PT101665B - Processo para a preparacao e purificacao de bis-(1,3-di-hidro-xipropilamida) de acido l-5-(2-hidroxiproppionilamiamino)-2,4,5-triodoisoftalico. - Google Patents

Processo para a preparacao e purificacao de bis-(1,3-di-hidro-xipropilamida) de acido l-5-(2-hidroxiproppionilamiamino)-2,4,5-triodoisoftalico. Download PDF

Info

Publication number: PT101665B
Authority: PT; Portugal
Prior art keywords: resin; iopamidol; purification; bis; acid
Prior art date: 1994-03-03

Application number

PT101665A

Other languages

English (en)

Portuguese (pt)

Other versions

PT101665A (pt

Inventor

Vincenzo Cannata

Valeriano Merli

Claudio Dal Santo

Original Assignee

Bracco Int Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-03

Filing date

1995-03-01

Publication date

1999-01-29

1995-03-01 Application filed by Bracco Int Bv filed Critical Bracco Int Bv

1995-09-12 Publication of PT101665A publication Critical patent/PT101665A/pt

1999-01-29 Publication of PT101665B publication Critical patent/PT101665B/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Treatment Of Liquids With Adsorbents In General (AREA)

PT101665A 1994-03-03 1995-03-01 Processo para a preparacao e purificacao de bis-(1,3-di-hidro-xipropilamida) de acido l-5-(2-hidroxiproppionilamiamino)-2,4,5-triodoisoftalico. PT101665B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI940378A IT1274027B (it)	1994-03-03	1994-03-03	Processo per la preparazione e purificazione di mezzi di contrasto iodurati

Publications (2)

Publication Number	Publication Date
PT101665A PT101665A (pt)	1995-09-12
PT101665B true PT101665B (pt)	1999-01-29

Family

ID=11368040

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT101665A PT101665B (pt)	1994-03-03	1995-03-01	Processo para a preparacao e purificacao de bis-(1,3-di-hidro-xipropilamida) de acido l-5-(2-hidroxiproppionilamiamino)-2,4,5-triodoisoftalico.

Country Status (22)

Country	Link
US (1)	US5550287A (no)
JP (1)	JP4143136B2 (no)
AT (1)	AT405052B (no)
BE (1)	BE1007938A3 (no)
CA (1)	CA2143805C (no)
CH (1)	CH689296A5 (no)
CZ (1)	CZ287640B6 (no)
DE (1)	DE19507294B4 (no)
DK (1)	DK171530B1 (no)
ES (1)	ES2105961B1 (no)
FI (1)	FI950977A (no)
FR (1)	FR2716881B1 (no)
GB (1)	GB2287024B (no)
HU (1)	HU216330B (no)
IE (1)	IE950154A1 (no)
IL (1)	IL112718A (no)
IT (1)	IT1274027B (no)
NL (1)	NL194332C (no)
NO (1)	NO304112B1 (no)
PT (1)	PT101665B (no)
SE (1)	SE510124C2 (no)
ZA (1)	ZA951748B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2929236A (en) *	1955-03-29	1960-03-22	Steward Construction Company	Building wall construction
PL187308B1 (pl) *	1995-05-23	2004-06-30	Bracco Imaging Spa	Sposób wytwarzania dichlorku kwasu dikarboksylowego i sposób oczyszczania i izolacji dichlorku kwasu dikarboksylowego
PT101720A (pt) *	1995-06-08	1997-01-31	Hovione Sociedade Quimica S A	Processo para a purificacao e cristalizacao de iopamidol
ES2162117T3 (es) *	1995-12-01	2001-12-16	Mallinckrodt Med Imaging Ie	Procedimiento cromatografico en fase inversa.
IT1283319B1 (it) *	1996-03-29	1998-04-16	Zambon Spa	Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1289519B1 (it) *	1996-12-24	1998-10-15	Zambon Spa	Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
IT1292127B1 (it) *	1997-06-11	1999-01-25	Bracco Spa	Processo per la dissalazione di sostanze instabili a ph acidi
DE19736472C1 (de) *	1997-08-21	1999-04-22	Bernhard Dr Sixt	Verfahren zum Herstellen von weitgehend nebenwirkungsfreien Kontrastmitteln
US6265610B1 (en)	1999-01-12	2001-07-24	The University Of North Carolina At Chapel Hill	Contrast media for angiography
US6803485B2 (en) *	1999-02-26	2004-10-12	Bracco Imaging S.P.A.	Process for the preparation of iopamidol
TWI288654B (en) *	2001-05-17	2007-10-21	Ind Tech Res Inst	Process for the purification of water-soluble non-ionic contrast agents
US20110017673A1 (en) *	2009-07-21	2011-01-27	Ge Healthcare As	Endotoxin removal in contrast media
IT1403988B1 (it) *	2010-07-15	2013-11-08	Bracco Imaging Spa	Processo per la preparazione di agenti di contrasto.
EP3066071B1 (en)	2013-11-05	2018-04-18	Bracco Imaging S.p.A	Process for the preparation of iopamidol
CN115403481A (zh) *	2022-04-13	2022-11-29	江苏宇田医药有限公司	一种通过离子交换树脂纯化碘海醇的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS4956989A (no) *	1972-10-09	1974-06-03
CH608189A5 (no) *	1974-12-13	1978-12-29	Savac Ag
IT1193211B (it) *	1979-08-09	1988-06-15	Bracco Ind Chimica Spa	Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
IT1207226B (it) *	1979-08-09	1989-05-17	Bracco Ind Chimica Spa	Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
ATE79368T1 (de) *	1987-05-22	1992-08-15	Bracco Spa	Herstellung von 5-acylamino-2,4,6-trijodo- oder tribromo-benzoesaeure-derivate.
JPH03244380A (ja) *	1990-02-23	1991-10-31	Asahi Chem Ind Co Ltd	精製酵素およびその製造方法
US5019371A (en) *	1990-11-21	1991-05-28	Mallinckrodt Medical, Inc.	Novel x-ray contrast agents, compositions and methods
IT1248741B (it) *	1991-02-26	1995-01-26	Bracco Spa	Processo di concentrazione e di purificazione di composti organici
IT1254991B (it) *	1992-06-24	1995-10-11	Chemi Spa	Procedimento per la preparazione di glicerofosfolipidi
DE10204861B4 (de) *	2002-02-06	2004-01-29	Wacker Construction Equipment Ag	Luftfederschlagwerk mit elektrodynamisch bewegtem Antriebskolben

1994
- 1994-03-03 IT ITMI940378A patent/IT1274027B/it active IP Right Grant
1995
- 1995-02-21 IL IL11271895A patent/IL112718A/xx not_active IP Right Cessation
- 1995-02-24 IE IE950154A patent/IE950154A1/en not_active IP Right Cessation
- 1995-02-27 FR FR9502242A patent/FR2716881B1/fr not_active Expired - Lifetime
- 1995-02-27 GB GB9503893A patent/GB2287024B/en not_active Expired - Lifetime
- 1995-03-01 PT PT101665A patent/PT101665B/pt not_active IP Right Cessation
- 1995-03-01 ES ES09500394A patent/ES2105961B1/es not_active Expired - Fee Related
- 1995-03-01 AT AT0036995A patent/AT405052B/de not_active IP Right Cessation
- 1995-03-02 CH CH00594/95A patent/CH689296A5/it not_active IP Right Cessation
- 1995-03-02 ZA ZA951748A patent/ZA951748B/xx unknown
- 1995-03-02 SE SE9500752A patent/SE510124C2/sv not_active IP Right Cessation
- 1995-03-02 DE DE19507294A patent/DE19507294B4/de not_active Expired - Lifetime
- 1995-03-02 CA CA002143805A patent/CA2143805C/en not_active Expired - Lifetime
- 1995-03-02 NO NO950814A patent/NO304112B1/no not_active IP Right Cessation
- 1995-03-02 NL NL9500415A patent/NL194332C/nl not_active IP Right Cessation
- 1995-03-02 DK DK021795A patent/DK171530B1/da not_active IP Right Cessation
- 1995-03-02 HU HU9500645A patent/HU216330B/hu unknown
- 1995-03-02 FI FI950977A patent/FI950977A/fi not_active Application Discontinuation
- 1995-03-02 BE BE9500182A patent/BE1007938A3/fr not_active IP Right Cessation
- 1995-03-03 US US08/397,955 patent/US5550287A/en not_active Expired - Lifetime
- 1995-03-03 JP JP04386495A patent/JP4143136B2/ja not_active Expired - Lifetime
- 1995-03-03 CZ CZ1995562A patent/CZ287640B6/cs not_active IP Right Cessation

Also Published As

Publication number	Publication date
CH689296A5 (it)	1999-02-15
CZ287640B6 (en)	2001-01-17
SE9500752L (sv)	1995-09-04
ATA36995A (de)	1998-09-15
NL194332C (nl)	2002-01-04
DE19507294B4 (de)	2005-12-15
NO950814L (no)	1995-09-04
BE1007938A3 (fr)	1995-11-21
IT1274027B (it)	1997-07-14
NL9500415A (nl)	1995-10-02
NO304112B1 (no)	1998-10-26
GB2287024A (en)	1995-09-06
IL112718A (en)	1999-05-09
ITMI940378A0 (it)	1994-03-03
NO950814D0 (no)	1995-03-02
CA2143805A1 (en)	1995-09-04
JPH07278081A (ja)	1995-10-24
ES2105961B1 (es)	1998-07-01
FR2716881B1 (fr)	1996-08-02
FI950977A (fi)	1995-09-04
JP4143136B2 (ja)	2008-09-03
ZA951748B (en)	1995-12-08
IE950154A1 (en)	1995-09-06
GB2287024B (en)	1998-07-08
DK171530B1 (da)	1996-12-23
AT405052B (de)	1999-05-25
IL112718A0 (en)	1995-05-26
DE19507294A1 (de)	1995-09-07
PT101665A (pt)	1995-09-12
FR2716881A1 (fr)	1995-09-08
HU9500645D0 (en)	1995-04-28
FI950977A0 (fi)	1995-03-02
ITMI940378A1 (it)	1995-09-04
HUT70401A (en)	1995-10-30
SE9500752D0 (sv)	1995-03-02
HU216330B (hu)	1999-06-28
US5550287A (en)	1996-08-27
SE510124C2 (sv)	1999-04-19
CA2143805C (en)	2004-12-28
ES2105961A1 (es)	1997-10-16
GB9503893D0 (en)	1995-04-19
DK21795A (da)	1995-09-04
CZ56295A3 (en)	1995-11-15
NL194332B (nl)	2001-09-03

Publication	Publication Date	Title
PT101665B (pt)	1999-01-29	Processo para a preparacao e purificacao de bis-(1,3-di-hidro-xipropilamida) de acido l-5-(2-hidroxiproppionilamiamino)-2,4,5-triodoisoftalico.
EP1150943B1 (en)	2003-09-10	Preparation of iodixanol
EP0340677A2 (en)	1989-11-08	Gabapentin monohydrate and a process for producing the same
WO2008104853A1 (en)	2008-09-04	Processes for the preparation of pure ioversol
US6596904B1 (en)	2003-07-22	Process for producing ioversol
RU2481325C2 (ru)	2013-05-10	Способ селективной кристаллизации z-изомера иопромида
EP0105752A1 (en)	1984-04-18	X-ray contrast agents
US6500341B2 (en)	2002-12-31	Process for the purification of water-soluble non-ionic contrast agents
KR100194506B1 (ko)	1999-06-15	비이온성 요오드화 화합물과 이의 제조방법 및 이를 함유하는 조영제
JPH0225456A (ja)	1990-01-26	新規なヨー素化非イオン性トリヨードベンゼン化合物
US6111142A (en)	2000-08-29	Process for the preparation of an aminoalcohol
JP4190032B2 (ja)	2008-12-03	アミノアルコールを精製する方法
JPS58188862A (ja)	1983-11-04	Ｎ−アシルカルノシンの製造法
HU194811B (en)	1988-03-28	Process for cleaning of verapamil

Legal Events

Date	Code	Title	Description
1999-01-29	FG3A	Patent granted, date of granting	Effective date: 19981019
1999-04-30	PC3A	Transfer or assignment	Free format text: 19990205 BRACCO INTERNATIONAL B.V. NL
2004-06-30	PC3A	Transfer or assignment	Free format text: BRACCO IMAGING S.P.A. IT Effective date: 20040420
2015-03-10	MM4A	Annulment/lapse due to non-payment of fees, searched and examined patent	Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20150302