[go: up one dir, main page]

NO941986L - Anti-kreft immunoterapeutisk vektorkonstruksjoner - Google Patents

Anti-kreft immunoterapeutisk vektorkonstruksjoner

Info

Publication number
NO941986L
NO941986L NO941986A NO941986A NO941986L NO 941986 L NO941986 L NO 941986L NO 941986 A NO941986 A NO 941986A NO 941986 A NO941986 A NO 941986A NO 941986 L NO941986 L NO 941986L
Authority
NO
Norway
Prior art keywords
altered
expression
vector constructs
recombinant virus
altered cellular
Prior art date
Application number
NO941986A
Other languages
English (en)
Other versions
NO941986D0 (no
Inventor
Sunil Chada
Mordechai Bodner
Douglas J Jolly
Jack R Barber
Caty E Dejesus
Original Assignee
Viagene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viagene Inc filed Critical Viagene Inc
Publication of NO941986D0 publication Critical patent/NO941986D0/no
Publication of NO941986L publication Critical patent/NO941986L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Foreliggende oppfinnelse tilveiebringer en fremgangsmåte for å ødelegge selekterte tumorceller, som omfatter at det til et varmblodig dyr administreres en vektorkonstruksjon som styrer ekspresjonen av minst en immunogen, ikke-tumorogen form av en endret cellulær komponent som normalt er assosiert med de selekterte tumorceller. Det tilveiebringes også vektor- konstruksjoner som styrer ekspresjonen av endrede cellulære komponenter. Representative endrede cellulære komponenter innbefatter ras', p53", Kb", endret protein som kodes av Wilms tumorgenet, ubikvitin", DCC, APC, MCC, neu, en endret reseptor og bcr/abl. Det tilveiebringes også rekombinante virus som er bærere av en vektorkonstruksjon, målceller infisert med det rekombinante virus og farmasøytiske preparater som omfatter det rekombinante virus og et farmasøytisk akseptabelt bærer- eller fortynningsmiddel.
NO941986A 1991-11-29 1994-05-27 Anti-kreft immunoterapeutisk vektorkonstruksjoner NO941986L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80032891A 1991-11-29 1991-11-29
PCT/US1992/010309 WO1993010814A1 (en) 1991-11-29 1992-11-30 Anti-cancer immunotherapeutic vector constructs

Publications (2)

Publication Number Publication Date
NO941986D0 NO941986D0 (no) 1994-05-27
NO941986L true NO941986L (no) 1994-07-27

Family

ID=25178122

Family Applications (1)

Application Number Title Priority Date Filing Date
NO941986A NO941986L (no) 1991-11-29 1994-05-27 Anti-kreft immunoterapeutisk vektorkonstruksjoner

Country Status (10)

