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NO893149L - Fremgangsmaate til mikrobiologisk fremstilling av humant serumalbumin og andre heterologe proteiner fra gjaer. - Google Patents

Fremgangsmaate til mikrobiologisk fremstilling av humant serumalbumin og andre heterologe proteiner fra gjaer.

Info

Publication number
NO893149L
NO893149L NO89893149A NO893149A NO893149L NO 893149 L NO893149 L NO 893149L NO 89893149 A NO89893149 A NO 89893149A NO 893149 A NO893149 A NO 893149A NO 893149 L NO893149 L NO 893149L
Authority
NO
Norway
Prior art keywords
serum albumin
humant
yours
procedure
microbiological preparation
Prior art date
Application number
NO89893149A
Other languages
English (en)
Other versions
NO893149D0 (no
Inventor
Reinhard Fleer
Hiroshi Fukuhara
Patrice Yeh
Original Assignee
Rhone Poulenc Sante
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8810615A external-priority patent/FR2635115B1/fr
Application filed by Rhone Poulenc Sante filed Critical Rhone Poulenc Sante
Publication of NO893149D0 publication Critical patent/NO893149D0/no
Publication of NO893149L publication Critical patent/NO893149L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

En mikrobiologisk metode til fremstilling av humant serumalbumin og andre hetero- loge (ikke-gjær) proteiner ved dyrking av en gjær, særlig av slekten Kluyveromyces, modifisert ved bruk av rekombinant-DNA- teknikker, er beskrevet.
NO89893149A 1988-08-05 1989-08-03 Fremgangsmaate til mikrobiologisk fremstilling av humant serumalbumin og andre heterologe proteiner fra gjaer. NO893149L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8810615A FR2635115B1 (fr) 1988-08-05 1988-08-05 Procede de preparation de la serum albumine humaine a partir d'une levure
FR898908897A FR2649991B2 (fr) 1988-08-05 1989-07-03 Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces

Publications (2)

Publication Number Publication Date
NO893149D0 NO893149D0 (no) 1989-08-03
NO893149L true NO893149L (no) 1990-02-06

Family

ID=26226839

Family Applications (1)

Application Number Title Priority Date Filing Date
NO89893149A NO893149L (no) 1988-08-05 1989-08-03 Fremgangsmaate til mikrobiologisk fremstilling av humant serumalbumin og andre heterologe proteiner fra gjaer.

Country Status (13)

