NO329676B1 - Kalsium(3S)tetrahydro-3-furanyl(1S,2R)-3-(((4-aminofenyl)sulfonyl)(isobutyl)amino)-1-benzyl-2-(fosfonoksy)propylkarbamat samt anvendelse og fremstilling derav og farmasoytisk preparat - Google Patents

Kalsium(3S)tetrahydro-3-furanyl(1S,2R)-3-(((4-aminofenyl)sulfonyl)(isobutyl)amino)-1-benzyl-2-(fosfonoksy)propylkarbamat samt anvendelse og fremstilling derav og farmasoytisk preparat Download PDF

Info

Publication number: NO329676B1
Authority: NO; Norway
Prior art keywords: compound; formula; water; producing; solvent
Prior art date: 1998-07-18

Application number

NO20010282A

Other languages

English (en)

Norwegian (no)

Other versions

NO20010282D0 (no

NO20010282L (no

Inventor

Andrew David Searle

Hardev Singh

Ian Gordon Armitage

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-18

Filing date

2001-01-17

Publication date

2010-11-29

2001-01-17 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2001-01-17 Publication of NO20010282D0 publication Critical patent/NO20010282D0/no

2001-03-07 Publication of NO20010282L publication Critical patent/NO20010282L/no

2010-11-29 Publication of NO329676B1 publication Critical patent/NO329676B1/no

Links

238000002360 preparation method Methods 0.000 title claims description 11
239000008194 pharmaceutical composition Substances 0.000 title claims description 10
-1 (4-aminophenyl) sulfonyl Chemical group 0.000 title description 11
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CBVCZFGXHXORBI-PXQQMZJSSA-N indinavir Chemical compound C([C@H](N(CC1)C[C@@H](O)C[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H]2C3=CC=CC=C3C[C@H]2O)C(=O)NC(C)(C)C)N1CC1=CC=CN=C1 CBVCZFGXHXORBI-PXQQMZJSSA-N 0.000 description 1
239000003701 inert diluent Substances 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
230000002458 infectious effect Effects 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
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KELNNWMENBUHNS-NSHDSACASA-N isopropyl (2s)-2-ethyl-7-fluoro-3-oxo-3,4-dihydroquinoxaline-1(2h)-carboxylate Chemical compound FC1=CC=C2NC(=O)[C@H](CC)N(C(=O)OC(C)C)C2=C1 KELNNWMENBUHNS-NSHDSACASA-N 0.000 description 1
229960001627 lamivudine Drugs 0.000 description 1
239000008141 laxative Substances 0.000 description 1
230000002475 laxative effect Effects 0.000 description 1
CJPLEFFCVDQQFZ-UHFFFAOYSA-N loviride Chemical compound CC(=O)C1=CC=C(C)C=C1NC(C(N)=O)C1=C(Cl)C=CC=C1Cl CJPLEFFCVDQQFZ-UHFFFAOYSA-N 0.000 description 1
229950006243 loviride Drugs 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
239000007932 molded tablet Substances 0.000 description 1
238000000465 moulding Methods 0.000 description 1
201000006417 multiple sclerosis Diseases 0.000 description 1
229960000884 nelfinavir Drugs 0.000 description 1
QAGYKUNXZHXKMR-HKWSIXNMSA-N nelfinavir Chemical compound CC1=C(O)C=CC=C1C(=O)N[C@H]([C@H](O)CN1[C@@H](C[C@@H]2CCCC[C@@H]2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 QAGYKUNXZHXKMR-HKWSIXNMSA-N 0.000 description 1