Country Link
US (1) US5693522A (no)
EP (1) EP0615453B1 (no)
JP (1) JPH07501942A (no)
AT (1) ATE152915T1 (no)
AU (1) AU671971B2 (no)
CA (1) CA2117303C (no)
DE (1) DE69219787T2 (no)
FI (1) FI942503L (no)
NO (1) NO941986L (no)
WO (1) WO1993010814A1 (no)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5662896A (en) * 1988-03-21 1997-09-02 Chiron Viagene, Inc. Compositions and methods for cancer immunotherapy
US5747469A (en) 1991-03-06 1998-05-05 Board Of Regents, The University Of Texas System Methods and compositions comprising DNA damaging agents and p53
US20030086935A1 (en) * 1992-07-22 2003-05-08 Levine Arnold J. p53 vaccine
AU4788693A (en) * 1992-07-22 1994-02-14 Trustees Of Princeton University, The P53 vaccine
JPH08504095A (ja) * 1992-09-18 1996-05-07 カンジ，インコーポレイテッド 腫瘍抑制遺伝子を有するレトロウイルスベクターによる遺伝子療法
US6953573B1 (en) * 1993-03-17 2005-10-11 University Of Washington Compounds for eliciting or enhancing immune reactivity to HER-2/neu protein for prevention or treatment of malignancies in which the HER-2/neu oncogene is associated
US5700657A (en) * 1993-12-13 1997-12-23 Genzyme Corporation Vectors and vector systems including genes encoding tumor suppressor proteins and producer cells transformed thereby
US5629192A (en) * 1994-02-04 1997-05-13 The United States Of America As Represented By The Department Of Health And Human Services ETS1 gene: a human tumor suppressor gene
AU697088B2 (en) * 1994-04-29 1998-09-24 Sidney Kimmel Cancer Center Enhancing the sensitivity of tumor cells to therapies
JP4303315B2 (ja) 1994-05-09 2009-07-29 オックスフォード バイオメディカ（ユーケー）リミテッド 非交差性レトロウイルスベクター
WO1997014426A1 (en) 1995-10-20 1997-04-24 University Of Nebraska Board Of Regents Compositions and methods for enhancing immune responses mediated by antigen-presenting cells
JP2002515734A (ja) * 1996-01-02 2002-05-28 カイロン コーポレイション 遺伝子改変された樹状細胞により媒介される免疫刺激
US6365151B1 (en) * 1996-01-19 2002-04-02 Philadelphia Health And Educational Corporation Cellular immunogens comprising cognate proto-oxogenes
US6942862B2 (en) * 1996-04-01 2005-09-13 University Of Washington Methods and compositions to generate immunity in humans against self tumor antigens by immunization with homologous foreign proteins
AU2800797A (en) 1996-04-05 1997-10-29 Chiron Corporation Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis
WO1998012332A1 (en) 1996-09-17 1998-03-26 Chiron Corporation Compositions and methods for treating intracellular diseases
US6884435B1 (en) * 1997-01-30 2005-04-26 Chiron Corporation Microparticles with adsorbent surfaces, methods of making same, and uses thereof
DK0991403T3 (da) * 1997-01-30 2003-07-28 Chiron Corp Anvendelse af mikropartikler med adsorberet antigen til stimulering af immunresponser
US20040202680A1 (en) * 1997-01-30 2004-10-14 O'hagan Derek Microparticles with adsorbent surfaces, methods of making same, and uses thereof
AU7486898A (en) 1997-05-13 1998-12-08 Stuart D Edwards Global medical treatment method and apparatus
FR2775601B1 (fr) * 1998-03-03 2001-09-21 Merial Sas Vaccins vivants recombines et adjuves
US6620382B1 (en) * 1998-05-22 2003-09-16 Biopheresis Technologies, Llc. Method and compositions for treatment of cancers
US7144581B2 (en) * 2000-10-09 2006-12-05 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US7329410B1 (en) 1998-09-30 2008-02-12 Corixa Corporation Compositions and method for WT1 specific immunotherapy
US7901693B2 (en) * 1998-09-30 2011-03-08 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US20030235557A1 (en) * 1998-09-30 2003-12-25 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US20030039635A1 (en) * 1998-09-30 2003-02-27 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US7115272B1 (en) 1998-09-30 2006-10-03 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US7063854B1 (en) * 1998-09-30 2006-06-20 Corixa Corporation Composition and methods for WTI specific immunotherapy
US7655249B2 (en) * 1998-09-30 2010-02-02 Corixa Corporation Compositions and methods for WT1 specific immunotherapy
US6787154B2 (en) * 1998-10-20 2004-09-07 Salvatore Albani Artificial antigen presenting cells
EP1123086B1 (en) 1998-10-20 2010-03-03 Androclus Technologies S.r.l. in liquidazione Artificial antigen-specific cells and related methods
US7807377B2 (en) 1998-10-20 2010-10-05 Salvatore Albani Method of isolating antigen-specific T cells employing artificial antigen presenting cells
GB9907414D0 (en) 1999-03-31 1999-05-26 Cancer Res Campaign Tech Improvements relating to prodrugs
US8647864B2 (en) 1999-04-14 2014-02-11 Novartis Ag Compositions and methods for generating an immune response utilizing alphavirus-based vector systems
US7049410B2 (en) * 1999-05-14 2006-05-23 Majumdar Adhip P N Antibodies to a novel EGF-receptor related protein (ERRP)
US6399743B1 (en) 1999-05-14 2002-06-04 Dept. Of Veterans Affairs Isolation and characterization of a rat epidermal growth factor related protein
AU6944100A (en) * 1999-09-01 2001-03-26 Johns Hopkins University, The Beta-catenin, tcf-4, and apc interact to prevent cancer
US6432409B1 (en) 1999-09-14 2002-08-13 Antigen Express, Inc. Hybrid peptides modulate the immune response
US20030235594A1 (en) * 1999-09-14 2003-12-25 Antigen Express, Inc. Ii-Key/antigenic epitope hybrid peptide vaccines
US9289487B2 (en) * 1999-09-14 2016-03-22 Antigen Express, Inc. II-key/antigenic epitope hybrid peptide vaccines
US6656718B2 (en) 2000-07-07 2003-12-02 Cancer Research Technology Limited Modified carboxypeptidase enzymes and their use
US7919467B2 (en) 2000-12-04 2011-04-05 Immunotope, Inc. Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer
US7083789B2 (en) 2000-12-04 2006-08-01 Immunotope, Inc. Cytotoxic T-lymphocyte-inducing immunogens for prevention, treatment, and diagnosis of cancer
WO2002099035A2 (en) 2001-05-31 2002-12-12 Chiron Corporation Chimeric alphavirus replicon particles
US7553494B2 (en) 2001-08-24 2009-06-30 Corixa Corporation WT1 fusion proteins
WO2004030616A2 (en) 2002-09-17 2004-04-15 Antigen Express, Inc. Ii-KEY/ANTIGENIC EPITOPE HYBRID PEPTIDE VACCINES
US7179645B2 (en) * 2002-09-24 2007-02-20 Antigen Express, Inc. Ii-Key/antigenic epitope hybrid peptide vaccines
WO2005087260A1 (en) * 2004-03-04 2005-09-22 Corixa Corporation Co-encapsulated wt1 polypeptide and immunostimulant microsphere formulations and methods thereof
EP1768662A2 (en) 2004-06-24 2007-04-04 Novartis Vaccines and Diagnostics, Inc. Small molecule immunopotentiators and assays for their detection
CA2571421A1 (en) 2004-06-24 2006-01-05 Nicholas Valiante Compounds for immunopotentiation
JP2009511636A (ja) 2005-10-18 2009-03-19 ノバルティス ヴァクシンズ アンド ダイアグノスティクス， インコーポレイテッド アルファウイルスレプリコン粒子による粘膜免疫および全身免疫
CA2647100A1 (en) * 2006-03-23 2007-09-27 Novartis Ag Methods for the preparation of imidazole-containing compounds
ES2388556T3 (es) * 2006-03-23 2012-10-16 Novartis Ag Compuestos inmunopotenciadores
ES2376492T3 (es) 2006-03-23 2012-03-14 Novartis Ag Compuestos de imidazoquinoxalina como inmunomoduladores.
CA3116266A1 (en) * 2008-01-28 2009-08-06 Implantica Patent Ltd. Blood clot removal device, system, and method
EP2391748A4 (en) * 2009-01-28 2012-08-01 Antigen Express Inc LI-KEY HYBRID PEPTIDES MODULATING IMMUNE RESPONSE TO FLU
WO2011149564A1 (en) 2010-05-28 2011-12-01 Tetris Online, Inc. Interactive hybrid asynchronous computer game infrastructure
EP3405212B1 (en) 2016-01-19 2020-07-08 Pfizer Inc Cancer vaccines

