HK1034261A1 - Calcium (3s) tetrahydro-3-furanyl(1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-(phosphonooxy) propylcarbamate - Google Patents

Calcium (3s) tetrahydro-3-furanyl(1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-(phosphonooxy) propylcarbamate

Info

Publication number: HK1034261A1
Authority: HK; Hong Kong
Prior art keywords: propylcarbamate; phosphonooxy; aminophenyl; furanyl; tetrahydro
Prior art date: 1998-07-18

Application number

HK01104903A

Other languages

English (en)

Inventor

Ian Gordon Armitage

Andrew David Searle

Hardev Singh

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-18

Filing date

2001-07-13

Publication date

2001-10-19

2001-07-13 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2001-10-19 Publication of HK1034261A1 publication Critical patent/HK1034261A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
General Chemical & Material Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Biochemistry (AREA)
Immunology (AREA)
Epidemiology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

HK01104903A 1998-07-18 2001-07-13 Calcium (3s) tetrahydro-3-furanyl(1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-(phosphonooxy) propylcarbamate HK1034261A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9815567.4A GB9815567D0 (en)	1998-07-18	1998-07-18	Antiviral compound
PCT/EP1999/004991 WO2000004033A1 (en)	1998-07-18	1999-07-15	Calcium (3s) tetrahydro-3-furanyl(1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino] -1-benzyl-2- (phosphonooxy) propylcarbamate

Publications (1)

Publication Number	Publication Date
HK1034261A1 true HK1034261A1 (en)	2001-10-19

Family

ID=10835689

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK01104903A HK1034261A1 (en)	1998-07-18	2001-07-13	Calcium (3s) tetrahydro-3-furanyl(1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-(phosphonooxy) propylcarbamate

Country Status (48)

Country	Link
US (3)	US6514953B1 (xx)
EP (2)	EP1098898B1 (xx)
JP (1)	JP3437553B2 (xx)
KR (1)	KR100694721B1 (xx)
CN (1)	CN1188422C (xx)
AP (1)	AP2001002039A0 (xx)
AR (1)	AR019388A1 (xx)
AT (1)	ATE229964T1 (xx)
AU (1)	AU766056B2 (xx)
BG (1)	BG105253A (xx)
BR (1)	BRPI9912156B8 (xx)
CA (1)	CA2337857C (xx)
CO (1)	CO5090836A1 (xx)
CZ (1)	CZ300447B6 (xx)
DE (1)	DE69904600T2 (xx)
DK (1)	DK1098898T3 (xx)
DZ (1)	DZ2845A1 (xx)
EA (1)	EA003191B1 (xx)
EE (1)	EE200100038A (xx)
ES (1)	ES2189450T3 (xx)
GB (1)	GB9815567D0 (xx)
GC (1)	GC0000105A (xx)
GE (1)	GEP20033030B (xx)
GT (1)	GT199900111A (xx)
HK (1)	HK1034261A1 (xx)
HR (1)	HRP20010046A2 (xx)
HU (1)	HU229700B1 (xx)
ID (1)	ID28070A (xx)
IL (1)	IL140824A (xx)
IS (1)	IS5808A (xx)
JO (1)	JO2114B1 (xx)
MA (1)	MA26660A1 (xx)
MY (1)	MY122323A (xx)
NO (1)	NO329676B1 (xx)
NZ (1)	NZ509291A (xx)
OA (1)	OA11706A (xx)
PA (1)	PA8477801A1 (xx)
PE (1)	PE20000869A1 (xx)
PL (1)	PL195736B1 (xx)
PT (1)	PT1098898E (xx)
SK (1)	SK285311B6 (xx)
SV (1)	SV1999000096A (xx)
TN (1)	TNSN99145A1 (xx)
TR (1)	TR200100111T2 (xx)
TW (1)	TWI245770B (xx)
WO (1)	WO2000004033A1 (xx)
YU (1)	YU3401A (xx)
ZA (1)	ZA200100417B (xx)

