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TW198024B - - Google Patents

Info

Publication number
TW198024B
TW198024B TW081101228A TW81101228A TW198024B TW 198024 B TW198024 B TW 198024B TW 081101228 A TW081101228 A TW 081101228A TW 81101228 A TW81101228 A TW 81101228A TW 198024 B TW198024 B TW 198024B
Authority
TW
Taiwan
Prior art keywords
compounds
useful
antidepressants
alzheimer
intermediates
Prior art date
Application number
TW081101228A
Other languages
English (en)
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Application granted granted Critical
Publication of TW198024B publication Critical patent/TW198024B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW081101228A 1991-01-18 1992-02-20 TW198024B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/642,952 US5100891A (en) 1991-01-18 1991-01-18 Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds

Publications (1)

Publication Number Publication Date
TW198024B true TW198024B (zh) 1993-01-11

Family

ID=24578739

Family Applications (1)

Application Number Title Priority Date Filing Date
TW081101228A TW198024B (zh) 1991-01-18 1992-02-20

Country Status (26)

Country Link
US (1) US5100891A (zh)
EP (1) EP0496314B1 (zh)
JP (1) JP2665422B2 (zh)
KR (1) KR100230881B1 (zh)
AT (1) ATE158790T1 (zh)
AU (1) AU650315B2 (zh)
BR (1) BR9200171A (zh)
CA (1) CA2059610C (zh)
CZ (1) CZ282732B6 (zh)
DE (1) DE69222444T2 (zh)
DK (1) DK0496314T3 (zh)
ES (1) ES2109953T3 (zh)
FI (2) FI102174B1 (zh)
GR (1) GR3025318T3 (zh)
HU (1) HUT67027A (zh)
IE (1) IE920149A1 (zh)
IL (1) IL100693A0 (zh)
MX (1) MX9200206A (zh)
NO (1) NO178397C (zh)
NZ (1) NZ241305A (zh)
PH (1) PH31429A (zh)
PL (2) PL167465B1 (zh)
RO (1) RO112505B1 (zh)
RU (1) RU2077530C1 (zh)
TW (1) TW198024B (zh)
ZA (1) ZA92341B (zh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5298626A (en) * 1991-01-18 1994-03-29 Hoechst-Roussel Pharmaceuticals Incorporated Select cyclopent[b]indoles
US5350762A (en) * 1993-03-08 1994-09-27 Hoechst-Roussel Pharmaceuticals Incorporated Tetrahydrocyclopent[B]indole methanamines and related compounds
KR100335169B1 (ko) * 1997-07-03 2002-05-04 야마모토 카즈모토 포화 고리를 갖는 신규한 트리시클릭 화합물 및 이를포함하는 의약 조성물
UA69420C2 (uk) * 1998-10-06 2004-09-15 Янссен Фармацевтика Н.В. ТРИЦИКЛІЧНІ <font face="Symbol">D3</font>-ПІПЕРИДИНИ ЯК <font face="Symbol">a<sub></font>2</sub>-АНТАГОНІСТИ
NZ510116A (en) * 1998-10-06 2002-10-25 Janssen Pharmaceutica Nv Tricyclic delta-3-piperidines as pharmaceuticals
UA70334C2 (en) * 1998-10-06 2004-10-15 Janssen Pharmaceutica N V Jans BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS BENZOTHIENO[3,2-c]PYRIDINES AS a2 ANTAGONISTS
IT1317926B1 (it) 2000-11-03 2003-07-15 Sigma Tau Ind Farmaceuti Derivati triciclici dell'indolo ad attivita' antiangiogenica.
DE602004017326D1 (de) 2003-06-10 2008-12-04 Smithkline Beecham Corp Tetrahydrocarbazolderivate und deren pharmazeutische verwendung
EP1646610B1 (en) * 2003-06-12 2009-07-22 SmithKline Beecham Corporation Tetrahydrocarbazole derivatives and their pharmaceutical use
JP2008520740A (ja) * 2004-11-23 2008-06-19 ピーティーシー セラピューティクス， インコーポレイテッド Ｖｅｇｆ産生を阻害する活性因子としての置換されたフェノール
GB2422828A (en) * 2005-02-03 2006-08-09 Hunter Fleming Ltd Tricyclic cytoprotective compounds comprising an indole residue
WO2013139929A1 (en) * 2012-03-22 2013-09-26 Ludwig-Maximilians-Universität München Novel means and methods for treating diseases of the central nervous system, metabolic and cardiac diseases and aging
KR20140013471A (ko) 2012-07-24 2014-02-05 주식회사 쎄코 진공증착용 발열조립체 및 이를 구비하는 진공증착장치
US10882821B1 (en) 2017-09-26 2021-01-05 The Board Of Trustees Of The Leland Stanford Junior University Enantiomeric compound for the reduction of the deleterious activity of extended nucleotide repeat containing genes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3514462A (en) * 1966-10-21 1970-05-26 Upjohn Co 1 and 2 ethoxy 3,4,5,10 - tetrahydroazepino(3,4-b) and (2,3-b)indoles and corresponding amino derivatives thereof
US3595874A (en) * 1969-02-28 1971-07-27 Upjohn Co 3,4,5,10-tetrahydroazepino(2,3-b)indol-5a (2h)-ols
BE787537A (fr) * 1971-08-16 1973-02-14 Sterling Drug Inc Tetrahydrocarbazoles
SU482086A1 (ru) * 1973-11-30 1976-03-15 Всесоюзный Научно-Исследовательски% Химико-Фармацевтический Институт Им.С.Орджоникидзе Способ получени производных 1- -амино1,2,3,4-тетрагидрокарбазола
JPS5111760A (zh) * 1974-06-18 1976-01-30 Ayerst Mckenna & Harrison
US4254134A (en) * 1978-03-17 1981-03-03 Endo Laboratories, Inc. Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles

Also Published As

Publication number Publication date
RU2077530C1 (ru) 1997-04-20
PH31429A (en) 1998-11-03
GR3025318T3 (en) 1998-02-27
PL293209A1 (en) 1993-04-05
AU1027992A (en) 1992-07-23
CZ282732B6 (cs) 1997-09-17
FI920192A (fi) 1992-07-19
NO178397C (no) 1996-03-20
EP0496314A1 (en) 1992-07-29
DK0496314T3 (da) 1998-05-18
JPH04334367A (ja) 1992-11-20
FI107919B (fi) 2001-10-31
HUT67027A (en) 1995-01-30
DE69222444D1 (de) 1997-11-06
ES2109953T3 (es) 1998-02-01
MX9200206A (es) 1992-08-01
FI102174B (fi) 1998-10-30
FI102174B1 (fi) 1998-10-30
DE69222444T2 (de) 1998-06-04
NO178397B (no) 1995-12-11
US5100891A (en) 1992-03-31
IE920149A1 (en) 1992-07-29
CA2059610C (en) 2002-04-02
IL100693A0 (en) 1992-09-06
PL296651A1 (en) 1993-07-26
NO920235L (no) 1992-07-20
AU650315B2 (en) 1994-06-16
ZA92341B (en) 1992-09-30
NO920235D0 (no) 1992-01-17
PL169417B1 (pl) 1996-07-31
ATE158790T1 (de) 1997-10-15
NZ241305A (en) 1994-10-26
CA2059610A1 (en) 1992-07-19
FI920192A0 (fi) 1992-01-16
KR920014777A (ko) 1992-08-25
PL167465B1 (pl) 1995-09-30
FI20001775A (fi) 2000-08-10
KR100230881B1 (ko) 1999-11-15
RO112505B1 (ro) 1997-10-30
BR9200171A (pt) 1992-10-06
CS12992A3 (en) 1992-08-12
JP2665422B2 (ja) 1997-10-22
HU9200172D0 (en) 1992-04-28
EP0496314B1 (en) 1997-10-01

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