NL8503055A - Werkwijze voor het vergroten van de vruchtbaarheid van zeugen. - Google Patents

Werkwijze voor het vergroten van de vruchtbaarheid van zeugen. Download PDF

Info

Publication number: NL8503055A
Authority: NL; Netherlands
Prior art keywords: steroid; derivative; sows; immunogenic; immunization
Prior art date: 1984-11-08

Application number

NL8503055A

Other languages

English (en)

Dutch (nl)

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-11-08

Filing date

1985-11-07

Publication date

1986-06-02

1985-11-07 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1986-06-02 Publication of NL8503055A publication Critical patent/NL8503055A/nl

Links

238000000034 method Methods 0.000 title claims description 31
230000035558 fertility Effects 0.000 title claims description 9
150000003431 steroids Chemical class 0.000 claims description 39
230000002163 immunogen Effects 0.000 claims description 33
239000003098 androgen Substances 0.000 claims description 19
229940011871 estrogen Drugs 0.000 claims description 19
239000000262 estrogen Substances 0.000 claims description 19
230000016087 ovulation Effects 0.000 claims description 19
241001465754 Metazoa Species 0.000 claims description 15
230000003053 immunization Effects 0.000 claims description 14
229940030486 androgens Drugs 0.000 claims description 12
230000013011 mating Effects 0.000 claims description 12
238000002649 immunization Methods 0.000 claims description 11
239000002671 adjuvant Substances 0.000 claims description 8
AEMFNILZOJDQLW-QAGGRKNESA-N androst-4-ene-3,17-dione Chemical class O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 AEMFNILZOJDQLW-QAGGRKNESA-N 0.000 claims description 8
230000012173 estrus Effects 0.000 claims description 8
MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims description 6
230000003637 steroidlike Effects 0.000 claims description 6
102000008100 Human Serum Albumin Human genes 0.000 claims description 5
108091006905 Human Serum Albumin Proteins 0.000 claims description 5
150000002167 estrones Chemical class 0.000 claims description 5
239000002253 acid Substances 0.000 claims description 4
230000000694 effects Effects 0.000 claims description 4
244000144980 herd Species 0.000 claims description 4
238000002360 preparation method Methods 0.000 claims description 4
DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 claims description 3
XSDCLHQDGODZPZ-WWNBULGVSA-N Estra-1,3,5-(10)-trien-17-one-3-oxyacetic acid Chemical group OC(=O)COC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 XSDCLHQDGODZPZ-WWNBULGVSA-N 0.000 claims description 3
DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 claims description 3
229930182558 Sterol Natural products 0.000 claims description 3
229960003399 estrone Drugs 0.000 claims description 3
OSVMTWJCGUFAOD-KZQROQTASA-N formestane Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1O OSVMTWJCGUFAOD-KZQROQTASA-N 0.000 claims description 3
150000003432 sterols Chemical class 0.000 claims description 3
235000003702 sterols Nutrition 0.000 claims description 3
229960003604 testosterone Drugs 0.000 claims description 3
150000003515 testosterones Chemical class 0.000 claims description 3
-1 2-carboxyethylthio Chemical group 0.000 claims description 2
WSCUHXPGYUMQEX-CRIVMUBDSA-N 11-Hydroxyandrostenedione Chemical compound O=C1CC[C@]2(C)[C@H]3C(O)C[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 WSCUHXPGYUMQEX-CRIVMUBDSA-N 0.000 claims 1
229920002491 Diethylaminoethyl-dextran Polymers 0.000 claims 1
239000000047 product Substances 0.000 description 9
108090000623 proteins and genes Proteins 0.000 description 9
102000004169 proteins and genes Human genes 0.000 description 8
241000282887 Suidae Species 0.000 description 7
229920002307 Dextran Polymers 0.000 description 6
239000000243 solution Substances 0.000 description 6
229960005471 androstenedione Drugs 0.000 description 5
AEMFNILZOJDQLW-UHFFFAOYSA-N androstenedione Natural products O=C1CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 AEMFNILZOJDQLW-UHFFFAOYSA-N 0.000 description 5
241001494479 Pecora Species 0.000 description 3
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
239000012153 distilled water Substances 0.000 description 3
229940088597 hormone Drugs 0.000 description 3
239000005556 hormone Substances 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 2
241000700159 Rattus Species 0.000 description 2
230000000890 antigenic effect Effects 0.000 description 2
239000003610 charcoal Substances 0.000 description 2
230000021615 conjugation Effects 0.000 description 2
230000006651 lactation Effects 0.000 description 2
244000144972 livestock Species 0.000 description 2
239000011550 stock solution Substances 0.000 description 2
DBHJTOHPFSRBBU-XEGGJJFLSA-N (8r,9s,10r,13s,14s)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthrene-3,17-dione Chemical class O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1.O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DBHJTOHPFSRBBU-XEGGJJFLSA-N 0.000 description 1
BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 description 1
YOETUEMZNOLGDB-UHFFFAOYSA-N 2-methylpropyl carbonochloridate Chemical compound CC(C)COC(Cl)=O YOETUEMZNOLGDB-UHFFFAOYSA-N 0.000 description 1
OZLABWUNIWIISO-UQHDCFDMSA-N 3-[[(7r,8r,9s,10r,13s,14s)-10,13-dimethyl-3,17-dioxo-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-7-yl]sulfanyl]propanoic acid Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3[C@H](SCCC(O)=O)CC2=C1 OZLABWUNIWIISO-UQHDCFDMSA-N 0.000 description 1
102000009027 Albumins Human genes 0.000 description 1
108010088751 Albumins Proteins 0.000 description 1
241000287828 Gallus gallus Species 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
102000009843 Thyroglobulin Human genes 0.000 description 1
108010034949 Thyroglobulin Proteins 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
230000001548 androgenic effect Effects 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
239000000872 buffer Substances 0.000 description 1
239000000969 carrier Substances 0.000 description 1
238000007865 diluting Methods 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
210000000981 epithelium Anatomy 0.000 description 1
230000001076 estrogenic effect Effects 0.000 description 1
239000006260 foam Substances 0.000 description 1
230000036039 immunity Effects 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000002347 injection Methods 0.000 description 1
238000011835 investigation Methods 0.000 description 1
230000003780 keratinization Effects 0.000 description 1
239000007788 liquid Substances 0.000 description 1
235000003715 nutritional status Nutrition 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
230000035935 pregnancy Effects 0.000 description 1
238000003127 radioimmunoassay Methods 0.000 description 1
239000012465 retentate Substances 0.000 description 1
210000001625 seminal vesicle Anatomy 0.000 description 1
238000013207 serial dilution Methods 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
230000001568 sexual effect Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
210000004291 uterus Anatomy 0.000 description 1
201000010653 vesiculitis Diseases 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Microbiology (AREA)
Mycology (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NL8503055A 1984-11-08 1985-11-07 Werkwijze voor het vergroten van de vruchtbaarheid van zeugen. NL8503055A (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8428201		1984-11-08
GB848428201A GB8428201D0 (en)	1984-11-08	1984-11-08	Biological preparations

