PL379989A1 - Sposoby leczenia bólu przez podawanie antagonisty czynnika wzrostu nerwów i przeciwbólowego opioidu oraz kompozycje je zawierające - Google Patents
Sposoby leczenia bólu przez podawanie antagonisty czynnika wzrostu nerwów i przeciwbólowego opioidu oraz kompozycje je zawierająceInfo
- Publication number
- PL379989A1 PL379989A1 PL379989A PL37998903A PL379989A1 PL 379989 A1 PL379989 A1 PL 379989A1 PL 379989 A PL379989 A PL 379989A PL 37998903 A PL37998903 A PL 37998903A PL 379989 A1 PL379989 A1 PL 379989A1
- Authority
- PL
- Poland
- Prior art keywords
- growth factor
- nerve growth
- opioid analgesic
- administering
- same
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41734702P | 2002-10-08 | 2002-10-08 | |
PCT/US2003/032113 WO2004096122A2 (en) | 2002-10-08 | 2003-10-08 | Use of ngf antagonists and opioids for treating pain |
Publications (1)
Publication Number | Publication Date |
---|---|
PL379989A1 true PL379989A1 (pl) | 2006-11-27 |
Family
ID=33415832
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL379989A PL379989A1 (pl) | 2002-10-08 | 2003-10-08 | Sposoby leczenia bólu przez podawanie antagonisty czynnika wzrostu nerwów i przeciwbólowego opioidu oraz kompozycje je zawierające |
Country Status (18)
Country | Link |
---|---|
US (1) | US20040131615A1 (pl) |
EP (2) | EP2100902B1 (pl) |
JP (1) | JP2006517524A (pl) |
KR (1) | KR20050067174A (pl) |
CN (1) | CN1878794B (pl) |
AT (1) | ATE434625T1 (pl) |
AU (1) | AU2003304060A1 (pl) |
BR (1) | BR0315167A (pl) |
CA (1) | CA2501694A1 (pl) |
DE (1) | DE60328128D1 (pl) |
ES (2) | ES2326881T3 (pl) |
MX (1) | MXPA05003501A (pl) |
NO (1) | NO20052221L (pl) |
PL (1) | PL379989A1 (pl) |
RU (1) | RU2005113996A (pl) |
UA (1) | UA80447C2 (pl) |
WO (1) | WO2004096122A2 (pl) |
ZA (1) | ZA200502611B (pl) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA03010911A (es) * | 2001-05-30 | 2004-02-17 | Genentech Inc | Anticuerpos contra ngf para el tratamiento de varios desordenes. |
CA2500901A1 (en) * | 2002-10-04 | 2004-04-22 | Rinat Neuroscience Corp. | Methods for treating cardiac arrhythmia and preventing death due to cardiac arrhythmia using ngf antagonists |
BR0315164A (pt) | 2002-10-08 | 2005-08-23 | Rinat Neuroscience Corp | Métodos para tratar dor pós-cirúrgica administrando um antagonista de fator de crescimento nervoso e composições contendo o mesmo |
US7255860B2 (en) | 2002-10-08 | 2007-08-14 | Rinat Neuroscience Corp. | Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody |
AU2003299898B2 (en) | 2002-12-24 | 2010-12-16 | Rinat Neuroscience Corp. | Anti-NGF antibodies and methods using same |
AU2011201157C1 (en) * | 2002-12-24 | 2017-09-07 | Rinat Neuroscience Corp. | Anti-NGF antibodies and methods using same |
US7569364B2 (en) * | 2002-12-24 | 2009-08-04 | Pfizer Inc. | Anti-NGF antibodies and methods using same |
US9498530B2 (en) | 2002-12-24 | 2016-11-22 | Rinat Neuroscience Corp. | Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same |
WO2004073653A2 (en) | 2003-02-19 | 2004-09-02 | Rinat Neuroscience Corp. | Methods for treating pain by administering a nerve growth factor antagonist and an nsaid and compositions containing the same |
ITRM20030601A1 (it) | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
PL1732949T3 (pl) | 2004-04-07 | 2010-06-30 | Rinat Neuroscience Corp | Sposoby leczenia nowotworowego bólu kości przez podawanie antagonisty czynnika wzrostu nerwów |
ITRM20050290A1 (it) | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
ITRM20050332A1 (it) * | 2005-06-24 | 2006-12-25 | Lay Line Genomics Spa | Uso di molecole in grado di bloccare l'attivita' di trka per potenziare gli effetti di analgesici oppiacei sul dolore. |
