[go: up one dir, main page]

PL3478832T3 - Sposób skriningu populacji organizmów pod kątem mutanta poprzez zastosowanie podejścia polegającego na łączeniu i dzieleniu - Google Patents

Sposób skriningu populacji organizmów pod kątem mutanta poprzez zastosowanie podejścia polegającego na łączeniu i dzieleniu

Info

Publication number
PL3478832T3
PL3478832T3 PL17733800T PL17733800T PL3478832T3 PL 3478832 T3 PL3478832 T3 PL 3478832T3 PL 17733800 T PL17733800 T PL 17733800T PL 17733800 T PL17733800 T PL 17733800T PL 3478832 T3 PL3478832 T3 PL 3478832T3
Authority
PL
Poland
Prior art keywords
pooling
mutant
organisms
population
screen
Prior art date
Application number
PL17733800T
Other languages
English (en)
Inventor
Toni Wendt
Ole Olsen
Søren Knudsen
Hanne Cecilie Thomsen
Alexander STRIEBECK
Birgitte Skadhauge
Magnus Wohlfahrt RASMUSSEN
Massimiliano CARCIOFI
Original Assignee
Carlsberg A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carlsberg A/S filed Critical Carlsberg A/S
Publication of PL3478832T3 publication Critical patent/PL3478832T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/6895Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01HNEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H4/00Plant reproduction by tissue culture techniques ; Tissue culture techniques therefor
    • A01H4/005Methods for micropropagation; Vegetative plant propagation using cell or tissue culture techniques
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01HNEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H6/00Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
    • A01H6/46Gramineae or Poaceae, e.g. ryegrass, rice, wheat or maize
    • A01H6/4624Hordeum vulgarus [barley]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102Mutagenizing nucleic acids
    • C12N15/1024In vivo mutagenesis using high mutation rate "mutator" host strains by inserting genetic material, e.g. encoding an error prone polymerase, disrupting a gene for mismatch repair
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6858Allele-specific amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/686Polymerase chain reaction [PCR]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/02Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/13Plant traits
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Botany (AREA)
  • Environmental Sciences (AREA)
  • Physiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PL17733800T 2016-07-01 2017-06-23 Sposób skriningu populacji organizmów pod kątem mutanta poprzez zastosowanie podejścia polegającego na łączeniu i dzieleniu PL3478832T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201670485 2016-07-01
EP17733800.1A EP3478832B1 (en) 2016-07-01 2017-06-23 Method to screen for a mutant within a population of organisms by applying a pooling and splitting approach
PCT/EP2017/065516 WO2018001884A1 (en) 2016-07-01 2017-06-23 Method to screen for a mutant within a population of organisms by applying a pooling and splitting approach

Publications (1)

Publication Number Publication Date
PL3478832T3 true PL3478832T3 (pl) 2022-06-06

Family

ID=56681913

Family Applications (1)

Application Number Title Priority Date Filing Date
PL17733800T PL3478832T3 (pl) 2016-07-01 2017-06-23 Sposób skriningu populacji organizmów pod kątem mutanta poprzez zastosowanie podejścia polegającego na łączeniu i dzieleniu

Country Status (25)