Country Link
EP (1) EP0361991B1 (no)
JP (1) JP3068139B2 (no)
KR (1) KR910004800A (no)
AT (1) ATE187775T1 (no)
AU (1) AU623425B2 (no)
DE (1) DE68929115T2 (no)
DK (1) DK175846B1 (no)
FI (1) FI893702L (no)
FR (1) FR2649991B2 (no)
HU (1) HUT51329A (no)
NO (1) NO893149L (no)
NZ (1) NZ230229A (no)
PT (1) PT91381B (no)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2017176A1 (en) * 1989-05-22 1990-11-22 Yoshitomi Pharmaceutical Industries Ltd. Albumin gene-containing plasmid, transformant carrying same, production of such transformant and production of albumin
FR2676070B1 (fr) * 1991-04-30 1994-09-30 Rhone Poulenc Rorer Sa Promoteur de levure et son utilisation.
FR2678636A1 (fr) * 1991-07-02 1993-01-08 Rhone Poulenc Rorer Sa Procede de production de proteines recombinantes et cellules hote utilisees.
US5849874A (en) * 1991-07-12 1998-12-15 Gist-Brocades, N.V. Process for the purification of serum albumin
DE69230273T2 (de) 1991-07-12 2000-05-31 Dsm N.V., Heerlen Verfahren zur Reinigung von Serumalbumin
FR2679920A1 (fr) * 1991-08-02 1993-02-05 Rhone Poulenc Rorer Sa Levures recombinantes hautement stables pour la production de proteines recombinantes, leur preparation et leur utilisation.
FR2686620B1 (fr) * 1992-01-27 1995-06-23 Rhone Poulenc Rorer Sa Serum-albumine humaine, preparation et utilisation.
FR2686900B1 (fr) * 1992-01-31 1995-07-21 Rhone Poulenc Rorer Sa Nouveaux polypeptides ayant une activite de stimulation des colonies de granulocytes, leur preparation et compositions pharmaceutiques les contenant.
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
FR2693475B1 (fr) * 1992-07-08 1994-09-02 Rhone Poulenc Rorer Sa Procédé d'identification et/ou de clonage de promoteurs transcriptionnels, et utilisation de ces promoteurs pour l'expression de gènes.
FR2693463B1 (fr) * 1992-07-08 1994-09-02 Rhone Poulenc Rorer Sa Promoteur de levure et son utilisation.
FR2693464B1 (fr) * 1992-07-08 1994-09-02 Rhone Poulenc Rorer Sa Promoteur de levure et son utilisation.
FR2694294B1 (fr) * 1992-07-30 1994-09-09 Rhone Poulenc Rorer Sa Promoteur de levure et son utilisateur.
DE4226971C2 (de) * 1992-08-14 1997-01-16 Widmar Prof Dr Tanner Modifizierte Pilzzellen und Verfahren zur Herstellung rekombinanter Produkte
US5728553A (en) 1992-09-23 1998-03-17 Delta Biotechnology Limited High purity albumin and method of producing
CA2136564C (en) * 1993-11-26 2008-04-08 Kaoru Kobayashi Process for producing human serum albumin
DK0699687T3 (da) * 1994-08-31 2004-04-26 Mitsubishi Pharma Corp Fremgangsmåde til oprensning af rekombinant humant serumalbumin
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
GB9902000D0 (en) 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
US8632785B2 (en) 2000-02-08 2014-01-21 Allergan, Inc. Clostridial toxin pharmaceutical composition containing a gelatin fragment
US20030118598A1 (en) 2000-02-08 2003-06-26 Allergan, Inc. Clostridial toxin pharmaceutical compositions
US7780967B2 (en) 2000-02-08 2010-08-24 Allergan, Inc. Reduced toxicity Clostridial toxin pharmaceutical compositions
EP1253932B1 (en) † 2000-02-08 2005-04-27 Allergan, Inc. Botulinum toxin pharmaceutical compositions
US20030199043A1 (en) 2000-04-12 2003-10-23 Ballance David J. Albumin fusion proteins
US6946134B1 (en) 2000-04-12 2005-09-20 Human Genome Sciences, Inc. Albumin fusion proteins
US7507413B2 (en) 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
EP2305314B1 (en) 2001-10-10 2015-12-23 ratiopharm GmbH Remodelling and glycoconjugation of antibodies
US20080194481A1 (en) 2001-12-21 2008-08-14 Human Genome Sciences, Inc. Albumin Fusion Proteins
JP5424521B2 (ja) 2001-12-21 2014-02-26 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド アルブミン融合タンパク質
KR100441384B1 (ko) * 2002-01-08 2004-07-21 주식회사 안지오랩 인간 혈청 알부민-팀프-2 융합 단백질 발현시스템 및재조합 인간 혈청 알부민-팀프-2 융합 단백질
WO2003066824A2 (en) 2002-02-07 2003-08-14 Aventis Behring Gmbh Albumin-fused kunitz domain peptides
US7517671B2 (en) 2002-02-28 2009-04-14 New England Biolabs, Inc. Methods and compositions for concentrating secreted recombinant protein
CN101172091B (zh) 2007-09-25 2011-04-27 北京美福源生物医药科技有限公司 含人血清白蛋白与皮肤细胞生长因子的融合蛋白护肤产品制备工艺和用途
GB0217033D0 (en) 2002-07-23 2002-08-28 Delta Biotechnology Ltd Gene and polypeptide sequences
CA2513213C (en) 2003-01-22 2013-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
NZ542586A (en) 2003-04-09 2009-11-27 Biogenerix Ag Method of forming a covalent conjugate between a G-CSF peptide and PEG
GB0329681D0 (en) * 2003-12-23 2004-01-28 Delta Biotechnology Ltd Gene expression technique
SI1729795T1 (sl) 2004-02-09 2016-04-29 Human Genome Sciences, Inc. Albuminski fuzijski proteini
US8591885B2 (en) 2004-04-30 2013-11-26 Allergan, Inc. Carbonic anhydrase inhibitor sustained release intraocular drug delivery systems
US8323666B2 (en) 2005-08-01 2012-12-04 Allergan, Inc. Botulinum toxin compositions
NZ597082A (en) 2005-10-13 2013-11-29 Human Genome Sciences Inc Methods and Compositions for Use in Treatment of Patients with Autoantibody Positive Diseases
WO2008019368A2 (en) 2006-08-07 2008-02-14 Teva Biopharmaceuticals Usa, Inc. Albumin-insulin fusion proteins
CA2695830A1 (en) 2007-08-08 2009-02-12 Novozymes Biopharma Dk A/S Transferrin variants and conjugates
CA2721202A1 (en) 2008-04-17 2009-10-22 Hilde Adi Pierrette Revets Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same
EP2313430B1 (en) 2008-06-24 2018-05-02 Technische Universität München Muteins of hngal and related proteins with affinity for a given target
NZ594056A (en) 2009-01-16 2013-03-28 Teva Pharma New stable formulations of recombinant human albumin-human granulocyte colony stimulating factor fusion protein
JP5936112B2 (ja) 2009-02-11 2016-06-15 アルブミディクス アクティーゼルスカブ アルブミン変異体及び複合体
AU2010280688A1 (en) 2009-08-05 2012-02-23 Allergan, Inc. Controlled release formulations of lipocalin muteins
AU2010329995B2 (en) 2009-12-07 2015-09-17 Pieris Ag Muteins of human lipocalin 2 (Lcn2, hNGAL) with affinity for a given target
CA2784861A1 (en) 2009-12-21 2011-07-14 Pharmathene, Inc. Recombinant butyrylcholinesterases and truncates thereof
RU2569745C2 (ru) 2010-06-08 2015-11-27 Пиерис АГ Мутеины липокалина слезы, связывающие альфа il-4 r
CA2808392C (en) 2010-08-16 2020-03-10 Pieris Ag Binding proteins for hepcidin
DK2640740T3 (en) 2010-11-15 2017-06-26 Pieris Pharmaceuticals Gmbh MUTEINS OF HUMAN LIPOCALIN 2 WITH AFFINITY FOR GLYPICAN-3 (GPC3)
US9221885B2 (en) 2010-12-02 2015-12-29 Pieris Ag Muteins of human lipocalin 2 with affinity for CTLA-4
JP6163162B2 (ja) 2011-12-13 2017-07-12 ピエリス ファーマシューティカルズ ゲーエムベーハー Ｉｌ−４および／またはｉｌ−１３のそれぞれの受容体への結合を阻害することによる特定の障害の予防または治療のための方法
US9522940B2 (en) 2012-05-23 2016-12-20 Pieris Pharmaceuticals Gmbh Lipocalin muteins with binding-affinity for glypican-3 (GPC-3) and use of lipocalin muteins for target-specific delivery to cells expressing GPC-3
JP6498601B2 (ja) 2012-07-13 2019-04-10 ザイムワークス，インコーポレイテッド 多価ヘテロ多量体足場設計および構築物
US10526384B2 (en) 2012-11-19 2020-01-07 Pieris Pharmaceuticals Gmbh Interleukin-17A-specific and interleukin-23-specific binding polypeptides and uses thereof
US10126304B2 (en) 2013-01-16 2018-11-13 George Mason Research Foundation, Inc. Binding domain mapping
RU2015142437A (ru) 2013-03-14 2017-04-27 Дайити Санкио Ко., Лтд Новые связывающие белки для pcsk9
US20140271538A1 (en) 2013-03-15 2014-09-18 Teva Pharmaceutical Industries Ltd. Recombinant Human Albumin-Human Granulocyte Colony Stimulating Factor for the Prevention of Neutropenia in Pediatric Patients
EP3094650A2 (en) 2014-01-13 2016-11-23 Pieris Pharmaceuticals GmbH Multi-specific polypeptide useful for localized tumor immunomodulation
ES2823563T3 (es) 2014-05-22 2021-05-07 Pieris Pharmaceuticals Gmbh Polipéptidos de unión específica novedosos y usos de los mismos
DE102014011653A1 (de) * 2014-06-20 2015-12-24 Ulrich Loos Nachweis von Autoantikörpern gegen den TSH-Rezeptor
CA2874083C (en) 2014-12-05 2024-01-02 Universite Laval Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases
CA2973640A1 (en) 2015-01-28 2016-08-04 Rachida Siham Bel Aiba Novel proteins specific for angiogenesis
TW201636364A (zh) 2015-02-18 2016-10-16 賽諾菲公司 對於螢光鐵載體及綠膿桿菌螯鐵蛋白具特異性之新穎蛋白
WO2016177802A1 (en) 2015-05-04 2016-11-10 Pieris Pharmaceuticals Gmbh Anti-cancer fusion polypeptide
JP6884708B2 (ja) 2015-05-04 2021-06-09 ピエリス ファーマシューティカルズ ゲーエムベーハー Ｃｄ１３７に特異的なタンパク質
SG11201707872WA (en) 2015-05-18 2017-10-30 Pieris Pharmaceuticals Gmbh Muteins of human lipocalin 2 with affinity for glypican-3 (gpc3)
CN108112253B (zh) 2015-05-18 2022-09-23 皮里斯制药有限公司 抗癌融合多肽
BR112017024141A2 (pt) 2015-05-19 2018-07-17 Univ Yale composições para tratar condições de calcificação patológicas e métodos de usar as mesmas
EP3115371A1 (en) 2015-07-07 2017-01-11 Sanofi Fusion molecules
WO2017009456A1 (en) 2015-07-15 2017-01-19 Pieris Pharmaceuticals Gmbh Novel proteins specific for lag-3
MX2018006559A (es) 2015-11-30 2019-06-12 Pieris Australia Pty Ltd Nuevos polipeptidos de fusion anti-angiogenicos.
TW201725212A (zh) 2015-12-10 2017-07-16 第一三共股份有限公司 特異性於降鈣素基因相關胜肽的新穎蛋白
WO2018087108A1 (en) 2016-11-09 2018-05-17 Pieris Pharmaceuticals Gmbh Proteins specific for cd137
BR112019014691A2 (pt) 2017-01-18 2020-04-07 Pieris Pharmaceuticals Gmbh muteínas de lipocalina com afinidade de ligação para lag-3
CN112789292A (zh) 2018-07-31 2021-05-11 皮里斯制药有限公司 对cd137和pd-l1特异性的新型融合蛋白
SG11202106353VA (en) 2019-02-26 2021-07-29 Pieris Pharmaceuticals Gmbh Novel fusion proteins specific for cd137 and gpc3
US20230227568A1 (en) 2020-06-05 2023-07-20 Pieris Pharmaceuticals Gmbh Multimeric immunomodulator targeting 4-1bb
US20240228562A1 (en) 2021-04-08 2024-07-11 Pieris Pharmaceuticals Gmbh Novel lipocalin muteins specific for connective tissue growth factor (ctgf)
WO2022243341A1 (en) 2021-05-18 2022-11-24 Pieris Pharmaceuticals Gmbh Lipocalin muteins with binding affinity for ox40
AU2023347921A1 (en) 2022-09-21 2025-03-20 Pieris Pharmaceuticals Gmbh Novel fusion protein specific for cd137 and cd228