CA3008270A1 (en) | 2005-09-21 | 2007-03-29 | The Regents Of The University Of California | Systems, compositions, and methods for local imaging and treatment of pain |
CA2790018C (en) * | 2006-12-21 | 2015-02-03 | Amgen Inc. | Formulations |
US8309088B2 (en) | 2007-08-10 | 2012-11-13 | Regeneron Pharmaceuticals, Inc. | Method of treating osteoarthritis with an antibody to NGF |
PL2187964T3 (pl) * | 2007-08-10 | 2015-03-31 | Regeneron Pharma | Ludzkie przeciwciała o wysokim powinowactwie przeciw ludzkiemu czynnikowi wzrostu nerwu |
AU2008337100B2 (en) * | 2007-12-17 | 2013-02-28 | Pfizer Limited | Treatment of interstitial cystitis |
JP5719596B2 (ja) | 2008-02-04 | 2015-05-20 | レイ ライン ジェノミクス エッセ.ピ.ア.Lay Line Genomics S.P.A. | 抗体及びその誘導体 |
US20090286832A1 (en) * | 2008-05-15 | 2009-11-19 | Kiichiro Nabeta | Narcotic emulsion formulations for treatment of surgical pain |
CN102171339B (zh) | 2008-09-24 | 2017-06-09 | 力博美科股份有限公司 | 针对ngf的适体及其用途 |
CA2746220A1 (en) | 2008-12-08 | 2010-07-08 | Vm Pharma Llc | Compositions of protein receptor tyrosine kinase inhibitors |
UA104890C2 (uk) | 2009-05-04 | 2014-03-25 | Ебботт Рісерч Б.В. | Антитіла проти фактора росту нервів (фрн), що мають підвищену стабільність in vivo |
WO2011118682A1 (ja) | 2010-03-24 | 2011-09-29 | 株式会社リボミック | Ngfに対するアプタマー及びその使用 |
WO2012024650A2 (en) | 2010-08-19 | 2012-02-23 | Abbott Laboratories | Anti-ngf antibodies and their use |
JP6105838B2 (ja) * | 2010-08-24 | 2017-03-29 | 国立大学法人 岡山大学 | 疼痛の治療剤 |
US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
KR102025848B1 (ko) | 2010-12-01 | 2019-11-05 | 앨더바이오 홀딩스 엘엘씨 | 항―ngf 조성물 및 그의 용도 |
NZ717704A (en) | 2011-05-20 | 2022-08-26 | H Lundbeck As | Use of anti-cgrp or anti-cgrp-r antibodies or antibody fragments to treat or prevent chronic and acute forms of diarrhea |
HUE055505T2 (hu) | 2011-05-20 | 2021-11-29 | H Lundbeck As | Anti-CGRP készítmények és alkalmazásuk |
CA2836800A1 (en) | 2011-05-20 | 2012-11-29 | Alderbio Holdings Llc | Use of anti-cgrp antibodies and antibody fragments to prevent or inhibit photophobia or light aversion in subjects in need thereof, especially migraine sufferers |
WO2013009582A1 (en) | 2011-07-12 | 2013-01-17 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
US20130295170A1 (en) * | 2012-05-03 | 2013-11-07 | Kydes Pharmaceuticals Llc | Compositions for control of drug abuse |
WO2013176970A1 (en) | 2012-05-22 | 2013-11-28 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
AU2013271564A1 (en) | 2012-06-06 | 2014-12-04 | Zoetis Services Llc | Caninized anti-NGF antibodies and methods thereof |
US8999992B2 (en) | 2013-03-15 | 2015-04-07 | Vm Pharma Llc | Crystalline forms of tryosine kinase inhibitors and their salts |
US20170114122A1 (en) | 2015-10-23 | 2017-04-27 | Alderbio Holdings Llc | Regulation of glucose metabolism using anti-cgrp antibodies |
WO2015039334A1 (en) | 2013-09-22 | 2015-03-26 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
WO2015039333A1 (en) | 2013-09-22 | 2015-03-26 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
SMT202100441T1 (it) | 2014-02-05 | 2021-09-14 | VM Oncology LLC | Composizioni di composti e loro usi |
WO2015143653A1 (en) | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
WO2015143652A1 (en) | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
WO2015143654A1 (en) | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
JP2017529356A (ja) | 2014-09-17 | 2017-10-05 | ムンディファーマ インターナショナル コーポレイション リミテッド | チロシンキナーゼ阻害剤及びその塩の結晶形態 |
WO2016161572A1 (en) | 2015-04-08 | 2016-10-13 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
CN105944084B (zh) * | 2016-05-19 | 2024-05-03 | 丽珠集团丽珠制药厂 | 一种神经生长因子组合物及其制备方法 |
BR112020017701A2 (pt) | 2018-03-12 | 2020-12-29 | Zoetis Services Llc | Anticorpos anti-ngf e métodos dos mesmos |