230000000926 neurological effect Effects 0.000 description 1
229960000689 nevirapine Drugs 0.000 description 1
229940042402 non-nucleoside reverse transcriptase inhibitor Drugs 0.000 description 1
239000002726 nonnucleoside reverse transcriptase inhibitor Substances 0.000 description 1
239000003921 oil Substances 0.000 description 1
238000003305 oral gavage Methods 0.000 description 1
239000002245 particle Substances 0.000 description 1
IPWFJLQDVFKJDU-UHFFFAOYSA-N pentanamide Chemical compound CCCCC(N)=O IPWFJLQDVFKJDU-UHFFFAOYSA-N 0.000 description 1
239000008177 pharmaceutical agent Substances 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
125000004193 piperazinyl group Chemical group 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
229940069328 povidone Drugs 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
230000000750 progressive effect Effects 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 description 1
125000001567 quinoxalinyl group Chemical class N1=C(C=NC2=CC=CC=C12)* 0.000 description 1
WTTIBCHOELPGFK-LBPRGKRZSA-N r82150 Chemical class C1N(CC=C(C)C)[C@@H](C)CN2C(=S)NC3=CC=CC1=C32 WTTIBCHOELPGFK-LBPRGKRZSA-N 0.000 description 1
230000005855 radiation Effects 0.000 description 1
229960000311 ritonavir Drugs 0.000 description 1
NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 description 1
229960001852 saquinavir Drugs 0.000 description 1
QWAXKHKRTORLEM-UGJKXSETSA-N saquinavir Chemical compound C([C@@H]([C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)C=1N=C2C=CC=CC2=CC=1)C1=CC=CC=C1 QWAXKHKRTORLEM-UGJKXSETSA-N 0.000 description 1
239000002002 slurry Substances 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
239000012453 solvate Substances 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000007916 tablet composition Substances 0.000 description 1
239000006068 taste-masking agent Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
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230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000029812 viral genome replication Effects 0.000 description 1
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230000006514 viral protein processing Effects 0.000 description 1
229960002555 zidovudine Drugs 0.000 description 1
HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
General Chemical & Material Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Biochemistry (AREA)
Immunology (AREA)
Epidemiology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO20010282A 1998-07-18 2001-01-17 Kalsium(3S)tetrahydro-3-furanyl(1S,2R)-3-(((4-aminofenyl)sulfonyl)(isobutyl)amino)-1-benzyl-2-(fosfonoksy)propylkarbamat samt anvendelse og fremstilling derav og farmasoytisk preparat NO329676B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9815567.4A GB9815567D0 (en)	1998-07-18	1998-07-18	Antiviral compound
PCT/EP1999/004991 WO2000004033A1 (fr)	1998-07-18	1999-07-15	Calcium (3s) tetrahydro-3-furanyle (1s,2r)-3-[[(4-aminophenyle) sulfonyle] (isobutyle) amino]-1-benzyle-2-(phosphonooxy) propylcarbamate

