prokidney
Application granted granted Critical
Publication of DK2994528T3 publication Critical patent/DK2994528T3/da

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0684Cells of the urinary tract or kidneys
    • C12N5/0686Kidney cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0697Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/25Urinary tract cells, renal cells
    • C12N2502/256Renal cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/28Vascular endothelial cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/003D culture
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/50Proteins
    • C12N2533/54Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Materials For Medical Uses (AREA)
DK14730323.4T 2013-05-08 2014-05-08 Organoider, der omfatter isolerede renale celler og anvendelser deraf DK2994528T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361855146P 2013-05-08 2013-05-08
US201361855152P 2013-05-09 2013-05-09
PCT/US2014/037275 WO2014182885A2 (en) 2013-05-08 2014-05-08 Organoids comprising isolated renal cells and uses thereof

Publications (1)

Publication Number Publication Date
DK2994528T3 true DK2994528T3 (da) 2024-02-05

Family

ID=50942860

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14730323.4T DK2994528T3 (da) 2013-05-08 2014-05-08 Organoider, der omfatter isolerede renale celler og anvendelser deraf

Country Status (18)

Country Link
US (2) US20160101133A1 (da)
EP (2) EP4299721A3 (da)
JP (4) JP6490669B2 (da)
KR (8) KR102668827B1 (da)
CN (1) CN105378062A (da)
AU (3) AU2014262670B2 (da)
BR (1) BR112015027996A8 (da)
CA (1) CA2911291A1 (da)
DK (1) DK2994528T3 (da)
ES (1) ES2970230T3 (da)
FI (1) FI2994528T3 (da)
HR (1) HRP20240170T1 (da)
HU (1) HUE065125T2 (da)
PL (1) PL2994528T3 (da)
PT (1) PT2994528T (da)
RU (1) RU2722361C2 (da)
SI (1) SI2994528T1 (da)
WO (1) WO2014182885A2 (da)

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CA2915143C (en) 2013-06-13 2021-08-03 Orgenesis Ltd. Cell populations, methods of transdifferentiation and methods of use thereof
ES2860423T3 (es) 2014-05-28 2021-10-05 Childrens Hospital Med Ct Métodos y sistemas para convertir células precursoras en tejidos gástricos mediante diferenciación dirigida
US11584916B2 (en) 2014-10-17 2023-02-21 Children's Hospital Medical Center Method of making in vivo human small intestine organoids from pluripotent stem cells
CA2969592C (en) 2014-12-05 2023-02-14 University Of Florida Research Foundation, Inc. 3d printing using phase changing materials as support
MA41296A (fr) 2014-12-30 2017-11-07 Orgenesis Ltd Procédés de transdifférenciation et procédés d'utilisation de ceux-ci
WO2016130953A1 (en) 2015-02-13 2016-08-18 University Of Florida Research Foundation, Inc. High speed 3d printing system for wound and tissue replacement
US11390835B2 (en) 2015-05-08 2022-07-19 University Of Florida Research Foundation, Inc. Growth media for three-dimensional cell culture
WO2017040981A1 (en) 2015-09-03 2017-03-09 University Of Florida Research Foundation, Inc. Valve incorporating temporary phase change material
EP3344264B1 (en) 2015-09-03 2023-03-15 The Brigham and Women's Hospital, Inc. Three-dimensional differentiation of epiblast spheroids to kidney organoids models stage-specific epithelial physiology, morphogenesis, and disease
US20180258382A1 (en) * 2015-09-18 2018-09-13 University Of Florida Research Foundation, Incorporated Apparatus for culturing and interacting with a three-dimensional cell culture
WO2017096263A1 (en) 2015-12-04 2017-06-08 University Of Florida Research Foundation, Incorporated Crosslinkable or functionalizable polymers for 3d printing of soft materials
US11066650B2 (en) 2016-05-05 2021-07-20 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
DK3460042T3 (da) 2016-05-18 2024-03-11 Univ Keio Celledyrkningsmedium til dyrkning af et organoid, dyrkningsfremgnagsmåde og organoid
US11124644B2 (en) 2016-09-01 2021-09-21 University Of Florida Research Foundation, Inc. Organic microgel system for 3D printing of silicone structures
NZ753873A (en) 2016-12-05 2023-01-27 Children’S Hospital Medical Center Colonic organoids and methods of making and using same
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
EP3635106A4 (en) 2017-05-08 2021-01-06 Orgenesis Ltd. POPULATIONS OF TRANSDIFFERENTIATED CELLS AND THEIR METHODS OF USE
WO2018220621A2 (en) * 2017-05-29 2018-12-06 Orgenesis Ltd. Vascular secretome, methods of making same, and methods of use thereof
US11834680B2 (en) 2017-06-28 2023-12-05 Rutgers, The State University Of New Jersey Single kidney cell-derived organoids
JP2019196342A (ja) * 2018-05-10 2019-11-14 学校法人大阪医科薬科大学 スタチン封入ナノ粒子製剤、それを含有する歯髄由来幹細胞及びそれを含む細胞製剤。
KR102094929B1 (ko) * 2018-07-06 2020-03-30 한국생명공학연구원 신장 스페로이드 및 그의 제조 방법
EP3843760A4 (en) * 2018-08-31 2022-11-09 Timothy Bertram COMPOSITIONS COMPRISING VESICLES OF CELLULAR ORIGIN AND ASSOCIATED USES
KR102118807B1 (ko) 2018-11-26 2020-06-03 숭실대학교산학협력단 3차원 오가노이드 제조용 형상변화형 하이드로젤 몰드 조성물 및 이를 통해 제조된 몰드
KR20200065892A (ko) * 2018-11-30 2020-06-09 오가노이드사이언스 주식회사 오가노이드의 생체 이식용 조성물
EP3952895B8 (en) 2019-04-11 2024-07-17 University of Pittsburgh - Of the Commonwealth System of Higher Education Minimally invasive cell transplant procedure to induce the development of in vivo organogenesis
US20230029554A1 (en) * 2019-12-12 2023-02-02 The Walter And Eliza Hall Institute Of Medecal Research Organoid cultures
KR20230007766A (ko) * 2021-07-06 2023-01-13 서강대학교산학협력단 혈관화된 신장 오가노이드 형성을 위한 세포기질의 최적화 및 오가노이드 칩 개발
CN114507642B (zh) * 2022-03-17 2024-02-02 上海纽仁生物医药科技有限公司 一种动物神经系统周细胞单细胞的分离方法
CN114732832A (zh) * 2022-04-08 2022-07-12 宁夏医科大学总医院 一种防宫腔粘连的可植入物
CN116159182B (zh) * 2023-02-02 2024-09-24 中国科学院苏州纳米技术与纳米仿生研究所 用于治疗脊髓损伤的神经类器官-水凝胶体系及制备方法