EP3796929B1 (en) * | 2018-05-21 | 2024-09-18 | Ipsen Biopharm Limited | Suppression of bone cancer-induced allodynia |
PH12021551478A1 (en) | 2019-01-08 | 2022-05-02 | H Lundbeck As | Acute treatment and rapid treatment of headache using anti-cgrp antibodies |
Family Cites Families (108)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
SU975016A1 (ru) * | 1979-12-17 | 1982-11-23 | Московский научно-исследовательский онкологический институт им.П.А.Герцена | Болеутол ющее средство |
US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
US4754065A (en) * | 1984-12-18 | 1988-06-28 | Cetus Corporation | Precursor to nucleic acid probe |
US4683202A (en) * | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4683195A (en) * | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4676980A (en) * | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
US4777127A (en) | 1985-09-30 | 1988-10-11 | Labsystems Oy | Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
US4800159A (en) * | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
US6548640B1 (en) * | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
GB8702816D0 (en) | 1987-02-07 | 1987-03-11 | Al Sumidaie A M K | Obtaining retrovirus-containing fraction |
US5219740A (en) * | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
WO1989009225A1 (en) | 1988-03-28 | 1989-10-05 | The Regents Of The University Of California | Nerve growth factor peptides |
US5422120A (en) | 1988-05-30 | 1995-06-06 | Depotech Corporation | Heterovesicular liposomes |
AP129A (en) | 1988-06-03 | 1991-04-17 | Smithkline Biologicals S A | Expression of retrovirus gag protein eukaryotic cells |
US5047335A (en) * | 1988-12-21 | 1991-09-10 | The Regents Of The University Of Calif. | Process for controlling intracellular glycosylation of proteins |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
JP2752788B2 (ja) | 1989-01-23 | 1998-05-18 | カイロン コーポレイション | 感染および過剰増殖障害の為の組換え療法 |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US6673776B1 (en) | 1989-03-21 | 2004-01-06 | Vical Incorporated | Expression of exogenous polynucleotide sequences in a vertebrate, mammal, fish, bird or human |
ES2116269T3 (es) | 1989-03-21 | 1998-07-16 | Vical Inc | Expresion de secuencias exogenas de polinucleotidos en un vertebrado. |
AU648261B2 (en) | 1989-08-18 | 1994-04-21 | Novartis Vaccines And Diagnostics, Inc. | Recombinant retroviruses delivering vector constructs to target cells |
US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
US5656435A (en) * | 1989-08-28 | 1997-08-12 | Takeda Chemical Industries, Ltd. | Antibodies to peptides having NGF-like activity, said antibodies having no substantial cross-reactivity with NGF, and use thereof |
US5013556A (en) * | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
NZ237464A (en) | 1990-03-21 | 1995-02-24 | Depotech Corp | Liposomes with at least two separate chambers encapsulating two separate biologically active substances |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
US5147294A (en) * | 1990-10-01 | 1992-09-15 | Trustees Of Boston University | Therapeutic method for reducing chronic pain in a living subject |
FR2669336B1 (fr) * | 1990-11-20 | 1993-01-22 | Adir | Nouveaux derives d'oxazolo pyridines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
US5278299A (en) * | 1991-03-18 | 1994-01-11 | Scripps Clinic And Research Foundation | Method and composition for synthesizing sialylated glycosyl compounds |
DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
GB9115364D0 (en) | 1991-07-16 | 1991-08-28 | Wellcome Found | Antibody |
AU663725B2 (en) | 1991-08-20 | 1995-10-19 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Adenovirus mediated transfer of genes to the gastrointestinal tract |
