[go: up one dir, main page]

RS67304A - Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles - Google Patents

Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles

Info

Publication number
RS67304A
RS67304A YU67304A YUP67304A RS67304A RS 67304 A RS67304 A RS 67304A YU 67304 A YU67304 A YU 67304A YU P67304 A YUP67304 A YU P67304A RS 67304 A RS67304 A RS 67304A
Authority
RS
Serbia
Prior art keywords
solid amorphous
dried solid
pressure nozzles
amorphous drug
homogeneous spray
Prior art date
Application number
YU67304A
Other languages
English (en)
Inventor
Ronald Arthur Beyerinck
Roderick Jack Ray
Daniel Elmont Dobry
Dana Marie Settell
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27663274&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS67304(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of RS67304A publication Critical patent/RS67304A/sr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682Processes
    • A61K9/1694Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Glanulating (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Disintegrating Or Milling (AREA)

Abstract

Homogene čvrste amorfne disperzije leka u polimerima koji povećavaju rastvorljivost su stvorene u željenim većim veličinama čestica sa minimumom sitnozrnih čestica upotrebom raspršivača i uslova sposobnih da proizvedu kapljice koje imaju srednji prečnik od najmanje 50 mikrona i D10 od najmanje 10 mikrona.
YU67304A 2002-02-01 2003-01-20 Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles RS67304A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35398602P 2002-02-01 2002-02-01
PCT/IB2003/000120 WO2003063821A2 (en) 2002-02-01 2003-01-20 Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles

Publications (1)

Publication Number Publication Date
RS67304A true RS67304A (en) 2006-10-27

Family

ID=27663274

Family Applications (1)

Application Number Title Priority Date Filing Date
YU67304A RS67304A (en) 2002-02-01 2003-01-20 Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles

Country Status (20)