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0079739A3 (en) * 1981-11-12 1984-08-08 The Upjohn Company Albumin-based nucleotides, their replication and use, and plasmids for use therein
EP0096910B1 (en) 1982-05-19 1989-04-19 Unilever N.V. Yeast of the genus kluyveromyces modified for the expression of preprothaumatin or its various allelic and modified forms or their maturation forms
FR2532656B2 (fr) 1982-06-02 1985-10-18 Elf Bio Rech Nouveau vecteur de clonage et d'expression, levure et bacterie transformees par ce vecteur
FR2579223B1 (fr) 1985-03-25 1988-12-09 Genetica Procede de preparation microbiologique de la serum-albumine humaine
GB8510219D0 (en) 1985-04-22 1985-05-30 Bass Plc Isolation of fermentation products
DK13087A (da) 1986-01-13 1987-07-14 Genex Corp Gensekvens til fremstilling af human serumalbumin i bacillus
FR2594846B1 (fr) 1986-02-21 1989-10-20 Genetica Procede de preparation de la serum albumine humaine mature
IT1203758B (it) * 1986-03-27 1989-02-23 Univ Roma Vettori di clonazione e di espressione di geni eterologhi in lieviti e lieviti trasformati con tali vettori
GB8620926D0 (en) * 1986-08-29 1986-10-08 Delta Biotechnology Ltd Yeast promoter
NO302485B1 (no) * 1987-07-28 1998-03-09 Gist Brocades Bv Fremgangsmåte for fremstilling av et polypeptid av interesse i en Klyveromyces vertscelle, transformert Klyveromyces vertscelle og anvendelse derav, plasmid og DNA konstruksjon
SE459586B (sv) * 1987-09-14 1989-07-17 Mta Szegedi Biolog Koezponti Strukturgen som kodar foer autentiskt humant serum albumin och foerfarande foer dess framstaellning
JP2791418B2 (ja) * 1987-12-02 1998-08-27 株式会社ミドリ十字 異種蛋白質の製造方法、組換えｄｎａ、形質転換体
IL89992A0 (en) * 1988-04-25 1989-12-15 Phillips Petroleum Co Expression of human serum albumin in methylotrophic yeasts
CA2017176A1 (en) * 1989-05-22 1990-11-22 Yoshitomi Pharmaceutical Industries Ltd. Albumin gene-containing plasmid, transformant carrying same, production of such transformant and production of albumin

Also Published As

Publication number Publication date
EP0361991A3 (en) 1992-10-14
JP3068139B2 (ja) 2000-07-24
AU623425B2 (en) 1992-05-14
NZ230229A (en) 1991-07-26
PT91381A (pt) 1990-03-08
AU3933289A (en) 1990-02-08
ATE187775T1 (de) 2000-01-15
DE68929115T2 (de) 2000-06-15
KR910004800A (ko) 1991-03-29
DK175846B1 (da) 2005-03-29
DK383189A (da) 1990-02-06
EP0361991B1 (en) 1999-12-15
FR2649991A2 (fr) 1991-01-25
JPH02276589A (ja) 1990-11-13
FI893702A0 (fi) 1989-08-04
DK383189D0 (da) 1989-08-04
FR2649991B2 (fr) 1994-03-04
NO893149D0 (no) 1989-08-03
FI893702L (fi) 1990-02-06
HUT51329A (en) 1990-04-28
EP0361991A2 (en) 1990-04-04
DE68929115D1 (de) 2000-01-20
PT91381B (pt) 1995-05-31

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