RU2005113996A - Способы лечения боли введением антагониста фактора роста нервов и опиоидного анальгетика, и содержащие их композиции - Google Patents
Способы лечения боли введением антагониста фактора роста нервов и опиоидного анальгетика, и содержащие их композиции Download PDFInfo
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- RU2005113996A RU2005113996A RU2005113996/14A RU2005113996A RU2005113996A RU 2005113996 A RU2005113996 A RU 2005113996A RU 2005113996/14 A RU2005113996/14 A RU 2005113996/14A RU 2005113996 A RU2005113996 A RU 2005113996A RU 2005113996 A RU2005113996 A RU 2005113996A
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- Prior art keywords
- ngf
- antagonist
- pain
- opioid analgesic
- antibody
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 13
- 208000002193 Pain Diseases 0.000 title claims abstract 10
- 239000005557 antagonist Substances 0.000 title claims abstract 10
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000000202 analgesic effect Effects 0.000 title 1
- 239000003102 growth factor Substances 0.000 title 1
- 229940122467 Nerve growth factor antagonist Drugs 0.000 claims abstract 10
- 102000015336 Nerve Growth Factor Human genes 0.000 claims abstract 9
- 108010025020 Nerve Growth Factor Proteins 0.000 claims abstract 9
- 239000000014 opioid analgesic Substances 0.000 claims abstract 8
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 4
- 101001111439 Homo sapiens Beta-nerve growth factor Proteins 0.000 claims 2
- 208000004550 Postoperative Pain Diseases 0.000 claims 2
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims 2
- XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 claims 2
- 102000046917 human NGF Human genes 0.000 claims 2
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims 2
- 229960005181 morphine Drugs 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 claims 1
- JAQUASYNZVUNQP-USXIJHARSA-N Levorphanol Chemical compound C1C2=CC=C(O)C=C2[C@]23CCN(C)[C@H]1[C@@H]2CCCC3 JAQUASYNZVUNQP-USXIJHARSA-N 0.000 claims 1
- IDBPHNDTYPBSNI-UHFFFAOYSA-N N-(1-(2-(4-Ethyl-5-oxo-2-tetrazolin-1-yl)ethyl)-4-(methoxymethyl)-4-piperidyl)propionanilide Chemical compound C1CN(CCN2C(N(CC)N=N2)=O)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 IDBPHNDTYPBSNI-UHFFFAOYSA-N 0.000 claims 1
- UQCNKQCJZOAFTQ-ISWURRPUSA-N Oxymorphone Chemical compound O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O UQCNKQCJZOAFTQ-ISWURRPUSA-N 0.000 claims 1
- 229960001391 alfentanil Drugs 0.000 claims 1
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 claims 1
- 229960001736 buprenorphine Drugs 0.000 claims 1
- IFKLAQQSCNILHL-QHAWAJNXSA-N butorphanol Chemical compound N1([C@@H]2CC3=CC=C(C=C3[C@@]3([C@]2(CCCC3)O)CC1)O)CC1CCC1 IFKLAQQSCNILHL-QHAWAJNXSA-N 0.000 claims 1
- 229960001113 butorphanol Drugs 0.000 claims 1
- 229960004126 codeine Drugs 0.000 claims 1
- 229960002069 diamorphine Drugs 0.000 claims 1
- RBOXVHNMENFORY-DNJOTXNNSA-N dihydrocodeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC RBOXVHNMENFORY-DNJOTXNNSA-N 0.000 claims 1
- 229960000920 dihydrocodeine Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960002428 fentanyl Drugs 0.000 claims 1
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims 1
- LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 claims 1
- 229960000240 hydrocodone Drugs 0.000 claims 1
- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 claims 1
- 229960001410 hydromorphone Drugs 0.000 claims 1
- 229960003406 levorphanol Drugs 0.000 claims 1
- 229960005118 oxymorphone Drugs 0.000 claims 1
- VOKSWYLNZZRQPF-GDIGMMSISA-N pentazocine Chemical compound C1C2=CC=C(O)C=C2[C@@]2(C)[C@@H](C)[C@@H]1N(CC=C(C)C)CC2 VOKSWYLNZZRQPF-GDIGMMSISA-N 0.000 claims 1
- 229960005301 pentazocine Drugs 0.000 claims 1
- GGCSSNBKKAUURC-UHFFFAOYSA-N sufentanil Chemical compound C1CN(CCC=2SC=CC=2)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 GGCSSNBKKAUURC-UHFFFAOYSA-N 0.000 claims 1
- 229960004739 sufentanil Drugs 0.000 claims 1
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 claims 1
- 229940053128 nerve growth factor Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (14)
1. Способ лечения боли у индивидуума, включающий введение индивидууму такого количества антагониста фактора роста нервов (NGF), и такого количества опиоидного анальгетика, при которых антагонист NGF и опиоидный анальгетик в сочетании обеспечивают эффективное облегчение боли.