Country Link
US (1) US7780988B2 (sr)
EP (1) EP1469830A2 (sr)
JP (1) JP2005523260A (sr)
KR (1) KR100758045B1 (sr)
CN (1) CN1787808A (sr)
AR (1) AR038369A1 (sr)
AU (1) AU2003239463B2 (sr)
BR (1) BR0307515A (sr)
CA (1) CA2474958A1 (sr)
GT (1) GT200300024A (sr)
MX (1) MXPA04007435A (sr)
PA (1) PA8565401A1 (sr)
PE (1) PE20030804A1 (sr)
PL (1) PL371593A1 (sr)
RS (1) RS67304A (sr)
RU (1) RU2288703C2 (sr)
TW (1) TW200404576A (sr)
UY (1) UY27645A1 (sr)
WO (1) WO2003063821A2 (sr)
ZA (1) ZA200405971B (sr)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
RS61604A (en) 2002-02-01 2006-10-27 Pfizer Products Inc. Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus
RS67304A (en) 2002-02-01 2006-10-27 Pfizer Products Inc. Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles
CL2004001884A1 (es) * 2003-08-04 2005-06-03 Pfizer Prod Inc Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros.
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
ES2339682T3 (es) 2004-06-01 2010-05-24 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Procedimiento para la preparacion de la forma amorfa de un farmaco.
CN107501099B (zh) 2004-06-24 2021-03-19 沃泰克斯药物股份有限公司 Atp-结合弹夹转运蛋白的调控剂
JP2007523896A (ja) 2004-12-01 2007-08-23 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ アスコマイシンの結晶形態とその調製方法
CA2594694A1 (en) * 2005-01-28 2006-08-03 Pfizer Products Inc. Drying of drug-containing particles
EP1909762A2 (en) 2005-07-28 2008-04-16 Isp Investments Inc. Amorphous efavirenz and the production thereof
CA2634056C (en) * 2005-12-21 2014-06-10 Eisai R&D Management Co., Ltd. Amorphous form of 1,2-dihydropyridine compound
EP1993360B1 (en) 2005-12-28 2017-02-08 Vertex Pharmaceuticals Incorporated Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
RU2457841C2 (ru) 2006-02-09 2012-08-10 Мерк Шарп Энд Домэ Корп. Полимерные композиции ингибиторов сетр
DK2029110T3 (da) * 2006-06-06 2011-12-19 Tibotec Pharm Ltd Fremgangsmåde til fremstilling af sprøjtetørrede formuleringer med TMC125
US8834929B2 (en) 2006-07-21 2014-09-16 Bend Research, Inc. Drying of drug-containing particles
WO2008080037A2 (en) 2006-12-21 2008-07-03 Isp Investments Inc. Carotenoids of enhanced bioavailability
EP2125938A2 (en) 2007-01-26 2009-12-02 Isp Investments Inc. Formulation process method to produce spray dried products
WO2008137134A2 (en) 2007-05-01 2008-11-13 Teva Pharmaceuticals Usa, Inc. Amorphous eletriptan hydrobromide and process for preparing it and other forms of eletriptan hydrobromide
US20100048912A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
AU2010210422A1 (en) 2009-02-05 2011-08-18 Tokai Pharmaceuticals, Inc. Novel prodrugs of steroidal CYP17 inhibitors/antiandrogens
EP2821400B1 (en) 2009-03-20 2017-09-27 Vertex Pharmaceuticals Incorporated Process for making modulators of cystic fibrosis transmembrane conductance regulator
EP3130396B1 (en) 2009-03-27 2021-03-17 Bend Research, Inc. Spray-drying process
ES2745113T3 (es) 2010-04-09 2020-02-27 Pacira Pharmaceuticals Inc Método para formular liposomas multivesiculares
JP5758486B2 (ja) 2010-06-09 2015-08-05 アボット・ラボラトリーズAbbott Laboratories キナーゼ阻害剤を含有する固体分散体
JP5847813B2 (ja) * 2010-06-23 2016-01-27 シマベイ セラピューティクス, インコーポレーテッド 5−エチル−2−{4−[4−(4−テトラゾル−1−イル−フェノキシメチル)−チアゾール−2−イル]−ピペリジン−1−イル}−ピリミジンの組成物
WO2012031129A2 (en) 2010-09-03 2012-03-08 Bend Research, Inc. Spray-drying apparatus and methods of using the same
EP2611530B1 (en) 2010-09-03 2019-01-16 Bend Research, Inc. Spray-drying apparatus and methods of using the same
EP2618924A1 (en) 2010-09-24 2013-07-31 Bend Research, Inc. High-temperature spray drying process and apparatus
EP2661254B1 (en) 2011-01-05 2017-08-02 Hospira, Inc. Spray drying vancomycin
TWI590821B (zh) * 2011-01-18 2017-07-11 輝瑞有限公司 固體分子分散液
PT106063B (pt) * 2011-12-19 2017-05-30 Inst Superior Tecnico Minociclina cristalina termorresistente produzida por recristalização com dióxido de carbono
NZ629199A (en) 2012-02-27 2017-01-27 Vertex Pharma Pharmaceutical compositions comprising a solid dispersion of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
MX368859B (es) 2012-05-31 2019-10-18 Merck Sharp & Dohme Formulaciones de dosis solida de un antagonista del receptor de orexina.
CN109897004A (zh) * 2012-09-11 2019-06-18 麦迪威森前列腺医疗有限责任公司 恩杂鲁胺制剂
KR20200060782A (ko) 2013-01-31 2020-06-01 길리애드 파마셋 엘엘씨 두 항바이러스 화합물의 병용 제형물
WO2014121137A2 (en) 2013-02-01 2014-08-07 Glialogix, Inc. Compositions and methods for the treatment of neurodegenerative and other diseases
EP4066841A1 (en) 2013-03-14 2022-10-05 University of Maryland, Baltimore Androgen receptor down-regulating agents and uses thereof
CN104043104B (zh) 2013-03-15 2018-07-10 浙江创新生物有限公司 含盐酸万古霉素的喷雾干粉及其工业化制备方法
KR20160058774A (ko) 2013-08-12 2016-05-25 토카이 파마슈티컬, 아이엔씨. 안드로겐-표적 치료제를 이용하는 종양 질환 치료를 위한 바이오마커
JP2016529293A (ja) 2013-08-27 2016-09-23 ギリアド ファーマセット エルエルシー 2つの抗ウイルス化合物の組合せ製剤
CN103694903B (zh) * 2013-12-02 2015-07-01 南通瑞普埃尔生物工程有限公司 一种瞬干胶粘剂及其制备方法
EP3076951B1 (en) * 2013-12-05 2020-09-30 Celal Albayrak Process for the production of drug formulations for oral administration
EP3171860B1 (en) 2014-07-25 2024-12-11 Laurent Pharmaceuticals Solid oral formulation of fenretinide
US10406127B2 (en) 2014-07-25 2019-09-10 Laurent Pharmaceuticals Solid oral formulation of fenretinide
WO2016057730A1 (en) 2014-10-07 2016-04-14 Strohmeier Mark Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
EP3212169B1 (en) 2014-10-31 2021-01-13 Bend Research, Inc. Process for forming active domains dispersed in a matrix
SMT202400518T1 (it) * 2014-12-05 2025-01-14 Aragon Pharmaceuticals Inc Composizioni anticancro
CA2969675C (en) 2014-12-05 2023-06-06 Aragon Pharmaceuticals, Inc. Anticancer compositions
RU2585023C1 (ru) * 2014-12-18 2016-05-27 Общество с ограниченной ответственностью "Нанолек" Способ гранулирования
US12133911B2 (en) 2015-06-09 2024-11-05 Capsugel Belgium Nv Formulations to achieve rapid dissolution of drug from spray-dried dispersions in capsules
CN109640980A (zh) 2016-04-15 2019-04-16 诺维拉治疗公司 包含壳体装配抑制剂的组合和方法
GB201609222D0 (en) 2016-05-25 2016-07-06 F2G Ltd Pharmaceutical formulation
US20180110760A1 (en) 2016-10-21 2018-04-26 Glialogix, Inc. Compositions and methods for the treatmentof neurodegenerative and other diseases
EP3765011A1 (en) 2018-03-14 2021-01-20 Janssen Sciences Ireland Unlimited Company Capsid assembly modulator dosing regimen
CA3107665A1 (en) 2018-07-30 2020-02-06 Chugai Seiyaku Kabushiki Kaisha Solid dispersion of hydantoin derivative
US11819503B2 (en) 2019-04-23 2023-11-21 F2G Ltd Method of treating coccidioides infection
WO2021091801A1 (en) * 2019-11-06 2021-05-14 Mannkind Corporation Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods of treatment comprising them
WO2021138485A1 (en) 2019-12-30 2021-07-08 Deciphera Pharmaceuticals, Llc Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea
SI4084778T1 (sl) 2019-12-30 2024-01-31 Deciphera Pharmaceuticals, Llc Formulacije inhibitorja amorfne kinaze in načini njihove uporabe
MX2022008097A (es) 2019-12-30 2022-09-19 Deciphera Pharmaceuticals Llc Composiciones de 1-(4-bromo-5-(1-etil-7-(metilamino)-2-oxo-1,2-dih idro-1,6-naftiridin-3-yl)-2-fluorofeil)-3-fenilurea.
CN116635015A (zh) 2020-09-29 2023-08-22 深圳市药欣生物科技有限公司 药物组合物