Publications (1)

Publication Number	Publication Date
NL8503055A true NL8503055A (nl)	1986-06-02

Family

ID=10569424

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8503055A NL8503055A (nl)	1984-11-08	1985-11-07	Werkwijze voor het vergroten van de vruchtbaarheid van zeugen.

Country Status (10)

Country	Link
JP (1)	JPS61115429A (xx)
DE (1)	DE3539557A1 (xx)
DK (1)	DK513185A (xx)
FR (1)	FR2572653B1 (xx)
GB (2)	GB8428201D0 (xx)
IT (1)	IT1219682B (xx)
NL (1)	NL8503055A (xx)
NZ (1)	NZ214107A (xx)
PH (1)	PH25536A (xx)
ZA (1)	ZA858580B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ220988A (en) *	1986-07-11	1989-12-21	Commw Scient Ind Res Org	A method for increasing fecundity in a flock of domesticated animals by immunising against certain steroids and an immunogenic mixture therefor
NZ221306A (en) *	1986-08-15	1990-02-26	Commw Scient Ind Res Org	2-component immunoadjuvant comprising a mycobacterial free immunoadjuvant oil and a polycationic polyelectrolyte immunoadjuvant and vaccines thereof
EP0609345B1 (en) *	1991-10-21	1999-09-22	Peptech Limited	Biocompatible implant for the timing of ovulation in mares
US6028057A (en) *	1998-02-19	2000-02-22	Thorn Bioscience, Llc	Regulation of estrus and ovulation in gilts
ES2555681T3 (es)	2003-10-03	2016-01-07	Thorn Bioscience, Llc	Procedimiento para la sincronización de la ovulación para la fecundación programada sin detección del celo
BRPI1014362A2 (pt)	2009-04-23	2016-04-05	Pennatek Llc	método e composição para sincronizar o tempo de inseminação
ES2808409T3 (es)	2012-11-28	2021-02-26	United Ah Ii Llc	Método para sincronizar el tiempo de inseminación en cerdas primerizas
CN107771742A (zh) *	2017-11-17	2018-03-09	凤台县瑞普农业发展有限公司	一种促进发情的后备种猪的饲养方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL171930C (nl) *	1972-05-11	1983-06-01	Akzo Nv	Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
JPS5341420A (en) *	1976-09-29	1978-04-14	Mochida Pharm Co Ltd	Immunochemically measuring methoa of hapten
US4331657A (en) *	1980-02-06	1982-05-25	Commonwealth Scientific And Industrial Research Organization	Fecundity of domestic livestock
NZ196126A (en) *	1980-02-07	1985-05-31	Commw Scient Ind Res Org	Increasing ovulation rate in female cattle
DE3485681D1 (de) *	1983-10-14	1992-06-04	Unilever Nv	Produktion von vieh oder davon abgeleitete erzeugnisse.

1984
- 1984-11-08 GB GB848428201A patent/GB8428201D0/en active Pending
1985
- 1985-11-07 JP JP60248149A patent/JPS61115429A/ja active Pending
- 1985-11-07 ZA ZA858580A patent/ZA858580B/xx unknown
- 1985-11-07 DK DK513185A patent/DK513185A/da not_active Application Discontinuation
- 1985-11-07 NL NL8503055A patent/NL8503055A/nl not_active Application Discontinuation
- 1985-11-07 PH PH33021A patent/PH25536A/en unknown
- 1985-11-07 NZ NZ214107A patent/NZ214107A/xx unknown
- 1985-11-07 DE DE19853539557 patent/DE3539557A1/de not_active Withdrawn
- 1985-11-07 FR FR858516509A patent/FR2572653B1/fr not_active Expired - Fee Related
- 1985-11-07 IT IT48753/85A patent/IT1219682B/it active
- 1985-11-07 GB GB8527437A patent/GB2166951B/en not_active Expired

Also Published As

Publication number	Publication date
GB8428201D0 (en)	1984-12-19
IT8548753A0 (it)	1985-11-07
ZA858580B (en)	1987-07-29
GB2166951B (en)	1989-07-12
PH25536A (en)	1991-07-24
DE3539557A1 (de)	1986-06-05
GB8527437D0 (en)	1985-12-11
GB2166951A (en)	1986-05-21
DK513185D0 (da)	1985-11-07
FR2572653B1 (fr)	1990-09-07
DK513185A (da)	1986-05-09
FR2572653A1 (fr)	1986-05-09
NZ214107A (en)	1989-06-28
JPS61115429A (ja)	1986-06-03
IT1219682B (it)	1990-05-24

Publication	Publication Date	Title
JP4949555B2 (ja)	2012-06-13	改良サポニンアジュバント組成物およびそれに関する方法
Wira et al.	1980	Hormonal regulation of immunoglobulins: influence of estradiol on immunoglobulins A and G in the rat uterus
Joshi et al.	1973	Synergistic effects of testosterone and oestrogens on accessory sex glands and sexual behaviour of the boar
JP2000512130A (ja)	2000-09-19	ホルモンまたはそのレセプターの活性の調節方法、ペプチド、抗体、ワクチンおよびこれらの使用
JPS6241690B2 (xx)	1987-09-04
NL8503055A (nl)	1986-06-02	Werkwijze voor het vergroten van de vruchtbaarheid van zeugen.
JPH0561252B2 (xx)	1993-09-06
Illingworth et al.	1974	Parturition in the guinea-pig; plasma levels of steroid hormones, steroid-binding proteins, and oxytocin, and the effect of corticosteroids, prostaglandins and adrenocorticotrophin
US20020169116A1 (en)	2002-11-14	Modulating the activity of hormones or their receptors - peptides, antibodies, vaccines and uses thereof
US4331657A (en)	1982-05-25	Fecundity of domestic livestock
JPH11515013A (ja)	1999-12-21	合成複合ワクチンの免疫原性担体としてのシュードモナスエクソトキシン
US4457914A (en)	1984-07-03	Fecundity of domestic livestock
IE50857B1 (en)	1986-08-06	Control of ovulation
EP0072880B1 (en)	1985-10-16	A composition for use in the control of ovulation of female bovines
AU600014B2 (en)	1990-08-02	Reduction of reproductive losses
Kumaresan et al.	1967	Effect of corticosterone upon mammary gland growth of pregnant rats
US4749567A (en)	1988-06-07	Method and product for increasing fertility in sheep using milk protein conjugates
Turkstra et al.	2006	Active immunisation against gonadotropin-releasing hormone, an active tool to block the fertility axis in mammals
JPH08154957A (ja)	1996-06-18	牛の過剰排卵誘起方法
Hoskinson et al.	1986	Effects of antibodies to steroid hormones on reproductive events of sheep and cattle
AU7642387A (en)	1988-01-29	Composition and method for immunological castration and spaying
Westphal	1986	Corticosteroid-binding globulin (CBG)
AU614496B2 (en)	1991-09-05	Improved female mammals
EP0140627B1 (en)	1992-04-29	Production of livestock or products derived therefrom
RU2092185C1 (ru)	1997-10-10	Вакцина для подавления половой функции млекопитающих

Legal Events

Date	Code	Title	Description
1993-01-04	BV	The patent application has lapsed