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DK393387D0 - Makrocykliske forbindelser - Google Patents

Makrocykliske forbindelser

Info

Publication number
DK393387D0
DK393387D0 DK393387A DK393387A DK393387D0 DK 393387 D0 DK393387 D0 DK 393387D0 DK 393387 A DK393387 A DK 393387A DK 393387 A DK393387 A DK 393387A DK 393387 D0 DK393387 D0 DK 393387D0
Authority
DK
Denmark
Prior art keywords
carbon atoms
groups
group
chain
straight
Prior art date
Application number
DK393387A
Other languages
English (en)
Other versions
DK393387A (da
DK171574B1 (da
Inventor
Heinz Gries
Bernd Raduechel
Ulrich Speck
Hans-Joachim Weinmann
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of DK393387D0 publication Critical patent/DK393387D0/da
Publication of DK393387A publication Critical patent/DK393387A/da
Application granted granted Critical
Publication of DK171574B1 publication Critical patent/DK171574B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polyethers (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK393387A 1986-07-28 1987-07-28 Makrocykliske forbindelser, diagnostisk middel indeholdende forbindelserne samt anvendelse af forbindelserne DK171574B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3625417 1986-07-28
DE3625417A DE3625417C2 (de) 1986-07-28 1986-07-28 Tetraazacyclododecan-Derivate

Publications (3)

Publication Number Publication Date
DK393387D0 true DK393387D0 (da) 1987-07-28
DK393387A DK393387A (da) 1988-01-29
DK171574B1 DK171574B1 (da) 1997-01-20

Family

ID=6306101

Family Applications (1)

Application Number Title Priority Date Filing Date
DK393387A DK171574B1 (da) 1986-07-28 1987-07-28 Makrocykliske forbindelser, diagnostisk middel indeholdende forbindelserne samt anvendelse af forbindelserne

Country Status (13)