CA2078539C (en) | 1991-09-18 | 2005-08-02 | Kenya Shitara | Process for producing humanized chimera antibody |
US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
CA2119930C (en) | 1991-09-23 | 2002-10-01 | Hendricus R. J. M. Hoogenboom | Production of chimeric antibodies - a combinatorial approach |
WO1993010218A1 (en) | 1991-11-14 | 1993-05-27 | The United States Government As Represented By The Secretary Of The Department Of Health And Human Services | Vectors including foreign genes and negative selective markers |
GB9125623D0 (en) | 1991-12-02 | 1992-01-29 | Dynal As | Cell modification |
US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
FR2688514A1 (fr) | 1992-03-16 | 1993-09-17 | Centre Nat Rech Scient | Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant. |
US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
EP0650370A4 (en) | 1992-06-08 | 1995-11-22 | Univ California | METHODS AND COMPOSITIONS TARGETED ON SPECIFIC TISSUES. |
US5342942A (en) * | 1992-06-09 | 1994-08-30 | Warner-Lambert Company | Pyrazoloquinazolone derivatives as neurotrophic agents |
CA2137361A1 (en) | 1992-06-10 | 1993-12-23 | W. French Anderson | Vector particles resistant to inactivation by human serum |
GB2269175A (en) | 1992-07-31 | 1994-02-02 | Imperial College | Retroviral vectors |
US6210671B1 (en) | 1992-12-01 | 2001-04-03 | Protein Design Labs, Inc. | Humanized antibodies reactive with L-selectin |
EP0905253A3 (en) | 1992-12-03 | 2000-11-02 | Genzyme Corporation | Adenoviral vector deleted of all E4-ORF except ORF6 |
US5604260A (en) * | 1992-12-11 | 1997-02-18 | Merck Frosst Canada Inc. | 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2 |
US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5409944A (en) * | 1993-03-12 | 1995-04-25 | Merck Frosst Canada, Inc. | Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase |
DE69431750T2 (de) | 1993-04-22 | 2003-04-03 | Skyepharma Inc., San Diego | Multivesikuläre liposomen mit verkapseltem cyclodextrin und pharmakologisch wirksamen verbindungen sowie verfahren zu deren verwendung |
US6180377B1 (en) | 1993-06-16 | 2001-01-30 | Celltech Therapeutics Limited | Humanized antibodies |
AU687829B2 (en) | 1993-06-24 | 1998-03-05 | Advec, Inc. | Adenovirus vectors for gene therapy |
US6015686A (en) | 1993-09-15 | 2000-01-18 | Chiron Viagene, Inc. | Eukaryotic layered vector initiation systems |
JPH09503657A (ja) | 1993-09-15 | 1997-04-15 | チロン ビアジーン インコーポレイティド | 組換えアルファウイルスベクター |
CA2173975C (en) | 1993-10-25 | 2007-06-12 | Richard J. Gregory | Recombinant adenoviral vector and methods of use |
NZ276305A (en) | 1993-11-16 | 1997-10-24 | Depotech Corp | Controlled release vesicle compositions |
EP0730646A1 (en) | 1993-11-23 | 1996-09-11 | Genentech, Inc. | PROTEIN TYROSINE KINASES NAMED Rse |
AU698975B2 (en) | 1993-11-23 | 1998-11-12 | Genentech Inc. | Kinase receptor activation assay |
GB9402331D0 (en) | 1994-02-07 | 1994-03-30 | Univ Mcgill | Nerve growth factor structural analogs and their uses |
US5877016A (en) | 1994-03-18 | 1999-03-02 | Genentech, Inc. | Human trk receptors and neurotrophic factor inhibitors |
US5844092A (en) | 1994-03-18 | 1998-12-01 | Genentech, Inc. | Human TRK receptors and neurotrophic factor inhibitors |
US6436908B1 (en) | 1995-05-30 | 2002-08-20 | Duke University | Use of exogenous β-adrenergic receptor and β-adrenergic receptor kinase gene constructs to enhance myocardial function |
CA2158977A1 (en) | 1994-05-09 | 1995-11-10 | James G. Respess | Retroviral vectors having a reduced recombination rate |
US6291247B1 (en) | 1994-05-11 | 2001-09-18 | Queen's University At Kingston | Methods of screening for factors that disrupt neurotrophin conformation and reduce neurotrophin biological activity |
