NO178397C - Substituerte 1,2,3,4-tetrahydrocyklopent[bÅindoler, 1,2,3,3a,4,8a-heksahydrocyklopent[bÅindoler og beslektede forbindelser, mellomprodukter og deres bruk som medikamenter - Google Patents

Substituerte 1,2,3,4-tetrahydrocyklopent[bÅindoler, 1,2,3,3a,4,8a-heksahydrocyklopent[bÅindoler og beslektede forbindelser, mellomprodukter og deres bruk som medikamenter

Info

Publication number: NO178397C
Authority: NO; Norway
Prior art keywords: indole; intermediates; tetrahydrocyclopentic; hexahydrocyclopentic; drugs
Prior art date: 1991-01-18

Application number

NO920235A

Other languages

English (en)

Norwegian (no)

Other versions

NO178397B (no

NO920235L (no

NO920235D0 (no

Inventor

Helen Hu Ong

Gerard Joseph O'malley

Michael Clayton Merriman

Mark Gabriel Palermo

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-01-18

Filing date

1992-01-17

Publication date

1996-03-20

1992-01-17 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1992-01-17 Publication of NO920235D0 publication Critical patent/NO920235D0/no

1992-07-20 Publication of NO920235L publication Critical patent/NO920235L/no

1995-12-11 Publication of NO178397B publication Critical patent/NO178397B/no

1996-03-20 Publication of NO178397C publication Critical patent/NO178397C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Neurosurgery (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Psychiatry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO920235A 1991-01-18 1992-01-17 Substituerte 1,2,3,4-tetrahydrocyklopent[bÅindoler, 1,2,3,3a,4,8a-heksahydrocyklopent[bÅindoler og beslektede forbindelser, mellomprodukter og deres bruk som medikamenter NO178397C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/642,952 US5100891A (en)	1991-01-18	1991-01-18	Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds

Publications (4)

Publication Number	Publication Date
NO920235D0 NO920235D0 (no)	1992-01-17
NO920235L NO920235L (no)	1992-07-20
NO178397B NO178397B (no)	1995-12-11
NO178397C true NO178397C (no)	1996-03-20

Family

ID=24578739

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO920235A NO178397C (no)	1991-01-18	1992-01-17	Substituerte 1,2,3,4-tetrahydrocyklopent[bÅindoler, 1,2,3,3a,4,8a-heksahydrocyklopent[bÅindoler og beslektede forbindelser, mellomprodukter og deres bruk som medikamenter

Country Status (26)

