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NO20054264L - Ikke-Nukleoside Revers Transkriptase-Inhibitorer I for behandling av HIV-medierte sydommer - Google Patents

Ikke-Nukleoside Revers Transkriptase-Inhibitorer I for behandling av HIV-medierte sydommer

Info

Publication number
NO20054264L
NO20054264L NO20054264A NO20054264A NO20054264L NO 20054264 L NO20054264 L NO 20054264L NO 20054264 A NO20054264 A NO 20054264A NO 20054264 A NO20054264 A NO 20054264A NO 20054264 L NO20054264 L NO 20054264L
Authority
NO
Norway
Prior art keywords
hiv
treatment
reverse transcriptase
formula
compounds
Prior art date
Application number
NO20054264A
Other languages
English (en)
Other versions
NO20054264D0 (no
NO334095B1 (no
Inventor
James Patrick Dunn
Steven Swallow
Zachary Kevin Sweeny
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20054264D0 publication Critical patent/NO20054264D0/no
Publication of NO20054264L publication Critical patent/NO20054264L/no
Publication of NO334095B1 publication Critical patent/NO334095B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/13—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)

Abstract

Foreliggende oppfinnelse angår nye heterosykliske forbindelser med formel I, hvor R1-R4, X1 og X2 er som definert i oppsummeringen, og farmasøytisk akseptable salter og solvater derav, metoder for a inhibere eller modulere humant immunsviktvirus(HIV)-reverstranskriptase med forbindelser med formel I, farmasøytiske preparater som inneholder formel I, blandet med minst ett løsningsmiddel, bærer eller hjelpestoff, og fremgangsmåter for fremstilling av forbindelser med formel I. Forbindelsene er anvendelige for behandling av lidelser, hvor HIV og genetisk relaterte virus er implisert.
NO20054264A 2003-03-24 2005-09-15 Ikke-Nukleoside Revers Transkriptase-Inhibitorer I for behandling av HIV-medierte sydommer NO334095B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45713003P 2003-03-24 2003-03-24
PCT/EP2004/002995 WO2004085411A1 (en) 2003-03-24 2004-03-22 Non-nucleoside reverse transcriptase inhibitors i for treating hiv mediated diseases

Publications (3)

Publication Number Publication Date
NO20054264D0 NO20054264D0 (no) 2005-09-15
NO20054264L true NO20054264L (no) 2005-10-14
NO334095B1 NO334095B1 (no) 2013-12-09

Family

ID=33098199

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20054264A NO334095B1 (no) 2003-03-24 2005-09-15 Ikke-Nukleoside Revers Transkriptase-Inhibitorer I for behandling av HIV-medierte sydommer

Country Status (20)

Country Link
US (2) US7208509B2 (no)
EP (1) EP1608633B1 (no)
JP (1) JP4708329B2 (no)
KR (1) KR101122456B1 (no)
CN (1) CN100588650C (no)
AR (1) AR043673A1 (no)
AU (1) AU2004224153B2 (no)
BR (2) BRPI0408767B8 (no)
CA (1) CA2518437C (no)
CL (1) CL2004000590A1 (no)
CO (1) CO5601029A2 (no)
ES (1) ES2574580T3 (no)
HR (1) HRP20050830A2 (no)
IL (1) IL170343A (no)
MX (1) MXPA05010210A (no)
NO (1) NO334095B1 (no)
NZ (1) NZ541829A (no)
RU (1) RU2342367C2 (no)
TW (1) TW200505441A (no)
WO (1) WO2004085411A1 (no)