GB9514160D0 (en) * | 1994-07-25 | 1995-09-13 | Zeneca Ltd | Aromatic compounds |
WO1996017072A2 (en) | 1994-11-30 | 1996-06-06 | Chiron Viagene, Inc. | Recombinant alphavirus vectors |
US6265150B1 (en) | 1995-06-07 | 2001-07-24 | Becton Dickinson & Company | Phage antibodies |
AU3695295A (en) | 1995-10-25 | 1997-05-15 | Queen's University At Kingston | Neurotrophin antagonists |
GB9525180D0 (en) | 1995-12-08 | 1996-02-07 | Univ Mcgill | Design of hormone-like antibodies with agonistic and antagonistic fuctions |
DE69739286D1 (de) | 1996-05-06 | 2009-04-16 | Oxford Biomedica Ltd | Rekombinationsunfähige retrovirale vektoren |
UA67725C2 (en) | 1996-06-03 | 2004-07-15 | Cephalon Inc | K-252a derivatives and a method for improvement of functioning and cell survival enhancement |
GB9616105D0 (en) | 1996-07-31 | 1996-09-11 | Univ Kingston | TrkA binding site of NGF |
ES2257768T3 (es) | 1996-10-21 | 2006-08-01 | Nps Allelix Corp. | Antagonistas de neurotropina para el tratamiento de epilepsia, enfermedad de alzheimer y el dolor. |
US6284794B1 (en) * | 1996-11-05 | 2001-09-04 | Head Explorer Aps | Method for treating tension-type headache with inhibitors of nitric oxide and nitric oxide synthase |
DE19732928C2 (de) | 1997-07-31 | 2000-05-18 | Gruenenthal Gmbh | Verwendung substituierter Imidazolidin-2,4-dion-Verbindungen als Schmerzmittel |
AU9692198A (en) | 1997-10-10 | 1999-05-03 | Kevin J. Donahue | Gene delivery compositions and methods |
GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
US6127401A (en) | 1998-06-05 | 2000-10-03 | Cephalon, Inc. | Bridged indenopyrrolocarbazoles |
US6652864B1 (en) | 1998-12-21 | 2003-11-25 | Asilomar Pharmaceuticals, Inc. | Compounds for intracellular delivery of therapeutic moieties to nerve cells |
AU3734900A (en) | 1999-03-09 | 2000-09-28 | University Of Southern California | Method of promoting myocyte proliferation and myocardial tissue repair |
US6468990B1 (en) | 1999-05-17 | 2002-10-22 | Queen's University At Kingston | Method of inhibiting binding of nerve growth factor to p75 NTR receptor |
US6492380B1 (en) * | 1999-05-17 | 2002-12-10 | Queen's University At Kingston | Method of inhibiting neurotrophin-receptor binding |
IT1306704B1 (it) | 1999-05-26 | 2001-10-02 | Sirs Societa Italiana Per La R | Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. |
US6399780B1 (en) * | 1999-08-20 | 2002-06-04 | Cephalon, Inc. | Isomeric fused pyrrolocarbazoles and isoindolones |
US6849425B1 (en) | 1999-10-14 | 2005-02-01 | Ixsys, Inc. | Methods of optimizing antibody variable region binding affinity |
US6548062B2 (en) * | 2000-02-29 | 2003-04-15 | Cephalon, Inc. | Method of treating cancer with anti-neurotrophin agents |
FR2807660A1 (fr) * | 2000-04-13 | 2001-10-19 | Warner Lambert Co | Utilisation d'antagonistes du ngf pour la prevention ou le traitement de douleurs viscerales chroniques |
US7022484B2 (en) * | 2000-06-08 | 2006-04-04 | Board Of Regents, The University Of Texas System | Methods for treating neuropathological states and neurogenic inflammatory states and methods for identifying compounds useful therein |
GB0020504D0 (en) | 2000-08-18 | 2000-10-11 | Univ Bristol | Therapeutic method |
US6630500B2 (en) | 2000-08-25 | 2003-10-07 | Cephalon, Inc. | Selected fused pyrrolocarbazoles |
AU2001288374A1 (en) | 2000-09-01 | 2002-03-22 | Glaxo Group Limited | Substituted oxindole derivatives as tyrosine kinase inhibitors |
MXPA03010911A (es) | 2001-05-30 | 2004-02-17 | Genentech Inc | Anticuerpos contra ngf para el tratamiento de varios desordenes. |
US20030008807A1 (en) * | 2001-06-14 | 2003-01-09 | The Regents Of The University Of California | Novel signaling pathway for the production of inflammatory pain and neuropathy |
