US5064633A
(en)
*
|
1984-06-04 |
1991-11-12 |
The Dow Chemical Company |
Macrocyclic aminophosphonic acid complexes, their formulations and use
|
US4885363A
(en)
*
|
1987-04-24 |
1989-12-05 |
E. R. Squibb & Sons, Inc. |
1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
|
US5132409A
(en)
*
|
1987-01-12 |
1992-07-21 |
Bracco Industria Chimica S.P.A. |
Macrocyclic chelating agents and chelates thereof
|
IT1224416B
(it)
*
|
1987-12-24 |
1990-10-04 |
Bracco Ind Chimica Spa |
Chelanti macrociclici e loro chelati
|
FR2637895B1
(fr)
*
|
1988-10-14 |
1992-11-06 |
Guerbet Sa |
Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands
|
FR2614020B1
(fr)
*
|
1987-04-14 |
1989-07-28 |
Guerbet Sa |
Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands.
|
US5049667A
(en)
*
|
1987-04-14 |
1991-09-17 |
Guerbet S.A. |
Nitrogen-containing cyclic ligands
|
DE3713842A1
(de)
*
|
1987-04-22 |
1988-11-17 |
Schering Ag |
Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
|
ES2086445T3
(es)
*
|
1987-07-16 |
1996-07-01 |
Nycomed Imaging As |
Acidos aminocarboxilicos y sus derivados.
|
US5531978A
(en)
*
|
1987-07-16 |
1996-07-02 |
Nycomed Imaging As |
Aminopolycarboxylic acids and derivatives thereof
|
GB8719042D0
(en)
|
1987-08-12 |
1987-09-16 |
Parker D |
Conjugate compounds
|
GB8719041D0
(en)
*
|
1987-08-12 |
1987-09-16 |
Parker D |
Conjugate compounds
|
JPH0720989B2
(ja)
*
|
1988-05-25 |
1995-03-08 |
アメリカ合衆国 |
大環状キレート化合物の抱合体と診断的テスト方法
|
ATE120457T1
(de)
*
|
1988-06-24 |
1995-04-15 |
Dow Chemical Co |
Macrocyclische bifunktionelle chelatbildner, komplexe davon und ihre konjugierten antikörper.
|
ZA894792B
(en)
*
|
1988-06-24 |
1991-04-24 |
Dow Chemical Co |
Macrocyclic bifunctional chelants,complexes thereof and their antibody conjugates
|
US5756065A
(en)
*
|
1988-06-24 |
1998-05-26 |
The Dow Chemical Company |
Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents
|
DE4001655A1
(de)
*
|
1990-01-18 |
1991-07-25 |
Schering Ag |
6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
|
US4889931A
(en)
*
|
1988-09-27 |
1989-12-26 |
Salutar, Inc. |
Manganese (II) chelate manufacture
|
US5314681A
(en)
*
|
1988-12-23 |
1994-05-24 |
Nycomed Innovation Ab |
Composition of positive and negative contrast agents for electron spin resonance enhanced magnetic resonance imaging
|
US5342936A
(en)
*
|
1989-02-10 |
1994-08-30 |
David Parker |
Tetra-aza macrocycles and processes for their preparation
|
JPH03504510A
(ja)
*
|
1989-02-10 |
1991-10-03 |
セルテック リミテッド |
アザマクロサイクルおよびその製法
|
US5247077A
(en)
*
|
1989-06-23 |
1993-09-21 |
Celltech Limited |
Tri-aza macrocycles and processes for their preparation
|
GB9320277D0
(en)
*
|
1993-10-01 |
1993-11-17 |
Nycomed Salutar Inc |
Chelants
|
GB8923843D0
(en)
*
|
1989-10-23 |
1989-12-13 |
Salutar Inc |
Compounds
|
US5446145A
(en)
*
|
1990-01-19 |
1995-08-29 |
Nycomed Salutar, Inc. |
Polychelant compounds
|
US5650133A
(en)
*
|
1990-01-19 |
1997-07-22 |
Nycomed Salutar |
Macrocyclic polyaza dichelates linked through ring nitrogens via an amide or ester functionality
|
US5972307A
(en)
*
|
1989-10-23 |
1999-10-26 |
Nycomed Salutar, Inc. |
Dichelants
|
JP3250220B2
(ja)
*
|
1989-10-23 |
2002-01-28 |
ニコムド サルター インコーポレーテッド |
マルチサイト金属キレート化剤
|
AU625529B2
(en)
*
|
1989-12-22 |
1992-07-16 |
E.R. Squibb & Sons, Inc. |
10-(2'-hydroxy-3'-alkoxy-1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecanes
|
AU6709390A
(en)
*
|
1989-12-22 |
1991-06-27 |
E.R. Squibb & Sons, Inc. |
10-(2'-hydroxy-3'-polyoxaalkyl)-1,4,7-tris-carboxymethyl -1,4,7,10-tetraazacyclododecane
|
CH679742A5
(no)
*
|
1990-01-09 |
1992-04-15 |
Byk Gulden Lomberg Chem Fab |
|
