DE3539557A1 - Biologische methode - Google Patents
Biologische methodeInfo
- Publication number
- DE3539557A1 DE3539557A1 DE19853539557 DE3539557A DE3539557A1 DE 3539557 A1 DE3539557 A1 DE 3539557A1 DE 19853539557 DE19853539557 DE 19853539557 DE 3539557 A DE3539557 A DE 3539557A DE 3539557 A1 DE3539557 A1 DE 3539557A1
- Authority
- DE
- Germany
- Prior art keywords
- steroid
- derivative
- immunogenic
- sows
- immunization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000010170 biological method Methods 0.000 title claims description 3
- 150000003431 steroids Chemical class 0.000 claims description 44
- 230000002163 immunogen Effects 0.000 claims description 30
- 238000000034 method Methods 0.000 claims description 28
- 239000003098 androgen Substances 0.000 claims description 19
- 229940011871 estrogen Drugs 0.000 claims description 17
- 239000000262 estrogen Substances 0.000 claims description 17
- 230000016087 ovulation Effects 0.000 claims description 17
- 230000003053 immunization Effects 0.000 claims description 16
- 241001465754 Metazoa Species 0.000 claims description 15
- 238000002649 immunization Methods 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 13
- 230000013011 mating Effects 0.000 claims description 12
- 229940030486 androgens Drugs 0.000 claims description 10
- AEMFNILZOJDQLW-QAGGRKNESA-N androst-4-ene-3,17-dione Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 AEMFNILZOJDQLW-QAGGRKNESA-N 0.000 claims description 10
- 239000002671 adjuvant Substances 0.000 claims description 7
- 230000035558 fertility Effects 0.000 claims description 7
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims description 6
- 102000008100 Human Serum Albumin Human genes 0.000 claims description 4
- 108091006905 Human Serum Albumin Proteins 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 4
- 150000002167 estrones Chemical class 0.000 claims description 4
- 244000144980 herd Species 0.000 claims description 4
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 claims description 3
- 230000001076 estrogenic effect Effects 0.000 claims description 3
- 229960003399 estrone Drugs 0.000 claims description 3
- 229960003604 testosterone Drugs 0.000 claims description 3
- 150000003515 testosterones Chemical class 0.000 claims description 3
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 claims description 2
- 229920002491 Diethylaminoethyl-dextran Polymers 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 239000000243 solution Substances 0.000 description 6
- 230000003637 steroidlike Effects 0.000 description 6
- 229920002307 Dextran Polymers 0.000 description 5
- AEMFNILZOJDQLW-UHFFFAOYSA-N androstenedione Natural products O=C1CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 AEMFNILZOJDQLW-UHFFFAOYSA-N 0.000 description 5
- 229960005471 androstenedione Drugs 0.000 description 4
- 230000012173 estrus Effects 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 2
- -1 2-carboxyethylthio Chemical group 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- 230000001548 androgenic effect Effects 0.000 description 2
- 230000000890 antigenic effect Effects 0.000 description 2
- 239000003610 charcoal Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- AEMFNILZOJDQLW-PMPKNJDSSA-N (8R,9S,10R,13S,14S)-10,13-dimethyl-1,2,6,7-tetratritio-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione Chemical compound C[C@@]12C(=O)CC[C@H]1[C@@H]1C(C(C3=CC(=O)C(C([C@]3(C)[C@H]1CC2)[3H])[3H])[3H])[3H] AEMFNILZOJDQLW-PMPKNJDSSA-N 0.000 description 1
- DBHJTOHPFSRBBU-XEGGJJFLSA-N (8r,9s,10r,13s,14s)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthrene-3,17-dione Chemical class O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1.O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DBHJTOHPFSRBBU-XEGGJJFLSA-N 0.000 description 1
- BTTWKVFKBPAFDK-UHFFFAOYSA-N (9beta,10alpha)-Androst-4-ene-3,17-dione Natural products OC1CCC2(C)C3CCC(C)(C(CC4)O)C4C3CCC2=C1 BTTWKVFKBPAFDK-UHFFFAOYSA-N 0.000 description 1
- YOETUEMZNOLGDB-UHFFFAOYSA-N 2-methylpropyl carbonochloridate Chemical compound CC(C)COC(Cl)=O YOETUEMZNOLGDB-UHFFFAOYSA-N 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- XSDCLHQDGODZPZ-WWNBULGVSA-N Estra-1,3,5-(10)-trien-17-one-3-oxyacetic acid Chemical group OC(=O)COC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 XSDCLHQDGODZPZ-WWNBULGVSA-N 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 102000009843 Thyroglobulin Human genes 0.000 description 1
