NO329618B1 - Nye krystallinske former av forbindelsen ZD1839, solvat derav, fremgangsmate for fremstilling av slike samt farmasoytisk preparat innholdende slike - Google Patents

Nye krystallinske former av forbindelsen ZD1839, solvat derav, fremgangsmate for fremstilling av slike samt farmasoytisk preparat innholdende slike Download PDF

Info

Publication number: NO329618B1
Authority: NO; Norway
Prior art keywords: compound; formula; approx; trihydrate; solvate
Prior art date: 2002-02-26

Application number

NO20044047A

Other languages

English (en)

Norwegian (no)

Other versions

NO20044047L (no

Inventor

Martin Bohlin

John Peter Gilday

Anthony Stephen Graham

Bo Ingvar Ymen

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-26

Filing date

2004-09-24

Publication date

2010-11-22

2002-02-26 Priority claimed from GB0204392A external-priority patent/GB0204392D0/en

2002-05-30 Priority claimed from GB0212462A external-priority patent/GB0212462D0/en

2004-09-24 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2004-11-16 Publication of NO20044047L publication Critical patent/NO20044047L/no

2010-11-22 Publication of NO329618B1 publication Critical patent/NO329618B1/no

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms

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Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

NO20044047A 2002-02-26 2004-09-24 Nye krystallinske former av forbindelsen ZD1839, solvat derav, fremgangsmate for fremstilling av slike samt farmasoytisk preparat innholdende slike NO329618B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0204392A GB0204392D0 (en)	2002-02-26	2002-02-26	Pharmaceutical compound
GB0212462A GB0212462D0 (en)	2002-05-30	2002-05-30	Pharmaceutical compound
PCT/GB2003/000794 WO2003072108A1 (en)	2002-02-26	2003-02-24	Novel crystalline forms of the anti-cancer compound zd1839

Publications (2)

Publication Number	Publication Date
NO20044047L NO20044047L (no)	2004-11-16
NO329618B1 true NO329618B1 (no)	2010-11-22

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NO20044047A NO329618B1 (no)	2002-02-26	2004-09-24	Nye krystallinske former av forbindelsen ZD1839, solvat derav, fremgangsmate for fremstilling av slike samt farmasoytisk preparat innholdende slike

Country Status (17)

Country	Link
US (2)	US7612077B2 (de)
EP (1)	EP1480650B1 (de)
JP (1)	JP4836404B2 (de)
KR (1)	KR20040086452A (de)
CN (1)	CN100404032C (de)
AT (1)	ATE465738T1 (de)
AU (1)	AU2003212500B2 (de)
BR (1)	BRPI0308023B1 (de)
CA (3)	CA2477350C (de)
DE (1)	DE60332322D1 (de)
ES (1)	ES2342660T3 (de)
HK (1)	HK1070582A1 (de)
IL (2)	IL163689A0 (de)
MX (1)	MXPA04008330A (de)
NO (1)	NO329618B1 (de)
NZ (1)	NZ534871A (de)
WO (1)	WO2003072108A1 (de)

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SG190361A1 (en)	2010-11-23	2013-06-28	Abbvie Inc	Salts and crystalline forms of an apoptosis-inducing agent
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LT2642999T (lt)	2010-11-23	2017-01-25	Abbvie Ireland Unlimited Company	Gydymo būdai, naudojant selektyviuosius bcl-2 inhibitorius
CN103319422B (zh) *	2012-03-21	2016-05-04	石药集团中奇制药技术（石家庄）有限公司	一种吉非替尼晶型及其制备方法
WO2014016848A2 (en)	2012-07-24	2014-01-30	Laurus Labs Private Limited	Solid forms of tyrosine kinase inhibitors, process for the preparation and their pharmaceutical composition thereof
CN103896862B (zh) *	2012-12-25	2017-05-10	江苏天士力帝益药业有限公司	一种吉非替尼Form 1晶型的制备方法
CN103896861A (zh) *	2012-12-26	2014-07-02	亚宝药业集团股份有限公司	抗癌化合物zd1839的无定形物及其制备方法
CN103896863B (zh) *	2012-12-26	2017-06-13	亚宝药业集团股份有限公司	抗癌化合物zd1839的晶型及其制备方法
CN103910690A (zh) *	2013-01-06	2014-07-09	上海科胜药物研发有限公司	一种吉非替尼新晶型及其制备方法
CN103102316A (zh) *	2013-01-17	2013-05-15	李彦	ZD1839Form 1晶型的制备方法
US20140275082A1 (en)	2013-03-14	2014-09-18	Abbvie Inc.	Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
CN103360326B (zh) *	2013-04-19	2016-03-30	南京优科生物医药研究有限公司	吉非替尼晶型i的精制方法
US20140357723A1 (en) *	2013-05-29	2014-12-04	Uwe-Bernd Bernd Ross	Tricholine Nasal Formulation and Method of Use
KR20150001936A (ko) *	2013-06-28	2015-01-07	제일약품주식회사	게피티닙의 신규한 결정형 및 이의 제조방법
WO2015170345A1 (en)	2014-05-09	2015-11-12	Council Of Scientific & Industrial Research	Pharmaceutical cocrystals of gefitinib
CN107106481A (zh) *	2014-08-28	2017-08-29	通用医疗公司	可注射的浆料及其制造和使用方法
US11471401B2 (en)	2014-08-28	2022-10-18	The General Hospital Corporation	Injectable slurries and methods of manufacturing the same
US11504322B2 (en)	2014-08-28	2022-11-22	The General Hospital Corporation	Injectable slurries and methods of manufacturing the same
CN104277005A (zh) *	2014-09-19	2015-01-14	成都新恒创药业有限公司	一种吉非替尼Form 1晶型的制备方法
EP3233064A1 (de)	2014-12-19	2017-10-25	Synthon BV	Pharmazeutische zusammensetzung mit gefifinib
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SG11201807138XA (en)	2016-02-26	2018-09-27	Massachusetts Gen Hospital	Medical ice slurry production and delivery systems and methods
CN106083739B (zh) *	2016-05-31	2019-05-14	华南理工大学	吉非替尼新晶型及其基于超临界反溶剂技术的制备方法
CN111454221B (zh) *	2020-04-21	2023-01-06	华南理工大学	一种吉非替尼和布美他尼药物共晶体及其制备方法
CN118221595A (zh) *	2020-06-15	2024-06-21	山东新时代药业有限公司	一种吉非替尼的有机酸盐
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GB9300059D0 (en) *	1992-01-20	1993-03-03	Zeneca Ltd	Quinazoline derivatives
GB9508538D0 (en)	1995-04-27	1995-06-14	Zeneca Ltd	Quinazoline derivatives
GB0008368D0 (en)	2000-04-06	2000-05-24	Astrazeneca Ab	Combination product
EP1480679B1 (de)	2002-02-26	2007-05-23	Astrazeneca AB	Pharmazeutische iressa zusammensetzung enthaltend ein wasserlösliches cellulosederivat