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CN100516065C (zh) * 2004-04-01 2009-07-22 安万特药物公司 1,3,4-二唑-2-酮作为PPAR-δ调节剂
US8293778B2 (en) 2004-07-27 2012-10-23 Roche Palo Alto Llc Heterocyclic antiviral compounds
BRPI0513858B8 (pt) * 2004-07-27 2021-05-25 Hoffmann La Roche compostos de benziltriazolona como inibidores não-nucleosídeos da transcriptase reversa, seu processo de preparação, seu uso e composição farmacêutica que os compreende
EP1863777A1 (en) * 2005-03-24 2007-12-12 F.Hoffmann-La Roche Ag 1,2,4 -triazole-5-one compounds as heterocyclic reverse transcriptase inhibitors
AR057455A1 (es) 2005-07-22 2007-12-05 Merck & Co Inc Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
EP1937651B1 (en) * 2005-09-30 2008-12-24 F.Hoffmann-La Roche Ag Nnrt inhibitors
CA2625047A1 (en) 2005-10-19 2007-04-26 F. Hoffmann-La Roche Ag Phenyl-acetamide nnrt inhibitors
JP2009519308A (ja) * 2005-12-15 2009-05-14 アストラゼネカ・アクチエボラーグ 呼吸器疾患の処置のための置換ジフェニルエーテル、アミン、スルフィドおよびメタン
WO2008010921A2 (en) 2006-07-07 2008-01-24 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
CL2007002105A1 (es) * 2006-07-21 2008-02-22 Hoffmann La Roche Compuestos derivados de 2-[3-(3-cianofenoxi)(fenoxi o fenilsulfanil)]-n-fenil acetamida, inhibidores de la transcriptasa inversa del vih; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar u
JP5216768B2 (ja) 2006-08-16 2013-06-19 エフ．ホフマン−ラ ロシュ アーゲー 非ヌクレオシド逆転写酵素阻害剤
TW200831085A (en) * 2006-12-13 2008-08-01 Merck & Co Inc Non-nucleoside reverse transcriptase inhibitors
KR101577698B1 (ko) * 2007-02-23 2015-12-15 길리애드 사이언시즈, 인코포레이티드 치료제의 약동학적 특성의 조절제
AU2008235549A1 (en) * 2007-04-09 2008-10-16 F. Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
ES2542153T3 (es) 2007-05-30 2015-07-31 F. Hoffmann-La Roche Ag Inhibidores no nucleósidos de la transcriptasa inversa
MX2009012706A (es) * 2007-05-30 2009-12-08 Hoffmann La Roche Proceso para preparar triazolonas.
WO2008157273A1 (en) * 2007-06-14 2008-12-24 Smithkline Beecham Corporation Chemical compounds
WO2008157330A1 (en) * 2007-06-14 2008-12-24 Smithkline Beecham Corporation Chemical compounds
AU2008267895A1 (en) * 2007-06-22 2008-12-31 F. Hoffmann-La Roche Ag Urea and carbamate derivatives as non-nucleoside reverse transcriptase inhibitors
US8492415B2 (en) * 2007-07-03 2013-07-23 Yale University Azoles and related derivatives as non-nucleoside reverse transcriptase inhibitors (NNRTIs) in antiviral therapy (HIV)
BRPI0821349A2 (pt) * 2007-12-21 2019-09-24 Hoffmann La Roche compostos antivirais heterocíclicos
US8486975B2 (en) * 2010-03-30 2013-07-16 Merck Canada Inc. Non-nucleoside reverse transcriptase inhibitors
CU23896B1 (es) * 2010-04-01 2013-05-31 Ct De Ingeniería Genética Y Biotecnología Método para inhibir la replicación del vih en células de mamíferos
JO3470B1 (ar) 2012-10-08 2020-07-05 Merck Sharp & Dohme مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv
CN104230929B (zh) * 2013-06-19 2015-11-18 华东师范大学 一种非核苷类hiv-1反转录酶抑制剂
US10004740B2 (en) 2014-04-01 2018-06-26 Merck Sharp & Dohme Corp. Prodrugs of HIV reverse transcriptase inhibitors

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US5436252A (en) * 1986-12-19 1995-07-25 Merrell Dow Pharmaceuticals Inc. 5-aryl-3H-1,2,4-triazol-3-ones and their use in the treatment of neurodegenerative disorders
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Also Published As

Publication number Publication date
RU2005132632A (ru) 2006-06-10
CN1759104A (zh) 2006-04-12
EP1608633A1 (en) 2005-12-28
CA2518437C (en) 2012-07-10
BRPI0408767B1 (pt) 2017-10-31
AU2004224153B2 (en) 2009-04-02
CL2004000590A1 (es) 2005-02-04
HRP20050830A2 (en) 2006-09-30
IL170343A (en) 2014-03-31
US7348345B2 (en) 2008-03-25
JP4708329B2 (ja) 2011-06-22
BR122016023941B1 (pt) 2021-10-13
TW200505441A (en) 2005-02-16
BRPI0408767B8 (pt) 2021-05-25
RU2342367C2 (ru) 2008-12-27
EP1608633B1 (en) 2016-04-20
KR101122456B1 (ko) 2012-04-26
MXPA05010210A (es) 2005-11-23
US20040192704A1 (en) 2004-09-30
WO2004085411A1 (en) 2004-10-07
BRPI0408767A (pt) 2006-03-28
CA2518437A1 (en) 2004-10-07
NO20054264D0 (no) 2005-09-15
ES2574580T3 (es) 2016-06-20
AR043673A1 (es) 2005-08-03
JP2006521319A (ja) 2006-09-21
NZ541829A (en) 2008-11-28
CN100588650C (zh) 2010-02-10
US20070179157A1 (en) 2007-08-02
CO5601029A2 (es) 2006-01-31
KR20050115294A (ko) 2005-12-07
AU2004224153A1 (en) 2004-10-07
NO334095B1 (no) 2013-12-09
US7208509B2 (en) 2007-04-24

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