- 108010034949 Thyroglobulin Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000001268 conjugating effect Effects 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000003715 nutritional status Nutrition 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 239000012465 retentate Substances 0.000 description 1
- 210000001625 seminal vesicle Anatomy 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 201000010653 vesiculitis Diseases 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848428201A GB8428201D0 (en) | 1984-11-08 | 1984-11-08 | Biological preparations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3539557A1 true DE3539557A1 (de) | 1986-06-05 |
Family
ID=10569424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19853539557 Withdrawn DE3539557A1 (de) | 1984-11-08 | 1985-11-07 | Biologische methode |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS61115429A (xx) |
| DE (1) | DE3539557A1 (xx) |
| DK (1) | DK513185A (xx) |
| FR (1) | FR2572653B1 (xx) |
| GB (2) | GB8428201D0 (xx) |
| IT (1) | IT1219682B (xx) |
| NL (1) | NL8503055A (xx) |
| NZ (1) | NZ214107A (xx) |
| PH (1) | PH25536A (xx) |
| ZA (1) | ZA858580B (xx) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ220988A (en) * | 1986-07-11 | 1989-12-21 | Commw Scient Ind Res Org | A method for increasing fecundity in a flock of domesticated animals by immunising against certain steroids and an immunogenic mixture therefor |
| NZ221306A (en) * | 1986-08-15 | 1990-02-26 | Commw Scient Ind Res Org | 2-component immunoadjuvant comprising a mycobacterial free immunoadjuvant oil and a polycationic polyelectrolyte immunoadjuvant and vaccines thereof |
| EP0609345B1 (en) * | 1991-10-21 | 1999-09-22 | Peptech Limited | Biocompatible implant for the timing of ovulation in mares |
| US6028057A (en) * | 1998-02-19 | 2000-02-22 | Thorn Bioscience, Llc | Regulation of estrus and ovulation in gilts |
| ES2555681T3 (es) | 2003-10-03 | 2016-01-07 | Thorn Bioscience, Llc | Procedimiento para la sincronización de la ovulación para la fecundación programada sin detección del celo |
| BRPI1014362A2 (pt) | 2009-04-23 | 2016-04-05 | Pennatek Llc | método e composição para sincronizar o tempo de inseminação |
| ES2808409T3 (es) | 2012-11-28 | 2021-02-26 | United Ah Ii Llc | Método para sincronizar el tiempo de inseminación en cerdas primerizas |
| CN107771742A (zh) * | 2017-11-17 | 2018-03-09 | 凤台县瑞普农业发展有限公司 | 一种促进发情的后备种猪的饲养方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL171930C (nl) * | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| JPS5341420A (en) * | 1976-09-29 | 1978-04-14 | Mochida Pharm Co Ltd | Immunochemically measuring methoa of hapten |
| US4331657A (en) * | 1980-02-06 | 1982-05-25 | Commonwealth Scientific And Industrial Research Organization | Fecundity of domestic livestock |
| NZ196126A (en) * | 1980-02-07 | 1985-05-31 | Commw Scient Ind Res Org | Increasing ovulation rate in female cattle |
| DE3485681D1 (de) * | 1983-10-14 | 1992-06-04 | Unilever Nv | Produktion von vieh oder davon abgeleitete erzeugnisse. |
-
1984
- 1984-11-08 GB GB848428201A patent/GB8428201D0/en active Pending
-
1985
- 1985-11-07 JP JP60248149A patent/JPS61115429A/ja active Pending
- 1985-11-07 ZA ZA858580A patent/ZA858580B/xx unknown
- 1985-11-07 DK DK513185A patent/DK513185A/da not_active Application Discontinuation
- 1985-11-07 NL NL8503055A patent/NL8503055A/nl not_active Application Discontinuation
- 1985-11-07 PH PH33021A patent/PH25536A/en unknown
- 1985-11-07 NZ NZ214107A patent/NZ214107A/xx unknown
- 1985-11-07 DE DE19853539557 patent/DE3539557A1/de not_active Withdrawn
- 1985-11-07 FR FR858516509A patent/FR2572653B1/fr not_active Expired - Fee Related
- 1985-11-07 IT IT48753/85A patent/IT1219682B/it active
- 1985-11-07 GB GB8527437A patent/GB2166951B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB8428201D0 (en) | 1984-12-19 |
| IT8548753A0 (it) | 1985-11-07 |
| ZA858580B (en) | 1987-07-29 |
| GB2166951B (en) | 1989-07-12 |
| NL8503055A (nl) | 1986-06-02 |
| PH25536A (en) | 1991-07-24 |
| GB8527437D0 (en) | 1985-12-11 |
| GB2166951A (en) | 1986-05-21 |
| DK513185D0 (da) | 1985-11-07 |
| FR2572653B1 (fr) | 1990-09-07 |
| DK513185A (da) | 1986-05-09 |
| FR2572653A1 (fr) | 1986-05-09 |
| NZ214107A (en) | 1989-06-28 |
| JPS61115429A (ja) | 1986-06-03 |
| IT1219682B (it) | 1990-05-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8141 | Disposal/no request for examination |