NO20092742L - 4,5-ringkondenserte indolderivater for behandling eller forebyggelse av HCV og beslektede virusinfeksjoner - Google Patents
4,5-ringkondenserte indolderivater for behandling eller forebyggelse av HCV og beslektede virusinfeksjonerInfo
- Publication number
- NO20092742L NO20092742L NO20092742A NO20092742A NO20092742L NO 20092742 L NO20092742 L NO 20092742L NO 20092742 A NO20092742 A NO 20092742A NO 20092742 A NO20092742 A NO 20092742A NO 20092742 L NO20092742 L NO 20092742L
- Authority
- NO
- Norway
- Prior art keywords
- prevention
- ring condensed
- treatment
- indole derivatives
- hcv
- Prior art date
Links
- 150000002475 indoles Chemical class 0.000 title abstract 4
- 229940054051 antipsychotic indole derivative Drugs 0.000 title abstract 3
- 208000036142 Viral infection Diseases 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title abstract 2
- 230000009385 viral infection Effects 0.000 title abstract 2
- 125000006163 5-membered heteroaryl group Chemical group 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000004366 heterocycloalkenyl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87687706P | 2006-12-22 | 2006-12-22 | |
PCT/US2007/025754 WO2008082484A1 (en) | 2006-12-22 | 2007-12-17 | 4,5-ring annulated indole derivatives for treating or preventing of hcv and related viral infections |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20092742L true NO20092742L (no) | 2009-09-21 |
Family
ID=39186835
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20092742A NO20092742L (no) | 2006-12-22 | 2009-07-21 | 4,5-ringkondenserte indolderivater for behandling eller forebyggelse av HCV og beslektede virusinfeksjoner |
Country Status (18)
Country | Link |
---|---|
US (1) | US8557848B2 (pt) |
EP (1) | EP2064180B1 (pt) |
JP (1) | JP5079818B2 (pt) |
KR (1) | KR20090094154A (pt) |
CN (1) | CN101631773A (pt) |
AR (1) | AR064428A1 (pt) |
AU (1) | AU2007339382B2 (pt) |
BR (1) | BRPI0720625A2 (pt) |
CA (1) | CA2673249C (pt) |
CL (1) | CL2007003686A1 (pt) |
CO (1) | CO6190515A2 (pt) |
EC (1) | ECSP099447A (pt) |
MX (1) | MX2009006880A (pt) |
NO (1) | NO20092742L (pt) |
PE (1) | PE20081608A1 (pt) |
RU (1) | RU2009127855A (pt) |
TW (1) | TW200831496A (pt) |
WO (1) | WO2008082484A1 (pt) |
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EP2064180B1 (en) | 2006-12-22 | 2016-07-13 | Merck Sharp & Dohme Corp. | 4,5-ring annulated indole derivatives for treating or preventing of hcv and related viral infections |
MX2009006877A (es) | 2006-12-22 | 2009-09-28 | Schering Corp | Derivados indolicos con anillo unido en las posiciones 5,6 y metodos de uso de los mismos. |
EP2064181A1 (en) | 2006-12-22 | 2009-06-03 | Schering Corporation | 4, 5-ring annulated indole derivatives for treating or preventing of hcv and related viral infections |
EP2197842B1 (en) * | 2007-08-29 | 2012-05-23 | Schering Corporation | 2, 3-substituted indole derivatives for treating viral infections |
CN101842374A (zh) | 2007-08-29 | 2010-09-22 | 先灵公司 | 用于治疗病毒感染的2,3-取代的氮杂吲哚衍生物 |
AU2008295484B2 (en) * | 2007-08-29 | 2013-09-26 | Merck Sharp & Dohme Llc | Substituted indole derivatives and methods of use thereof |