Country Link
EP (1) EP0255471B1 (da)
JP (1) JPH0753720B2 (da)
AT (1) ATE80391T1 (da)
CA (1) CA1341176C (da)
DE (2) DE3625417C2 (da)
DK (1) DK171574B1 (da)
ES (1) ES2052599T3 (da)
GR (1) GR3005808T3 (da)
IE (1) IE60677B1 (da)
NO (1) NO174048C (da)
NZ (1) NZ221225A (da)
PT (1) PT85410B (da)
ZA (1) ZA875561B (da)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
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US5132409A (en) * 1987-01-12 1992-07-21 Bracco Industria Chimica S.P.A. Macrocyclic chelating agents and chelates thereof
IT1224416B (it) * 1987-12-24 1990-10-04 Bracco Ind Chimica Spa Chelanti macrociclici e loro chelati
FR2637895B1 (fr) * 1988-10-14 1992-11-06 Guerbet Sa Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands
FR2614020B1 (fr) * 1987-04-14 1989-07-28 Guerbet Sa Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands.
US5049667A (en) * 1987-04-14 1991-09-17 Guerbet S.A. Nitrogen-containing cyclic ligands
DE3713842A1 (de) * 1987-04-22 1988-11-17 Schering Ag Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
ES2086445T3 (es) * 1987-07-16 1996-07-01 Nycomed Imaging As Acidos aminocarboxilicos y sus derivados.
US5531978A (en) * 1987-07-16 1996-07-02 Nycomed Imaging As Aminopolycarboxylic acids and derivatives thereof
GB8719042D0 (en) 1987-08-12 1987-09-16 Parker D Conjugate compounds
GB8719041D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds
JPH0720989B2 (ja) * 1988-05-25 1995-03-08 アメリカ合衆国 大環状キレート化合物の抱合体と診断的テスト方法
ATE120457T1 (de) * 1988-06-24 1995-04-15 Dow Chemical Co Macrocyclische bifunktionelle chelatbildner, komplexe davon und ihre konjugierten antikörper.
ZA894792B (en) * 1988-06-24 1991-04-24 Dow Chemical Co Macrocyclic bifunctional chelants,complexes thereof and their antibody conjugates
US5756065A (en) * 1988-06-24 1998-05-26 The Dow Chemical Company Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents
DE4001655A1 (de) * 1990-01-18 1991-07-25 Schering Ag 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US4889931A (en) * 1988-09-27 1989-12-26 Salutar, Inc. Manganese (II) chelate manufacture
US5314681A (en) * 1988-12-23 1994-05-24 Nycomed Innovation Ab Composition of positive and negative contrast agents for electron spin resonance enhanced magnetic resonance imaging
US5342936A (en) * 1989-02-10 1994-08-30 David Parker Tetra-aza macrocycles and processes for their preparation
JPH03504510A (ja) * 1989-02-10 1991-10-03 セルテック　リミテッド アザマクロサイクルおよびその製法
US5247077A (en) * 1989-06-23 1993-09-21 Celltech Limited Tri-aza macrocycles and processes for their preparation
GB9320277D0 (en) * 1993-10-01 1993-11-17 Nycomed Salutar Inc Chelants
GB8923843D0 (en) * 1989-10-23 1989-12-13 Salutar Inc Compounds
US5446145A (en) * 1990-01-19 1995-08-29 Nycomed Salutar, Inc. Polychelant compounds
US5650133A (en) * 1990-01-19 1997-07-22 Nycomed Salutar Macrocyclic polyaza dichelates linked through ring nitrogens via an amide or ester functionality
US5972307A (en) * 1989-10-23 1999-10-26 Nycomed Salutar, Inc. Dichelants
JP3250220B2 (ja) * 1989-10-23 2002-01-28 ニコムド サルター インコーポレーテッド マルチサイト金属キレート化剤
AU625529B2 (en) * 1989-12-22 1992-07-16 E.R. Squibb & Sons, Inc. 10-(2'-hydroxy-3'-alkoxy-1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecanes
AU6709390A (en) * 1989-12-22 1991-06-27 E.R. Squibb & Sons, Inc. 10-(2'-hydroxy-3'-polyoxaalkyl)-1,4,7-tris-carboxymethyl -1,4,7,10-tetraazacyclododecane
CH679742A5 (da) * 1990-01-09 1992-04-15 Byk Gulden Lomberg Chem Fab
US5679810A (en) * 1990-01-19 1997-10-21 Salutar, Inc. Linear oligomeric polychelant compounds
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
EP0522007A4 (en) * 1990-03-26 1993-06-16 Us Commerce A fonctionalized complexand
DK0455380T3 (da) * 1990-04-18 1997-02-03 Celltech Therapeutics Ltd Tetraaza-makrocykler, fremgangsmåder til fremstilling deraf og deres anvendelse til magnetisk resona ns-visualisering
US5684135A (en) * 1990-04-18 1997-11-04 Celltech Therapeutics Limited Conjugate compounds containing aza-macro-cycles and processes for their preparation
CA2039399C (en) * 1990-04-25 2000-09-05 C. Allen Chang Dual functioning excipient for metal chelate contrast agents
US5162109A (en) * 1990-09-13 1992-11-10 Mallinckrodt Medical, Inc. Magnetic resonance imaging agents
GB9024208D0 (en) * 1990-11-07 1990-12-19 Salutar Inc Compounds
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
EP0660925A1 (en) * 1990-11-21 1995-07-05 Mallinckrodt Medical, Inc. Alkoxyamide derivatized chelates for mri
DE4115789A1 (de) * 1991-05-10 1992-11-12 Schering Ag Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4237943C2 (de) * 1992-11-06 1997-10-23 Schering Ag Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
DE4140779A1 (de) * 1991-12-06 1993-06-09 Schering Ag Berlin Und Bergkamen, 1000 Berlin, De Verfahren zur herstellung von mono-n-substituierten tetraazamakrocyclen
CA2092596A1 (en) * 1992-03-27 1993-09-28 Kan Kubomura Tetraazacyclododecane derivative and its use
US5310535A (en) * 1992-04-24 1994-05-10 The Dow Chemical Company Carboxamide modified polyamine chelators and radioactive complexes thereof for conjugation to antibodies
DE4218744C2 (de) * 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
WO1994008630A1 (en) * 1992-10-13 1994-04-28 Mallinckrodt Medical, Inc. Novel compositions for magnetic resonance imaging
DE4317588C2 (de) * 1993-05-24 1998-04-16 Schering Ag Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung
DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
GB9318550D0 (en) * 1993-09-07 1993-10-20 Nycomed Salutar Inc Chelants