Country Link
US (2) US11884972B2 (pl)
EP (3) EP3792357A1 (pl)
JP (2) JP7208797B2 (pl)
CN (2) CN114959098A (pl)
AR (1) AR110103A1 (pl)
AU (3) AU2017288960B2 (pl)
BR (1) BR112018076429A2 (pl)
CA (1) CA3026016A1 (pl)
CL (1) CL2018003710A1 (pl)
CO (1) CO2019000828A2 (pl)
CR (1) CR20190040A (pl)
CU (1) CU20180158A7 (pl)
DK (1) DK3478832T3 (pl)
EA (1) EA201892809A1 (pl)
ES (1) ES2916221T3 (pl)
IL (1) IL263451B (pl)
MA (3) MA45531A (pl)
MX (2) MX2018016110A (pl)
PE (1) PE20190228A1 (pl)
PL (1) PL3478832T3 (pl)
PT (1) PT3478832T (pl)
SG (1) SG11201811021YA (pl)
UY (1) UY37312A (pl)
WO (1) WO2018001884A1 (pl)
ZA (3) ZA201808218B (pl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA128692C2 (uk) 2017-12-28 2024-10-02 Карлсберг А/С Зернова рослина з поліпшеними властивостями клітинної стінки
CN108913698B (zh) * 2018-07-25 2021-10-26 安徽农业大学 一种与小麦穗发芽抗性/感性相关的caps标记及其应用
CN110724741B (zh) * 2019-07-24 2020-05-19 艾普拜生物科技(苏州)有限公司 一种检测微小残留白血病相关融合基因的引物、探针及其试剂盒
EP3785529A1 (en) 2019-08-28 2021-03-03 Carlsberg A/S Barley plants with altered protein content in grains
JP2023502317A (ja) 2019-10-10 2023-01-24 カールスバーグ アグシャセルスガーブ 変異体植物の調製方法
CN115297717B (zh) 2020-03-02 2024-05-17 嘉士伯有限公司 具有高极限糊精酶活性的大麦植物
EP4029935A1 (en) 2021-01-14 2022-07-20 Carlsberg A/S S. eubayanus strain and hybrids thereof
EP4423297A1 (en) * 2021-10-25 2024-09-04 GT Molecular, Inc. Off-target blocking sequences to improve target discrimination by polymerase chain reaction
EP4451853A1 (en) 2021-12-22 2024-10-30 Basf Agricultural Solutions Seed Us Llc Improved screening method for genome edited events
EP4490736A1 (en) 2022-03-11 2025-01-15 Carlsberg A/S Modulation of protein levels
WO2024105148A1 (en) 2022-11-16 2024-05-23 University Of Copenhagen Plants with low seed glucosinolate content
WO2024133900A1 (en) 2022-12-22 2024-06-27 University Of Copenhagen Improved (-)-sparteine production
WO2024227748A1 (en) 2023-05-01 2024-11-07 Carlsberg A/S Barley with improved properties
CN117965576B (zh) * 2024-02-01 2024-08-27 北京林业大学 一种王百合苷生物合成基因LlHCT1及其应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4351760A (en) 1979-09-07 1982-09-28 Syva Company Novel alkyl substituted fluorescent compounds and polyamino acid conjugates
US5188934A (en) 1989-11-14 1993-02-23 Applied Biosystems, Inc. 4,7-dichlorofluorescein dyes as molecular probes
JP2001507570A (ja) 1996-11-26 2001-06-12 バイラー・カレッジ・オブ・メディスン 染色体末端へのテロメラーゼのアクセスを阻害する阻害剤の同定
US6187544B1 (en) 1997-06-04 2001-02-13 Smithkline Beecham Corporation Methods for rapid cloning for full length cDNAs using a pooling strategy
WO1999051774A2 (en) 1998-04-02 1999-10-14 Tellus Genetic Resources, Inc. A method for obtaining a plant with a genetic lesion in a gene sequence
GB9812768D0 (en) 1998-06-13 1998-08-12 Zeneca Ltd Methods
WO2003000905A2 (en) * 2001-06-22 2003-01-03 Syngenta Participations Ag Identification and characterization of plant genes
GB0127564D0 (en) 2001-11-16 2002-01-09 Medical Res Council Emulsion compositions
US7420105B2 (en) 2004-03-11 2008-09-02 Carlsberg A/S Barley for production of flavor-stable beverage
EP4512526A2 (en) 2008-09-23 2025-02-26 Bio-Rad Laboratories, Inc. Droplet-based assay system
US9005565B2 (en) 2010-06-24 2015-04-14 Hamid-Reza Jahangiri-Famenini Method and apparatus for forming graphene
WO2012122571A1 (en) * 2011-03-10 2012-09-13 Gen-Probe Incorporated Methods and compositions for the selection and optimization of oligonucleotide tag sequences
US9017979B2 (en) 2011-04-11 2015-04-28 Roche Molecular Systems, Inc. DNA polymerases with improved activity
ES2898460T3 (es) 2014-02-27 2022-03-07 Monsanto Technology Llc Composiciones y procedimientos para la modificación genómica dirigida al sitio
GB201411603D0 (en) 2014-06-30 2014-08-13 Vela Operations Pte Ltd Compositions for quantitative and/or semiquantitative mutation detection methods