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4405712A (en) * 1981-07-01 1983-09-20 The United States Of America As Represented By The Department Of Health And Human Services LTR-Vectors
US4965196A (en) * 1983-01-19 1990-10-23 Genentech, Inc. Polycistronic expression vector construction
GB8424757D0 (en) * 1984-10-01 1984-11-07 Pasteur Institut Retroviral vector
US4797368A (en) * 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US4871838A (en) * 1985-07-23 1989-10-03 The Board Of Rijks Universiteit Leiden Probes and methods for detecting activated ras oncogenes
US4931275A (en) * 1985-12-02 1990-06-05 Yeda Research & Development Co., Ltd. Anti-tumor vaccines and their preparation
CA1310924C (en) * 1986-04-24 1992-12-01 Francis P. Mccormick Infective drug delivery system
US4861719A (en) * 1986-04-25 1989-08-29 Fred Hutchinson Cancer Research Center DNA constructs for retrovirus packaging cell lines
US4980289A (en) * 1987-04-27 1990-12-25 Wisconsin Alumni Research Foundation Promoter deficient retroviral vector
EP0293181B1 (en) * 1987-05-29 1995-08-16 Dana Farber Cancer Institute Cis-acting repression sequences, cis-acting anti-repression sequences, vectors, methods of preparation and use
WO1989001973A2 (en) * 1987-09-02 1989-03-09 Applied Biotechnology, Inc. Recombinant pox virus for immunization against tumor-associated antigens
WO1989002468A1 (en) * 1987-09-11 1989-03-23 Whitehead Institute For Biomedical Research Transduced fibroblasts and uses therefor
WO1989005349A1 (en) * 1987-12-09 1989-06-15 The Australian National University Method of combating viral infections
US4957859A (en) * 1988-02-16 1990-09-18 Hoffmann-La Roche Inc. Antibodies for transforming ras protein
JP3082204B2 (ja) * 1988-09-01 2000-08-28 ホワイトヘッド・インスティチュート・フォー・バイオメディカル・リサーチ 両栄養性および環境栄養性宿主域を持つ組換え体レトロウイルス
CA2357538A1 (en) * 1989-03-21 1990-10-04 Wisconsin Alumni Research Foundation Expression of exogenous polynucleotide sequences in a vertebrate
ES2106033T3 (es) * 1989-05-19 1997-11-01 Genentech Inc Dominio extracelular de her2.
FR2668064B1 (fr) * 1990-10-23 1994-12-16 Transgene Sa Composition pharmaceutique pour le traitement ou la prevention d'une tumeur maligne.

Also Published As

Publication number Publication date
AU671971B2 (en) 1996-09-19
US5693522A (en) 1997-12-02
FI942503A0 (fi) 1994-05-27
CA2117303A1 (en) 1993-06-10
FI942503L (fi) 1994-05-27
DE69219787T2 (de) 1997-08-28
JPH07501942A (ja) 1995-03-02
AU3229793A (en) 1993-06-28
EP0615453A1 (en) 1994-09-21
DE69219787D1 (de) 1997-06-19
CA2117303C (en) 2000-10-17
WO1993010814A1 (en) 1993-06-10
NO941986D0 (no) 1994-05-27
EP0615453B1 (en) 1997-05-14
ATE152915T1 (de) 1997-05-15

Similar Documents

Publication Publication Date Title
NO941986L (no) Anti-kreft immunoterapeutisk vektorkonstruksjoner
WO1991002805A3 (en) Recombinant retroviruses delivering vector constructs to target cells
IL89701A0 (en) Recombinant retroviruses,method for the production thereof and pharmaceutical composition containing the same
DK0526905T3 (da) Multimerer af TNF-receptorers oplöselige former, deres fremstilling og farmaceutiske præparater indeholdende dem
NO885213L (no) Stabiliserte legemidler, fremgangsmaate til deres fremstilling samt stabile legemiddeltilberedninger.
DK551989A (da) 3-piperidinyl-1,2-benzisoxazoler, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende samme
PT642581E (pt) Vacinas de clostridium perfringens
BR9401183A (pt) Composto e formulação farmacêutica
KR860005636A (ko) 활성성분으로 스페르구알린(Spergualin)을 함유하는 주사제 조성물과 그 제조방법.
NO974693L (no) Farmasöytisk preparat inneholdende N-klorfenylkarbamater, N-klorfenyltiokarbamater og N-fosfonoglycin-derivater for å inhibere vekst av cancer og virus i pattedyr
DK1149910T3 (da) Farmaceutisk præparat til behandling af papillomavirustumorer og -infektion
ATE184798T1 (de) Hgh enthaltende pharmazeutische zubereitungen
AU4826493A (en) Anti-feline immunodeficiency virus (fiv) vaccines
DK0516588T3 (da) Substituerede diaminophthalimider og analoger
AU597090B2 (en) 2-acyloxypropylamine derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
WO2000052045A3 (en) Mage-3 derived immunogenic peptides presented by mhc of class ii and the use thereof
DE69431662D1 (de) Stabilisierte tablettenformulierung
DK630088D0 (da) Azelastinembonat, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater med indhold af denne forbindelse som aktivt middel
EP0370090A4 (en) Immunogens and biologically active peptides derived from shared sequences from antigens and anti-idiotypic antibodies or antibodies specific for cellular receptors of the antigens
GB2021581A (en) Stabilisation of PGl2 derivatives
DK598184A (da) 3-aryl-1,2-benzisoxazolsulfonyl- og -sulfinylalkansyrer og farmaceutisk acceptable salte deraf, deres fremstilling og anvendelse som laegemidler
ATE264395T1 (de) Herstellung von bacillus thuringiensis integrants
ITMI922332A1 (it) Composizioni farmaceutiche per la somministrazione di paratormone, suoi frammenti biologicamente attivi o peptidi correlati per via rettale.