US5358704A (en) * 1993-09-30 1994-10-25 Bristol-Myers Squibb Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
DE4340809C2 (de) * 1993-11-24 2000-08-03 Schering Ag 1.4,7,10-Tetraazacyclododecan-Derivate, diese enthaltende pharmazeutische Mittel und Verfahren zu deren Herstellung
US6693190B1 (en) 1994-05-11 2004-02-17 Bracco International B.V. Enhanced relaxivity monomeric and multimeric compounds
CA2225453C (en) * 1995-06-26 2004-12-14 Concat, Ltd. Compounds with chelation affinity and selectivity for first transition series elements, and their use in medical therapy and diagnosis
DE19652386A1 (de) * 1996-12-04 1998-06-10 Schering Ag Verfahren zur Herstellung von Metallkomplexcarbonsäureamiden
DE19744003B4 (de) * 1997-09-26 2004-07-08 Schering Ag Kontrastmittel für das Infarkt- und Nekroseimaging
IT1297035B1 (it) * 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
DE19849465A1 (de) * 1998-10-21 2000-04-27 Schering Ag Dimere Ionenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als Kontrastmittel
WO2000076556A2 (en) 1999-06-11 2000-12-21 Neorx Corporation High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
WO2001028982A1 (fr) * 1999-10-22 2001-04-26 Mitsubishi Pharma Corporation Derives d'acide diethylenetriaminepenta acetique
FR2802928B1 (fr) * 1999-12-22 2003-01-31 Air Liquide Polyazacycloalcanes eventuellement greffes sur une matrice solide, complexes organometalliques les incorporant comme ligands. utilisation desdits composes a l'extraction de metaux lourds
JP2004536034A (ja) 2001-01-08 2004-12-02 ネオルクス コーポレイション 治療的および診断的化合物、組成物および方法
WO2006124726A2 (en) 2005-05-12 2006-11-23 The General Hospital Corporation Novel biotinylated compositions
DE102007002726A1 (de) 2007-01-18 2008-07-31 Bayer Schering Pharma Aktiengesellschaft Neue Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
US10189803B2 (en) 2008-02-22 2019-01-29 Illinois Institute Of Technology Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
WO2010011367A2 (en) * 2008-02-22 2010-01-28 Illinois Institute Of Technology Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using
US9446995B2 (en) 2012-05-21 2016-09-20 Illinois Institute Of Technology Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions
US10556873B2 (en) 2008-02-22 2020-02-11 Illinois Institute Of Technology Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using
DE102009053171B4 (de) 2009-11-04 2011-07-21 Bayer Schering Pharma Aktiengesellschaft, 13353 Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol)
WO2011054480A1 (de) 2009-11-09 2011-05-12 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels keramischer membran
DE102009057274B4 (de) 2009-12-02 2011-09-01 Bayer Schering Pharma Aktiengesellschaft Gadobutrolherstellung mittels Trioxobicyclo-octan
DE102010013833A1 (de) 2010-03-29 2011-09-29 Bayer Schering Pharma Aktiengesellschaft Herstellung von Gadobutrol mittels Dimethylformamiddimethylacetal
DK2896405T3 (da) 2011-04-21 2020-04-06 Bayer Ip Gmbh Fremstilling af gadobutrol med høj renhed
EP2890788A1 (en) 2012-08-31 2015-07-08 The General Hospital Corporation Biotin complexes for treatment and diagnosis of alzheimer's disease
WO2015051362A1 (en) 2013-10-04 2015-04-09 Illinois Institute Of Technology Multifunctional chelators, complexes, and compositions thereof, and methods of using same
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
CA3002897C (en) * 2015-12-10 2022-03-29 Bracco Imaging Spa Dimeric contrast agents
DK3519394T3 (da) 2016-09-27 2020-08-17 Bayer Pharma AG Fremgangsmåde til fremstilling af den krystallinske form af modifikation a af calcobutrol
CA3044877A1 (en) 2016-11-28 2018-05-31 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
HUE056114T2 (hu) * 2016-12-12 2022-01-28 Bracco Imaging Spa Dimer kontrasztanyagok
CN108358954B (zh) * 2018-01-17 2019-10-29 南开大学 一种手性稀土-氮氧自由基单链磁体及其制备方法
EP3883613A1 (en) 2018-11-23 2021-09-29 Bayer Aktiengesellschaft Formulation of contrast media and process of preparation thereof
CN110357828B (zh) * 2019-08-13 2021-03-19 牡丹江医学院 一种核磁共振造影剂及其制备方法和用途
CN118955414B (zh) * 2024-10-17 2025-03-18 南昌大学 两亲性Eu配合物及其制备方法与在检测四环素中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL194579C (nl) * 1983-01-21 2002-08-05 Schering Ag Diagnostisch middel.
DE3316703A1 (de) * 1983-05-04 1984-11-08 Schering AG, 1000 Berlin und 4709 Bergkamen Orales kontrastmittel fuer die kernspintomographie und dessen herstellung
US4639365A (en) * 1984-10-18 1987-01-27 The Board Of Regents, The University Of Texas System Gadolinium chelates as NMR contrast agents
DE3772785D1 (de) * 1986-01-23 1991-10-17 Squibb & Sons Inc 1-substituiertes-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecan und analoga.
GB8603537D0 (en) * 1986-02-13 1986-03-19 Parker D Conjugate compound

Also Published As

Publication number Publication date
IE60677B1 (en) 1994-08-10
NO873132L (no) 1988-01-29
AU7621787A (en) 1988-02-04
CA1341176C (en) 2001-01-30
EP0255471B1 (de) 1992-09-09
NZ221225A (en) 1990-09-26
PT85410B (pt) 1990-06-29
DE3781620D1 (de) 1992-10-15
DE3625417C2 (de) 1998-10-08
ZA875561B (en) 1989-03-29
ATE80391T1 (de) 1992-09-15
PT85410A (de) 1987-08-01
GR3005808T3 (da) 1993-06-07
NO873132D0 (no) 1987-07-27
NO174048C (no) 1994-03-09
JPS6341468A (ja) 1988-02-22
DK393387A (da) 1988-01-29
AU604249B2 (en) 1990-12-13
DK171574B1 (da) 1997-01-20
ES2052599T3 (es) 1994-07-16
EP0255471A1 (de) 1988-02-03
IE872038L (en) 1988-01-28
JPH0753720B2 (ja) 1995-06-07
NO174048B (no) 1993-11-29
DE3625417A1 (de) 1988-02-11

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired