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PE20071068A1 - Acido 3-(4-{[4-(4-{[3-(3,3-dimetil-1-piperidinil)propil]oxi}fenil)-1-piperidinil]carbonil}-1-naftalenil)propanoico o propenoico, sales de los mismos, como antagonistas de los receptores h1 y h3 - Google Patents

Acido 3-(4-{[4-(4-{[3-(3,3-dimetil-1-piperidinil)propil]oxi}fenil)-1-piperidinil]carbonil}-1-naftalenil)propanoico o propenoico, sales de los mismos, como antagonistas de los receptores h1 y h3

Info

Publication number
PE20071068A1
PE20071068A1 PE2006001620A PE2006001620A PE20071068A1 PE 20071068 A1 PE20071068 A1 PE 20071068A1 PE 2006001620 A PE2006001620 A PE 2006001620A PE 2006001620 A PE2006001620 A PE 2006001620A PE 20071068 A1 PE20071068 A1 PE 20071068A1
Authority
PE
Peru
Prior art keywords
piperidinyl
naphthalenyl
oxy
receptors
carbonyl
Prior art date
Application number
PE2006001620A
Other languages
English (en)
Inventor
Simon Teanby Hodgson
Panayiotis Alexandrou Procopiou
Brugarolas Maria Victoria Vinader
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0525897A external-priority patent/GB0525897D0/en
Priority claimed from GB0623217A external-priority patent/GB0623217D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20071068A1 publication Critical patent/PE20071068A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

REFERIDA A UN COMPUESTO DERIVADO DE NAFTALENO DE FORMULA (I), DONDE R1 ES -CH2CH2COOH O -CH=C(CH3)COOH. UN COMPUESTO PREFERIDO ES EL ACIDO 3-(4-{[4-(4-{[3,3-DIMETIL-1-PIPERIDINIL)PROPIL]OXI}FENIL)-1-PIPERIDINIL]CARBONIL}-1-NAFTALENIL)PROPANOICO O UNA SAL DEL MISMO. DICHOS COMPUESTOS SON ANTAGONISTAS DUALES DE LOS RECEPTORES H1 Y H3 DE HISTAMINA Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS INFLAMATORIOS Y/O ALERGICOS
PE2006001620A 2005-12-20 2006-12-18 Acido 3-(4-{[4-(4-{[3-(3,3-dimetil-1-piperidinil)propil]oxi}fenil)-1-piperidinil]carbonil}-1-naftalenil)propanoico o propenoico, sales de los mismos, como antagonistas de los receptores h1 y h3 PE20071068A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0525897A GB0525897D0 (en) 2005-12-20 2005-12-20 Compounds
GB0623217A GB0623217D0 (en) 2006-11-21 2006-11-21 Compounds

Publications (1)

Publication Number Publication Date
PE20071068A1 true PE20071068A1 (es) 2007-12-13

Family

ID=37845266

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001620A PE20071068A1 (es) 2005-12-20 2006-12-18 Acido 3-(4-{[4-(4-{[3-(3,3-dimetil-1-piperidinil)propil]oxi}fenil)-1-piperidinil]carbonil}-1-naftalenil)propanoico o propenoico, sales de los mismos, como antagonistas de los receptores h1 y h3

Country Status (25)

Country Link
US (1) US7989629B2 (es)
EP (2) EP2157087A1 (es)
JP (2) JP4445570B2 (es)
KR (1) KR20080087102A (es)
AR (1) AR058109A1 (es)
AT (1) ATE449769T1 (es)
AU (1) AU2006328512B2 (es)
BR (1) BRPI0620218A2 (es)
CA (1) CA2634391A1 (es)
CR (1) CR10102A (es)
CY (1) CY1110601T1 (es)
DE (1) DE602006010737D1 (es)
DK (1) DK1963307T3 (es)
EA (1) EA014354B1 (es)
ES (1) ES2337187T3 (es)
HK (1) HK1120265A1 (es)
IL (1) IL191967A0 (es)
MA (1) MA30373B1 (es)
NO (1) NO20082695L (es)
PE (1) PE20071068A1 (es)
PL (1) PL1963307T3 (es)
PT (1) PT1963307E (es)
SI (1) SI1963307T1 (es)
TW (1) TW200730498A (es)
WO (1) WO2007071691A1 (es)

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EA019819B1 (ru) 2008-05-23 2014-06-30 ПАНМИРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Кристаллическая полиморфная форма с ингибитора белка, активирующего 5-липоксигеназу, фармацевтическая композиция на ее основе и применение в лечении
WO2011000765A1 (en) 2009-06-29 2011-01-06 Glaxo Group Limited New medical use
JP4785963B2 (ja) 2009-10-09 2011-10-05 キヤノン株式会社 固体撮像装置
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
EP3142694A2 (en) 2014-05-12 2017-03-22 Glaxosmithkline Intellectual Property (No. 2) Limited Pharmaceutical compositions comprising danirixin for treating infectious diseases
KR101640756B1 (ko) 2014-10-28 2016-07-19 이종찬 전동 드릴 장착용 내시경 캡
EP3758689A4 (en) * 2018-03-01 2022-01-12 Ferox Therapeutics LLC METHODS FOR THE PREVENTION AND TREATMENT OF HYPOGLYCEMIA IN PATIENTS WITH TYPE 1 AND TYPE 2 DIABETES
CN116194114A (zh) 2020-03-26 2023-05-30 葛兰素史密斯克莱知识产权发展有限公司 用于防止或治疗病毒感染的组织蛋白酶抑制剂

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Also Published As

Publication number Publication date
DK1963307T3 (da) 2010-04-06
PL1963307T3 (pl) 2010-05-31
EA014354B1 (ru) 2010-10-29
BRPI0620218A2 (pt) 2011-11-01
JP2009235087A (ja) 2009-10-15
KR20080087102A (ko) 2008-09-30
TW200730498A (en) 2007-08-16
JP4445570B2 (ja) 2010-04-07
AU2006328512B2 (en) 2011-06-23
SI1963307T1 (sl) 2010-03-31
EA200801342A1 (ru) 2008-12-30
IL191967A0 (en) 2008-12-29
CY1110601T1 (el) 2015-04-29
EP1963307B1 (en) 2009-11-25
EP1963307A1 (en) 2008-09-03
JP2009520001A (ja) 2009-05-21
ATE449769T1 (de) 2009-12-15
EP2157087A1 (en) 2010-02-24
WO2007071691A1 (en) 2007-06-28
DE602006010737D1 (de) 2010-01-07
NO20082695L (no) 2008-09-16
CR10102A (es) 2008-09-22
PT1963307E (pt) 2010-03-03
MA30373B1 (fr) 2009-05-04
ES2337187T3 (es) 2010-04-21
HK1120265A1 (en) 2009-03-27
CA2634391A1 (en) 2007-06-28
AU2006328512A1 (en) 2007-06-28
AR058109A1 (es) 2008-01-23
US7989629B2 (en) 2011-08-02
US20080312280A1 (en) 2008-12-18

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