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PE20090321A1 - Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica - Google Patents

Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica

Info

Publication number
PE20090321A1
PE20090321A1 PE2008000929A PE2008000929A PE20090321A1 PE 20090321 A1 PE20090321 A1 PE 20090321A1 PE 2008000929 A PE2008000929 A PE 2008000929A PE 2008000929 A PE2008000929 A PE 2008000929A PE 20090321 A1 PE20090321 A1 PE 20090321A1
Authority
PE
Peru
Prior art keywords
hvr
seq
notch1 nrr
preparation
sequence
Prior art date
Application number
PE2008000929A
Other languages
English (en)
Inventor
Yan Wu
Christian Siebel
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39735560&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20090321(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PE20090321A1 publication Critical patent/PE20090321A1/es

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C12N5/10—Cells modified by introduction of foreign genetic material
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Abstract

REFERIDA A ANTICUERPOS HUMANIZADOS anti-NOTCH1 NRR (REGION REGULADORA NEGATIVA), QUE SE CARACTERIZA POR SER INICIALMENTE AISLADO DE HUMANO O RATON; UNIRSE A UN RECEPTOR NOTCH1 NRR CON UN Kd DE 1X10-7 A MAS; Y QUE COMPRENDE: a)AL MENOS 1 A 5 SECUENCIAS DE LA REGION HIPERVARIABLE (HVR) SELECCIONADA DE; HVR-L1 QUE ES LA SECUENCIA RASQDVSTAVA (SEQ ID NO:7), HVR-L2 QUE ES LA SECUENCIA SASFLYS (SEQ ID NO:8), HVR-H3 QUE ES LA SECUENCIA ARGSGFRWVMDY (SEQ ID NO:6), ENTRE OTRAS; b)AL MENOS UNA VARIANTE DE HVR, DE ALMENOS UN RESIDUO DE LA SEQ ID NOS: 1 A 12. SE REFIERE TAMBIEN A UN POLINUCLEOTIDO CODIFICADOR, UN VECTOR DE EXPRESION, CELULAS HUESPED, UN METODO DE PREPARACION DEL INMUNOCONJUGADO Y COMPOSICION FARMACEUTICA. DICHOS ANTICUERPOS SON INICIALMENTE AISLADOS DE HUMANO O RATON Y DISMINUYEN LA SENALIZACION DE NOTCH1 LA CUAL ES IMPORTANTE EN EL CRECIMIENTO TUMORAL
PE2008000929A 2007-06-04 2008-06-02 Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica PE20090321A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93307207P 2007-06-04 2007-06-04
US99464607P 2007-09-20 2007-09-20

Publications (1)

Publication Number Publication Date
PE20090321A1 true PE20090321A1 (es) 2009-04-20

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PE2008000929A PE20090321A1 (es) 2007-06-04 2008-06-02 Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica

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US (5) US8846871B2 (es)
EP (1) EP2152748B1 (es)
JP (4) JP5623272B2 (es)
KR (2) KR20100021581A (es)
CN (1) CN101796074B (es)
AR (1) AR066846A1 (es)
BR (1) BRPI0811382A2 (es)
CA (1) CA2687866C (es)
CL (1) CL2008001634A1 (es)
CO (1) CO6150200A2 (es)
CR (2) CR11139A (es)
CY (1) CY1114690T1 (es)
DK (1) DK2152748T3 (es)
EC (1) ECSP099785A (es)
ES (1) ES2432798T3 (es)
HK (1) HK1141040A1 (es)
HR (1) HRP20131107T1 (es)
IL (3) IL202183A0 (es)
MA (1) MA31502B1 (es)
MX (1) MX2009013199A (es)
NZ (1) NZ581303A (es)
PE (1) PE20090321A1 (es)
PH (1) PH12015500550A1 (es)
PL (1) PL2152748T3 (es)
PT (1) PT2152748E (es)
RU (1) RU2476443C2 (es)
SI (1) SI2152748T1 (es)
TW (1) TWI458737B (es)
WO (1) WO2008150525A1 (es)

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US6984522B2 (en) * 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
JP2009539403A (ja) 2006-06-13 2009-11-19 オンコメッド ファーマシューティカルズ インコーポレイテッド 癌を診断および処置するための組成物および方法
BRPI0715989A8 (pt) 2006-10-19 2018-03-13 Genentech Inc "seqüencia variável da cadeia pesada ("vh"), região da cadeia vh, seqüências variável da cadeia leve ("vl"), região da cadeia vl, seqüencias da cadeia vh, ácidos nucléicos, vetor, célula, anticorpos ou fragmentos anticorpos, anticorpos, método para a produção de anticorpo, uso de um anticorpo, epítopos de ligação do notch3, composição e uso da composição"
PE20080891A1 (es) 2006-10-19 2008-08-25 Genentech Inc Anticuerpos anti-notch3 y composiciones que los comprenden
JP5386364B2 (ja) 2006-12-18 2014-01-15 ジェネンテック， インコーポレイテッド 抗Ｎｏｔｃｈ３アンタゴニスト抗体とＮｏｔｃｈ３関連疾患の予防及び治療におけるその使用
WO2008091641A2 (en) 2007-01-24 2008-07-31 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
PE20090321A1 (es) 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
EP2899211A1 (en) 2008-07-08 2015-07-29 OncoMed Pharmaceuticals, Inc. Notch1 receptor binding agents and methods of use thereof
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
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