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SV2009003157A - Profarmaco de compuesto de cinamida - Google Patents

Profarmaco de compuesto de cinamida

Info

Publication number
SV2009003157A
SV2009003157A SV2009003157A SV2009003157A SV2009003157A SV 2009003157 A SV2009003157 A SV 2009003157A SV 2009003157 A SV2009003157 A SV 2009003157A SV 2009003157 A SV2009003157 A SV 2009003157A SV 2009003157 A SV2009003157 A SV 2009003157A
Authority
SV
El Salvador
Prior art keywords
profarmaco
cinamide
group
formula
similar
Prior art date
Application number
SV2009003157A
Other languages
English (en)
Inventor
Teiji Kimura
Koki Kawano
Noritaka Kitazawa
Mamoru Takaishi
Toshihiko Kaneko
Koichi Ito
Ikuo Kushida
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of SV2009003157A publication Critical patent/SV2009003157A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Cultivation Of Plants (AREA)
  • Seasonings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

LA DESCRIPCIÓN ES UN PROFÁRMACO ÓPTIMO DE UN COMPUESTO DE CINAMIDA REPRESENTADO POR LA FÓRMULA (I) A CONTINUACIÓN: (VER FORMULA); EN LA FÓRMULA, RA Y RB RESPECTIVAMENTE REPRESENTAN UN 0 GRUPO ALQUILO CL-6 O LOS SIMILARES; XA REPRESENTA UN GRUPO METOXI O UN ÁTOMO DE FLÚOR; Y REPRESENTA UN GRUPO FOSFONO O LOS SIMILARES; Y A REPRESENTA UN DERIVADO DE LACTAMA CÍCLICO
SV2009003157A 2006-07-28 2009-01-28 Profarmaco de compuesto de cinamida SV2009003157A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US82076106P 2006-07-28 2006-07-28
JP2006206007 2006-07-28
US86925906P 2006-12-08 2006-12-08
JP2006331274 2006-12-08

Publications (1)

Publication Number Publication Date
SV2009003157A true SV2009003157A (es) 2010-01-12

Family

ID=38981524

Family Applications (1)

Application Number Title Priority Date Filing Date
SV2009003157A SV2009003157A (es) 2006-07-28 2009-01-28 Profarmaco de compuesto de cinamida

Country Status (25)

Country Link
US (1) US7737141B2 (es)
EP (1) EP2048143A4 (es)
JP (1) JPWO2008013213A1 (es)
KR (1) KR20090033910A (es)
AR (1) AR062095A1 (es)
AU (1) AU2007277729A1 (es)
CA (1) CA2658037A1 (es)
CO (1) CO6150153A2 (es)
CR (1) CR10499A (es)
EA (1) EA200970172A1 (es)
EC (1) ECSP099091A (es)
GE (1) GEP20115176B (es)
HN (1) HN2009000157A (es)
IL (1) IL196351A0 (es)
MA (1) MA30636B1 (es)
MX (1) MX2008015504A (es)
MY (1) MY144971A (es)
NO (1) NO20090541L (es)
NZ (1) NZ574102A (es)
PE (1) PE20080281A1 (es)
SA (1) SA07280403B1 (es)
SV (1) SV2009003157A (es)
TN (1) TN2009000024A1 (es)
TW (1) TW200821319A (es)
WO (1) WO2008013213A1 (es)

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TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
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CN110478343A (zh) * 2013-03-12 2019-11-22 比皮艾思药物研发有限公司 氨基甲酸苯酯化合物和包含该化合物的用于预防或治疗神经性毒气引起的疾病的组合物
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Also Published As

Publication number Publication date
EP2048143A1 (en) 2009-04-15
US20090048213A1 (en) 2009-02-19
NO20090541L (no) 2009-02-03
US7737141B2 (en) 2010-06-15
TN2009000024A1 (en) 2010-08-19
EP2048143A4 (en) 2010-11-03
TW200821319A (en) 2008-05-16
SA07280403B1 (ar) 2010-12-01
WO2008013213A1 (en) 2008-01-31
CA2658037A1 (en) 2008-01-31
ECSP099091A (es) 2009-02-27
MX2008015504A (es) 2008-12-18
NZ574102A (en) 2010-10-29
AU2007277729A1 (en) 2008-01-31
JPWO2008013213A1 (ja) 2009-12-17
MA30636B1 (fr) 2009-08-03
CR10499A (es) 2009-03-20
PE20080281A1 (es) 2008-05-05
AR062095A1 (es) 2008-10-15
GEP20115176B (en) 2011-03-10
EA200970172A1 (ru) 2009-08-28
IL196351A0 (en) 2009-09-22
MY144971A (en) 2011-11-30
CO6150153A2 (es) 2010-04-20
HN2009000157A (es) 2011-01-24
KR20090033910A (ko) 2009-04-06

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