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DK1575951T3 (da) *	2002-12-06	2014-09-15	Debiopharm Int Sa	Heterocykliske forbindelser, fremgangsmåder til fremstilling deraf og deres anvendelse i terapi
CA2519429C (en)	2003-03-17	2013-08-06	Affinium Pharmaceuticals, Inc.	Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics
ATE490788T1 (de)	2003-04-25	2010-12-15	Gilead Sciences Inc	Antivirale phosphonate analoge
US7470724B2 (en)	2003-04-25	2008-12-30	Gilead Sciences, Inc.	Phosphonate compounds having immuno-modulatory activity
US7432261B2 (en)	2003-04-25	2008-10-07	Gilead Sciences, Inc.	Anti-inflammatory phosphonate compounds
WO2005002626A2 (en)	2003-04-25	2005-01-13	Gilead Sciences, Inc.	Therapeutic phosphonate compounds
WO2004096287A2 (en)	2003-04-25	2004-11-11	Gilead Sciences, Inc.	Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
CA2522845A1 (en)	2003-04-25	2004-11-11	Gilead Sciences, Inc.	Kinase inhibitor phosphonate conjugates
US7407965B2 (en)	2003-04-25	2008-08-05	Gilead Sciences, Inc.	Phosphonate analogs for treating metabolic diseases
US7452901B2 (en)	2003-04-25	2008-11-18	Gilead Sciences, Inc.	Anti-cancer phosphonate analogs
WO2004096285A2 (en)	2003-04-25	2004-11-11	Gilead Sciences, Inc.	Anti-infective phosphonate conjugates
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EP1778251B1 (en)	2004-07-27	2011-04-13	Gilead Sciences, Inc.	Nucleoside phosphonate conjugates as anti hiv agents
ES2341120T3 (es)	2004-11-26	2010-06-15	Ucl Business Plc	Composiciones que comprenden ornitina y fenilacetato o fenilbutirato para tratar encefalopatia hepatica.
JP2009518399A (ja) *	2005-12-05	2009-05-07	アフィニウムファーマシューティカルズ，インク．	Ｆａｂｉ阻害剤および抗菌剤としてのヘテロ環アクリルアミド化合物
EP2687533B1 (en)	2006-07-20	2017-07-19	Debiopharm International SA	Acrylamide derivatives as FAB I inhibitors
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CN102816111B (zh)	2007-03-12	2014-08-06	尼克塔治疗公司	低聚物-蛋白酶抑制剂偶联物
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ES2393962T3 (es)	2008-07-08	2013-01-03	Gilead Sciences, Inc.	Sales de compuestos inhibidores del VIH.
CA2998344C (en)	2009-04-03	2020-06-02	Ocera Therapeutics, Inc.	L-ornithine phenyl acetate and methods of making thereof
EP2432788A1 (en) *	2009-05-20	2012-03-28	Ranbaxy Laboratories Limited	Amorphous fosamprenavir calcium
MX2011013129A (es)	2009-06-08	2012-03-14	Ucl Business Plc	Tratamiento de hipertension portal y restauracion de la funcion hepatica usando fenilacetato de l-ornitina.
WO2010144869A2 (en)	2009-06-12	2010-12-16	Nektar Therapeutics	Protease inhibitors
EP2448949A1 (en) *	2009-06-30	2012-05-09	Ranbaxy Laboratories Limited	Crystalline form of fosamprenavir calcium
EP2477996A1 (en)	2009-09-16	2012-07-25	Ranbaxy Laboratories Limited	Process for the preparation of fosamprenavir calcium
WO2011085130A1 (en) *	2010-01-07	2011-07-14	Pliva Hrvatska D.O.O.	Solid state forms of fosamprenavir calcium salt and process for preparation thereof
DK3127542T3 (en)	2010-01-27	2018-11-12	Viiv Healthcare Co	ANTIVIRAL THERAPY
US20110224443A1 (en) *	2010-03-15	2011-09-15	Venkata Naga Brahmeshwara Rao Mandava	Preparation of fosamprenavir calcium
WO2011114212A1 (en)	2010-03-19	2011-09-22	Lupin Limited	Ammonium, calcium and tris salts of fosamprenavir
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US8993786B2 (en)	2011-02-10	2015-03-31	Mylan Laboratories Ltd.	Crystalline fosamprenavir calcium and process for the preparation thereof
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AU2015353703B2 (en)	2014-11-24	2021-04-01	Ucl Business Plc	Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies
JP6990170B2 (ja)	2015-08-18	2022-01-12	オセラセラピューティクス，インコーポレイテッド	Ｌ－オルニチンをフェニルアセテートおよびフェニルブチレートのうちの少なくとも１つと組み合わせて用いる筋肉喪失の治療および予防