US8765757B2 (en) * | 2007-11-16 | 2014-07-01 | Merck Sharp & Dohme Corp. | 3-heterocyclic substituted indole derivatives and methods of use thereof |
CN102317285A (zh) * | 2007-11-16 | 2012-01-11 | 先灵公司 | 3-氨基磺酰基取代的吲哚衍生物及其使用方法 |
CA2727620A1 (en) * | 2008-06-13 | 2009-12-17 | Schering Corporation | Tricyclic indole derivatives and methods of use thereof |
EP2334662A1 (en) * | 2008-09-26 | 2011-06-22 | F. Hoffmann-La Roche AG | Pyrine or pyrazine derivatives for treating hcv |
CN102256968A (zh) | 2008-12-22 | 2011-11-23 | 弗·哈夫曼-拉罗切有限公司 | 杂环抗病毒化合物 |
EP2403844A1 (en) * | 2009-03-06 | 2012-01-11 | F. Hoffmann-La Roche AG | Heterocyclic antiviral compounds |
AU2010253791A1 (en) | 2009-05-29 | 2011-11-24 | Merck Sharp & Dohme Corp. | Antiviral compounds composed of three linked Aryl moieties to treat diseases such as Hepatitis C |
WO2011000566A2 (en) * | 2009-06-30 | 2011-01-06 | Savira Pharmaceuticals Gmbh | Compounds and pharmaceutical compositions for the treatment of negative-sense ssrna virus infections |
WO2011066241A1 (en) | 2009-11-25 | 2011-06-03 | Schering Corporation | Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases |
WO2011087740A1 (en) | 2009-12-22 | 2011-07-21 | Schering Corporation | Fused tricyclic compounds and methods of use thereof for the treatment of viral diseases |
JP2013522202A (ja) | 2010-03-09 | 2013-06-13 | メルク・シャープ・エンド・ドーム・コーポレイション | 縮合三環式シリル化合物およびウイルス疾患の治療のためのその使用方法 |
EP2598149A4 (en) | 2010-07-26 | 2014-09-10 | Merck Sharp & Dohme | SUBSTITUTED BIPHENYLENE COMPOUNDS AND METHOD FOR USE THEREOF FOR THE TREATMENT OF VIRUS DISEASES |
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WO2012142075A1 (en) | 2011-04-13 | 2012-10-18 | Merck Sharp & Dohme Corp. | 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
WO2013033899A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases |
WO2013033900A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases |
WO2013033901A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases |
WO2013039876A1 (en) | 2011-09-14 | 2013-03-21 | Merck Sharp & Dohme Corp. | Silyl-containing heterocyclic compounds and methods of use thereof for the treatment of viral diseases |
AR092959A1 (es) | 2012-10-17 | 2015-05-06 | Merck Sharp & Dohme | Derivados de nucleosidos 2-metil sustituidos y metodos de uso de los mismos para el tratamiento de enfermedades virales |
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WO2014205593A1 (en) | 2013-06-24 | 2014-12-31 | Merck Sharp & Dohme Corp. | Substituted benzofuran compounds and methods of use thereof for treatment of viral diseases |
WO2014205592A1 (en) | 2013-06-24 | 2014-12-31 | Merck Sharp & Dohme Corp. | Heterocyclic compounds and methods of use thereof for treatment of hepatitis c |
WO2015065817A1 (en) | 2013-10-30 | 2015-05-07 | Merck Sharp & Dohme Corp. | Pseudopolymorphs of an hcv ns5a inhibitor and uses thereof |
CN106810557B (zh) * | 2015-11-27 | 2021-05-04 | 南京圣和药物研发有限公司 | 杂环化合物及其应用 |
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EP2064180B1 (en) | 2006-12-22 | 2016-07-13 | Merck Sharp & Dohme Corp. | 4,5-ring annulated indole derivatives for treating or preventing of hcv and related viral infections |
