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PE20080281A1 - COMPUESTOS CINAMIDA COMO INHIBIDORES DE LA SINTESIS DEL ß-AMILOIDE 40 Y 42 - Google Patents

COMPUESTOS CINAMIDA COMO INHIBIDORES DE LA SINTESIS DEL ß-AMILOIDE 40 Y 42

Info

Publication number
PE20080281A1
PE20080281A1 PE2007000966A PE2007000966A PE20080281A1 PE 20080281 A1 PE20080281 A1 PE 20080281A1 PE 2007000966 A PE2007000966 A PE 2007000966A PE 2007000966 A PE2007000966 A PE 2007000966A PE 20080281 A1 PE20080281 A1 PE 20080281A1
Authority
PE
Peru
Prior art keywords
alkyl
compounds
methyl
members
trifluoroacetate
Prior art date
Application number
PE2007000966A
Other languages
English (en)
Inventor
Teiji Kimura
Koki Kawano
Noritaka Kitazawa
Nobuaki Sato
Toshihiko Kaneko
Koichi Ito
Mamoru Takaishi
Ikuo Kushida
Original Assignee
Eisai Randd Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Randd Man Co Ltd filed Critical Eisai Randd Man Co Ltd
Publication of PE20080281A1 publication Critical patent/PE20080281A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Cultivation Of Plants (AREA)
  • Seasonings (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS CINAMIDA DE FORMULA (I) DONDE Ra Y Rb SON CADA UNO H O ALQUILO(C1-C6); Xa ES METOXI O F; Y ES -CO-(O)n-Rc.Ma-, DONDE Rc ES ALQUILO(C1-C6), ANILLO AROMATICO DE 6 A 14 MIEMBROS, HETEROCICLO DE 5 A 14 MIEMBROS, ENTRE OTROS; n ES 0 O 1; Ma- ES UN ANION; A ES UN COMPUESTO DE FORMULA (A-1), ENTRE OTROS, DONDE R1, R2, R3 Y R4 SON CADA UNO H O ALQUILO(C1-C6); X1 ES ALQUILENO(C1-C6) OPCIONALMENTE SUSTITUIDO CON HIDROXILO O ALQUILO(C1-C6); X2 ES O U METILENO OPCIONALMENTE SUSTITUIDO CON ALQUILO(C1-C6); Ar1 ES X1-a-Ar1-a, DONDE Ar1-a ES UN ANILLO AROMATICO DE 6 A 14 MIEMBROS O UN HETEROCICLO DE 5 A 14 MIEMBROS; X1-a ES UN ENLACE SIMPLE U O. SON COMPUESTOS PREFERIDOS: 3-{4-{1-[(S)-1-(4-FLUOROFENIL)ETIL]-2-OXOPIPERIDIN-(3E)-ILIDENOMETIL}-2-METOXIFENIL}-5-METIL-1-(FOSFONOXIMETIL)-3H-IMIDAZOL-1-IO TRIFLUOROACETATO, 3-{4-{1-[(1R,2R)-2-HIDROXI-1-(3,4,5-TRIFLUOROFENIL)PROPIL]-2-OXOPIPERIDIN-(3E)-ILIDENOMETIL}-2-METOXIFENIL}-5-METIL-1-(FOSFONOXIMETIL)-3H-IMIDAZOL-1-IO TRIFLUOROACETATO, 3-[2-FLUORO-4-[(S)-4-[(1R,2R)-2-HIDROXI-1-(3,4,5-TRIFLUOROFENIL)PROPIL]-6-METIL-3-OXOMORFOLINA-(2Z)-ILIDENOMETIL]FENIL]-5-METIL-1-FOSFONOXIMETIL-3H-IMIDAZOL-1-IO TRIFLUOROACETATO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA SINTESIS DEL B-AMILOIDE 40 Y 42 SIENDO UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER, DEMENCIA SENIL, AMILOIDOSIS
PE2007000966A 2006-07-28 2007-07-26 COMPUESTOS CINAMIDA COMO INHIBIDORES DE LA SINTESIS DEL ß-AMILOIDE 40 Y 42 PE20080281A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US82076106P 2006-07-28 2006-07-28
JP2006206007 2006-07-28
US86925906P 2006-12-08 2006-12-08
JP2006331274 2006-12-08

Publications (1)

Publication Number Publication Date
PE20080281A1 true PE20080281A1 (es) 2008-05-05

Family

ID=38981524

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000966A PE20080281A1 (es) 2006-07-28 2007-07-26 COMPUESTOS CINAMIDA COMO INHIBIDORES DE LA SINTESIS DEL ß-AMILOIDE 40 Y 42

Country Status (25)

Country Link
US (1) US7737141B2 (es)
EP (1) EP2048143A4 (es)
JP (1) JPWO2008013213A1 (es)
KR (1) KR20090033910A (es)
AR (1) AR062095A1 (es)
AU (1) AU2007277729A1 (es)
CA (1) CA2658037A1 (es)
CO (1) CO6150153A2 (es)
CR (1) CR10499A (es)
EA (1) EA200970172A1 (es)
EC (1) ECSP099091A (es)
GE (1) GEP20115176B (es)
HN (1) HN2009000157A (es)
IL (1) IL196351A0 (es)
MA (1) MA30636B1 (es)
MX (1) MX2008015504A (es)
MY (1) MY144971A (es)
NO (1) NO20090541L (es)
NZ (1) NZ574102A (es)
PE (1) PE20080281A1 (es)
SA (1) SA07280403B1 (es)
SV (1) SV2009003157A (es)
TN (1) TN2009000024A1 (es)
TW (1) TW200821319A (es)
WO (1) WO2008013213A1 (es)

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Also Published As

Publication number Publication date
CO6150153A2 (es) 2010-04-20
US7737141B2 (en) 2010-06-15
MA30636B1 (fr) 2009-08-03
KR20090033910A (ko) 2009-04-06
SV2009003157A (es) 2010-01-12
NO20090541L (no) 2009-02-03
NZ574102A (en) 2010-10-29
EP2048143A1 (en) 2009-04-15
MY144971A (en) 2011-11-30
TW200821319A (en) 2008-05-16
CA2658037A1 (en) 2008-01-31
WO2008013213A1 (en) 2008-01-31
TN2009000024A1 (en) 2010-08-19
GEP20115176B (en) 2011-03-10
EP2048143A4 (en) 2010-11-03
US20090048213A1 (en) 2009-02-19
MX2008015504A (es) 2008-12-18
SA07280403B1 (ar) 2010-12-01
HN2009000157A (es) 2011-01-24
EA200970172A1 (ru) 2009-08-28
JPWO2008013213A1 (ja) 2009-12-17
IL196351A0 (en) 2009-09-22
ECSP099091A (es) 2009-02-27
AR062095A1 (es) 2008-10-15
AU2007277729A1 (en) 2008-01-31
CR10499A (es) 2009-03-20

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