PL371593A1 - Sposób wytwarzania leków w formie homogenicznych,suszonych rozpyłowo, stałych, bezpostaciowych dyspersji z zastosowaniem dysz ciśnieniowych - Google Patents
Sposób wytwarzania leków w formie homogenicznych,suszonych rozpyłowo, stałych, bezpostaciowych dyspersji z zastosowaniem dysz ciśnieniowychInfo
- Publication number
- PL371593A1 PL371593A1 PL03371593A PL37159303A PL371593A1 PL 371593 A1 PL371593 A1 PL 371593A1 PL 03371593 A PL03371593 A PL 03371593A PL 37159303 A PL37159303 A PL 37159303A PL 371593 A1 PL371593 A1 PL 371593A1
- Authority
- PL
- Poland
- Prior art keywords
- dried solid
- pressure nozzles
- solid amorphous
- amorphous drug
- homogeneous spray
- Prior art date
Links
- 239000006185 dispersion Substances 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000007787 solid Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Glanulating (AREA)
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Disintegrating Or Milling (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35398602P | 2002-02-01 | 2002-02-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL371593A1 true PL371593A1 (pl) | 2005-06-27 |
Family
ID=27663274
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL03371593A PL371593A1 (pl) | 2002-02-01 | 2003-01-20 | Sposób wytwarzania leków w formie homogenicznych,suszonych rozpyłowo, stałych, bezpostaciowych dyspersji z zastosowaniem dysz ciśnieniowych |
Country Status (20)
Country | Link |
---|---|
US (1) | US7780988B2 (pl) |
EP (1) | EP1469830A2 (pl) |
JP (1) | JP2005523260A (pl) |
KR (1) | KR100758045B1 (pl) |
CN (1) | CN1787808A (pl) |
AR (1) | AR038369A1 (pl) |
AU (1) | AU2003239463B2 (pl) |
BR (1) | BR0307515A (pl) |
CA (1) | CA2474958A1 (pl) |
GT (1) | GT200300024A (pl) |
MX (1) | MXPA04007435A (pl) |
PA (1) | PA8565401A1 (pl) |
PE (1) | PE20030804A1 (pl) |
PL (1) | PL371593A1 (pl) |
RS (1) | RS67304A (pl) |
RU (1) | RU2288703C2 (pl) |
TW (1) | TW200404576A (pl) |
UY (1) | UY27645A1 (pl) |
WO (1) | WO2003063821A2 (pl) |
ZA (1) | ZA200405971B (pl) |
Families Citing this family (63)
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DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
CN1787808A (zh) | 2002-02-01 | 2006-06-14 | 辉瑞产品公司 | 应用压力喷嘴制备均匀的喷雾干燥固态无定形药物分散体的方法 |
CA2472028C (en) | 2002-02-01 | 2010-03-30 | Pfizer Products Inc. | Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus |
CL2004001884A1 (es) | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
CA2560984A1 (en) | 2004-06-01 | 2005-12-15 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Process for preparation of amorphous form of a drug |
DK2502911T3 (en) | 2004-06-24 | 2017-06-06 | Vertex Pharma | Modulators of ATP-binding cassette transporters |
EP1817315A1 (en) | 2004-12-01 | 2007-08-15 | Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság | Processes for producing crystalline macrolides |
US9265731B2 (en) | 2005-01-28 | 2016-02-23 | Bend Research, Inc. | Drying of drug-containing particles |
US20100047338A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
CN101272769B (zh) | 2005-07-28 | 2013-04-24 | Isp投资有限公司 | 生物利用度提高的苯醌类化合物 |
CN101304970A (zh) * | 2005-12-21 | 2008-11-12 | 卫材R&D管理有限公司 | 1,2-二氢吡啶化合物的无定形物 |
LT1993360T (lt) | 2005-12-28 | 2017-06-12 | Vertex Pharmaceuticals Incorporated | N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma |
BRPI0707584A2 (pt) | 2006-02-09 | 2011-05-10 | Merck & Co Inc | composiÇço farmacÊutica, uso da composiÇço farmacÊutica, e, formulaÇço farmacÊutica |
MX2008015686A (es) | 2006-06-06 | 2009-01-12 | Tibotec Pharm Ltd | Procedimiento para preparar formulaciones secadas por aspersion de etravirina. |
US8834929B2 (en) | 2006-07-21 | 2014-09-16 | Bend Research, Inc. | Drying of drug-containing particles |
US8613946B2 (en) | 2006-12-21 | 2013-12-24 | Isp Investment Inc. | Carotenoids of enhanced bioavailability |
US10189957B2 (en) | 2007-01-26 | 2019-01-29 | Isp Investments Llc | Formulation process method to produce spray dried products |
EP2093225A1 (en) | 2007-05-01 | 2009-08-26 | Plus Chemicals B.V. | Process for preparing crystalline eletriptan hydrobromide form ß |
WO2010091306A1 (en) | 2009-02-05 | 2010-08-12 | Tokai Pharmaceuticals | Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens |
RU2543714C2 (ru) | 2009-03-20 | 2015-03-10 | Вертекс Фармасьютикалз Инкорпорейтед | Способ получения модуляторов регулятора трансмембранной проводимости кистозного фиброза |
WO2010111132A2 (en) | 2009-03-27 | 2010-09-30 | Bend Research, Inc. | Spray-drying process |
EP2813220A3 (en) | 2010-04-09 | 2015-06-17 | Pacira Pharmaceuticals, Inc. | Method for formulating large diameter synthetic membrane vesicles |
UA108886C2 (ru) | 2010-06-09 | 2015-06-25 | Еббві Бахамаз Лтд. | Твердые дисперсии, содержащие ингибиторы киназ |
WO2011163090A1 (en) | 2010-06-23 | 2011-12-29 | Metabolex, Inc. | Compositions of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
EP2611529B1 (en) | 2010-09-03 | 2019-01-23 | Bend Research, Inc. | Spray-drying method |
PT2611530T (pt) | 2010-09-03 | 2019-05-09 | Bend Res Inc | Aparelho de secagem por pulverização e métodos de utilização do mesmo |
WO2012040502A1 (en) | 2010-09-24 | 2012-03-29 | Bend Research, Inc. | High-temperature spray drying process and apparatus |
AU2012204462A1 (en) | 2011-01-05 | 2013-07-11 | Hospira, Inc. | Spray drying vancomycin |
TWI520732B (zh) * | 2011-01-18 | 2016-02-11 | 輝瑞有限公司 | 固體分子分散液 |
PT106063B (pt) * | 2011-12-19 | 2017-05-30 | Inst Superior Tecnico | Minociclina cristalina termorresistente produzida por recristalização com dióxido de carbono |
BR112014021090B1 (pt) | 2012-02-27 | 2023-01-24 | Vertex Pharmaceuticals Incorporated | Composição farmacêutica e uso de n-[2,4-bis(1,1-dimetiletil)-5-hidróxifenil]-1,4-di-hidro-4-oxoquinolina3-carboxamida na preparação da mesma |
RU2699358C2 (ru) | 2012-05-31 | 2019-09-05 | Мерк Шарп И Доум Корп. | Составы твердых дозированных лекарственных форм антагониста орексинового рецептора |
CN105358535B (zh) * | 2012-09-11 | 2019-01-04 | 麦迪威森前列腺医疗有限责任公司 | 恩杂鲁胺制剂 |
BR112014011938B1 (pt) | 2013-01-31 | 2021-03-16 | Gilead Pharmasset Llc | composição farmacêutica na forma de um comprimido com uma combinação de dose fixa de dois compostos antivirais, forma de dosagem farmacêutica compreendendo a referida composição e uso da referida composição |
WO2014121137A2 (en) | 2013-02-01 | 2014-08-07 | Glialogix, Inc. | Compositions and methods for the treatment of neurodegenerative and other diseases |
EP4066841A1 (en) | 2013-03-14 | 2022-10-05 | University of Maryland, Baltimore | Androgen receptor down-regulating agents and uses thereof |
CN104043104B (zh) | 2013-03-15 | 2018-07-10 | 浙江创新生物有限公司 | 含盐酸万古霉素的喷雾干粉及其工业化制备方法 |
SG11201600525XA (en) | 2013-08-12 | 2016-02-26 | Tokai Pharmaceuticals Inc | Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies |
PL3650014T3 (pl) | 2013-08-27 | 2022-01-31 | Gilead Pharmasset Llc | Preparat złożony dwóch związków przeciwwirusowych |
CN103694903B (zh) * | 2013-12-02 | 2015-07-01 | 南通瑞普埃尔生物工程有限公司 | 一种瞬干胶粘剂及其制备方法 |