Country	Link
US (1)	US5100891A (de)
EP (1)	EP0496314B1 (de)
JP (1)	JP2665422B2 (de)
KR (1)	KR100230881B1 (de)
AT (1)	ATE158790T1 (de)
AU (1)	AU650315B2 (de)
BR (1)	BR9200171A (de)
CA (1)	CA2059610C (de)
CZ (1)	CZ282732B6 (de)
DE (1)	DE69222444T2 (de)
DK (1)	DK0496314T3 (de)
ES (1)	ES2109953T3 (de)
FI (2)	FI102174B1 (de)
GR (1)	GR3025318T3 (de)
HU (1)	HUT67027A (de)
IE (1)	IE920149A1 (de)
IL (1)	IL100693A0 (de)
MX (1)	MX9200206A (de)
NO (1)	NO178397C (de)
NZ (1)	NZ241305A (de)
PH (1)	PH31429A (de)
PL (2)	PL167465B1 (de)
RO (1)	RO112505B1 (de)
RU (1)	RU2077530C1 (de)
TW (1)	TW198024B (de)
ZA (1)	ZA92341B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5298626A (en) *	1991-01-18	1994-03-29	Hoechst-Roussel Pharmaceuticals Incorporated	Select cyclopent[b]indoles
US5350762A (en) *	1993-03-08	1994-09-27	Hoechst-Roussel Pharmaceuticals Incorporated	Tetrahydrocyclopent[B]indole methanamines and related compounds
KR100335169B1 (ko) *	1997-07-03	2002-05-04	야마모토 카즈모토	포화 고리를 갖는 신규한 트리시클릭 화합물 및 이를포함하는 의약 조성물
UA69420C2 (uk) *	1998-10-06	2004-09-15	Янссен Фармацевтика Н.В.	ТРИЦИКЛІЧНІ <font face="Symbol">D3</font>-ПІПЕРИДИНИ ЯК <font face="Symbol">a<sub></font>2</sub>-АНТАГОНІСТИ
NZ510116A (en) *	1998-10-06	2002-10-25	Janssen Pharmaceutica Nv	Tricyclic delta-3-piperidines as pharmaceuticals
UA70334C2 (en) *	1998-10-06	2004-10-15	Janssen Pharmaceutica N V Jans	BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS
IT1317926B1 (it)	2000-11-03	2003-07-15	Sigma Tau Ind Farmaceuti	Derivati triciclici dell'indolo ad attivita' antiangiogenica.
DE602004017326D1 (de)	2003-06-10	2008-12-04	Smithkline Beecham Corp	Tetrahydrocarbazolderivate und deren pharmazeutische verwendung
EP1646610B1 (de) *	2003-06-12	2009-07-22	SmithKline Beecham Corporation	Tetrahydrocarbazolderivate und deren pharmazeutische verwendung
JP2008520740A (ja) *	2004-11-23	2008-06-19	ピーティーシーセラピューティクス，インコーポレイテッド	Ｖｅｇｆ産生を阻害する活性因子としての置換されたフェノール
GB2422828A (en) *	2005-02-03	2006-08-09	Hunter Fleming Ltd	Tricyclic cytoprotective compounds comprising an indole residue
WO2013139929A1 (en) *	2012-03-22	2013-09-26	Ludwig-Maximilians-Universität München	Novel means and methods for treating diseases of the central nervous system, metabolic and cardiac diseases and aging
KR20140013471A (ko)	2012-07-24	2014-02-05	주식회사 쎄코	진공증착용 발열조립체 및 이를 구비하는 진공증착장치
US10882821B1 (en)	2017-09-26	2021-01-05	The Board Of Trustees Of The Leland Stanford Junior University	Enantiomeric compound for the reduction of the deleterious activity of extended nucleotide repeat containing genes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3514462A (en) *	1966-10-21	1970-05-26	Upjohn Co	1 and 2 ethoxy 3,4,5,10 - tetrahydroazepino(3,4-b) and (2,3-b)indoles and corresponding amino derivatives thereof
US3595874A (en) *	1969-02-28	1971-07-27	Upjohn Co	3,4,5,10-tetrahydroazepino(2,3-b)indol-5a (2h)-ols
BE787537A (fr) *	1971-08-16	1973-02-14	Sterling Drug Inc	Tetrahydrocarbazoles
SU482086A1 (ru) *	1973-11-30	1976-03-15	Всесоюзный Научно-Исследовательски% Химико-Фармацевтический Институт Им.С.Орджоникидзе	Способ получени производных 1- -амино1,2,3,4-тетрагидрокарбазола
JPS5111760A (de) *	1974-06-18	1976-01-30	Ayerst Mckenna & Harrison
US4254134A (en) *	1978-03-17	1981-03-03	Endo Laboratories, Inc.	Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles

1991
- 1991-01-18 US US07/642,952 patent/US5100891A/en not_active Expired - Lifetime
1992
- 1992-01-15 NZ NZ241305A patent/NZ241305A/en unknown
- 1992-01-15 RO RO149168A patent/RO112505B1/ro unknown
- 1992-01-16 PL PL92296651A patent/PL167465B1/pl unknown
- 1992-01-16 CZ CS92129A patent/CZ282732B6/cs not_active IP Right Cessation
- 1992-01-16 KR KR1019920000543A patent/KR100230881B1/ko not_active IP Right Cessation
- 1992-01-16 FI FI920192A patent/FI102174B1/fi active
- 1992-01-16 PL PL92293209A patent/PL169417B1/pl unknown
- 1992-01-17 IE IE014992A patent/IE920149A1/en not_active IP Right Cessation
- 1992-01-17 CA CA002059610A patent/CA2059610C/en not_active Expired - Lifetime
- 1992-01-17 RU SU925010763A patent/RU2077530C1/ru active
- 1992-01-17 IL IL100693A patent/IL100693A0/xx unknown
- 1992-01-17 MX MX9200206A patent/MX9200206A/es unknown
- 1992-01-17 ZA ZA92341A patent/ZA92341B/xx unknown
- 1992-01-17 HU HU9200172A patent/HUT67027A/hu unknown
- 1992-01-17 JP JP4006681A patent/JP2665422B2/ja not_active Expired - Lifetime
- 1992-01-17 NO NO920235A patent/NO178397C/no unknown
- 1992-01-17 AU AU10279/92A patent/AU650315B2/en not_active Ceased
- 1992-01-18 DK DK92100816.5T patent/DK0496314T3/da active
- 1992-01-18 AT AT92100816T patent/ATE158790T1/de not_active IP Right Cessation
- 1992-01-18 ES ES92100816T patent/ES2109953T3/es not_active Expired - Lifetime
- 1992-01-18 DE DE69222444T patent/DE69222444T2/de not_active Expired - Lifetime
- 1992-01-18 EP EP92100816A patent/EP0496314B1/de not_active Expired - Lifetime
- 1992-01-21 BR BR929200171A patent/BR9200171A/pt not_active Application Discontinuation
- 1992-02-20 TW TW081101228A patent/TW198024B/zh active
- 1992-11-20 PH PH43793A patent/PH31429A/en unknown
1997
- 1997-11-07 GR GR970402960T patent/GR3025318T3/el unknown
2000
- 2000-08-10 FI FI20001775A patent/FI107919B/fi active

