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PE20210629A1 - Anticuerpos anti-klk5 y metodos de uso - Google Patents

Anticuerpos anti-klk5 y metodos de uso

Info

Publication number
PE20210629A1
PE20210629A1 PE2020001391A PE2020001391A PE20210629A1 PE 20210629 A1 PE20210629 A1 PE 20210629A1 PE 2020001391 A PE2020001391 A PE 2020001391A PE 2020001391 A PE2020001391 A PE 2020001391A PE 20210629 A1 PE20210629 A1 PE 20210629A1
Authority
PE
Peru
Prior art keywords
seq
amino acid
acid sequence
hvr
group
Prior art date
Application number
PE2020001391A
Other languages
English (en)
Inventor
Cecilia P C Chiu
Hilda Y Hernandez-Barry
David B Iaea
Moulay Hicham Alaoui Ismaili
James T Koerber
wei yu Lin
Kelly Loyet
Jawahar Sudhamsu
Yonglian Sun
Benjamin T Walters
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PE20210629A1 publication Critical patent/PE20210629A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6871—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting an enzyme
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6445—Kallikreins (3.4.21.34; 3.4.21.35)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invencion se refiere a un anticuerpo anti-KLK5 que comprende: (a) una HVR-H1 que comprende la secuencia de aminoacidos de la SEQ ID NO: 28; (b) una HVR-H2 que comprende la secuencia de aminoacidos seleccionada del grupo que consiste en la SEQ ID NO: 38, la SEQ ID NO: 45 y la SEQ ID NO: 54; (c) una HVR-H3 que comprende la secuencia de aminoacidos seleccionada del grupo que consiste en la SEQ ID NO: 65, la SEQ ID NO: 69 y la SEQ ID NO: 72; (d) una HVR-L1 que comprende la secuencia de aminoacidos de la SEQ ID NO: 96; (e) una HVR-L2 que comprende la secuencia de aminoacidos de la SEQ ID NO: 109; y (f) una HVL-L3 que comprende la secuencia de aminoacidos de la SEQ ID NO: 127, tambien se refiere a un anticuerpo anti-KLK5 que comprende: (a) una HVR-H1 que comprende la secuencia de aminoacidos seleccionada del grupo que consiste en la SEQ ID NO: 17, SEQ ID NO: 22 y SEQ ID NO: 24; (b) una HVR-H2 que comprende la secuencia de aminoacidos seleccionada del grupo que consiste en la SEQ ID NO: 35, SEQ ID NO: 36, SEQ ID NO: 37, SEQ ID NO: 42, SEQ ID NO: 43, SEQ ID NO: 44, SEQ ID NO: 48, SEQ ID NO: 49, SEQ ID NO: 50, SEQ ID NO: 51, SEQ ID NO: 52 y SEQ ID NO: 53; (c) una HVR-H3 que comprende la secuencia de aminoacidos seleccionada del grupo que consiste en la SEQ ID NO: 65, SEQ ID NO: 69 y SEQ ID NO: 72; (d) una HVR-L1 que comprende la secuencia de aminoacidos seleccionada del grupo que consiste en la SEQ ID NO: 82, SEQ ID NO: 87 y SEQ ID NO: 91; (e) una HVR-L2 que comprende la secuencia de aminoacidos seleccionada del grupo que consiste en la SEQ ID NO: 99, SEQ ID NO: 101 y SEQ ID NO: 105; y (f) una HVR-L3 que comprende la secuencia de aminoacidos seleccionada del grupo que consiste en la SEQ ID NO: 115, SEQ ID NO: 119 y SEQ ID NO: 122, dichos anticuerpos inhiben la actividad biologica de la KLK5 y son utiles en el tratamiento del sindrome de Netherton, asma, dermatitis atopica, psoriasis, esofagitis eosinofilica, rosacea, entre otros
PE2020001391A 2018-03-14 2019-03-14 Anticuerpos anti-klk5 y metodos de uso PE20210629A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862643034P 2018-03-14 2018-03-14
PCT/US2019/022192 WO2019178316A1 (en) 2018-03-14 2019-03-14 Anti-klk5 antibodies and methods of use

Publications (1)

Publication Number Publication Date
PE20210629A1 true PE20210629A1 (es) 2021-03-23

Family

ID=66175479

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2020001391A PE20210629A1 (es) 2018-03-14 2019-03-14 Anticuerpos anti-klk5 y metodos de uso

Country Status (20)

Country Link
US (3) US20200040103A1 (es)
EP (1) EP3765606A1 (es)
JP (2) JP7422671B2 (es)
KR (1) KR20200130823A (es)
CN (1) CN111868241A (es)
AR (1) AR114281A1 (es)
AU (1) AU2019235881A1 (es)
BR (1) BR112020018571A2 (es)
CA (1) CA3091836A1 (es)
CL (1) CL2020002333A1 (es)
CR (1) CR20200404A (es)
IL (1) IL277212A (es)
MA (1) MA52014A (es)
MX (1) MX2020009465A (es)
PE (1) PE20210629A1 (es)
PH (1) PH12020551336A1 (es)
RU (1) RU2020133229A (es)
SG (1) SG11202008049XA (es)
TW (1) TW201946935A (es)
WO (1) WO2019178316A1 (es)

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PH12022550646A1 (en) 2019-09-18 2023-04-03 Genentech Inc Anti-klk7 antibodies, anti-klk5 antibodies, multispecific anti-klk5/klk7 antibodies, and methods of use
GB202001447D0 (en) * 2020-02-03 2020-03-18 Ucb Biopharma Sprl Antibodies
WO2022133089A1 (en) * 2020-12-18 2022-06-23 Bioardis, Llc Cea6 binding molecules and uses thereof
EP4304732A1 (en) 2021-03-12 2024-01-17 Genentech, Inc. Anti-klk7 antibodies, anti-klk5 antibodies, multispecific anti-klk5/klk7 antibodies, and methods of use
WO2023158431A1 (en) * 2022-02-18 2023-08-24 Adlai Nortye Usa Inc. Anti-tnfr2 antibody and application thereof
WO2024052922A1 (en) 2022-09-11 2024-03-14 Yeda Research And Development Co. Ltd. Anti-klk4 antibodies and uses thereof
WO2024091870A2 (en) * 2022-10-24 2024-05-02 Phanes Therapeutics, Inc. Anti-egfrviii antibodies and uses thereof

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