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Also Published As

Publication number Publication date
AU2014262670A1 (en) 2015-11-26
CN105378062A (zh) 2016-03-02
KR102225312B1 (ko) 2021-03-10
HRP20240170T1 (hr) 2024-04-12
HUE065125T2 (hu) 2024-05-28
KR20240090622A (ko) 2024-06-21
AU2020203860B2 (en) 2023-04-27
KR102710014B1 (ko) 2024-09-26
PL2994528T3 (pl) 2024-04-22
JP7062605B2 (ja) 2022-05-06
AU2023206151A1 (en) 2023-08-10
KR20210029285A (ko) 2021-03-15
BR112015027996A8 (pt) 2017-09-26
KR20210094671A (ko) 2021-07-29
JP2024105523A (ja) 2024-08-06
PT2994528T (pt) 2024-02-13
AU2020203860A1 (en) 2020-07-02
JP2016519930A (ja) 2016-07-11
KR20240001290A (ko) 2024-01-03
CA2911291A1 (en) 2014-11-13
US20220249569A1 (en) 2022-08-11
JP2022071069A (ja) 2022-05-13
KR20220005636A (ko) 2022-01-13
NZ752702A (en) 2021-11-26
WO2014182885A2 (en) 2014-11-13
KR102556951B1 (ko) 2023-07-18
ES2970230T3 (es) 2024-05-27
JP7493252B2 (ja) 2024-05-31
KR102757386B1 (ko) 2025-01-21
SI2994528T1 (sl) 2024-04-30
KR20240144472A (ko) 2024-10-02
EP2994528A2 (en) 2016-03-16
KR102349183B1 (ko) 2022-01-07
KR20160005037A (ko) 2016-01-13
KR102281921B1 (ko) 2021-07-28
RU2015152257A (ru) 2017-06-09
EP4299721A2 (en) 2024-01-03
NZ713875A (en) 2021-11-26
FI2994528T3 (fi) 2024-02-07
US20160101133A1 (en) 2016-04-14
JP2019122381A (ja) 2019-07-25
JP6490669B2 (ja) 2019-03-27
EP2994528B1 (en) 2023-11-08
EP4299721A3 (en) 2024-04-24
AU2014262670B2 (en) 2020-07-09
RU2722361C2 (ru) 2020-05-29
KR102618557B1 (ko) 2023-12-28
WO2014182885A3 (en) 2015-04-16
KR102668827B1 (ko) 2024-05-27
BR112015027996A2 (pt) 2017-09-12
KR20230110834A (ko) 2023-07-25

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