NO161674C - Analogifremgangsm te for fremstilling av terapeutisk aktive 6-substituert-s-triazolo(3,4-a)-ftalazinderivater. - Google Patents

Analogifremgangsm te for fremstilling av terapeutisk aktive 6-substituert-s-triazolo(3,4-a)-ftalazinderivater.

Info

Publication number: NO161674C
Authority: NO; Norway
Prior art keywords: triazolo; preparation; derivatives; tthalazine; substituted
Prior art date: 1982-01-18

Application number

NO830110A

Other languages

English (en)

Other versions

NO161674B (no

NO830110L (no

Inventor

Domenico Barone

Giorgio Tarzia

Emilio Occelli

Adele Giunta

Original Assignee

Lepetit Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-01-18

Filing date

1983-01-14

Publication date

1989-09-13

1983-01-14 Application filed by Lepetit Spa filed Critical Lepetit Spa

1983-07-19 Publication of NO830110L publication Critical patent/NO830110L/no

1989-06-05 Publication of NO161674B publication Critical patent/NO161674B/no

1989-09-13 Publication of NO161674C publication Critical patent/NO161674C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Anesthesiology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

NO830110A 1982-01-18 1983-01-14 Analogifremgangsm te for fremstilling av terapeutisk aktive 6-substituert-s-triazolo(3,4-a)-ftalazinderivater. NO161674C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB8201273		1982-01-18

Publications (3)

Publication Number	Publication Date
NO830110L NO830110L (no)	1983-07-19
NO161674B NO161674B (no)	1989-06-05
NO161674C true NO161674C (no)	1989-09-13

Family

ID=10527683

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO830110A NO161674C (no)	1982-01-18	1983-01-14	Analogifremgangsm te for fremstilling av terapeutisk aktive 6-substituert-s-triazolo(3,4-a)-ftalazinderivater.

Country Status (20)