Also Published As

Publication number	Publication date
RU2077530C1 (ru)	1997-04-20
PH31429A (en)	1998-11-03
GR3025318T3 (en)	1998-02-27
PL293209A1 (en)	1993-04-05
AU1027992A (en)	1992-07-23
CZ282732B6 (cs)	1997-09-17
FI920192A (fi)	1992-07-19
EP0496314A1 (de)	1992-07-29
DK0496314T3 (da)	1998-05-18
TW198024B (de)	1993-01-11
JPH04334367A (ja)	1992-11-20
FI107919B (fi)	2001-10-31
HUT67027A (en)	1995-01-30
DE69222444D1 (de)	1997-11-06
ES2109953T3 (es)	1998-02-01
MX9200206A (es)	1992-08-01
FI102174B (fi)	1998-10-30
FI102174B1 (fi)	1998-10-30
DE69222444T2 (de)	1998-06-04
NO178397B (no)	1995-12-11
US5100891A (en)	1992-03-31
IE920149A1 (en)	1992-07-29
CA2059610C (en)	2002-04-02
IL100693A0 (en)	1992-09-06
PL296651A1 (en)	1993-07-26
NO920235L (no)	1992-07-20
AU650315B2 (en)	1994-06-16
ZA92341B (en)	1992-09-30
NO920235D0 (no)	1992-01-17
PL169417B1 (pl)	1996-07-31
ATE158790T1 (de)	1997-10-15
NZ241305A (en)	1994-10-26
CA2059610A1 (en)	1992-07-19
FI920192A0 (fi)	1992-01-16
KR920014777A (ko)	1992-08-25
PL167465B1 (pl)	1995-09-30
FI20001775A (fi)	2000-08-10
KR100230881B1 (ko)	1999-11-15
RO112505B1 (ro)	1997-10-30
BR9200171A (pt)	1992-10-06
CS12992A3 (en)	1992-08-12
JP2665422B2 (ja)	1997-10-22
HU9200172D0 (en)	1992-04-28
EP0496314B1 (de)	1997-10-01

Publication	Publication Date	Title
NO178397C (no)	1996-03-20	Substituerte 1,2,3,4-tetrahydrocyklopent[bÅindoler, 1,2,3,3a,4,8a-heksahydrocyklopent[bÅindoler og beslektede forbindelser, mellomprodukter og deres bruk som medikamenter
PT669920E (pt)	2003-06-30	3-aminoalquilamino-1,2-benzoxazoles substituidos ecompostos relacionados
DK0773943T3 (da)	2002-03-04	Forbindelser, der er anvendelige som antiproliferative midler og garft-inhibitorer
DE69216293D1 (de)	1997-02-13	1,4-Disubstituierte Piperidinderivate, ihre Herstellung und therapeutische Verwendung
DK0517221T3 (da)	1996-04-22	((Arylalkylpiperidin-4-yl)-methyl)-2alfa,3,4,5-tetrahydro-1(2H)-acenaphthylen-1-oner og beslægtede forbindelser, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler
DK0385658T3 (da)	1995-02-20	Ringsubstituerede 2-amino-1,2,3,4-tetrahydronaphthalener og 3-aminochromaner
DE69839753D1 (de)	2008-09-04	2-(Arylphenyl)amino-imidazolin-Derivate
DK0535645T3 (da)	2001-08-13	Carbamatderivater af 4-amino-3-isoxazolidinoner og 3-amino-1-hydroxypyrrolidin-2-oner, fremgangsmåde til deres fremstilling samt deres anvendelse som lægemidler
DK0614888T3 (da)	1997-11-03	Tetrahydrocyclopentab indol-methanaminer og beslægtede forbindelser, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler.
DE69533214D1 (de)	2004-08-05	2,3-Dihydro-1H-isoindolderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Hemmer der Serotoninwiederaufnahme
BR9707004A (pt)	1999-07-20	Composto processo para preparar o mesmo composição farmacêutica utilização do composto e processos para tratamento de doenças do sistema endocinológico e para a manufatura de um medicamento
BR0115042A (pt)	2004-02-03	Ligandos de receptores de aminoalquilpirrolidina serotonina e composições, seus usos farmacêuticos, e processos para a sua sìntese
DK0709378T3 (da)	2003-07-14	Aminoalkyloximer, en fremgangsmåde til deres fremstilling, deres anvendelse som lægemidler og mellemproduktforbindelser
DK0401779T3 (da)	1995-10-16	4,5,5a,6-Tetrahydro-3H-isoazolo(5,4,3-kl)acridinderivater, en fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler