NO830110L - 6-substituert-s-triazolo(3,4-a)ftalazinderivater og fremgangsmaate for deres fremstilling - Google Patents

6-substituert-s-triazolo(3,4-a)ftalazinderivater og fremgangsmaate for deres fremstilling

Info

Publication number: NO830110L
Authority: NO; Norway
Prior art keywords: triazolo; preparation; derivatives; phtalazine; procedures
Prior art date: 1982-01-18

Application number

NO830110A

Other languages

English (en)

Other versions

NO161674B (no

NO161674C (no

Inventor

Domenico Barone

Giorgio Tarzia

Emilio Occelli

Adele Giunta

Original Assignee

Lepetit Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-01-18

Filing date

1983-01-14

Publication date

1983-07-19

1983-01-14 Application filed by Lepetit Spa filed Critical Lepetit Spa

1983-07-19 Publication of NO830110L publication Critical patent/NO830110L/no

1989-06-05 Publication of NO161674B publication Critical patent/NO161674B/no

1989-09-13 Publication of NO161674C publication Critical patent/NO161674C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Anesthesiology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

NO830110A 1982-01-18 1983-01-14 Analogifremgangsm te for fremstilling av terapeutisk aktive 6-substituert-s-triazolo(3,4-a)-ftalazinderivater. NO161674C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB8201273		1982-01-18

Publications (3)

Publication Number	Publication Date
NO830110L true NO830110L (no)	1983-07-19
NO161674B NO161674B (no)	1989-06-05
NO161674C NO161674C (no)	1989-09-13

Family

ID=10527683

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO830110A NO161674C (no)	1982-01-18	1983-01-14	Analogifremgangsm te for fremstilling av terapeutisk aktive 6-substituert-s-triazolo(3,4-a)-ftalazinderivater.

Country Status (20)