Publications (3)

Publication Number	Publication Date
NO20010282D0 NO20010282D0 (no)	2001-01-17
NO20010282L NO20010282L (no)	2001-03-07
NO329676B1 true NO329676B1 (no)	2010-11-29

Family

ID=10835689

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20010282A NO329676B1 (no)	1998-07-18	2001-01-17	Kalsium(3S)tetrahydro-3-furanyl(1S,2R)-3-(((4-aminofenyl)sulfonyl)(isobutyl)amino)-1-benzyl-2-(fosfonoksy)propylkarbamat samt anvendelse og fremstilling derav og farmasoytisk preparat

Country Status (48)

Country	Link
US (3)	US6514953B1 (fr)
EP (2)	EP1098898B1 (fr)
JP (1)	JP3437553B2 (fr)
KR (1)	KR100694721B1 (fr)
CN (1)	CN1188422C (fr)
AP (1)	AP2001002039A0 (fr)
AR (1)	AR019388A1 (fr)
AT (1)	ATE229964T1 (fr)
AU (1)	AU766056B2 (fr)
BG (1)	BG105253A (fr)
BR (1)	BRPI9912156B8 (fr)
CA (1)	CA2337857C (fr)
CO (1)	CO5090836A1 (fr)
CZ (1)	CZ300447B6 (fr)
DE (1)	DE69904600T2 (fr)
DK (1)	DK1098898T3 (fr)
DZ (1)	DZ2845A1 (fr)
EA (1)	EA003191B1 (fr)
EE (1)	EE200100038A (fr)
ES (1)	ES2189450T3 (fr)
GB (1)	GB9815567D0 (fr)
GC (1)	GC0000105A (fr)
GE (1)	GEP20033030B (fr)
GT (1)	GT199900111A (fr)
HK (1)	HK1034261A1 (fr)
HR (1)	HRP20010046A2 (fr)
HU (1)	HU229700B1 (fr)
ID (1)	ID28070A (fr)
IL (1)	IL140824A (fr)
IS (1)	IS5808A (fr)
JO (1)	JO2114B1 (fr)
MA (1)	MA26660A1 (fr)
MY (1)	MY122323A (fr)
NO (1)	NO329676B1 (fr)
NZ (1)	NZ509291A (fr)
OA (1)	OA11706A (fr)
PA (1)	PA8477801A1 (fr)
PE (1)	PE20000869A1 (fr)
PL (1)	PL195736B1 (fr)
PT (1)	PT1098898E (fr)
SK (1)	SK285311B6 (fr)
SV (1)	SV1999000096A (fr)
TN (1)	TNSN99145A1 (fr)
TR (1)	TR200100111T2 (fr)
TW (1)	TWI245770B (fr)
WO (1)	WO2000004033A1 (fr)
YU (1)	YU3401A (fr)
ZA (1)	ZA200100417B (fr)

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1998
- 1998-07-18 GB GBGB9815567.4A patent/GB9815567D0/en not_active Ceased
1999
- 1999-07-14 AR ARP990103446A patent/AR019388A1/es not_active Application Discontinuation
- 1999-07-14 DZ DZ990145A patent/DZ2845A1/fr active
- 1999-07-14 GC GCP1999203 patent/GC0000105A/xx active
- 1999-07-15 ES ES99934698T patent/ES2189450T3/es not_active Expired - Lifetime
- 1999-07-15 WO PCT/EP1999/004991 patent/WO2000004033A1/fr active IP Right Grant
- 1999-07-15 GE GEAP19995716A patent/GEP20033030B/en unknown
- 1999-07-15 TR TR2001/00111T patent/TR200100111T2/xx unknown
- 1999-07-15 SV SV1999000096A patent/SV1999000096A/es not_active Application Discontinuation
- 1999-07-15 EP EP99934698A patent/EP1098898B1/fr not_active Expired - Lifetime
- 1999-07-15 PE PE1999000714A patent/PE20000869A1/es not_active Application Discontinuation
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- 1999-07-15 DE DE69904600T patent/DE69904600T2/de not_active Expired - Lifetime
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2001
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2002
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Also Published As

Publication number	Publication date
GEP20033030B (en)	2003-07-25
DE69904600T2 (de)	2003-11-13
GC0000105A (en)	2005-06-29
SK762001A3 (en)	2001-10-08
EP1240903A2 (fr)	2002-09-18
GT199900111A (es)	2001-01-05
ID28070A (id)	2001-05-03
AR019388A1 (es)	2002-02-13
TNSN99145A1 (fr)	2005-11-10
GB9815567D0 (en)	1998-09-16
NO20010282D0 (no)	2001-01-17
NZ509291A (en)	2003-05-30
YU3401A (sh)	2005-06-10
SK285311B6 (sk)	2006-10-05
JP3437553B2 (ja)	2003-08-18
EP1098898B1 (fr)	2002-12-18
BRPI9912156B1 (pt)	2016-07-26
ZA200100417B (en)	2002-02-27
IL140824A (en)	2004-09-27
US20030100537A1 (en)	2003-05-29
DZ2845A1 (fr)	2003-12-01
EP1098898A1 (fr)	2001-05-16
US6514953B1 (en)	2003-02-04
JO2114B1 (en)	2000-05-21
HU229700B1 (en)	2014-05-28
MY122323A (en)	2006-04-29
PL345620A1 (en)	2002-01-02
EA003191B1 (ru)	2003-02-27
EA200100053A1 (ru)	2001-08-27
CN1324363A (zh)	2001-11-28
HK1034261A1 (en)	2001-10-19
CO5090836A1 (es)	2001-10-30
KR100694721B1 (ko)	2007-03-15
ES2189450T3 (es)	2003-07-01
IL140824A0 (en)	2002-02-10
EE200100038A (et)	2002-06-17
AP2001002039A0 (en)	2001-03-31
PL195736B1 (pl)	2007-10-31
EP1240903A3 (fr)	2003-02-12
ATE229964T1 (de)	2003-01-15
NO20010282L (no)	2001-03-07
AU766056B2 (en)	2003-10-09
MA26660A1 (fr)	2004-12-20
US20030096795A1 (en)	2003-05-22
BR9912156A (pt)	2001-04-10
DE69904600D1 (de)	2003-01-30
PT1098898E (pt)	2003-04-30
HUP0103432A3 (en)	2003-01-28
CA2337857A1 (fr)	2000-01-27
WO2000004033A1 (fr)	2000-01-27
CZ300447B6 (cs)	2009-05-20
IS5808A (is)	2001-01-12
SV1999000096A (es)	2000-07-06
CN1188422C (zh)	2005-02-09
CZ2001219A3 (cs)	2001-07-11
BG105253A (en)	2001-12-29
AU5037999A (en)	2000-02-07
PA8477801A1 (es)	2000-05-24
HUP0103432A2 (hu)	2002-04-29
OA11706A (en)	2005-01-13
DK1098898T3 (da)	2003-04-07
JP2003521447A (ja)	2003-07-15
CA2337857C (fr)	2011-01-25
PE20000869A1 (es)	2000-09-08
KR20010071952A (ko)	2001-07-31
TR200100111T2 (tr)	2002-02-21
TWI245770B (en)	2005-12-21
HRP20010046A2 (en)	2002-02-28
BRPI9912156B8 (pt)	2021-05-25

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EA020489B1 (ru)	2014-11-28	Модуляторы фармакокинетических свойств лекарственных средств
WO2017086829A1 (fr)	2017-05-26	Dichloroacétates de n4-[2-(diméthyl-phosphinoyl)phényl]-n4-(2-méthoxy-4-pipéridin-1-ylphényl)-5-chlor-pirimidin-2,4-diamines substituées en tant que modulateurs d'alk et d'egfr destinés au traitement du cancer
JP6154878B2 (ja)	2017-06-28	アタザナビルを含む錠剤組成物
JP4774053B2 (ja)	2011-09-14	Ｎ−ヒドロキシ−４−｛５−［４−（５−イソプロピル−２−メチル−１，３−チアゾール−４−イル）フェノキシ］ペントキシ｝メンズアミジン２メタンスルホン酸塩
WO2015158648A1 (fr)	2015-10-22	Formes solides d'un composé pharmaceutiquement actif
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MXPA01000617A (en)	2001-12-04	Calcium (3s) tetrahydro-3- furanyl(1s,2r)-3-[[(4-aminophenyl) sulfonyl](isobutyl) amino]-1-benzyl-2- (phosphonooxy) propylcarbamate
CN103864756A (zh)	2014-06-18	丁二磺酸达比加群酯及其制备方法和用途
JP2010521524A (ja)	2010-06-24	Ｎ−ヒドロキシ−４−｛５−［４−（５−イソプロピル−２−メチル−１，３−チアゾール−４−イル）フェノキシ］ペントキシ｝ベンズアミジン２エタンスルホン酸塩、その製造方法およびそれを含む薬学組成物
KR101632839B1 (ko)	2016-06-23	레스베라트톨 유도체를 유효성분으로 포함하는 간경화 또는 간섬유화 예방 또는 치료용 약학 조성물
DK200200115U3 (da)	2002-06-28	Hidtil ukendte salte af 4-amino-1-hydroxybutyliden-1, 1-bisphosphonsyre, deres fremstilling og anvendelse
JPH04247033A (ja)	1992-09-03	神経細胞壊死抑制剤
JPH0352855A (ja)	1991-03-07	アクリル酸塩、それらの製造方法、それらを含む薬剤組成物および医学におけるそれらの用途
JPS63295580A (ja)	1988-12-01	骨粗鬆症治療剤
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