FI830100L - Nya 6-substituerade s-triazolo /3,4-a/ ftalazinderivat - Google Patents

Nya 6-substituerade s-triazolo /3,4-a/ ftalazinderivat

Info

Publication number: FI830100L
Authority: FI; Finland
Prior art keywords: triazolo; derivatives; pthalazine; substituerade; nya
Prior art date: 1982-01-18

Application number

FI830100A

Other languages

English (en)

Other versions

FI830100A0 (fi

FI81350C (fi

FI81350B (fi

Inventor

Emilio Occelli

Domenico Barone

Giorgio Tarzia

Adele Giunta

Original Assignee

Lepetit Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-01-18

Filing date

1983-01-12

Publication date

1983-07-19

1983-01-12 Application filed by Lepetit Spa filed Critical Lepetit Spa

1983-01-12 Publication of FI830100A0 publication Critical patent/FI830100A0/fi

1983-07-19 Publication of FI830100L publication Critical patent/FI830100L/fi

1990-06-29 Application granted granted Critical

1990-06-29 Publication of FI81350B publication Critical patent/FI81350B/fi

1990-10-10 Publication of FI81350C publication Critical patent/FI81350C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Anesthesiology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

FI830100A 1982-01-18 1983-01-12 Analogfoerfarande foer framstaellning av nya, farmakologiskt aktiva 6-substituerade s-triatsolo/3,4-a/ ftalazinderivat. FI81350C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8201273		1982-01-18
GB8201273		1982-01-18

Publications (4)

Publication Number	Publication Date
FI830100A0 FI830100A0 (fi)	1983-01-12
FI830100L true FI830100L (fi)	1983-07-19
FI81350B FI81350B (fi)	1990-06-29
FI81350C FI81350C (fi)	1990-10-10

Family

ID=10527683

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI830100A FI81350C (fi)	1982-01-18	1983-01-12	Analogfoerfarande foer framstaellning av nya, farmakologiskt aktiva 6-substituerade s-triatsolo/3,4-a/ ftalazinderivat.

Country Status (20)

Country	Link
US (1)	US4788186A (fi)
EP (1)	EP0085840B1 (fi)
JP (1)	JPS58124786A (fi)
KR (1)	KR890000184B1 (fi)
AT (1)	ATE22562T1 (fi)
AU (1)	AU564026B2 (fi)
CA (1)	CA1214168A (fi)
DE (1)	DE3366494D1 (fi)
DK (1)	DK163145C (fi)
ES (1)	ES8601995A1 (fi)
FI (1)	FI81350C (fi)
GR (1)	GR78442B (fi)
HU (1)	HU193033B (fi)
IE (1)	IE55032B1 (fi)
IL (1)	IL67697A (fi)
NO (1)	NO161674C (fi)
NZ (1)	NZ203021A (fi)
PH (1)	PH21834A (fi)
PT (1)	PT76107A (fi)
ZA (1)	ZA83224B (fi)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1194310B (it) *	1983-07-12	1988-09-14	Lepetit Spa	Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
AU723098B2 (en) *	1996-07-25	2000-08-17	Merck Sharp & Dohme Limited	Substituted triazolo-pyridazine derivatives as ligands for GABA receptors
JP2000515851A (ja) *	1996-07-25	2000-11-28	メルクシヤープエンドドームリミテツド	ＧＡＢＡ▲下Ａα５▼レセプターサブタイプの逆アゴニストとしての置換のあるトリアゾロピリダジン誘導体
AU732455C (en) *	1997-05-08	2002-09-05	Merck Sharp & Dohme Limited	Substituted 1,2,4-triazolo{3,4-a}phthalazine derivatives as gaba alpha 5 ligands
ES2137113B1 (es) *	1997-07-29	2000-09-16	Almirall Prodesfarma Sa	Nuevos derivados de triazolo-piridazinas heterociclicos.
GB9715977D0 (en) *	1997-07-29	1997-10-01	Merck Sharp & Dohme	Therapeutic agents
AU1041599A (en) *	1997-11-13	1999-06-07	Jose Luis Castro Pineiro	Therapeutic uses of triazolo-pyridazine derivatives
GB9726699D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
GB9723999D0 (en)	1997-11-13	1998-01-14	Merck Sharp & Dohme	Therapeutic use
GB9726702D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
GB9726701D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
US6110915A (en) *	1997-12-18	2000-08-29	Merck & Co., Inc.	Antiemetic use of triazolo-pyridazine derivatives
WO1999036423A1 (en) *	1998-01-14	1999-07-22	Merck Sharp & Dohme Limited	Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9801234D0 (en) *	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
HUP0100575A3 (en)	1998-01-21	2003-03-28	Merck Sharp & Dohme Ltd Hoddes	Triazolo-pyridazine derivatives as ligands for gaba receptors
GB9801210D0 (en) *	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801202D0 (en)	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801208D0 (en)	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801397D0 (en)	1998-01-22	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801538D0 (en)	1998-01-23	1998-03-25	Merck Sharp & Dohme	Pharmaceutical product
JP2002504554A (ja) *	1998-02-25	2002-02-12	メルクシャープエンドドームリミテッド	置換１，２，４−トリアゾロ［３，４−ａ］ピリダジン
YU46500A (sh)	1998-02-25	2002-11-15	Merck Charp & Dohme Limited	Substituisani 1,2,4-triazolo /3,4-a/piridazin
JP2002529468A (ja)	1998-11-12	2002-09-10	メルクエンドカムパニーインコーポレーテッド	ＧＡＢＡ−Ａα−５逆活性薬の治療性多形およびそのパモエート組成物
GB9824897D0 (en)	1998-11-12	1999-01-06	Merck Sharp & Dohme	Therapeutic compounds
GB9929569D0 (en) *	1999-12-14	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB0028583D0 (en)	2000-11-23	2001-01-10	Merck Sharp & Dohme	Therapeutic compounds
AU2002307163B2 (en) *	2001-04-10	2006-06-29	Merck & Co., Inc.	A method of treating cancer
WO2002083140A1 (en) *	2001-04-10	2002-10-24	Merck & Co., Inc.	Inhibitors of akt activity
US20060142178A1 (en) *	2002-04-08	2006-06-29	Barnett Stanley F	Method of treating cancer
US20050054647A1 (en) *	2002-12-27	2005-03-10	Detlev Schuppan	New pharmaceutical combination
ATE471324T1 (de)	2004-09-02	2010-07-15	Nycomed Gmbh	Triazolophthalazine
CA2591991C (en) *	2005-01-05	2013-11-19	Altana Pharma Ag	Triazolophthalazines
NZ555661A (en) *	2005-01-05	2010-11-26	Nycomed Gmbh	Triazolophthalazines as PDE2-inhibitors
PH12012501361A1 (en)	2009-12-31	2012-10-22	Centro Nac De Investigaciones Oncologicas Cnio	Tricyclic compounds for use as kinase inhibitors
CN103694244B (zh) *	2014-01-09	2016-03-30	郑州大学	3,6位取代-1,2,4-三氮唑并[3,4-a]酞嗪类化合物及其制备和用途
CN104016986B (zh) *	2014-03-13	2016-02-03	郑州大学	3-取代-6-(1-取代哌嗪基)-1,2,4-三氮唑并[3,4-a]酞嗪类化合物、其制备方法和用途
EP4279074A1 (en) *	2022-05-19	2023-11-22	Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin	Azolo compounds for treatment of fibrotic diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2484029A (en) *	1945-12-21	1949-10-11	Ciba Pharm Prod Inc	Hydrazine derivatives of pyridazine compounds
GB629177A (en) *	1945-12-21	1949-09-14	Ciba Ltd	Manufacture of new hydrazine compounds and derivatives thereof
JPS5132598A (en) *	1974-09-13	1976-03-19	Eisai Co Ltd	Toriazoro * 3 44 ee * futarajinjudotai no goseiho
JPS603080B2 (ja) *	1976-08-10	1985-01-25	三菱化学株式会社	Ｓ―トリアゾロ〔３，４ ―α〕〔５，６，７，８〕テトラヒドロフタラジン類
GR70309B (fi) *	1979-10-29	1982-09-08	Dow Chemical Co

1983
- 1983-01-12 FI FI830100A patent/FI81350C/fi not_active IP Right Cessation
- 1983-01-12 PH PH28380A patent/PH21834A/en unknown
- 1983-01-13 GR GR70257A patent/GR78442B/el unknown
- 1983-01-13 CA CA000419398A patent/CA1214168A/en not_active Expired
- 1983-01-13 EP EP83100232A patent/EP0085840B1/en not_active Expired
- 1983-01-13 NZ NZ203021A patent/NZ203021A/en unknown
- 1983-01-13 DE DE8383100232T patent/DE3366494D1/de not_active Expired
- 1983-01-13 AT AT83100232T patent/ATE22562T1/de not_active IP Right Cessation
- 1983-01-13 ZA ZA83224A patent/ZA83224B/xx unknown
- 1983-01-14 NO NO830110A patent/NO161674C/no unknown
- 1983-01-17 IE IE82/83A patent/IE55032B1/en not_active IP Right Cessation
- 1983-01-17 IL IL67697A patent/IL67697A/xx unknown
- 1983-01-17 HU HU83141A patent/HU193033B/hu not_active IP Right Cessation
- 1983-01-18 DK DK017983A patent/DK163145C/da not_active IP Right Cessation
- 1983-01-18 JP JP58005413A patent/JPS58124786A/ja active Granted
- 1983-01-18 AU AU10550/83A patent/AU564026B2/en not_active Ceased
- 1983-01-18 KR KR1019830000174A patent/KR890000184B1/ko not_active Expired
- 1983-01-18 PT PT76107A patent/PT76107A/pt unknown
1984
- 1984-04-10 ES ES531458A patent/ES8601995A1/es not_active Expired
1987
- 1987-10-20 US US07/112,015 patent/US4788186A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES531458A0 (es)	1985-11-01
KR840003254A (ko)	1984-08-20
FI830100A0 (fi)	1983-01-12
IL67697A (en)	1990-02-09
IE55032B1 (en)	1990-05-09
ES8601995A1 (es)	1985-11-01
AU1055083A (en)	1983-07-28
NO161674B (no)	1989-06-05
DK17983D0 (da)	1983-01-18
FI81350C (fi)	1990-10-10
DK163145B (da)	1992-01-27
CA1214168A (en)	1986-11-18
PH21834A (en)	1988-03-17
JPS58124786A (ja)	1983-07-25
KR890000184B1 (ko)	1989-03-09
NO830110L (no)	1983-07-19
US4788186A (en)	1988-11-29
DK17983A (da)	1983-07-19
DK163145C (da)	1992-06-22
DE3366494D1 (de)	1986-11-06
EP0085840B1 (en)	1986-10-01
HU193033B (en)	1987-08-28
PT76107A (en)	1983-02-01
ZA83224B (en)	1983-10-26
FI81350B (fi)	1990-06-29
NZ203021A (en)	1986-05-09
ATE22562T1 (de)	1986-10-15
AU564026B2 (en)	1987-07-30
JPH048428B2 (fi)	1992-02-17
IE830082L (en)	1983-07-18
IL67697A0 (en)	1983-05-15
EP0085840A1 (en)	1983-08-17
GR78442B (fi)	1984-09-27
NO161674C (no)	1989-09-13

Publication	Publication Date	Title
FI830100A0 (fi)	1983-01-12	Nya 6-substituerade s-triazolo /3,4-a/ ftalazinderivat
ES527776A0 (es)	1987-07-16	Procedimiento de preparacion de derivados de 1,4-dihidropiridinas.
NO854194L (no)	1986-04-23	Fremgangsmaate for fremstilling av farmasoeytiske preparater inneholdende antracyklinglykosider.
IL58775A0 (en)	1980-02-29	Hydroxyethyl-azole compounds,their production and pharmaceutical compositions containing them
IL64292A (en)	1985-07-31	D-homoandrostane-17alpha-carboxylic acids,derivatives thereof and 17alpha-spiroethers,their manufacture and pharmaceutical compositions containing them
FI832004A7 (fi)	1983-12-04	Menetelmä 1-sulfo-2-oksoatsetidiini- johdannaisten valmistamiseksi.
IL56413A (en)	1982-11-30	Substituted heterocyclic benzamides,their preparation and pharmaceutical compositions containing them
FI831192A7 (fi)	1983-10-09	Menetelmä substituoitujen 2- aminobentsimidatsolien valmistamiseksi.
FI791424A7 (fi)	1981-01-01	Substituoidut 8-hydroksi-1-fenyyli-2,3,4,5-tetrahydro-1H-3- bentsatsepiinit, menetelmä niiden valmistamiseksi jniitä sisältävät farmaseuttiset seokset.
NL189406C (nl)	1993-04-01	Werkwijze voor de bereiding van 3,3'- of 3,4'-diaminobenzofenon.
FI842972A7 (fi)	1985-02-16	Menetelmä 2,3-dihydrobentsopyranonijohdannaisten valmistamiseksi.
ES522652A0 (es)	1985-02-01	Procedimiento de preparacion de derivados de piperacina.
NO164773C (no)	1990-11-14	Analogifremgangsmaate for fremstilling av forbindelser medfarmasoeytisk virkning.
IT8323010A0 (it)	1983-09-27	Derivati 15-cicloalifatici di 13,14-dideidro carboprostacicline eprocedimento per la loro preparazione.
RO86358A2 (ro)	1985-03-15	Procedeu pentru prepararea unor 1,2,4-triazolil-u-il-propionitrili
FI831008A7 (fi)	1983-09-28	Pyridoni-2- johdannaisia, menetelmiä niiden valmistamiseksi ja niitä sisältäviä lääkeaineita.
ES518725A0 (es)	1984-06-16	Procedimiento de preparacion de nuevos derivados del azabiciclo (3.2.0) heptano.
FI883499A7 (fi)	1989-01-29	Menetelmä aryyli- tai heteroaryylimetyylisubstituoitujen 2.2'-bi-1H-imidatsolien valmistamiseksi
SE8401916D0 (sv)	1984-04-05	Condensed benzopyrone derivatives
IT8223632A0 (it)	1982-10-06	Procedimento per la preparazione di 2,2-dialchilamino-1-nitroeteni.
NL192985B (nl)	1998-03-02	Werkwijze voor de bereiding van indolinederivaten.
ES523567A0 (es)	1984-11-01	Procedimiento para la preparacion de derivados de 1,2,4-tiadiazol.
ES518050A0 (es)	1984-01-16	Procedimiento de preparacion de 3,7-dihidro-1h-purinas-2,6-diona sustituidas.
AR226096A1 (es)	1982-05-31	Procedimiento para la preparacion de n,n-dimetil-10-(1-aza(2,2,2)-biciclo-3-octil)10h-2-fenotiazinsulfonamida
IT8223967A0 (it)	1982-10-28	Procedimento per la preparazione di derivati di fenetilpiperidine.

Legal Events

Date	Code	Title	Description
2004-08-31	MM	Patent lapsed	Owner name: GRUPPO LEPETIT S.P.A.