Country	Link
US (1)	US4788186A (no)
EP (1)	EP0085840B1 (no)
JP (1)	JPS58124786A (no)
KR (1)	KR890000184B1 (no)
AT (1)	ATE22562T1 (no)
AU (1)	AU564026B2 (no)
CA (1)	CA1214168A (no)
DE (1)	DE3366494D1 (no)
DK (1)	DK163145C (no)
ES (1)	ES8601995A1 (no)
FI (1)	FI81350C (no)
GR (1)	GR78442B (no)
HU (1)	HU193033B (no)
IE (1)	IE55032B1 (no)
IL (1)	IL67697A (no)
NO (1)	NO161674C (no)
NZ (1)	NZ203021A (no)
PH (1)	PH21834A (no)
PT (1)	PT76107A (no)
ZA (1)	ZA83224B (no)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1194310B (it) *	1983-07-12	1988-09-14	Lepetit Spa	Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
AU723098B2 (en) *	1996-07-25	2000-08-17	Merck Sharp & Dohme Limited	Substituted triazolo-pyridazine derivatives as ligands for GABA receptors
JP2000515851A (ja) *	1996-07-25	2000-11-28	メルクシヤープエンドドームリミテツド	ＧＡＢＡ▲下Ａα５▼レセプターサブタイプの逆アゴニストとしての置換のあるトリアゾロピリダジン誘導体
AU732455C (en) *	1997-05-08	2002-09-05	Merck Sharp & Dohme Limited	Substituted 1,2,4-triazolo{3,4-a}phthalazine derivatives as gaba alpha 5 ligands
ES2137113B1 (es) *	1997-07-29	2000-09-16	Almirall Prodesfarma Sa	Nuevos derivados de triazolo-piridazinas heterociclicos.
GB9715977D0 (en) *	1997-07-29	1997-10-01	Merck Sharp & Dohme	Therapeutic agents
AU1041599A (en) *	1997-11-13	1999-06-07	Jose Luis Castro Pineiro	Therapeutic uses of triazolo-pyridazine derivatives
GB9726699D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
GB9723999D0 (en)	1997-11-13	1998-01-14	Merck Sharp & Dohme	Therapeutic use
GB9726702D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
GB9726701D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
US6110915A (en) *	1997-12-18	2000-08-29	Merck & Co., Inc.	Antiemetic use of triazolo-pyridazine derivatives
WO1999036423A1 (en) *	1998-01-14	1999-07-22	Merck Sharp & Dohme Limited	Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9801234D0 (en) *	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
HUP0100575A3 (en)	1998-01-21	2003-03-28	Merck Sharp & Dohme Ltd Hoddes	Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9801210D0 (en) *	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801202D0 (en)	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801208D0 (en)	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801397D0 (en)	1998-01-22	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801538D0 (en)	1998-01-23	1998-03-25	Merck Sharp & Dohme	Pharmaceutical product
JP2002504554A (ja) *	1998-02-25	2002-02-12	メルクシャープエンドドームリミテッド	置換１，２，４−トリアゾロ［３，４−ａ］ピリダジン
YU46500A (sh)	1998-02-25	2002-11-15	Merck Charp & Dohme Limited	Substituisani 1,2,4-triazolo /3,4-a/piridazin
JP2002529468A (ja)	1998-11-12	2002-09-10	メルクエンドカムパニーインコーポレーテッド	ＧＡＢＡ−Ａα−５逆活性薬の治療性多形およびそのパモエート組成物
GB9824897D0 (en)	1998-11-12	1999-01-06	Merck Sharp & Dohme	Therapeutic compounds
GB9929569D0 (en) *	1999-12-14	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB0028583D0 (en)	2000-11-23	2001-01-10	Merck Sharp & Dohme	Therapeutic compounds
AU2002307163B2 (en) *	2001-04-10	2006-06-29	Merck & Co., Inc.	A method of treating cancer
WO2002083140A1 (en) *	2001-04-10	2002-10-24	Merck & Co., Inc.	Inhibitors of akt activity
US20060142178A1 (en) *	2002-04-08	2006-06-29	Barnett Stanley F	Method of treating cancer
US20050054647A1 (en) *	2002-12-27	2005-03-10	Detlev Schuppan	New pharmaceutical combination
ATE471324T1 (de)	2004-09-02	2010-07-15	Nycomed Gmbh	Triazolophthalazine
CA2591991C (en) *	2005-01-05	2013-11-19	Altana Pharma Ag	Triazolophthalazines
NZ555661A (en) *	2005-01-05	2010-11-26	Nycomed Gmbh	Triazolophthalazines as PDE2-inhibitors
PH12012501361A1 (en)	2009-12-31	2012-10-22	Centro Nac De Investigaciones Oncologicas Cnio	Tricyclic compounds for use as kinase inhibitors
CN103694244B (zh) *	2014-01-09	2016-03-30	郑州大学	3,6位取代-1,2,4-三氮唑并[3,4-a]酞嗪类化合物及其制备和用途
CN104016986B (zh) *	2014-03-13	2016-02-03	郑州大学	3-取代-6-(1-取代哌嗪基)-1,2,4-三氮唑并[3,4-a]酞嗪类化合物、其制备方法和用途
EP4279074A1 (en) *	2022-05-19	2023-11-22	Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin	Azolo compounds for treatment of fibrotic diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2484029A (en) *	1945-12-21	1949-10-11	Ciba Pharm Prod Inc	Hydrazine derivatives of pyridazine compounds
GB629177A (en) *	1945-12-21	1949-09-14	Ciba Ltd	Manufacture of new hydrazine compounds and derivatives thereof
JPS5132598A (en) *	1974-09-13	1976-03-19	Eisai Co Ltd	Toriazoro * 3 44 ee * futarajinjudotai no goseiho
JPS603080B2 (ja) *	1976-08-10	1985-01-25	三菱化学株式会社	Ｓ―トリアゾロ〔３，４ ―α〕〔５，６，７，８〕テトラヒドロフタラジン類
GR70309B (no) *	1979-10-29	1982-09-08	Dow Chemical Co