MY189221A (en)	2016-02-26	2022-01-31	Debiopharm Int Sa	Medicament for treatment of diabetic foot infections
JP7126520B2 (ja)	2017-05-11	2022-08-26	オセラセラピューティクス，インコーポレイテッド	Ｌ－オルニチンフェニルアセテートを製造する方法
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1998
- 1998-07-18 GB GBGB9815567.4A patent/GB9815567D0/en not_active Ceased
1999
- 1999-07-14 AR ARP990103446A patent/AR019388A1/es not_active Application Discontinuation
- 1999-07-14 DZ DZ990145A patent/DZ2845A1/xx active
- 1999-07-14 GC GCP1999203 patent/GC0000105A/xx active
- 1999-07-15 ES ES99934698T patent/ES2189450T3/es not_active Expired - Lifetime
- 1999-07-15 WO PCT/EP1999/004991 patent/WO2000004033A1/en active IP Right Grant
- 1999-07-15 GE GEAP19995716A patent/GEP20033030B/en unknown
- 1999-07-15 TR TR2001/00111T patent/TR200100111T2/xx unknown
- 1999-07-15 SV SV1999000096A patent/SV1999000096A/es not_active Application Discontinuation
- 1999-07-15 EP EP99934698A patent/EP1098898B1/en not_active Expired - Lifetime
- 1999-07-15 PE PE1999000714A patent/PE20000869A1/es not_active Application Discontinuation
- 1999-07-15 HU HU0103432A patent/HU229700B1/hu unknown
- 1999-07-15 YU YU3401A patent/YU3401A/sh unknown
- 1999-07-15 GT GT199900111A patent/GT199900111A/es unknown
- 1999-07-15 AU AU50379/99A patent/AU766056B2/en not_active Expired
- 1999-07-15 CZ CZ20010219A patent/CZ300447B6/cs not_active IP Right Cessation
- 1999-07-15 OA OA1200100016A patent/OA11706A/fr unknown
- 1999-07-15 DE DE69904600T patent/DE69904600T2/de not_active Expired - Lifetime
- 1999-07-15 KR KR1020017000740A patent/KR100694721B1/ko not_active IP Right Cessation
- 1999-07-15 CO CO99044882A patent/CO5090836A1/es unknown
- 1999-07-15 EE EEP200100038A patent/EE200100038A/xx unknown
- 1999-07-15 JO JO19992114A patent/JO2114B1/en active
- 1999-07-15 SK SK76-2001A patent/SK285311B6/sk not_active IP Right Cessation
- 1999-07-15 CN CNB998108383A patent/CN1188422C/zh not_active Expired - Lifetime
- 1999-07-15 NZ NZ509291A patent/NZ509291A/en not_active IP Right Cessation
- 1999-07-15 DK DK99934698T patent/DK1098898T3/da active
- 1999-07-15 EP EP02013136A patent/EP1240903A3/en not_active Withdrawn
- 1999-07-15 EA EA200100053A patent/EA003191B1/ru not_active IP Right Cessation
- 1999-07-15 CA CA2337857A patent/CA2337857C/en not_active Expired - Lifetime
- 1999-07-15 JP JP2000560139A patent/JP3437553B2/ja not_active Expired - Lifetime
- 1999-07-15 MA MA25684A patent/MA26660A1/fr unknown
- 1999-07-15 ID IDW20010145A patent/ID28070A/id unknown
- 1999-07-15 PT PT99934698T patent/PT1098898E/pt unknown
- 1999-07-15 IL IL14082499A patent/IL140824A/en not_active IP Right Cessation
- 1999-07-15 PL PL99345620A patent/PL195736B1/pl unknown
- 1999-07-15 TN TNTNSN99145A patent/TNSN99145A1/fr unknown
- 1999-07-15 AP APAP/P/2001/002039A patent/AP2001002039A0/en unknown
- 1999-07-15 BR BRPI9912156A patent/BRPI9912156B8/pt not_active IP Right Cessation
- 1999-07-15 MY MYPI99002983A patent/MY122323A/en unknown
- 1999-07-15 US US09/744,051 patent/US6514953B1/en not_active Expired - Lifetime
- 1999-07-15 AT AT99934698T patent/ATE229964T1/de active
- 1999-07-16 PA PA19998477801A patent/PA8477801A1/es unknown
- 1999-08-06 TW TW088113428A patent/TWI245770B/zh not_active IP Right Cessation
2001
- 2001-01-12 IS IS5808A patent/IS5808A/is unknown
- 2001-01-15 ZA ZA200100417A patent/ZA200100417B/en unknown
- 2001-01-17 NO NO20010282A patent/NO329676B1/no not_active IP Right Cessation
- 2001-01-17 HR HR20010046A patent/HRP20010046A2/hr not_active Application Discontinuation
- 2001-02-14 BG BG105253A patent/BG105253A/xx unknown
- 2001-07-13 HK HK01104903A patent/HK1034261A1/xx not_active IP Right Cessation
2002
- 2002-11-25 US US10/303,366 patent/US20030096795A1/en not_active Abandoned
- 2002-11-25 US US10/303,213 patent/US20030100537A1/en not_active Abandoned