2. Способ по п.1, где опиоидный анальгетик выбран из группы, состоящей из морфина, кодеина, дигидрокодеина, диацетилморфина, гидрокодона, гидроморфона, леворфанола, оксиморфона, алфентанила, бупренорфина, буторфанола, фентанила, суфентанила, меперидина, метадона, налбуфина, пропоксифена и пентазоцина.
3. Способ по п.2, где опиоидный анальгетик представляет собой морфин.
4. Способ по п.1, где антагонист NGF представляет собой антитело против NGF.
5. Способ по п.3, где антагонист NGF представляет собой антитело против NGF.
6. Способ по п.п.4 или 5, где антитело против NGF связывает человеческий NGF.
7. Способ по п.6, где антитело против NGF связывает человеческий NGF при аффинитете связывания приблизительно 10 нМ или менее, чем приблизительно 10 нМ.
8. Способ по п.5, где антитело против NGF представляет собой человеческое антитело.
9. Способ по п.5, где антитело против NGF представляет собой гуманизированное антитело.
10. Способ по п.1, где боль представляет собой послеоперационную боль.
11. Способ по п.4, где боль представляет собой послеоперационную боль.
12. Фармацевтическая композиция для применения при лечении боли, содержащая антагонист NGF и фармацевтически приемлемый носитель, причем указанное применение включает одновременное или последовательное введение опиоидного анальгетика.
13. Фармацевтическая композиция по п.12, где антагонист NGF представляет собой антитело против NGF.
14. Набор для лечения боли, содержащий антагонист NGF и инструкции по введению антагониста NGF и опиоидного анальгетика одновременно или последовательно для эффективного лечения боли.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41734702P | 2002-10-08 | 2002-10-08 | |
| US60/417,347 | 2002-10-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2005113996A true RU2005113996A (ru) | 2005-10-27 |
Family
ID=33415832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005113996/14A RU2005113996A (ru) | 2002-10-08 | 2003-10-08 | Способы лечения боли введением антагониста фактора роста нервов и опиоидного анальгетика, и содержащие их композиции |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20040131615A1 (ru) |
| EP (2) | EP1575522B1 (ru) |
| JP (1) | JP2006517524A (ru) |
| KR (1) | KR20050067174A (ru) |
| CN (1) | CN1878794B (ru) |
| AT (1) | ATE434625T1 (ru) |
| AU (1) | AU2003304060A1 (ru) |
| BR (1) | BR0315167A (ru) |
| CA (1) | CA2501694A1 (ru) |
| DE (1) | DE60328128D1 (ru) |
| ES (2) | ES2767744T3 (ru) |
| MX (1) | MXPA05003501A (ru) |
| NO (1) | NO20052221L (ru) |
| PL (1) | PL379989A1 (ru) |
| RU (1) | RU2005113996A (ru) |
| UA (1) | UA80447C2 (ru) |
| WO (1) | WO2004096122A2 (ru) |
| ZA (1) | ZA200502611B (ru) |
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| US20060147450A1 (en) * | 2002-10-04 | 2006-07-06 | Shelton David L | Methods for treating cardiac arrhythmia and preventing death due to cardiac arrhythmia using ngf antagonists |
| WO2005000194A2 (en) * | 2002-10-08 | 2005-01-06 | Rinat Neuroscience Corp. | Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody and compositions containing the same |
| ZA200502612B (en) | 2002-10-08 | 2007-07-25 | Rinat Neuroscience Corp | Methods for treating post-surgical pain by administering a nerve crowth factor antagonist and compositions containing the same |
| ES2382918T3 (es) | 2002-12-24 | 2012-06-14 | Rinat Neuroscience Corp. | Anticuerpos anti-NGF y procedimientos que usan los mismos |
| US9498530B2 (en) | 2002-12-24 | 2016-11-22 | Rinat Neuroscience Corp. | Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same |
| AU2011201157C1 (en) * | 2002-12-24 | 2017-09-07 | Rinat Neuroscience Corp. | Anti-NGF antibodies and methods using same |
| US7569364B2 (en) * | 2002-12-24 | 2009-08-04 | Pfizer Inc. | Anti-NGF antibodies and methods using same |
| MXPA05008815A (es) | 2003-02-19 | 2006-05-25 | Rinat Neuroscience Corp | Metodos para tratar el dolor al administrar un antagonista del factor de crecimiento de nervios y un farmaco antiinflamatorio no esteroidal y composiciones que contienen los mismos. |
| ITRM20030601A1 (it) | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
| KR101504729B1 (ko) | 2004-04-07 | 2015-03-19 | 리나트 뉴로사이언스 코프. | 신경성장인자 길항제의 투여에 의한 골암 통증 치료용 약학적 조성물 |
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| ITRM20050332A1 (it) * | 2005-06-24 | 2006-12-25 | Lay Line Genomics Spa | Uso di molecole in grado di bloccare l'attivita' di trka per potenziare gli effetti di analgesici oppiacei sul dolore. |
| CA2862540C (en) | 2005-09-21 | 2018-07-31 | The Regents Of The University Of California | Systems, compositions, and methods for local imaging and treatment of pain |
| EP2129401B8 (en) * | 2006-12-21 | 2020-01-15 | Amgen Inc. | Stable buffered formulations containing polypeptides |
| PL2187964T3 (pl) * | 2007-08-10 | 2015-03-31 | Regeneron Pharma | Ludzkie przeciwciała o wysokim powinowactwie przeciw ludzkiemu czynnikowi wzrostu nerwu |
| US8309088B2 (en) | 2007-08-10 | 2012-11-13 | Regeneron Pharmaceuticals, Inc. | Method of treating osteoarthritis with an antibody to NGF |
| BRPI0822049B1 (pt) * | 2007-12-17 | 2021-11-16 | Pfizer Limited | Composiqao farmaceutica compreendendo anticorpo antagonista anti-ngf, kit e uso de um anticorpo antingf |
| AP2929A (en) | 2008-02-04 | 2014-06-30 | Lay Line Genomics Spa | Anti-TRKA antibodies and derivatives thereof |
| US20090286832A1 (en) * | 2008-05-15 | 2009-11-19 | Kiichiro Nabeta | Narcotic emulsion formulations for treatment of surgical pain |
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| WO2016161572A1 (en) | 2015-04-08 | 2016-10-13 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF |
| CN105944084B (zh) * | 2016-05-19 | 2024-05-03 | 丽珠集团丽珠制药厂 | 一种神经生长因子组合物及其制备方法 |
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| JP2021525251A (ja) * | 2018-05-21 | 2021-09-24 | イプセン バイオファーム リミテッドＩｐｓｅｎ Ｂｉｏｐｈａｒｍ Ｌｉｍｉｔｅｄ | 骨癌誘発性アロディニアの抑制 |
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- 2003-08-10 UA UAA200504332A patent/UA80447C2/uk unknown
- 2003-10-08 AU AU2003304060A patent/AU2003304060A1/en not_active Abandoned
- 2003-10-08 AT AT03816571T patent/ATE434625T1/de not_active IP Right Cessation
- 2003-10-08 ES ES09163527T patent/ES2767744T3/es not_active Expired - Lifetime
- 2003-10-08 BR BR0315167-0A patent/BR0315167A/pt not_active IP Right Cessation
- 2003-10-08 KR KR1020057006105A patent/KR20050067174A/ko not_active Ceased
- 2003-10-08 JP JP2004571457A patent/JP2006517524A/ja not_active Withdrawn
- 2003-10-08 CA CA002501694A patent/CA2501694A1/en not_active Abandoned
- 2003-10-08 MX MXPA05003501A patent/MXPA05003501A/es not_active Application Discontinuation
- 2003-10-08 EP EP03816571A patent/EP1575522B1/en not_active Revoked
- 2003-10-08 PL PL379989A patent/PL379989A1/pl not_active Application Discontinuation
- 2003-10-08 CN CN2003801053379A patent/CN1878794B/zh not_active Expired - Lifetime
- 2003-10-08 US US10/682,332 patent/US20040131615A1/en not_active Abandoned
- 2003-10-08 ES ES03816571T patent/ES2326881T3/es not_active Expired - Lifetime
- 2003-10-08 WO PCT/US2003/032113 patent/WO2004096122A2/en active Search and Examination
- 2003-10-08 EP EP09163527.6A patent/EP2100902B1/en not_active Revoked
- 2003-10-08 DE DE60328128T patent/DE60328128D1/de not_active Expired - Lifetime
- 2003-10-08 RU RU2005113996/14A patent/RU2005113996A/ru not_active Application Discontinuation
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Also Published As
| Publication number | Publication date |
|---|---|
| UA80447C2 (en) | 2007-09-25 |
| CA2501694A1 (en) | 2004-11-11 |
| ES2767744T3 (es) | 2020-06-18 |
| EP2100902A1 (en) | 2009-09-16 |
| BR0315167A (pt) | 2005-08-23 |
| CN1878794B (zh) | 2011-11-30 |
| NO20052221L (no) | 2005-07-07 |
| AU2003304060A1 (en) | 2004-11-23 |
| ES2326881T3 (es) | 2009-10-21 |
| US20040131615A1 (en) | 2004-07-08 |
| DE60328128D1 (de) | 2009-08-06 |
| EP2100902B1 (en) | 2019-12-18 |
| MXPA05003501A (es) | 2005-10-19 |
| WO2004096122A2 (en) | 2004-11-11 |
| ATE434625T1 (de) | 2009-07-15 |
| PL379989A1 (pl) | 2006-11-27 |
| JP2006517524A (ja) | 2006-07-27 |
| ZA200502611B (en) | 2006-06-28 |
| NO20052221D0 (no) | 2005-05-06 |
| EP1575522A2 (en) | 2005-09-21 |
| EP1575522B1 (en) | 2009-06-24 |
| KR20050067174A (ko) | 2005-06-30 |
| EP1575522A4 (en) | 2007-05-30 |
| WO2004096122A3 (en) | 2006-06-01 |
| CN1878794A (zh) | 2006-12-13 |
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