1983
- 1983-01-12 FI FI830100A patent/FI81350C/fi not_active IP Right Cessation
- 1983-01-12 PH PH28380A patent/PH21834A/en unknown
- 1983-01-13 GR GR70257A patent/GR78442B/el unknown
- 1983-01-13 CA CA000419398A patent/CA1214168A/en not_active Expired
- 1983-01-13 EP EP83100232A patent/EP0085840B1/en not_active Expired
- 1983-01-13 NZ NZ203021A patent/NZ203021A/en unknown
- 1983-01-13 DE DE8383100232T patent/DE3366494D1/de not_active Expired
- 1983-01-13 AT AT83100232T patent/ATE22562T1/de not_active IP Right Cessation
- 1983-01-13 ZA ZA83224A patent/ZA83224B/xx unknown
- 1983-01-14 NO NO830110A patent/NO161674C/no unknown
- 1983-01-17 IE IE82/83A patent/IE55032B1/en not_active IP Right Cessation
- 1983-01-17 IL IL67697A patent/IL67697A/xx unknown
- 1983-01-17 HU HU83141A patent/HU193033B/hu not_active IP Right Cessation
- 1983-01-18 DK DK017983A patent/DK163145C/da not_active IP Right Cessation
- 1983-01-18 JP JP58005413A patent/JPS58124786A/ja active Granted
- 1983-01-18 AU AU10550/83A patent/AU564026B2/en not_active Ceased
- 1983-01-18 KR KR1019830000174A patent/KR890000184B1/ko not_active Expired
- 1983-01-18 PT PT76107A patent/PT76107A/pt unknown
1984
- 1984-04-10 ES ES531458A patent/ES8601995A1/es not_active Expired
1987
- 1987-10-20 US US07/112,015 patent/US4788186A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES531458A0 (es)	1985-11-01
KR840003254A (ko)	1984-08-20
FI830100A0 (fi)	1983-01-12
IL67697A (en)	1990-02-09
IE55032B1 (en)	1990-05-09
ES8601995A1 (es)	1985-11-01
AU1055083A (en)	1983-07-28
NO161674B (no)	1989-06-05
DK17983D0 (da)	1983-01-18
FI81350C (fi)	1990-10-10
DK163145B (da)	1992-01-27
CA1214168A (en)	1986-11-18
PH21834A (en)	1988-03-17
JPS58124786A (ja)	1983-07-25
KR890000184B1 (ko)	1989-03-09
US4788186A (en)	1988-11-29
DK17983A (da)	1983-07-19
DK163145C (da)	1992-06-22
DE3366494D1 (de)	1986-11-06
EP0085840B1 (en)	1986-10-01
HU193033B (en)	1987-08-28
PT76107A (en)	1983-02-01
ZA83224B (en)	1983-10-26
FI81350B (fi)	1990-06-29
NZ203021A (en)	1986-05-09
ATE22562T1 (de)	1986-10-15
AU564026B2 (en)	1987-07-30
JPH048428B2 (no)	1992-02-17
IE830082L (en)	1983-07-18
FI830100L (fi)	1983-07-19
IL67697A0 (en)	1983-05-15
EP0085840A1 (en)	1983-08-17
GR78442B (no)	1984-09-27
NO161674C (no)	1989-09-13

Publication	Publication Date	Title
NO830110L (no)	1983-07-19	6-substituert-s-triazolo(3,4-a)ftalazinderivater og fremgangsmaate for deres fremstilling
ES527776A0 (es)	1987-07-16	Procedimiento de preparacion de derivados de 1,4-dihidropiridinas.
MX7199E (es)	1987-12-23	Procedimiento para preparar derivados de 3-cetodelta-4,9,19-nor-esteroides
NO154905C (no)	1987-01-14	Fremgangsmaate for fremstilling av preparater for behandling av melanomer.
IL58775A (en)	1984-02-29	Hydroxyethyl-azole compounds,their production and pharmaceutical compositions containing them
NZ192195A (en)	1981-10-19	1-triazolyl-2-hydroxy-2-phenyl-3-aryl-propanes and pharmaceutical compositions
FI832004A7 (fi)	1983-12-04	Menetelmä 1-sulfo-2-oksoatsetidiini- johdannaisten valmistamiseksi.
DE2961609D1 (en)	1982-02-11	Sila-substituted 1,4-dihydropyridine derivatives, processes for their preparation, pharmaceutical compositions and process for their preparation
AU539847B2 (en)	1984-10-18	3,4,5-trihydroxypiperidine compounds
DE3262124D1 (en)	1985-03-14	Saturated derivatives of aminocyclitols, their preparation and pharmaceutical preparations containing them
DE3462688D1 (en)	1987-04-23	1,7-diphenyl-3-methylaza-7-cyano-8-methylnonane useful in combating diseases
DK319384A (da)	1985-01-03	1-0-alkyl-3-amino-propan-1,2-diol-2-0-phospholipider, fremgangsmaade til deres fremstilling samt farmaceutiske praeparater indeholdende disse
RO86358A2 (ro)	1985-03-15	Procedeu pentru prepararea unor 1,2,4-triazolil-u-il-propionitrili
FI842972A7 (fi)	1985-02-16	Menetelmä 2,3-dihydrobentsopyranonijohdannaisten valmistamiseksi.
SE8401916D0 (sv)	1984-04-05	Condensed benzopyrone derivatives
DK551183D0 (da)	1983-12-01	Substituerede 9h-8-oxo-pyrimido(2,1-f)purin-2,4-dioner, fremgangsmade til deres fremstilling og farmaceutiske kompositioner indeholdende forbindelserne
SE8305361D0 (sv)	1983-09-30	New substituted phenylazacycloalkanes, processes for preparation and pharmaceutical preparations for such compounds
AR226096A1 (es)	1982-05-31	Procedimiento para la preparacion de n,n-dimetil-10-(1-aza(2,2,2)-biciclo-3-octil)10h-2-fenotiazinsulfonamida
IE862894L (en)	1987-05-05	Pharmaceutical compositions
DK311284D0 (da)	1984-06-26	3-(4'-aminobutylamino)-propylamino-bleomycin-derivater, deres fremstilling og deres anvendelse som laegemidler