2003
- 2003-02-24 EP EP03708319A patent/EP1480650B1/de not_active Expired - Lifetime
- 2003-02-24 AU AU2003212500A patent/AU2003212500B2/en not_active Expired
- 2003-02-24 CN CNB038091623A patent/CN100404032C/zh not_active Expired - Lifetime
- 2003-02-24 MX MXPA04008330A patent/MXPA04008330A/es active IP Right Grant
- 2003-02-24 CA CA2477350A patent/CA2477350C/en not_active Expired - Lifetime
- 2003-02-24 CA CA2702297A patent/CA2702297C/en not_active Expired - Lifetime
- 2003-02-24 WO PCT/GB2003/000794 patent/WO2003072108A1/en active Application Filing
- 2003-02-24 US US10/505,690 patent/US7612077B2/en not_active Expired - Fee Related
- 2003-02-24 AT AT03708319T patent/ATE465738T1/de not_active IP Right Cessation
- 2003-02-24 CA CA2833470A patent/CA2833470C/en not_active Expired - Lifetime
- 2003-02-24 KR KR10-2004-7013341A patent/KR20040086452A/ko not_active Application Discontinuation
- 2003-02-24 BR BRPI0308023-4A patent/BRPI0308023B1/pt not_active IP Right Cessation
- 2003-02-24 NZ NZ534871A patent/NZ534871A/en not_active IP Right Cessation
- 2003-02-24 ES ES03708319T patent/ES2342660T3/es not_active Expired - Lifetime
- 2003-02-24 IL IL16368903A patent/IL163689A0/xx active IP Right Grant
- 2003-02-24 DE DE60332322T patent/DE60332322D1/de not_active Expired - Lifetime
- 2003-02-24 JP JP2003570854A patent/JP4836404B2/ja not_active Expired - Lifetime
2004
- 2004-08-23 IL IL163689A patent/IL163689A/en unknown
- 2004-09-24 NO NO20044047A patent/NO329618B1/no not_active IP Right Cessation
2005
- 2005-04-19 HK HK05103350.3A patent/HK1070582A1/xx not_active IP Right Cessation
2009
- 2009-09-17 US US12/561,835 patent/US20100137304A1/en not_active Abandoned

Also Published As

Publication number	Publication date
BRPI0308023B1 (pt)	2021-07-27
JP2005525354A (ja)	2005-08-25
US7612077B2 (en)	2009-11-03
HK1070582A1 (en)	2005-06-24
ATE465738T1 (de)	2010-05-15
JP4836404B2 (ja)	2011-12-14
AU2003212500B2 (en)	2008-01-03
CA2702297C (en)	2014-02-04
US20050209229A1 (en)	2005-09-22
NO20044047L (no)	2004-11-16
EP1480650B1 (de)	2010-04-28
CA2833470A1 (en)	2003-09-04
AU2003212500A1 (en)	2003-09-09
US20100137304A1 (en)	2010-06-03
WO2003072108A1 (en)	2003-09-04
ES2342660T3 (es)	2010-07-12
CA2477350C (en)	2013-02-12
EP1480650A1 (de)	2004-12-01
CA2477350A1 (en)	2003-09-04
IL163689A (en)	2011-10-31
IL163689A0 (en)	2005-12-18
CA2833470C (en)	2016-03-29
MXPA04008330A (es)	2004-11-26
BR0308023A (pt)	2004-12-28
CN1652790A (zh)	2005-08-10
CA2702297A1 (en)	2003-09-04
NZ534871A (en)	2007-05-31
DE60332322D1 (de)	2010-06-10
CN100404032C (zh)	2008-07-23
KR20040086452A (ko)	2004-10-08

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