JP6505705B2 (ja) * | 2013-12-05 | 2019-04-24 | アルライズ バイオシステムズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 経口投与用製剤の製造方法 |
JP6649378B2 (ja) * | 2014-07-25 | 2020-02-19 | ローラン・ファーマシューティカルズ | フェンレチニドの固体経口処方物 |
US10406127B2 (en) | 2014-07-25 | 2019-09-10 | Laurent Pharmaceuticals | Solid oral formulation of fenretinide |
RU2749213C2 (ru) | 2014-10-07 | 2021-06-07 | Вертекс Фармасьютикалз Инкорпорейтед | Сокристаллы модуляторов регулятора трансмембранной проводимости при кистозном фиброзе |
WO2016067132A1 (en) | 2014-10-31 | 2016-05-06 | Bend Research Inc. | Process for forming active domains dispersed in a matrix |
WO2016090105A1 (en) | 2014-12-05 | 2016-06-09 | Aragon Pharmaceuticals, Inc. | Anticancer compositions |
SG11201704267VA (en) * | 2014-12-05 | 2017-06-29 | Aragon Pharmaceuticals Inc | Anticancer compositions |
RU2585023C1 (ru) * | 2014-12-18 | 2016-05-27 | Общество с ограниченной ответственностью "Нанолек" | Способ гранулирования |
EP3307246A1 (en) | 2015-06-09 | 2018-04-18 | Capsugel Belgium NV | Formulations to achieve rapid dissolution of drug from spray-dried dispersions in capsules |
KR20180129943A (ko) | 2016-04-15 | 2018-12-05 | 노비라 테라퓨틱스, 인코포레이티드 | 캡시드 조립 억제제를 포함하는 배합물 및 방법 |
GB201609222D0 (en) | 2016-05-25 | 2016-07-06 | F2G Ltd | Pharmaceutical formulation |
TW201818933A (zh) | 2016-10-21 | 2018-06-01 | 美商吉利亞洛吉克斯公司 | 用於神經退化性及其他疾病的治療之組成物和方法 |
MA52019A (fr) | 2018-03-14 | 2021-01-20 | Janssen Sciences Ireland Unlimited Co | Schéma posologique de modulateur d'assemblage de capside |
BR112021001170A2 (pt) | 2018-07-30 | 2021-04-27 | Chugai Seiyaku Kabushiki Kaisha | dispersão sólida de derivado de hidantoína |
US11819503B2 (en) | 2019-04-23 | 2023-11-21 | F2G Ltd | Method of treating coccidioides infection |
JP2022554352A (ja) * | 2019-11-06 | 2022-12-28 | マンカインド コーポレイション | クロファジミンの組成物、それを含む組合せ、その調製プロセス、それを含む使用及び処置方法 |
WO2021138485A1 (en) | 2019-12-30 | 2021-07-08 | Deciphera Pharmaceuticals, Llc | Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea |
FI4084779T3 (fi) | 2019-12-30 | 2024-12-16 | Deciphera Pharmaceuticals Llc | 1-(4-bromi-5-(1-etyyli-7-(metyyliamino)-2-okso-1,2-dihydro-1,6-naftyridin-3-yyli)-2-fluorifenyyli)-3-fenyyliurean koostumuksia |
FI4084778T3 (fi) | 2019-12-30 | 2023-12-18 | Deciphera Pharmaceuticals Llc | Amorfisia kinaasi-inhibiittoriformulaatioita ja menetelmiä niiden käyttämiseksi |
KR20230097021A (ko) | 2020-09-29 | 2023-06-30 | 선전 파마신 컴퍼니 리미티드 | 약학 조성물 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1131242A (en) | 1965-02-18 | 1968-10-23 | Gen Foods Ltd | Improvements in or relating to spray-drying apparatus |
DE2201111A1 (de) | 1971-01-19 | 1972-07-27 | Niro Atomizer As | Zerstaeubungstrocknungsvorrichtung zur Herstellung von Pulver,z.B. Milchpulver |
IT1025765B (it) | 1974-11-18 | 1978-08-30 | Gastaldi Francesco | Essiccatore perfezionato a spruzzo |
DE2741196A1 (de) * | 1977-09-13 | 1979-03-15 | Bayer Ag | Verfahren zur herstellung von perlpolymeren |
US4187617A (en) | 1978-12-18 | 1980-02-12 | Becker James J Jr | Spray dryer |
US4702799A (en) | 1985-09-03 | 1987-10-27 | Nestec S.A. | Dryer and drying method |
US6068859A (en) | 1994-05-06 | 2000-05-30 | Pfizer Inc. | Controlled-release dosage forms of Azithromycin |
US5958458A (en) * | 1994-06-15 | 1999-09-28 | Dumex-Alpharma A/S | Pharmaceutical multiple unit particulate formulation in the form of coated cores |
DE19613691A1 (de) * | 1996-04-05 | 1997-10-09 | Boehringer Ingelheim Int | Arzneimittel für die Behandlung von Tumorerkrankungen |
US5858409A (en) * | 1996-04-17 | 1999-01-12 | Fmc Corporation | Hydrolyzed cellulose granulations for pharmaceuticals |