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1131242A (en) 1965-02-18 1968-10-23 Gen Foods Ltd Improvements in or relating to spray-drying apparatus
GB1329791A (en) 1971-01-19 1973-09-12 Niro Atomizer As Spray drying devices for the production of powder eg milk powder
IT1025765B (it) 1974-11-18 1978-08-30 Gastaldi Francesco Essiccatore perfezionato a spruzzo
DE2741196A1 (de) * 1977-09-13 1979-03-15 Bayer Ag Verfahren zur herstellung von perlpolymeren
US4187617A (en) 1978-12-18 1980-02-12 Becker James J Jr Spray dryer
US4702799A (en) 1985-09-03 1987-10-27 Nestec S.A. Dryer and drying method
JP2977907B2 (ja) 1994-05-06 1999-11-15 ファイザー・インコーポレーテッド アジスロマイシンの放出調節された剤形
US5958458A (en) * 1994-06-15 1999-09-28 Dumex-Alpharma A/S Pharmaceutical multiple unit particulate formulation in the form of coated cores
DE19613691A1 (de) * 1996-04-05 1997-10-09 Boehringer Ingelheim Int Arzneimittel für die Behandlung von Tumorerkrankungen
US5858409A (en) * 1996-04-17 1999-01-12 Fmc Corporation Hydrolyzed cellulose granulations for pharmaceuticals
ATE364374T1 (de) 1997-08-11 2007-07-15 Pfizer Prod Inc Feste pharmazeutische dispersionen mit erhöhter bioverfügbarkeit
DE60039802D1 (de) 1999-02-10 2008-09-25 Pfizer Prod Inc Vorrichtung mit matrixgesteuerter Wirkstofffreisetzung
US6706283B1 (en) * 1999-02-10 2004-03-16 Pfizer Inc Controlled release by extrusion of solid amorphous dispersions of drugs
ES2307482T3 (es) 1999-02-10 2008-12-01 Pfizer Products Inc. Dispersiones farmaceuticas solidas.
ATE433318T1 (de) 1999-02-10 2009-06-15 Pfizer Prod Inc Osmotisches system zur verabreichung von wirkstoffen, die feste amorphe dispersionen enthalten
UY26615A1 (es) * 2000-03-16 2001-10-25 Pfizer Prod Inc Inhibidor de la glucogeno fosforilasa.
AR027656A1 (es) 2000-03-16 2003-04-09 Pfizer Prod Inc Composiciones farmaceuticas de inhibidores de la glucogeno-fosforilasa
US7115279B2 (en) * 2000-08-03 2006-10-03 Curatolo William J Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors
RS67304A (en) 2002-02-01 2006-10-27 Pfizer Products Inc. Method for making homogeneous spray-dried solid amorphous drug dispersions using pressure nozzles
RS61604A (en) * 2002-02-01 2006-10-27 Pfizer Products Inc. Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus

Also Published As

Publication number Publication date
AR038369A1 (es) 2005-01-12
US20030185893A1 (en) 2003-10-02
PL371593A1 (en) 2005-06-27
RU2288703C2 (ru) 2006-12-10
BR0307515A (pt) 2004-12-07
EP1469830A2 (en) 2004-10-27
GT200300024A (es) 2003-09-22
KR100758045B1 (ko) 2007-09-11
JP2005523260A (ja) 2005-08-04
WO2003063821A3 (en) 2003-11-13
UY27645A1 (es) 2003-09-30
PA8565401A1 (es) 2003-12-10
PE20030804A1 (es) 2003-09-19
US7780988B2 (en) 2010-08-24
MXPA04007435A (es) 2004-10-11
KR20040083491A (ko) 2004-10-02
CN1787808A (zh) 2006-06-14
RU2004123639A (ru) 2005-04-20
AU2003239463B2 (en) 2007-10-18
ZA200405971B (en) 2006-05-31
WO2003063821A2 (en) 2003-08-07
CA2474958A1 (en) 2003-08-07
TW200404576A (en) 2004-04-01

Similar Documents

Publication Publication Date Title
MXPA04007435A (es) Metodo para preparar dispersiones solidas amorfas de farmacos secadas por pulverizacion utilizando inyectores a presion.
WO2007109906A8 (en) Method and apparatus for nanopowder and micropowder production using axial injection plasma spray
WO2003063822A3 (en) Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus
WO2005000456A3 (fr) Procede de preparation de particules spheriques a base de polyamide
AU4913500A (en) Method for producing bead polymers
EP1886673A3 (en) Solid dosage form of enteric solid dispersion and method for producing the same
DE602004017643D1 (sr)
WO2006078826A3 (en) Processes for forming nanoparticles in a flame spray system
WO2005011636A3 (en) Spray drying processes for forming solid amorphous dispersions of drugs and polymers
EP1541637A4 (en) NEW METHOD FOR PRODUCING PIGMENT NANOPARTICULATE
AU2002223558A1 (en) Method for producing polymer coated pigment particles by precipitation
WO2009001894A1 (ja) ポリテトラフルオロエチレン水性分散液及びその製造方法
CA2430318A1 (en) Powder formulation and method for producing the same
AU2002317809A1 (en) Method for producing an aqueous dispersion of particles composed of a polymer and a fine-particle inorganic solid
WO2009080896A8 (en) Device and method for producing particles
EP1688169A4 (en) METHOD FOR PRODUCING FINE PARTICLES OF AN ORGANIC COMPOUND
WO2002083797A3 (de) Anionisch stabilisierte, wässrige dispersionen von nanopartikulärem zinkoxid, verfahren zu deren herstellung sowie deren verwendung
CA2426259A1 (en) Process for agglomeration and densification of nanometer sized particles
DE602005009224D1 (de) Verfahren zur herstellung von partikeln aus thermoplastischen polymeren und daraus gewonnenes pulver
WO2006097725A3 (en) Pharmaceutical compositions comprising microparticles for delivery into neurons
EP2168557A3 (en) Production method of gelatin particles
EP1886672A3 (en) Solid dosage form comprising solid dispersion and method for producing the same
EP1548509A3 (en) Process for producing toner, and apparatus for modifying surfaces of toner particles
WO2008099615A1 (ja) 微粒子油性懸濁液を含む医薬組成物
WO2003020348A1 (fr) Dispositif d'aspiration