EP2064181A1 (en) | 2006-12-22 | 2009-06-03 | Schering Corporation | 4, 5-ring annulated indole derivatives for treating or preventing of hcv and related viral infections |
CN101842374A (zh) | 2007-08-29 | 2010-09-22 | 先灵公司 | 用于治疗病毒感染的2,3-取代的氮杂吲哚衍生物 |
AU2008295484B2 (en) | 2007-08-29 | 2013-09-26 | Merck Sharp & Dohme Llc | Substituted indole derivatives and methods of use thereof |
EP2197842B1 (en) | 2007-08-29 | 2012-05-23 | Schering Corporation | 2, 3-substituted indole derivatives for treating viral infections |
US8765757B2 (en) | 2007-11-16 | 2014-07-01 | Merck Sharp & Dohme Corp. | 3-heterocyclic substituted indole derivatives and methods of use thereof |
CN102317285A (zh) | 2007-11-16 | 2012-01-11 | 先灵公司 | 3-氨基磺酰基取代的吲哚衍生物及其使用方法 |
CA2727620A1 (en) | 2008-06-13 | 2009-12-17 | Schering Corporation | Tricyclic indole derivatives and methods of use thereof |
-
2007
- 2007-12-17 EP EP07862998.7A patent/EP2064180B1/en active Active
- 2007-12-17 CA CA2673249A patent/CA2673249C/en active Active
- 2007-12-17 AU AU2007339382A patent/AU2007339382B2/en not_active Ceased
- 2007-12-17 KR KR1020097015298A patent/KR20090094154A/ko not_active Application Discontinuation
- 2007-12-17 JP JP2009542835A patent/JP5079818B2/ja not_active Expired - Fee Related
- 2007-12-17 BR BRPI0720625-9A2A patent/BRPI0720625A2/pt not_active Application Discontinuation
- 2007-12-17 CN CN200780051419A patent/CN101631773A/zh active Pending
- 2007-12-17 RU RU2009127855/04A patent/RU2009127855A/ru not_active Application Discontinuation
- 2007-12-17 US US12/519,715 patent/US8557848B2/en active Active
- 2007-12-17 WO PCT/US2007/025754 patent/WO2008082484A1/en active Application Filing
- 2007-12-17 MX MX2009006880A patent/MX2009006880A/es unknown
- 2007-12-18 AR ARP070105705A patent/AR064428A1/es not_active Application Discontinuation
- 2007-12-18 TW TW096148504A patent/TW200831496A/zh unknown
- 2007-12-18 CL CL200703686A patent/CL2007003686A1/es unknown
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2008
- 2008-01-02 PE PE2008000053A patent/PE20081608A1/es not_active Application Discontinuation
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2009
- 2009-06-18 CO CO09063496A patent/CO6190515A2/es not_active Application Discontinuation
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Also Published As
Publication number | Publication date |
---|---|
JP2010513490A (ja) | 2010-04-30 |
PE20081608A1 (es) | 2008-11-12 |
US8557848B2 (en) | 2013-10-15 |
AU2007339382B2 (en) | 2013-05-02 |
CA2673249C (en) | 2013-04-30 |
KR20090094154A (ko) | 2009-09-03 |
MX2009006880A (es) | 2009-07-03 |
RU2009127855A (ru) | 2011-01-27 |
WO2008082484A1 (en) | 2008-07-10 |
EP2064180B1 (en) | 2016-07-13 |
CN101631773A (zh) | 2010-01-20 |
US20100098661A1 (en) | 2010-04-22 |
CO6190515A2 (es) | 2010-08-19 |
EP2064180A1 (en) | 2009-06-03 |
BRPI0720625A2 (pt) | 2014-03-25 |
CL2007003686A1 (es) | 2008-06-27 |
JP5079818B2 (ja) | 2012-11-21 |
ECSP099447A (es) | 2009-07-31 |
CA2673249A1 (en) | 2008-07-10 |
AU2007339382A1 (en) | 2008-07-10 |
TW200831496A (en) | 2008-08-01 |
AR064428A1 (es) | 2009-04-01 |
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