US5679810A
(en)
*
|
1990-01-19 |
1997-10-21 |
Salutar, Inc. |
Linear oligomeric polychelant compounds
|
DE4009119A1
(de)
*
|
1990-03-19 |
1991-09-26 |
Schering Ag |
1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
|
EP0522007A4
(en)
*
|
1990-03-26 |
1993-06-16 |
Us Commerce |
A fonctionalized complexand
|
DK0455380T3
(da)
*
|
1990-04-18 |
1997-02-03 |
Celltech Therapeutics Ltd |
Tetraaza-makrocykler, fremgangsmåder til fremstilling deraf og deres anvendelse til magnetisk resona ns-visualisering
|
US5684135A
(en)
*
|
1990-04-18 |
1997-11-04 |
Celltech Therapeutics Limited |
Conjugate compounds containing aza-macro-cycles and processes for their preparation
|
CA2039399C
(en)
*
|
1990-04-25 |
2000-09-05 |
C. Allen Chang |
Dual functioning excipient for metal chelate contrast agents
|
US5162109A
(en)
*
|
1990-09-13 |
1992-11-10 |
Mallinckrodt Medical, Inc. |
Magnetic resonance imaging agents
|
GB9024208D0
(en)
*
|
1990-11-07 |
1990-12-19 |
Salutar Inc |
Compounds
|
DE4035760A1
(de)
*
|
1990-11-08 |
1992-05-14 |
Schering Ag |
Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
|
EP0660925A1
(en)
*
|
1990-11-21 |
1995-07-05 |
Mallinckrodt Medical, Inc. |
Alkoxyamide derivatized chelates for mri
|
DE4115789A1
(de)
*
|
1991-05-10 |
1992-11-12 |
Schering Ag |
Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
|
DE4237943C2
(de)
*
|
1992-11-06 |
1997-10-23 |
Schering Ag |
Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
|
DE4140779A1
(de)
*
|
1991-12-06 |
1993-06-09 |
Schering Ag Berlin Und Bergkamen, 1000 Berlin, De |
Verfahren zur herstellung von mono-n-substituierten tetraazamakrocyclen
|
CA2092596A1
(en)
*
|
1992-03-27 |
1993-09-28 |
Kan Kubomura |
Tetraazacyclododecane derivative and its use
|
US5310535A
(en)
*
|
1992-04-24 |
1994-05-10 |
The Dow Chemical Company |
Carboxamide modified polyamine chelators and radioactive complexes thereof for conjugation to antibodies
|
DE4218744C2
(de)
*
|
1992-06-04 |
1997-11-06 |
Schering Ag |
Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
|
WO1994008630A1
(en)
*
|
1992-10-13 |
1994-04-28 |
Mallinckrodt Medical, Inc. |
Novel compositions for magnetic resonance imaging
|
DE4317588C2
(de)
*
|
1993-05-24 |
1998-04-16 |
Schering Ag |
Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung
|
DE4318369C1
(de)
*
|
1993-05-28 |
1995-02-09 |
Schering Ag |
Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
|
GB9318550D0
(en)
*
|
1993-09-07 |
1993-10-20 |
Nycomed Salutar Inc |
Chelants
|
US5358704A
(en)
*
|
1993-09-30 |
1994-10-25 |
Bristol-Myers Squibb |
Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
|
DE4340809C2
(de)
*
|
1993-11-24 |
2000-08-03 |
Schering Ag |
1.4,7,10-Tetraazacyclododecan-Derivate, diese enthaltende pharmazeutische Mittel und Verfahren zu deren Herstellung
|
US6693190B1
(en)
|
1994-05-11 |
2004-02-17 |
Bracco International B.V. |
Enhanced relaxivity monomeric and multimeric compounds
|
CA2225453C
(en)
*
|
1995-06-26 |
2004-12-14 |
Concat, Ltd. |
Compounds with chelation affinity and selectivity for first transition series elements, and their use in medical therapy and diagnosis
|
DE19652386A1
(de)
*
|
1996-12-04 |
1998-06-10 |
Schering Ag |
Verfahren zur Herstellung von Metallkomplexcarbonsäureamiden
|
DE19744003B4
(de)
*
|
1997-09-26 |
2004-07-08 |
Schering Ag |
Kontrastmittel für das Infarkt- und Nekroseimaging
|
IT1297035B1
(it)
*
|
1997-12-30 |
1999-08-03 |
Bracco Spa |
Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
|
DE19849465A1
(de)
*
|
1998-10-21 |
2000-04-27 |
Schering Ag |
Dimere Ionenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als Kontrastmittel
|
WO2000076556A2
(en)
|
1999-06-11 |
2000-12-21 |
Neorx Corporation |
High dose radionuclide complexes for bone marrow suppression
|
US7094885B2
(en)
|
1999-07-11 |
2006-08-22 |
Neorx Corporation |
Skeletal-targeted radiation to treat bone-associated pathologies
|
WO2001028982A1
(fr)
*
|
1999-10-22 |
2001-04-26 |
Mitsubishi Pharma Corporation |
Derives d'acide diethylenetriaminepenta acetique
|
FR2802928B1
(fr)
*
|
1999-12-22 |
2003-01-31 |
Air Liquide |
Polyazacycloalcanes eventuellement greffes sur une matrice solide, complexes organometalliques les incorporant comme ligands. utilisation desdits composes a l'extraction de metaux lourds
|
JP2004536034A
(ja)
|
2001-01-08 |
2004-12-02 |
ネオルクス コーポレイション |
治療的および診断的化合物、組成物および方法
|
WO2006124726A2
(en)
|
2005-05-12 |
2006-11-23 |
The General Hospital Corporation |
Novel biotinylated compositions
|
DE102007002726A1
(de)
|
2007-01-18 |
2008-07-31 |
Bayer Schering Pharma Aktiengesellschaft |
Neue Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
|
US10189803B2
(en)
|
2008-02-22 |
2019-01-29 |
Illinois Institute Of Technology |
Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
|
WO2010011367A2
(en)
*
|
2008-02-22 |
2010-01-28 |
Illinois Institute Of Technology |
Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using
|
US9446995B2
(en)
|
2012-05-21 |
2016-09-20 |
Illinois Institute Of Technology |
Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
|
US10556873B2
(en)
|
2008-02-22 |
2020-02-11 |
Illinois Institute Of Technology |
Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using
|
DE102009053171B4
(de)
|
2009-11-04 |
2011-07-21 |
Bayer Schering Pharma Aktiengesellschaft, 13353 |
Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol)
|
WO2011054480A1
(de)
|
2009-11-09 |
2011-05-12 |
Bayer Schering Pharma Aktiengesellschaft |
Gadobutrolherstellung mittels keramischer membran
|
DE102009057274B4
(de)
|
2009-12-02 |
2011-09-01 |
Bayer Schering Pharma Aktiengesellschaft |
Gadobutrolherstellung mittels Trioxobicyclo-octan
|
DE102010013833A1
(de)
|
2010-03-29 |
2011-09-29 |
Bayer Schering Pharma Aktiengesellschaft |
Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal
|
DK2896405T3
(da)
|
2011-04-21 |
2020-04-06 |
Bayer Ip Gmbh |
Fremstilling af gadobutrol med høj renhed
|
EP2890788A1
(en)
|
2012-08-31 |
2015-07-08 |
The General Hospital Corporation |
Biotin complexes for treatment and diagnosis of alzheimer's disease
|
WO2015051362A1
(en)
|
2013-10-04 |
2015-04-09 |
Illinois Institute Of Technology |
Multifunctional chelators, complexes, and compositions thereof, and methods of using same
|
EP3101012A1
(en)
|
2015-06-04 |
2016-12-07 |
Bayer Pharma Aktiengesellschaft |
New gadolinium chelate compounds for use in magnetic resonance imaging
|
CA3002897C
(en)
*
|
2015-12-10 |
2022-03-29 |
Bracco Imaging Spa |
Dimeric contrast agents
|
DK3519394T3
(da)
|
2016-09-27 |
2020-08-17 |
Bayer Pharma AG |
Fremgangsmåde til fremstilling af den krystallinske form af modifikation a af calcobutrol
|
CA3044877A1
(en)
|
2016-11-28 |
2018-05-31 |
Bayer Pharma Aktiengesellschaft |
High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
|
HUE056114T2
(hu)
*
|
2016-12-12 |
2022-01-28 |
Bracco Imaging Spa |
Dimer kontrasztanyagok
|
CN108358954B
(zh)
*
|
2018-01-17 |
2019-10-29 |
南开大学 |
一种手性稀土-氮氧自由基单链磁体及其制备方法
|
EP3883613A1
(en)
|
2018-11-23 |
2021-09-29 |
Bayer Aktiengesellschaft |
Formulation of contrast media and process of preparation thereof
|
CN110357828B
(zh)
*
|
2019-08-13 |
2021-03-19 |
牡丹江医学院 |
一种核磁共振造影剂及其制备方法和用途
|
CN118955414B
(zh)
*
|
2024-10-17 |
2025-03-18 |
南昌大学 |
两亲性Eu配合物及其制备方法与在检测四环素中的应用
|