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Publication number	Publication date
GEP20033030B (en)	2003-07-25
DE69904600T2 (de)	2003-11-13
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SK762001A3 (en)	2001-10-08
EP1240903A2 (en)	2002-09-18
GT199900111A (es)	2001-01-05
ID28070A (id)	2001-05-03
AR019388A1 (es)	2002-02-13
TNSN99145A1 (fr)	2005-11-10
GB9815567D0 (en)	1998-09-16
NO20010282D0 (no)	2001-01-17
NZ509291A (en)	2003-05-30
YU3401A (sh)	2005-06-10
SK285311B6 (sk)	2006-10-05
JP3437553B2 (ja)	2003-08-18
EP1098898B1 (en)	2002-12-18
BRPI9912156B1 (pt)	2016-07-26
ZA200100417B (en)	2002-02-27
IL140824A (en)	2004-09-27
US20030100537A1 (en)	2003-05-29
DZ2845A1 (fr)	2003-12-01
NO329676B1 (no)	2010-11-29
EP1098898A1 (en)	2001-05-16
US6514953B1 (en)	2003-02-04
JO2114B1 (en)	2000-05-21
HU229700B1 (en)	2014-05-28
MY122323A (en)	2006-04-29
PL345620A1 (en)	2002-01-02
EA003191B1 (ru)	2003-02-27
EA200100053A1 (ru)	2001-08-27
CN1324363A (zh)	2001-11-28
CO5090836A1 (es)	2001-10-30
KR100694721B1 (ko)	2007-03-15
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IL140824A0 (en)	2002-02-10
EE200100038A (et)	2002-06-17
AP2001002039A0 (en)	2001-03-31
PL195736B1 (pl)	2007-10-31
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AU766056B2 (en)	2003-10-09
MA26660A1 (fr)	2004-12-20
US20030096795A1 (en)	2003-05-22
BR9912156A (pt)	2001-04-10
DE69904600D1 (de)	2003-01-30
PT1098898E (pt)	2003-04-30
HUP0103432A3 (en)	2003-01-28
CA2337857A1 (en)	2000-01-27
WO2000004033A1 (en)	2000-01-27
CZ300447B6 (cs)	2009-05-20
IS5808A (is)	2001-01-12
SV1999000096A (es)	2000-07-06
CN1188422C (zh)	2005-02-09
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BG105253A (en)	2001-12-29
AU5037999A (en)	2000-02-07
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Publication	Publication Date	Title
PL345620A1 (en)	2002-01-02	Calcium (3s) tetrahydro-3-furanyl(1s,2r)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) amino] -1-benzyl-2- (phosphonooxy) propylcarbamate
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HK1025580A1 (en)	2000-11-17	Calcium phosphopeptide complexes
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AU5818100A (en)	2001-01-31	Derivatives of (3s) tetrahydro-3-furanyl (1s,2r)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1-benzy -2-(phosphonooxy)propylcarbamate
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SI1098898T1 (en)	2003-08-31	Calcium (3s) tetrahydro-3-furanyl(1s,2r)-3-(((4-aminophenyl) sulfonyl) (isobutyl) amino) -1-benzyl-2- (phosphonooxy) propylcarbamate
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AUPP265298A0 (en)	1998-04-23	Simulated illumination of planar, two dimensional shapes
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TW335892U (en)	1998-07-01	Measuring device for feather curves, arch degrees
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HN1999000113A (es)	2001-01-08	(3s) tetrahidro - 3 - funaril (15, 2r) - 3 - [[4 - aminofenil) sulfonil)] (isobutil) amino] - 1 - bencil - 2 (fosfonooxi) propilcarbamato de calcio.
AU4377999A (en)	2000-01-05	Hydrogel body
ITBO980069A0 (it)	1998-02-11	Piattaforma rotante per autoveicoli.
SE9802165D0 (sv)	1998-06-17	Visarinstrument för fordon
IL126956A0 (en)	1999-09-22	Bone velocity determination
AU2000222537A1 (en)	2000-03-09	Intramedullary reference datum instrument for bone resection
AU5080499A (en)	2000-02-14	Human calcium regulatory proteins

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2019-07-26	PE	Patent expired	Effective date: 20190714