Country	Link
US (1)	US4788186A (no)
EP (1)	EP0085840B1 (no)
JP (1)	JPS58124786A (no)
KR (1)	KR890000184B1 (no)
AT (1)	ATE22562T1 (no)
AU (1)	AU564026B2 (no)
CA (1)	CA1214168A (no)
DE (1)	DE3366494D1 (no)
DK (1)	DK163145C (no)
ES (1)	ES8601995A1 (no)
FI (1)	FI81350C (no)
GR (1)	GR78442B (no)
HU (1)	HU193033B (no)
IE (1)	IE55032B1 (no)
IL (1)	IL67697A (no)
NO (1)	NO161674C (no)
NZ (1)	NZ203021A (no)
PH (1)	PH21834A (no)
PT (1)	PT76107A (no)
ZA (1)	ZA83224B (no)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1194310B (it) *	1983-07-12	1988-09-14	Lepetit Spa	Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
JP2000515851A (ja)	1996-07-25	2000-11-28	メルクシヤープエンドドームリミテツド	ＧＡＢＡ▲下Ａα５▼レセプターサブタイプの逆アゴニストとしての置換のあるトリアゾロピリダジン誘導体
TR199900047T2 (xx) *	1996-07-25	1999-03-22	Merck Sharp & Dohme Limited	Gaba resept�rleri ligandlar� olarak ikame triazolo-piridazin t�revleri
JP4672820B2 (ja)	1997-05-08	2011-04-20	メルクシャープエンドドームリミテッド	ＧＡＢＡα５リガンドとしての置換１，２，４−トリアゾロ［３，４−ａ］フタラジン誘導体
GB9715977D0 (en) *	1997-07-29	1997-10-01	Merck Sharp & Dohme	Therapeutic agents
ES2137113B1 (es) *	1997-07-29	2000-09-16	Almirall Prodesfarma Sa	Nuevos derivados de triazolo-piridazinas heterociclicos.
GB9726699D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
GB9726701D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
AU1041599A (en) *	1997-11-13	1999-06-07	Jose Luis Castro Pineiro	Therapeutic uses of triazolo-pyridazine derivatives
GB9723999D0 (en)	1997-11-13	1998-01-14	Merck Sharp & Dohme	Therapeutic use
GB9726702D0 (en) *	1997-12-18	1998-02-18	Merck Sharp & Dohme	Therapeutic use
US6110915A (en) *	1997-12-18	2000-08-29	Merck & Co., Inc.	Antiemetic use of triazolo-pyridazine derivatives
AU746866B2 (en)	1998-01-14	2002-05-02	Merck Sharp & Dohme Limited	Triazolo-pyridazine derivatives as ligands for GABA receptors
GB9801202D0 (en)	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801210D0 (en)	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801208D0 (en)	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
CZ290883B6 (cs)	1998-01-21	2002-11-13	Merck Sharp And Dohme Limited	Triazolopyridazinové deriváty, způsob jejich výroby a farmaceutický prostředek je obsahující
GB9801234D0 (en) *	1998-01-21	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801397D0 (en)	1998-01-22	1998-03-18	Merck Sharp & Dohme	Therapeutic agents
GB9801538D0 (en)	1998-01-23	1998-03-25	Merck Sharp & Dohme	Pharmaceutical product
EA002824B1 (ru) *	1998-02-25	2002-10-31	Мерк Шарп Энд Домэ Лимитед	ЗАМЕЩЕННЫЙ 1,2,4-ТРИАЗОЛО[3,4-а]ПИРИДАЗИН
IL137117A0 (en)	1998-02-25	2001-06-14	Merck Sharp & Dohme	Substituted 1,2,4-triazolo [3,4-a] pyridazine
GB9824897D0 (en)	1998-11-12	1999-01-06	Merck Sharp & Dohme	Therapeutic compounds
WO2000027849A2 (en)	1998-11-12	2000-05-18	Merck & Co., Inc.	Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist and pamoate formulations of the same
GB9929569D0 (en) *	1999-12-14	2000-02-09	Merck Sharp & Dohme	Therapeutic agents
GB0028583D0 (en)	2000-11-23	2001-01-10	Merck Sharp & Dohme	Therapeutic compounds
JP2004527531A (ja) *	2001-04-10	2004-09-09	メルク　エンド　カムパニー　インコーポレーテッド	癌を治療する方法
WO2002083140A1 (en) *	2001-04-10	2002-10-24	Merck & Co., Inc.	Inhibitors of akt activity
US20060142178A1 (en) *	2002-04-08	2006-06-29	Barnett Stanley F	Method of treating cancer
US20050054647A1 (en) *	2002-12-27	2005-03-10	Detlev Schuppan	New pharmaceutical combination
CN101133057B (zh) *	2004-09-02	2011-03-09	尼科梅德有限责任公司	三唑并酞嗪化合物
EA012505B1 (ru) *	2005-01-05	2009-10-30	Никомед Гмбх	Триазолофталазины в качестве ингибиторов pde-2
JP5130053B2 (ja) *	2005-01-05	2013-01-30	ニコメッドゲゼルシャフトミットベシュレンクテルハフツング	トリアゾロフタラジン
PH12012501361A1 (en)	2009-12-31	2012-10-22	Centro Nac De Investigaciones Oncologicas Cnio	Tricyclic compounds for use as kinase inhibitors
CN103694244B (zh) *	2014-01-09	2016-03-30	郑州大学	3,6位取代-1,2,4-三氮唑并[3,4-a]酞嗪类化合物及其制备和用途
CN104016986B (zh) *	2014-03-13	2016-02-03	郑州大学	3-取代-6-(1-取代哌嗪基)-1,2,4-三氮唑并[3,4-a]酞嗪类化合物、其制备方法和用途
EP4279074A1 (en) *	2022-05-19	2023-11-22	Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin	Azolo compounds for treatment of fibrotic diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2484029A (en) *	1945-12-21	1949-10-11	Ciba Pharm Prod Inc	Hydrazine derivatives of pyridazine compounds
GB629177A (en) *	1945-12-21	1949-09-14	Ciba Ltd	Manufacture of new hydrazine compounds and derivatives thereof
JPS5132598A (en) *	1974-09-13	1976-03-19	Eisai Co Ltd	Toriazoro * 3 44 ee * futarajinjudotai no goseiho
JPS603080B2 (ja) *	1976-08-10	1985-01-25	三菱化学株式会社	Ｓ―トリアゾロ〔３，４ ―α〕〔５，６，７，８〕テトラヒドロフタラジン類
GR70309B (no) *	1979-10-29	1982-09-08	Dow Chemical Co

