PE20091041A1 - Producto de dispersion solida que contiene un compuesto a base de n-aril urea - Google Patents
Producto de dispersion solida que contiene un compuesto a base de n-aril ureaInfo
- Publication number
- PE20091041A1 PE20091041A1 PE2008001785A PE2008001785A PE20091041A1 PE 20091041 A1 PE20091041 A1 PE 20091041A1 PE 2008001785 A PE2008001785 A PE 2008001785A PE 2008001785 A PE2008001785 A PE 2008001785A PE 20091041 A1 PE20091041 A1 PE 20091041A1
- Authority
- PE
- Peru
- Prior art keywords
- acceptable
- solid dispersion
- alcoxy
- union
- absent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
REFERIDA A UNA DISPERSION SOLIDA QUE COMPRENDE: A) UN GENTE ACTIVO DE FORMULA I, DONDE X1 ES N, CR1; X2 ES N, CR2; X3 ES N, CR3, CR3; X4 ES UNION, N, CR4; X5 ES N, C; Z1 ES O, NH, S; Z2 ES UNION, NH, O; Ar1 ES INDAZOL, ISOQUINOLIN SUSTITUIDO; R1, R3, R5, R6 Y R7 SON CADA UNO H, ALCOXI, ALQUILO, ALQUILTIO, ENTRE OTROS; R2 Y R4 SON CADA UNO H, ALQUENILO, ALCOXI, ALQUILCARBONILO, ENTRE OTROS; R8a ESTA AUSENTE O ES H, ALQUILO; R8b ESTA AUSENTE O ES H, ALCOXI, HALOGENO, ENTRE OTROS ; B) AGENTE FORMADOR DE MATRIZ ACEPTABLE PARA USO FARMACEUTICO SELECCIONADO ENTRE POLI N-VINILPIRROLIDONAS, ACETATO DE VINILO, COPOLIMEROS DE N-VINIL PIRROLIDONA Y COMBINACIONES DE LOS MISMOS; C) UNA COMBINACION DE 2 O MAS TENSIOACTIVOS ACEPTABLES PARA USO FARMACEUTICO DE PREFERENCIA SUCCINATO DE ALFA-TOCOFERIL POLIETILENGLICOL Y GLICERIDO POLALCOXILADO D) AL MENOS UN SOLVENTE. LA RELACION DE MASA ENTRE EL AGENTE ACTIVO Y AGENTE FORMADOR DE MATRIZ ES 0,1:1 Y 1:3. UN AGENTE ACTIVO PREFERIDO ES: N-(5-TERT-BUTIL-2,3-DIHIDRO-1H-INDEN-1-IL)-N'-5-ISOQUINOLINILUREA. DICHO PRODUCTO DE DISPERSION PERMITE UNA FORMULACION SOLIDA DE AGENTE ACTIVOS DE BAJA SOLUBILIDAD CON CONCENTRACION ALTA DE DROGA Y BIODISPONIBILIDAD ACEPTABLE
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99961307P | 2007-10-19 | 2007-10-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091041A1 true PE20091041A1 (es) | 2009-08-22 |
Family
ID=40089072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008001785A PE20091041A1 (es) | 2007-10-19 | 2008-10-17 | Producto de dispersion solida que contiene un compuesto a base de n-aril urea |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20090143423A1 (es) |
| EP (1) | EP2197426A2 (es) |
| JP (1) | JP2011500647A (es) |
| KR (1) | KR20100090689A (es) |
| CN (1) | CN101827585A (es) |
| AR (1) | AR068916A1 (es) |
| AU (1) | AU2008313620A1 (es) |
| BR (1) | BRPI0818339A2 (es) |
| CA (1) | CA2699335A1 (es) |
| CL (1) | CL2008003092A1 (es) |
| CO (1) | CO6270303A2 (es) |
| CR (1) | CR11441A (es) |
| DO (1) | DOP2010000114A (es) |
| EC (1) | ECSP10010184A (es) |
| GT (1) | GT201000095A (es) |
| MX (1) | MX2010004292A (es) |
| PE (1) | PE20091041A1 (es) |
| RU (1) | RU2010119924A (es) |
| TW (1) | TW200922549A (es) |
| UA (1) | UA100866C2 (es) |
| UY (1) | UY31406A1 (es) |
| WO (1) | WO2009050289A2 (es) |
| ZA (1) | ZA201002130B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010045402A1 (en) * | 2008-10-17 | 2010-04-22 | Abbott Laboratories | Trpv1 antagonists |
| US8604053B2 (en) * | 2008-10-17 | 2013-12-10 | Abbvie Inc. | TRPV1 antagonists |
| US20100210682A1 (en) * | 2009-02-19 | 2010-08-19 | Abbott Laboratories | Repeated Dosing of TRPV1 Antagonists |
| CN102573755A (zh) * | 2009-09-18 | 2012-07-11 | 巴斯夫欧洲公司 | 制备具有低水溶性的物质的制剂的方法 |
| WO2012085236A1 (en) | 2010-12-23 | 2012-06-28 | Abbott Gmbh & Co. Kg | Solid retard formulations based on solid dispersions |
| EP2663292B9 (en) * | 2011-01-10 | 2017-11-08 | Celgene Corporation | Oral dosage forms of cyclopropanecarboxylic acid {2-[(1s)-1-(3-ethoxy-4-methoxy-phenyl]-2-methanesulfonyl-ethyl]-3-oxo-2,3-dihydro-1h-isoindol-4-yl}-amide |
| US20130172239A1 (en) * | 2011-12-29 | 2013-07-04 | Abbvie Inc. | Solid compositions |
| US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
| TW201431570A (zh) | 2012-11-22 | 2014-08-16 | Ucb Pharma Gmbh | 用於經皮投服羅替戈汀（Ｒｏｔｉｇｏｔｉｎｅ）之多天式貼片 |
| BR112014011938B1 (pt) | 2013-01-31 | 2021-03-16 | Gilead Pharmasset Llc | composição farmacêutica na forma de um comprimido com uma combinação de dose fixa de dois compostos antivirais, forma de dosagem farmacêutica compreendendo a referida composição e uso da referida composição |
| AU2014233705C1 (en) | 2013-03-15 | 2019-10-10 | Boehringer Ingelheim International Gmbh | Solid oral dosage formulation of HCV inhibitor in the amorphous state |
| CA2916183C (en) | 2013-07-03 | 2022-03-29 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system with electronic component |
| PL3650014T3 (pl) | 2013-08-27 | 2022-01-31 | Gilead Pharmasset Llc | Preparat złożony dwóch związków przeciwwirusowych |
| EP3145504B1 (en) | 2014-05-20 | 2023-07-26 | LTS Lohmann Therapie-Systeme AG | Transdermal delivery system including an interface mediator |
| CN106456567A (zh) | 2014-05-20 | 2017-02-22 | Lts勒曼治疗系统股份公司 | 在经皮递送系统中调节活性剂释放的方法 |
| US11633367B2 (en) | 2014-05-20 | 2023-04-25 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system containing rotigotine |
| EP3307246A1 (en) | 2015-06-09 | 2018-04-18 | Capsugel Belgium NV | Formulations to achieve rapid dissolution of drug from spray-dried dispersions in capsules |
| US12186314B2 (en) * | 2015-12-22 | 2025-01-07 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Compositions and methods for treatment, amelioration, and prevention of anesthesia-induced hypothermia |
| SG11202104208RA (en) * | 2018-10-30 | 2021-05-28 | Peloton Therapeutics Inc | Solid dispersions and pharmaceutical compositions comprising a substituted indane and methods for the preparation and use thereof |
| WO2021039023A1 (ja) | 2019-08-23 | 2021-03-04 | 持田製薬株式会社 | ヘテロシクリデンアセトアミド誘導体の製造方法 |
| EP4410989A3 (en) | 2019-08-23 | 2024-12-11 | Mochida Pharmaceutical Co., Ltd. | Method for producing heterocyclidene acetamide derivatives |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5362878A (en) * | 1991-03-21 | 1994-11-08 | Pfizer Inc. | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) |
| US6001860A (en) * | 1992-05-28 | 1999-12-14 | Pfizer Inc. | N-aryl and N-heteroarylurea derivatives as inhibitors of acyl coenzyme A: Cholesterol acyl transferase (ACAT) |
| CA2302735A1 (en) * | 1998-07-14 | 2000-01-27 | Em Industries, Inc. | Microdisperse drug delivery systems |
| US7015233B2 (en) * | 2003-06-12 | 2006-03-21 | Abbott Laboratories | Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor |
| RU2373923C2 (ru) * | 2004-06-08 | 2009-11-27 | Вертекс Фармасьютикалз Инкорпорейтед | Фармацевтические композиции |
| ES2306216T3 (es) * | 2004-08-27 | 2008-11-01 | Bayer Pharmaceuticals Corporation | Composiciones farmaceuticas en forma de dispersiones solidas para el tratamiento de cancer. |
| EP1877042A4 (en) * | 2005-04-18 | 2011-03-02 | Rubicon Res Private Ltd | BIOLOGICALLY IMPROVED COMPOSITIONS |
| KR100715355B1 (ko) * | 2005-09-30 | 2007-05-07 | 주식회사유한양행 | 프란루카스트를 함유하는 분무-건조 과립 및 그의 제조방법 |
| CN101346128B (zh) * | 2005-10-25 | 2013-10-02 | 雅培制药有限公司 | 包含低水溶解度药物的配方及其使用方法 |
| WO2007066189A2 (en) * | 2005-12-09 | 2007-06-14 | Pfizer Products Inc. | Salts, prodrugs and formulations of 1-[5-(4-amino-7-isopropyl-7h-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-2-methoxy-phenyl]-3-(2,4-dichloro-phenyl)-urea |
| US7745448B2 (en) * | 2005-12-28 | 2010-06-29 | Abbott Laboratories Inc. | Crystalline N-(4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl)-N′-(2-fluoro-5-(trifluoromethyl)phenyl)urea ethanolate |
| BRPI0707584A2 (pt) * | 2006-02-09 | 2011-05-10 | Merck & Co Inc | composiÇço farmacÊutica, uso da composiÇço farmacÊutica, e, formulaÇço farmacÊutica |
-
2008
- 2008-10-17 TW TW097140229A patent/TW200922549A/zh unknown
- 2008-10-17 AR ARP080104542A patent/AR068916A1/es not_active Application Discontinuation
- 2008-10-17 MX MX2010004292A patent/MX2010004292A/es not_active Application Discontinuation
- 2008-10-17 UA UAA201006030A patent/UA100866C2/ru unknown
- 2008-10-17 UY UY31406A patent/UY31406A1/es not_active Application Discontinuation
- 2008-10-17 RU RU2010119924/15A patent/RU2010119924A/ru not_active Application Discontinuation
- 2008-10-17 CN CN200880112161A patent/CN101827585A/zh active Pending
- 2008-10-17 AU AU2008313620A patent/AU2008313620A1/en not_active Abandoned
- 2008-10-17 EP EP08840773A patent/EP2197426A2/en not_active Withdrawn
- 2008-10-17 BR BRPI0818339 patent/BRPI0818339A2/pt not_active IP Right Cessation
- 2008-10-17 PE PE2008001785A patent/PE20091041A1/es not_active Application Discontinuation
- 2008-10-17 CL CL2008003092A patent/CL2008003092A1/es unknown
- 2008-10-17 US US12/253,499 patent/US20090143423A1/en not_active Abandoned
- 2008-10-17 CA CA2699335A patent/CA2699335A1/en not_active Abandoned
- 2008-10-17 WO PCT/EP2008/064073 patent/WO2009050289A2/en active Application Filing
- 2008-10-17 KR KR1020107010874A patent/KR20100090689A/ko not_active Application Discontinuation
- 2008-10-17 JP JP2010529406A patent/JP2011500647A/ja active Pending
-
2010
- 2010-03-25 ZA ZA2010/02130A patent/ZA201002130B/en unknown
- 2010-04-15 GT GT201000095A patent/GT201000095A/es unknown
- 2010-04-16 DO DO2010000114A patent/DOP2010000114A/es unknown
- 2010-04-27 CO CO10049270A patent/CO6270303A2/es not_active Application Discontinuation
- 2010-05-17 EC EC2010010184A patent/ECSP10010184A/es unknown
- 2010-05-19 CR CR11441A patent/CR11441A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR068916A1 (es) | 2009-12-16 |
| TW200922549A (en) | 2009-06-01 |
| CN101827585A (zh) | 2010-09-08 |
| EP2197426A2 (en) | 2010-06-23 |
| CO6270303A2 (es) | 2011-04-20 |
| KR20100090689A (ko) | 2010-08-16 |
| UY31406A1 (es) | 2009-05-29 |
| UA100866C2 (ru) | 2013-02-11 |
| CR11441A (es) | 2010-10-25 |
| RU2010119924A (ru) | 2011-11-27 |
| JP2011500647A (ja) | 2011-01-06 |
| ECSP10010184A (es) | 2010-06-29 |
| BRPI0818339A2 (pt) | 2015-04-22 |
| CA2699335A1 (en) | 2009-04-23 |
| WO2009050289A3 (en) | 2010-03-25 |
| GT201000095A (es) | 2012-04-03 |
| AU2008313620A1 (en) | 2009-04-23 |
| CL2008003092A1 (es) | 2009-11-27 |
| MX2010004292A (es) | 2010-08-02 |
| DOP2010000114A (es) | 2010-05-15 |
| WO2009050289A2 (en) | 2009-04-23 |
| ZA201002130B (en) | 2011-11-30 |
| US20090143423A1 (en) | 2009-06-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |