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PE69098A1 - Preparacion concentrada de anticuerpos - Google Patents

Preparacion concentrada de anticuerpos

Info

Publication number
PE69098A1
PE69098A1 PE1997000415A PE00041597A PE69098A1 PE 69098 A1 PE69098 A1 PE 69098A1 PE 1997000415 A PE1997000415 A PE 1997000415A PE 00041597 A PE00041597 A PE 00041597A PE 69098 A1 PE69098 A1 PE 69098A1
Authority
PE
Peru
Prior art keywords
antibody
antibodies
preparation
concentrated preparation
iselectric
Prior art date
Application number
PE1997000415A
Other languages
English (en)
Inventor
Julian Marcus Relton
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10794316&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE69098(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE69098A1 publication Critical patent/PE69098A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2893—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE REFIERE A UN PREPARADO DE ANTICUERPOS MONOCLONALES, DE PREFERENCIA LIBRE DE AGREGADOS, CARACTERIZADO POR PRESENTAR UNA CONCENTRACION MAYOR DE 100 mg/ml Y POR UN pH DIFERENTE DEL pH DEL PUNTO ISOELECTRICO DEL ANTICUERPO, PARA MAXIMIZAR LA SOLUBILIDAD DEL ANTICUERPO EN LA SOLUCION CONCENTRADA, EN DONDE DICHO ANTICUERPO ES RECOMBINANTE, DE PREFERENCIA, QUIMERICO O HUMANIZADO (TAL COMO UN INJERTADO DE CDR), O ES UN ISOTIPO DE INMUNOGLOBULINA G. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION DE DICHO CONCENTRADO DE ANTICUERPOS MONOCLONALES, QUE COMPRENDE ULTRAFILTRACION DE FLUJO TANGENCIAL. LOS ANTICUERPOS OBTENIDOS SE PUEDEN PREPARAR EN CONCENTRACIONES VARIAS VECES MAYORES QUE LOS OBTENIDOS A PARTIR DEL PROCESAMIENTO DE LA SANGRE, SIENDO ADMINISTRADOS POR VIA SUBCUTANEA, PARA EL TRATAMIENTO DEL CANCER, DE DESORDENES MEDIADOS POR CELULAS T, TALES COMO VASCULITIS SEVERA O ARTRITIS REUMATOIDEA Y DE DESORDENES AUTOINMUNES, ENTRE OTROS
PE1997000415A 1996-05-24 1997-05-23 Preparacion concentrada de anticuerpos PE69098A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9610992.1A GB9610992D0 (en) 1996-05-24 1996-05-24 Concentrated antibody preparation

Publications (1)

Publication Number Publication Date
PE69098A1 true PE69098A1 (es) 1998-12-02

Family

ID=10794316

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1997000415A PE69098A1 (es) 1996-05-24 1997-05-23 Preparacion concentrada de anticuerpos

Country Status (28)

Country Link
US (1) US6252055B1 (es)
EP (1) EP0907378B1 (es)
JP (1) JP3338060B2 (es)
KR (1) KR20000015935A (es)
CN (1) CN1219882A (es)
AP (1) AP9801392A0 (es)
AR (1) AR007249A1 (es)
AT (1) ATE318146T1 (es)
AU (1) AU731950B2 (es)
BR (1) BR9709267A (es)
CA (1) CA2254983A1 (es)
CO (1) CO4850562A1 (es)
CZ (1) CZ382498A3 (es)
DE (1) DE69735295T2 (es)
EA (1) EA001860B1 (es)
ES (1) ES2258277T3 (es)
GB (1) GB9610992D0 (es)
ID (1) ID16966A (es)
IL (1) IL126940A0 (es)
IS (1) IS4892A (es)
NO (1) NO985464L (es)
NZ (1) NZ332625A (es)
PE (1) PE69098A1 (es)
PL (1) PL330111A1 (es)
TR (1) TR199802423T2 (es)
WO (1) WO1997045140A1 (es)
YU (1) YU53098A (es)
ZA (1) ZA974486B (es)

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Also Published As

Publication number Publication date
YU53098A (sh) 2000-03-21
EA199800946A1 (ru) 1999-06-24
TR199802423T2 (xx) 1999-02-22
US6252055B1 (en) 2001-06-26
NO985464D0 (no) 1998-11-23
EA001860B1 (ru) 2001-10-22
CA2254983A1 (en) 1997-12-04
EP0907378B1 (en) 2006-02-22
AU2958997A (en) 1998-01-05
CZ382498A3 (cs) 1999-05-12
AP9801392A0 (en) 1998-12-31
WO1997045140A1 (en) 1997-12-04
DE69735295T2 (de) 2006-10-05
BR9709267A (pt) 1999-08-10
ID16966A (id) 1997-11-27
NO985464L (no) 1999-01-18
KR20000015935A (ko) 2000-03-15
PL330111A1 (en) 1999-04-26
AR007249A1 (es) 1999-10-27
AU731950B2 (en) 2001-04-05
ES2258277T3 (es) 2006-08-16
DE69735295D1 (de) 2006-04-27
EP0907378A1 (en) 1999-04-14
CN1219882A (zh) 1999-06-16
JP3338060B2 (ja) 2002-10-28
IS4892A (is) 1998-11-10
JPH11512753A (ja) 1999-11-02
IL126940A0 (en) 1999-09-22
CO4850562A1 (es) 1999-10-26
GB9610992D0 (en) 1996-07-31
NZ332625A (en) 2000-04-28
ZA974486B (en) 1998-11-23
ATE318146T1 (de) 2006-03-15

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