NO307449B1 - Parenterale emulsjoner og anvendelse derav i røntgenkontrastmidler - Google Patents
Parenterale emulsjoner og anvendelse derav i røntgenkontrastmidlerInfo
- Publication number
- NO307449B1 NO307449B1 NO933807A NO933807A NO307449B1 NO 307449 B1 NO307449 B1 NO 307449B1 NO 933807 A NO933807 A NO 933807A NO 933807 A NO933807 A NO 933807A NO 307449 B1 NO307449 B1 NO 307449B1
- Authority
- NO
- Norway
- Prior art keywords
- pct
- ray contrast
- emulsion
- emulsions
- cyclopenta
- Prior art date
Links
- 239000000839 emulsion Substances 0.000 title abstract 6
- 239000002872 contrast media Substances 0.000 title abstract 3
- YQDSWSPIWVQKBC-UHFFFAOYSA-N 1h-cyclopenta[l]phenanthrene Chemical class C12=CC=CC=C2C2=CC=CC=C2C2=C1CC=C2 YQDSWSPIWVQKBC-UHFFFAOYSA-N 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 239000003995 emulsifying agent Substances 0.000 abstract 2
- KZJWDPNRJALLNS-VPUBHVLGSA-N (-)-beta-Sitosterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]([C@H](CC[C@@H](C(C)C)CC)C)CC4)CC3)CC=2)CC1 KZJWDPNRJALLNS-VPUBHVLGSA-N 0.000 abstract 1
- CSVWWLUMXNHWSU-UHFFFAOYSA-N (22E)-(24xi)-24-ethyl-5alpha-cholest-22-en-3beta-ol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(CC)C(C)C)C1(C)CC2 CSVWWLUMXNHWSU-UHFFFAOYSA-N 0.000 abstract 1
- KLEXDBGYSOIREE-UHFFFAOYSA-N 24xi-n-propylcholesterol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CCC)C(C)C)C1(C)CC2 KLEXDBGYSOIREE-UHFFFAOYSA-N 0.000 abstract 1
- SGNBVLSWZMBQTH-FGAXOLDCSA-N Campesterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]([C@H](CC[C@H](C(C)C)C)C)CC4)CC3)CC=2)CC1 SGNBVLSWZMBQTH-FGAXOLDCSA-N 0.000 abstract 1
- LPZCCMIISIBREI-MTFRKTCUSA-N Citrostadienol Natural products CC=C(CC[C@@H](C)[C@H]1CC[C@H]2C3=CC[C@H]4[C@H](C)[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C LPZCCMIISIBREI-MTFRKTCUSA-N 0.000 abstract 1
- ARVGMISWLZPBCH-UHFFFAOYSA-N Dehydro-beta-sitosterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)CCC(CC)C(C)C)CCC33)C)C3=CC=C21 ARVGMISWLZPBCH-UHFFFAOYSA-N 0.000 abstract 1
- BTEISVKTSQLKST-UHFFFAOYSA-N Haliclonasterol Natural products CC(C=CC(C)C(C)(C)C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C BTEISVKTSQLKST-UHFFFAOYSA-N 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- HZYXFRGVBOPPNZ-KAFSRORWSA-N Sigmasterol Natural products CC[C@H](CC=C(C)[C@H]1CC[C@@H]2[C@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C)C(C)C HZYXFRGVBOPPNZ-KAFSRORWSA-N 0.000 abstract 1
- MJVXAPPOFPTTCA-UHFFFAOYSA-N beta-Sistosterol Natural products CCC(CCC(C)C1CCC2C3CC=C4C(C)C(O)CCC4(C)C3CCC12C)C(C)C MJVXAPPOFPTTCA-UHFFFAOYSA-N 0.000 abstract 1
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 abstract 1
- NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 abstract 1
- 235000000431 campesterol Nutrition 0.000 abstract 1
- SGNBVLSWZMBQTH-PODYLUTMSA-N campesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](C)C(C)C)[C@@]1(C)CC2 SGNBVLSWZMBQTH-PODYLUTMSA-N 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- -1 phytosterol Chemical compound 0.000 abstract 1
- 235000015500 sitosterol Nutrition 0.000 abstract 1
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 abstract 1
- 229950005143 sitosterol Drugs 0.000 abstract 1
- NLQLSVXGSXCXFE-UHFFFAOYSA-N sitosterol Natural products CC=C(/CCC(C)C1CC2C3=CCC4C(C)C(O)CCC4(C)C3CCC2(C)C1)C(C)C NLQLSVXGSXCXFE-UHFFFAOYSA-N 0.000 abstract 1
- 210000000952 spleen Anatomy 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0461—Dispersions, colloids, emulsions or suspensions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Colloid Chemistry (AREA)
- Transceivers (AREA)
- Mobile Radio Communication Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9101214A SE470086B (sv) | 1991-04-23 | 1991-04-23 | Organspecifik emulsion |
| PCT/SE1992/000261 WO1992018169A1 (en) | 1991-04-23 | 1992-04-22 | An organ specific emulsion |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO933807L NO933807L (no) | 1993-10-22 |
| NO307449B1 true NO307449B1 (no) | 2000-04-10 |
Family
ID=20382533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO933807A NO307449B1 (no) | 1991-04-23 | 1993-10-22 | Parenterale emulsjoner og anvendelse derav i røntgenkontrastmidler |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5445811A (no) |
| EP (1) | EP0581842B1 (no) |
| JP (1) | JPH06506932A (no) |
| AT (1) | ATE181241T1 (no) |
| AU (1) | AU660974B2 (no) |
| CA (1) | CA2109094A1 (no) |
| DE (1) | DE69229441D1 (no) |
| DK (1) | DK0581842T3 (no) |
| ES (1) | ES2135405T3 (no) |
| FI (1) | FI934690L (no) |
| GR (1) | GR3031053T3 (no) |
| HU (1) | HU210577B (no) |
| IE (1) | IE921289A1 (no) |
| NO (1) | NO307449B1 (no) |
| NZ (1) | NZ242436A (no) |
| PT (1) | PT100418B (no) |
| SE (1) | SE470086B (no) |
| WO (1) | WO1992018169A1 (no) |
| ZA (1) | ZA922930B (no) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0605477B2 (en) * | 1991-09-17 | 2007-06-20 | GE Healthcare AS | Gaseous ultrasound contrast media |
| MX9205298A (es) * | 1991-09-17 | 1993-05-01 | Steven Carl Quay | Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido |
| US5409688A (en) * | 1991-09-17 | 1995-04-25 | Sonus Pharmaceuticals, Inc. | Gaseous ultrasound contrast media |
| IL108416A (en) | 1993-01-25 | 1998-10-30 | Sonus Pharma Inc | Colloids with phase difference as contrast ultrasound agents |
| US5558855A (en) * | 1993-01-25 | 1996-09-24 | Sonus Pharmaceuticals | Phase shift colloids as ultrasound contrast agents |
| DE69427185T2 (de) * | 1993-01-25 | 2001-12-06 | Sonus Pharmaceutical, Inc. | Phase-Stift Kolloide zur Verwendung als Ultraschallkontrastmittel |
| US5851510A (en) * | 1994-05-16 | 1998-12-22 | The Board Of Regents Of The University Of Michigan | Hepatocyte-selective oil-in-water emulsion |
| US6423363B1 (en) * | 1997-08-22 | 2002-07-23 | Lipton, Division Of Conopco, Inc. | Aqueous dispersion |
| ES2187201T3 (es) * | 1998-10-14 | 2003-05-16 | Cognis Deutschland Gmbh | Empleo de esteroles y de esterolesteres a nanoescala. |
| US6274574B1 (en) | 1999-02-26 | 2001-08-14 | Kraft Foods, Inc. | Use of mesophase-stabilized compositions for delivery of cholesterol-reducing sterols and stanols in food products |
| EP1499206A1 (en) * | 2002-04-10 | 2005-01-26 | Thomas P. Binder | Hydrothermically processed compositions containing phytosterols |
| US7306819B2 (en) * | 2002-06-12 | 2007-12-11 | The Coca-Cola Company | Beverages containing plant sterols |
| CA2534426A1 (en) * | 2003-08-08 | 2005-02-17 | Barnes-Jewish Hospital | Emulsion particles for imaging and therapy and methods of use thereof |
| CA2545524C (en) * | 2003-10-24 | 2012-06-26 | The Coca-Cola Company | Process for preparing phytosterol dispersions for application in beverages |
| CH712511B1 (de) * | 2006-09-18 | 2017-11-30 | Forim-X Ag C/O Prof Dr Med Richard Dirnhofer | Röntgenkontrastmittel für die postmortale, experimentelle und diagnostische Angiographie. |
| ES2640456T3 (es) | 2006-09-18 | 2017-11-03 | Fumedica Ag | Agente de contraste de rayos X para la angiografía post mortem, experimental y diagnóstica |
| FR3039767B1 (fr) | 2015-08-04 | 2017-09-08 | Guerbet Sa | Composition destinee a vectoriser un agent anticancereux |
| US20220151886A1 (en) * | 2019-04-01 | 2022-05-19 | Conopco, Inc., D/B/A Unilever | Multiple emulsion comprising an oil continuous nanoemulsion and a method for using the same |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB676738A (en) * | 1949-11-16 | 1952-07-30 | Bayer Ag | Parenterally administrable x-ray contrast agents |
| GB721264A (en) * | 1952-10-13 | 1955-01-05 | Astra Apotekarnes Kem Fab | Improvements relating to contrast preparations for visualising the vascular system by x-ray |
| US3356575A (en) * | 1965-04-13 | 1967-12-05 | Leo Ab | Autosterile injectable iodinated oil X-ray contrast medium |
| US4192859A (en) * | 1978-09-29 | 1980-03-11 | E. R. Squibb & Sons, Inc. | Contrast media containing liposomes as carriers |
| JPS6030652B2 (ja) * | 1979-05-07 | 1985-07-17 | 株式会社ミドリ十字 | 静脈注射用脂肪乳剤 |
| US4404182A (en) * | 1980-01-08 | 1983-09-13 | The United States Of America As Represented By The Department Of Health And Human Services | Ethiodized oil emulsion for intravenous hepatography |
| GB2156345B (en) * | 1984-03-30 | 1987-07-08 | Squibb & Sons Inc | Alkylamine salts of 3,5-diacetylamino-2,4,6-triiodobenzoic acid as x-ray contrast agents |
| US5041278A (en) * | 1985-10-15 | 1991-08-20 | The Liposome Company, Inc. | Alpha tocopherol-based vesicles |
| CH672733A5 (no) * | 1987-05-22 | 1989-12-29 | Bracco Ind Chimica Spa | |
| ES2054706T3 (es) * | 1987-06-11 | 1994-08-16 | Kabi Pharmacia Ab | Emulsion que contiene yodo. |
| GB8900376D0 (en) * | 1989-01-09 | 1989-03-08 | Nycomed As | Iodinated esters |
| AU642066B2 (en) * | 1991-01-25 | 1993-10-07 | Nanosystems L.L.C. | X-ray contrast compositions useful in medical imaging |
| DE4111939A1 (de) * | 1991-04-12 | 1992-10-22 | Fresenius Ag | Parenteral verabreichbare, hitzesterilisierbare o/w-emulsion eines roentgenkontrastmittels |
| SE9101709L (sv) * | 1991-06-03 | 1992-12-04 | Karlshamns Lipidteknik Ab | Lipidderivat som diagnostikum eller kontrastmedel |
| US5318768A (en) * | 1992-05-01 | 1994-06-07 | Sterling Winthrop Inc. | Polymeric x-ray contrast compositions containing an organic crystalline x-ray contrast agent |
-
1991
- 1991-04-23 SE SE9101214A patent/SE470086B/sv not_active IP Right Cessation
-
1992
- 1992-04-22 US US08/137,061 patent/US5445811A/en not_active Expired - Fee Related
- 1992-04-22 JP JP4509031A patent/JPH06506932A/ja active Pending
- 1992-04-22 DE DE69229441T patent/DE69229441D1/de not_active Expired - Fee Related
- 1992-04-22 HU HU9303005A patent/HU210577B/hu not_active IP Right Cessation
- 1992-04-22 EP EP92909891A patent/EP0581842B1/en not_active Expired - Lifetime
- 1992-04-22 ES ES92909891T patent/ES2135405T3/es not_active Expired - Lifetime
- 1992-04-22 PT PT100418A patent/PT100418B/pt not_active IP Right Cessation
- 1992-04-22 DK DK92909891T patent/DK0581842T3/da active
- 1992-04-22 AT AT92909891T patent/ATE181241T1/de not_active IP Right Cessation
- 1992-04-22 WO PCT/SE1992/000261 patent/WO1992018169A1/en active IP Right Grant
- 1992-04-22 NZ NZ242436A patent/NZ242436A/en unknown
- 1992-04-22 CA CA002109094A patent/CA2109094A1/en not_active Abandoned
- 1992-04-22 AU AU16805/92A patent/AU660974B2/en not_active Ceased
- 1992-04-22 IE IE128992A patent/IE921289A1/en not_active Application Discontinuation
- 1992-04-23 ZA ZA922930A patent/ZA922930B/xx unknown
-
1993
- 1993-10-22 FI FI934690A patent/FI934690L/fi unknown
- 1993-10-22 NO NO933807A patent/NO307449B1/no not_active IP Right Cessation
-
1999
- 1999-08-23 GR GR990402131T patent/GR3031053T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE181241T1 (de) | 1999-07-15 |
| JPH06506932A (ja) | 1994-08-04 |
| DE69229441D1 (de) | 1999-07-22 |
| WO1992018169A1 (en) | 1992-10-29 |
| FI934690A0 (fi) | 1993-10-22 |
| NO933807L (no) | 1993-10-22 |
| SE9101214L (sv) | 1992-10-24 |
| EP0581842B1 (en) | 1999-06-16 |
| HU9303005D0 (en) | 1994-01-28 |
| ZA922930B (en) | 1994-10-07 |
| SE470086B (sv) | 1993-11-08 |
| HU210577B (en) | 1995-05-29 |
| EP0581842A1 (en) | 1994-02-09 |
| GR3031053T3 (en) | 1999-12-31 |
| NZ242436A (en) | 1994-03-25 |
| IE921289A1 (en) | 1992-11-04 |
| HUT65882A (en) | 1994-07-28 |
| US5445811A (en) | 1995-08-29 |
| DK0581842T3 (da) | 1999-11-22 |
| ES2135405T3 (es) | 1999-11-01 |
| AU1680592A (en) | 1992-11-17 |
| AU660974B2 (en) | 1995-07-13 |
| CA2109094A1 (en) | 1992-10-24 |
| PT100418A (pt) | 1993-08-31 |
| SE9101214D0 (sv) | 1991-04-23 |
| PT100418B (pt) | 1999-08-31 |
| FI934690L (fi) | 1993-10-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |
Free format text: LAPSED IN OCTOBER 2001 |