1983
- 1983-01-12 PH PH28380A patent/PH21834A/en unknown
- 1983-01-12 FI FI830100A patent/FI81350C/fi not_active IP Right Cessation
- 1983-01-13 ZA ZA83224A patent/ZA83224B/xx unknown
- 1983-01-13 DE DE8383100232T patent/DE3366494D1/de not_active Expired
- 1983-01-13 AT AT83100232T patent/ATE22562T1/de not_active IP Right Cessation
- 1983-01-13 GR GR70257A patent/GR78442B/el unknown
- 1983-01-13 EP EP83100232A patent/EP0085840B1/en not_active Expired
- 1983-01-13 NZ NZ203021A patent/NZ203021A/en unknown
- 1983-01-13 CA CA000419398A patent/CA1214168A/en not_active Expired
- 1983-01-14 NO NO830110A patent/NO161674C/no unknown
- 1983-01-17 IL IL67697A patent/IL67697A/xx unknown
- 1983-01-17 IE IE82/83A patent/IE55032B1/en not_active IP Right Cessation
- 1983-01-17 HU HU83141A patent/HU193033B/hu not_active IP Right Cessation
- 1983-01-18 KR KR1019830000174A patent/KR890000184B1/ko not_active IP Right Cessation
- 1983-01-18 JP JP58005413A patent/JPS58124786A/ja active Granted
- 1983-01-18 PT PT76107A patent/PT76107A/pt unknown
- 1983-01-18 AU AU10550/83A patent/AU564026B2/en not_active Ceased
- 1983-01-18 DK DK017983A patent/DK163145C/da not_active IP Right Cessation
1984
- 1984-04-10 ES ES531458A patent/ES8601995A1/es not_active Expired
1987
- 1987-10-20 US US07/112,015 patent/US4788186A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
GR78442B (no)	1984-09-27
IL67697A (en)	1990-02-09
FI81350C (fi)	1990-10-10
DE3366494D1 (de)	1986-11-06
DK163145C (da)	1992-06-22
DK17983D0 (da)	1983-01-18
IE830082L (en)	1983-07-18
JPS58124786A (ja)	1983-07-25
ES531458A0 (es)	1985-11-01
CA1214168A (en)	1986-11-18
PH21834A (en)	1988-03-17
FI81350B (fi)	1990-06-29
DK17983A (da)	1983-07-19
ZA83224B (en)	1983-10-26
EP0085840B1 (en)	1986-10-01
AU564026B2 (en)	1987-07-30
EP0085840A1 (en)	1983-08-17
NO161674B (no)	1989-06-05
KR840003254A (ko)	1984-08-20
ES8601995A1 (es)	1985-11-01
AU1055083A (en)	1983-07-28
IE55032B1 (en)	1990-05-09
IL67697A0 (en)	1983-05-15
DK163145B (da)	1992-01-27
US4788186A (en)	1988-11-29
PT76107A (en)	1983-02-01
NO830110L (no)	1983-07-19
NZ203021A (en)	1986-05-09
JPH048428B2 (no)	1992-02-17
HU193033B (en)	1987-08-28
ATE22562T1 (de)	1986-10-15
FI830100L (fi)	1983-07-19
FI830100A0 (fi)	1983-01-12
KR890000184B1 (ko)	1989-03-09

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