PT901786E (pt) | 1997-08-11 | 2007-08-07 | Pfizer Prod Inc | Disperções farmacêuticas sólidas com biodisponibilidade melhorada |
EP1027887B1 (en) | 1999-02-10 | 2008-08-13 | Pfizer Products Inc. | Matrix controlled release device |
EP1027888B1 (en) | 1999-02-10 | 2009-06-10 | Pfizer Products Inc. | Osmotic system for delivery of solid amorphous dispersions of drugs |
US6706283B1 (en) * | 1999-02-10 | 2004-03-16 | Pfizer Inc | Controlled release by extrusion of solid amorphous dispersions of drugs |
EP1027886B1 (en) | 1999-02-10 | 2008-07-09 | Pfizer Products Inc. | Pharmaceutical solid dispersions |
AR027656A1 (es) | 2000-03-16 | 2003-04-09 | Pfizer Prod Inc | Composiciones farmaceuticas de inhibidores de la glucogeno-fosforilasa |
UY26615A1 (es) * | 2000-03-16 | 2001-10-25 | Pfizer Prod Inc | Inhibidor de la glucogeno fosforilasa. |
US7115279B2 (en) * | 2000-08-03 | 2006-10-03 | Curatolo William J | Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors |
CN1787808A (zh) | 2002-02-01 | 2006-06-14 | 辉瑞产品公司 | 应用压力喷嘴制备均匀的喷雾干燥固态无定形药物分散体的方法 |
CA2472028C (en) * | 2002-02-01 | 2010-03-30 | Pfizer Products Inc. | Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus |
-
2003
- 2003-01-20 CN CNA038047640A patent/CN1787808A/zh active Pending
- 2003-01-20 RU RU2004123639/04A patent/RU2288703C2/ru not_active IP Right Cessation
- 2003-01-20 WO PCT/IB2003/000120 patent/WO2003063821A2/en active Application Filing
- 2003-01-20 PL PL03371593A patent/PL371593A1/pl not_active Application Discontinuation
- 2003-01-20 JP JP2003563515A patent/JP2005523260A/ja active Pending
- 2003-01-20 RS YU67304A patent/RS67304A/sr unknown
- 2003-01-20 BR BR0307515-0A patent/BR0307515A/pt not_active IP Right Cessation
- 2003-01-20 CA CA002474958A patent/CA2474958A1/en not_active Abandoned
- 2003-01-20 KR KR1020047011807A patent/KR100758045B1/ko not_active IP Right Cessation
- 2003-01-20 EP EP20030700071 patent/EP1469830A2/en not_active Withdrawn
- 2003-01-20 AU AU2003239463A patent/AU2003239463B2/en not_active Ceased
- 2003-01-20 MX MXPA04007435A patent/MXPA04007435A/es active IP Right Grant
- 2003-01-24 US US10/351,568 patent/US7780988B2/en active Active
- 2003-01-28 TW TW092101817A patent/TW200404576A/zh unknown
- 2003-01-29 PE PE2003000096A patent/PE20030804A1/es not_active Application Discontinuation
- 2003-01-30 GT GT200300024A patent/GT200300024A/es unknown
- 2003-01-30 AR ARP030100268A patent/AR038369A1/es unknown
- 2003-01-31 UY UY27645A patent/UY27645A1/es not_active Application Discontinuation
- 2003-02-03 PA PA20038565401A patent/PA8565401A1/es unknown
-
2004
- 2004-07-27 ZA ZA200405971A patent/ZA200405971B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2003239463B2 (en) | 2007-10-18 |
AR038369A1 (es) | 2005-01-12 |
EP1469830A2 (en) | 2004-10-27 |
BR0307515A (pt) | 2004-12-07 |
MXPA04007435A (es) | 2004-10-11 |
KR100758045B1 (ko) | 2007-09-11 |
US7780988B2 (en) | 2010-08-24 |
JP2005523260A (ja) | 2005-08-04 |
PA8565401A1 (es) | 2003-12-10 |
RU2004123639A (ru) | 2005-04-20 |
ZA200405971B (en) | 2006-05-31 |
WO2003063821A2 (en) | 2003-08-07 |
GT200300024A (es) | 2003-09-22 |
CN1787808A (zh) | 2006-06-14 |
TW200404576A (en) | 2004-04-01 |
PE20030804A1 (es) | 2003-09-19 |
US20030185893A1 (en) | 2003-10-02 |
UY27645A1 (es) | 2003-09-30 |
RU2288703C2 (ru) | 2006-12-10 |
RS67304A (en) | 2006-10-27 |
WO2003063821A3 (en) | 2003-11-13 |
CA2474958A1 (en) | 2003-08-07 |
KR20040083491A (ko) | 2004-10-02 |
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