PE20240883A1 - Anticuerpos capaces de unirse a cd27, variantes y usos de los mismos - Google Patents
Anticuerpos capaces de unirse a cd27, variantes y usos de los mismosInfo
- Publication number
- PE20240883A1 PE20240883A1 PE2024000383A PE2024000383A PE20240883A1 PE 20240883 A1 PE20240883 A1 PE 20240883A1 PE 2024000383 A PE2024000383 A PE 2024000383A PE 2024000383 A PE2024000383 A PE 2024000383A PE 20240883 A1 PE20240883 A1 PE 20240883A1
- Authority
- PE
- Peru
- Prior art keywords
- binding
- antibodies
- antibody
- variants
- region
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invencion se refiere a anticuerpos capaces de unirse a CD27 humano y a variantes de los mismos que comprenden una region Fc modificada que comprende una o mas mutaciones que mejoran la interaccion Fc-Fc del anticuerpo. En particular, se refiere a un anticuerpo que comprende al menos una region de union a antigeno capaz de unirse a CD27 humano, caracterizado porque dicho anticuerpo comprende una region variable de cadena pesada (VH) CDR1, CDR2 y CDR3 que comprende las secuencias establecidas en SEQ ID N.º: 5, 6 y 7, respectivamente, y una region variable de cadena ligera (VL) CDR1, CDR2 y CDR3 que comprende las secuencias tal como se establece en SEQ ID N.º: 9, 10 y 11, respectivamente. La invencion proporciona, ademas, composiciones farmaceuticas que comprenden los anticuerpos y el uso de los anticuerpos para procedimientos terapeuticos y de diagnostico, en particular, en el tratamiento del cancer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21195118 | 2021-09-06 | ||
| EP22173126 | 2022-05-12 | ||
| PCT/EP2022/074696 WO2023031473A1 (en) | 2021-09-06 | 2022-09-06 | Antibodies capable of binding to cd27, variants thereof and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20240883A1 true PE20240883A1 (es) | 2024-04-24 |
Family
ID=83400576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2024000383A PE20240883A1 (es) | 2021-09-06 | 2022-09-06 | Anticuerpos capaces de unirse a cd27, variantes y usos de los mismos |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20230109496A1 (es) |
| EP (1) | EP4399227A1 (es) |
| JP (1) | JP2024533234A (es) |
| KR (1) | KR20240051280A (es) |
| AR (1) | AR127743A1 (es) |
| AU (1) | AU2022338208A1 (es) |
| CA (1) | CA3231003A1 (es) |
| CL (1) | CL2024000669A1 (es) |
| CO (1) | CO2024003578A2 (es) |
| IL (1) | IL311141A (es) |
| MX (1) | MX2024002781A (es) |
| PE (1) | PE20240883A1 (es) |
| TW (1) | TW202328192A (es) |
| WO (1) | WO2023031473A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4522657A1 (en) * | 2022-05-12 | 2025-03-19 | Genmab A/S | Binding agents capable of binding to cd27 in combination therapy |
| WO2024235862A1 (en) * | 2023-05-12 | 2024-11-21 | Genmab A/S | Antibodies capable of binding to ox40, variants thereof and uses thereof |
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-
2022
- 2022-09-06 PE PE2024000383A patent/PE20240883A1/es unknown
- 2022-09-06 EP EP22773622.0A patent/EP4399227A1/en active Pending
- 2022-09-06 MX MX2024002781A patent/MX2024002781A/es unknown
- 2022-09-06 IL IL311141A patent/IL311141A/en unknown
- 2022-09-06 JP JP2024514484A patent/JP2024533234A/ja active Pending
- 2022-09-06 KR KR1020247011157A patent/KR20240051280A/ko active Pending
- 2022-09-06 AR ARP220102407A patent/AR127743A1/es unknown
- 2022-09-06 US US17/929,799 patent/US20230109496A1/en active Pending
- 2022-09-06 AU AU2022338208A patent/AU2022338208A1/en active Pending
- 2022-09-06 TW TW111133765A patent/TW202328192A/zh unknown
- 2022-09-06 WO PCT/EP2022/074696 patent/WO2023031473A1/en active Application Filing
- 2022-09-06 CA CA3231003A patent/CA3231003A1/en active Pending
- 2022-11-14 US US18/055,362 patent/US20230212301A1/en not_active Abandoned
-
2024
- 2024-03-06 CL CL2024000669A patent/CL2024000669A1/es unknown
- 2024-03-22 CO CONC2024/0003578A patent/CO2024003578A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20230109496A1 (en) | 2023-04-06 |
| CO2024003578A2 (es) | 2024-08-08 |
| JP2024533234A (ja) | 2024-09-12 |
| CL2024000669A1 (es) | 2024-08-09 |
| WO2023031473A1 (en) | 2023-03-09 |
| KR20240051280A (ko) | 2024-04-19 |
| AR127743A1 (es) | 2024-02-28 |
| TW202328192A (zh) | 2023-07-16 |
| IL311141A (en) | 2024-04-01 |
| MX2024002781A (es) | 2024-04-16 |
| AU2022338208A1 (en) | 2024-03-21 |
| US20230212301A1 (en) | 2023-07-06 |
| CA3231003A1 (en) | 2023-03-09 |
| EP4399227A1 (en) | 2024-07-17 |
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