WO2003022261A1 (en) * | 2001-09-13 | 2003-03-20 | Miller Kenneth E | Method of alleviating pain |
US20040038874A1 (en) * | 2002-08-22 | 2004-02-26 | Osemwota Omoigui | Method of treatment of persistent pain |
US6919426B2 (en) * | 2002-09-19 | 2005-07-19 | Amgen Inc. | Peptides and related molecules that modulate nerve growth factor activity |
BR0315164A (pt) * | 2002-10-08 | 2005-08-23 | Rinat Neuroscience Corp | Métodos para tratar dor pós-cirúrgica administrando um antagonista de fator de crescimento nervoso e composições contendo o mesmo |
AU2003299898B2 (en) * | 2002-12-24 | 2010-12-16 | Rinat Neuroscience Corp. | Anti-NGF antibodies and methods using same |
WO2004073653A2 (en) * | 2003-02-19 | 2004-09-02 | Rinat Neuroscience Corp. | Methods for treating pain by administering a nerve growth factor antagonist and an nsaid and compositions containing the same |
NZ599196A (en) * | 2003-07-15 | 2014-01-31 | Amgen Inc | Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors |
PL1732949T3 (pl) * | 2004-04-07 | 2010-06-30 | Rinat Neuroscience Corp | Sposoby leczenia nowotworowego bólu kości przez podawanie antagonisty czynnika wzrostu nerwów |
-
2003
- 2003-08-10 UA UAA200504332A patent/UA80447C2/uk unknown
- 2003-10-08 ES ES03816571T patent/ES2326881T3/es not_active Expired - Lifetime
- 2003-10-08 RU RU2005113996/14A patent/RU2005113996A/ru not_active Application Discontinuation
- 2003-10-08 DE DE60328128T patent/DE60328128D1/de not_active Expired - Lifetime
- 2003-10-08 CA CA002501694A patent/CA2501694A1/en not_active Abandoned
- 2003-10-08 EP EP09163527.6A patent/EP2100902B1/en not_active Revoked
- 2003-10-08 CN CN2003801053379A patent/CN1878794B/zh not_active Expired - Lifetime
- 2003-10-08 ES ES09163527T patent/ES2767744T3/es not_active Expired - Lifetime
- 2003-10-08 EP EP03816571A patent/EP1575522B1/en not_active Revoked
- 2003-10-08 MX MXPA05003501A patent/MXPA05003501A/es not_active Application Discontinuation
- 2003-10-08 AT AT03816571T patent/ATE434625T1/de not_active IP Right Cessation
- 2003-10-08 AU AU2003304060A patent/AU2003304060A1/en not_active Abandoned
- 2003-10-08 US US10/682,332 patent/US20040131615A1/en not_active Abandoned
- 2003-10-08 PL PL379989A patent/PL379989A1/pl not_active Application Discontinuation
- 2003-10-08 BR BR0315167-0A patent/BR0315167A/pt not_active IP Right Cessation
- 2003-10-08 WO PCT/US2003/032113 patent/WO2004096122A2/en active Search and Examination
- 2003-10-08 JP JP2004571457A patent/JP2006517524A/ja not_active Withdrawn
- 2003-10-08 KR KR1020057006105A patent/KR20050067174A/ko not_active Application Discontinuation
-
2005
- 2005-03-31 ZA ZA200502611A patent/ZA200502611B/en unknown
- 2005-05-06 NO NO20052221A patent/NO20052221L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2004096122A3 (en) | 2006-06-01 |
CN1878794B (zh) | 2011-11-30 |
DE60328128D1 (de) | 2009-08-06 |
EP1575522A2 (en) | 2005-09-21 |
CN1878794A (zh) | 2006-12-13 |
MXPA05003501A (es) | 2005-10-19 |
EP1575522B1 (en) | 2009-06-24 |
ES2326881T3 (es) | 2009-10-21 |
EP2100902B1 (en) | 2019-12-18 |
KR20050067174A (ko) | 2005-06-30 |
UA80447C2 (en) | 2007-09-25 |
ZA200502611B (en) | 2006-06-28 |
JP2006517524A (ja) | 2006-07-27 |
US20040131615A1 (en) | 2004-07-08 |
RU2005113996A (ru) | 2005-10-27 |
ES2767744T3 (es) | 2020-06-18 |
BR0315167A (pt) | 2005-08-23 |
CA2501694A1 (en) | 2004-11-11 |
NO20052221D0 (no) | 2005-05-06 |
AU2003304060A1 (en) | 2004-11-23 |
EP2100902A1 (en) | 2009-09-16 |
NO20052221L (no) | 2005-07-07 |
WO2004096122A2 (en) | 2004-11-11 |
EP1575522A4 (en) | 2007-05-30 |
ATE434625T1 (de) | 2009-07-15 |
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