Also Published As

Publication number Publication date
AU2019268103A1 (en) 2019-12-12
CR20190040A (es) 2019-05-09
CO2019000828A2 (es) 2019-04-30
ZA201907775B (en) 2022-09-28
AR110103A1 (es) 2019-02-27
CU20180158A7 (es) 2019-08-06
CL2018003710A1 (es) 2019-03-22
CN109477087B (zh) 2022-06-24
CN109477087A (zh) 2019-03-15
AU2017288960A1 (en) 2019-01-17
ZA201808218B (en) 2020-02-26
AU2019268102A1 (en) 2019-12-12
US11884972B2 (en) 2024-01-30
US20240182961A1 (en) 2024-06-06
MA54568A (fr) 2021-10-27
EA201892809A1 (ru) 2019-06-28
DK3478832T3 (da) 2022-05-30
MX2022014965A (es) 2023-01-11
JP2019524083A (ja) 2019-09-05
WO2018001884A1 (en) 2018-01-04
MX2018016110A (es) 2019-05-30
US20190194723A1 (en) 2019-06-27
SG11201811021YA (en) 2019-01-30
CA3026016A1 (en) 2018-01-04
AU2019268102B2 (en) 2020-03-05
PT3478832T (pt) 2022-05-19
EP3478832A1 (en) 2019-05-08
IL263451B (en) 2022-08-01
AU2019268103B2 (en) 2020-03-12
UY37312A (es) 2018-02-28
JP7208797B2 (ja) 2023-01-19
EP3792357A1 (en) 2021-03-17
MA45531A (fr) 2019-05-08
ZA201907774B (en) 2022-07-27
EP3478832B1 (en) 2022-02-23
PE20190228A1 (es) 2019-02-13
MA52594A (fr) 2021-03-17
JP2022101703A (ja) 2022-07-06
ES2916221T3 (es) 2022-06-29
IL263451A (en) 2019-01-31
EP3693458A1 (en) 2020-08-12
AU2017288960B2 (en) 2019-12-12
JP7539428B2 (ja) 2024-08-23
BR112018076429A2 (pt) 2019-10-01
CN114959098A (zh) 2022-08-30

Similar Documents

Publication Publication Date Title
ZA201808218B (en) Method to screen for a mutant within a population of organisms by applying a pooling and splitting approach
EP3207467A4 (en) System and method for providing follow-up responses to prior natural language inputs of a user
EP3114540A4 (en) Neural network and method of neural network training
EP3408653A4 (en) Methods and apparatus adapted to quantify a specimen from multiple lateral views
EP3335183A4 (en) METHOD AND DEVICE FOR PROVIDING A PRESENTATION OF A CLOTHING PIECE MODEL
EP3440659A4 (en) CPR EXERCISE SYSTEM AND PROCEDURE
EP3484816A4 (en) DEVICE AND METHOD FOR THE LARGE PRODUCTION OF GRAPHS
EP3117345A4 (en) Natural language question answering method and apparatus
EP3209811A4 (en) Method and apparatus for cladding a surface of an article
EP3219161A4 (en) Method and system for dynamic optimization of time-domain frame structure
HUE053174T2 (hu) Eljárás és berendezés egy jármû kinematikai viselkedésének befolyásolására
GB201515339D0 (en) A seperation matrix and a method of seperating antibodies
EP3152679A4 (en) Method and apparatus for recommendation by applying efficient adaptive matrix factorization
EP3532640A4 (en) METHOD AND SYSTEM FOR PREDICTING THE RESPONSE OF A SUBJECT TO ANTIDEPRESSANT TREATMENT
GB201805354D0 (en) System and method for representing a cause and effect matrix as a set of numerical representations
EP3155200A4 (en) Spacer frame and method of making same
EP3430538A4 (en) SYSTEM AND METHOD FOR MANAGING THE CONFORMITY OF REGULATED PRODUCTS
EP3328253A4 (en) TOILET DEVICE AND METHOD OF USE
EP3465349A4 (en) IMPROVED METHOD FOR COMPUTER MODELING AND SIMULATION OF NEGATIVE DEVELOPABLE PHOTORESISTS
EP3353676A4 (en) METHOD AND SYSTEM FOR CARRYING OUT TRANSLATION
EP3515119A4 (en) METHOD AND APPARATUS USED TO MANAGE LINKS
EP3122216A4 (en) Method and system using setpoint control to maintain quality of oil in a fryer
EP3238028A4 (en) Method and apparatus for expanding a mask to a vector of mask values
GB201716667D0 (en) Educational system method computer program product and kit of parts
EP3177781A4 (en) A gluelam structural member and a method of producing such a gluelam structural member