NL8102369A - Preparaat van een antimicrobisch middel en werkwijze ter bereiding daarvan. - Google Patents
Preparaat van een antimicrobisch middel en werkwijze ter bereiding daarvan. Download PDFInfo
- Publication number
- NL8102369A NL8102369A NL8102369A NL8102369A NL8102369A NL 8102369 A NL8102369 A NL 8102369A NL 8102369 A NL8102369 A NL 8102369A NL 8102369 A NL8102369 A NL 8102369A NL 8102369 A NL8102369 A NL 8102369A
- Authority
- NL
- Netherlands
- Prior art keywords
- effective amount
- treating
- preparation
- alkaloid
- composition according
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims description 80
- 238000000034 method Methods 0.000 title claims description 35
- 230000003377 anti-microbal effect Effects 0.000 title 1
- INVGWHRKADIJHF-UHFFFAOYSA-N Sanguinarin Chemical compound C1=C2OCOC2=CC2=C3[N+](C)=CC4=C(OCO5)C5=CC=C4C3=CC=C21 INVGWHRKADIJHF-UHFFFAOYSA-N 0.000 claims description 120
- FCEXWTOTHXCQCQ-UHFFFAOYSA-N Ethoxydihydrosanguinarine Natural products C12=CC=C3OCOC3=C2C(OCC)N(C)C(C2=C3)=C1C=CC2=CC1=C3OCO1 FCEXWTOTHXCQCQ-UHFFFAOYSA-N 0.000 claims description 53
- YZRQUTZNTDAYPJ-UHFFFAOYSA-N sanguinarine pseudobase Natural products C1=C2OCOC2=CC2=C3N(C)C(O)C4=C(OCO5)C5=CC=C4C3=CC=C21 YZRQUTZNTDAYPJ-UHFFFAOYSA-N 0.000 claims description 53
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical group [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 48
- 239000000203 mixture Substances 0.000 claims description 43
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 41
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 31
- 150000003839 salts Chemical class 0.000 claims description 29
- 238000011282 treatment Methods 0.000 claims description 26
- 229910052751 metal Inorganic materials 0.000 claims description 23
- 239000002184 metal Substances 0.000 claims description 23
- 235000005074 zinc chloride Nutrition 0.000 claims description 23
- 239000011592 zinc chloride Substances 0.000 claims description 23
- 235000011187 glycerol Nutrition 0.000 claims description 19
- 229940084560 sanguinarine Drugs 0.000 claims description 19
- 229930015421 benzophenanthridine alkaloid Natural products 0.000 claims description 18
- 239000000243 solution Substances 0.000 claims description 16
- 230000000845 anti-microbial effect Effects 0.000 claims description 15
- 208000015181 infectious disease Diseases 0.000 claims description 15
- 239000000463 material Substances 0.000 claims description 15
- 229930013930 alkaloid Natural products 0.000 claims description 14
- WEEFNMFMNMASJY-UHFFFAOYSA-M 1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium;chloride Chemical compound [Cl-].C1=C2OCOC2=CC2=CC=C3C4=CC=C(OC)C(OC)=C4C=[N+](C)C3=C21 WEEFNMFMNMASJY-UHFFFAOYSA-M 0.000 claims description 13
- -1 alkaloid salt Chemical class 0.000 claims description 13
- 208000028169 periodontal disease Diseases 0.000 claims description 12
- LLEJIEBFSOEYIV-UHFFFAOYSA-N Chelerythrine Natural products C1=C2OCOC2=CC2=CC=C3C4=CC=C(OC)C(OC)=C4C=[N+](C)C3=C21 LLEJIEBFSOEYIV-UHFFFAOYSA-N 0.000 claims description 11
- RATMHCJTVBHJSU-UHFFFAOYSA-N Dihydrochelerythrine Natural products C1=C2OCOC2=CC2=C(N(C)C(O)C=3C4=CC=C(C=3OC)OC)C4=CC=C21 RATMHCJTVBHJSU-UHFFFAOYSA-N 0.000 claims description 11
- 208000002925 dental caries Diseases 0.000 claims description 11
- 208000002474 Tinea Diseases 0.000 claims description 10
- 241000893966 Trichophyton verrucosum Species 0.000 claims description 10
- GPTFURBXHJWNHR-UHFFFAOYSA-N protopine Chemical compound C1=C2C(=O)CC3=CC=C4OCOC4=C3CN(C)CCC2=CC2=C1OCO2 GPTFURBXHJWNHR-UHFFFAOYSA-N 0.000 claims description 10
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 150000003797 alkaloid derivatives Chemical class 0.000 claims description 9
- 239000004599 antimicrobial Substances 0.000 claims description 9
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 8
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 8
- 239000002253 acid Substances 0.000 claims description 8
- 206010012735 Diarrhoea Diseases 0.000 claims description 7
- 239000002904 solvent Substances 0.000 claims description 7
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 claims description 7
- 229960002799 stannous fluoride Drugs 0.000 claims description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- 150000004673 fluoride salts Chemical group 0.000 claims description 6
- GIZKAXHWLRYMLE-UHFFFAOYSA-M sanguinarium chloride Chemical group [Cl-].C1=C2OCOC2=CC2=C3[N+](C)=CC4=C(OCO5)C5=CC=C4C3=CC=C21 GIZKAXHWLRYMLE-UHFFFAOYSA-M 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 201000009030 Carcinoma Diseases 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- GTRPODKMSBFDOI-UHFFFAOYSA-N Protopine Natural products CN1Cc2c3OCOc3ccc2C4C1Cc5cc6OCOc6cc5C4=O GTRPODKMSBFDOI-UHFFFAOYSA-N 0.000 claims description 5
- ZAALQOFZFANFTF-UHFFFAOYSA-N Pseudoprotipine Natural products C1=C2C(=O)CC3=CC=4OCOC=4C=C3CN(C)CCC2=CC2=C1OCO2 ZAALQOFZFANFTF-UHFFFAOYSA-N 0.000 claims description 5
- CHWPMFMUQATVNK-ARYYTZDLSA-N dihydrosporogen AO-1 Natural products O[C@H]1[C@]2(C(C)=C)O[C@@H]2[C@]2(C)[C@@H](C)[C@H](O)CCC2=C1 CHWPMFMUQATVNK-ARYYTZDLSA-N 0.000 claims description 5
- 208000007565 gingivitis Diseases 0.000 claims description 5
- 231100000252 nontoxic Toxicity 0.000 claims description 5
- 230000003000 nontoxic effect Effects 0.000 claims description 5
- 235000013024 sodium fluoride Nutrition 0.000 claims description 5
- 239000011775 sodium fluoride Substances 0.000 claims description 5
- 229910002651 NO3 Inorganic materials 0.000 claims description 4
- 206010029098 Neoplasm skin Diseases 0.000 claims description 4
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 4
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 4
- OWUNMSGLMUPGEZ-UHFFFAOYSA-N benzo[k]phenanthridine Chemical compound C1=CC=CC2=C3C4=CC=CC=C4C=CC3=CN=C21 OWUNMSGLMUPGEZ-UHFFFAOYSA-N 0.000 claims description 4
- 150000007522 mineralic acids Chemical class 0.000 claims description 4
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 3
- 241000124008 Mammalia Species 0.000 claims 7
- 230000001413 cellular effect Effects 0.000 claims 2
- 239000013078 crystal Substances 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 1
- 239000003929 acidic solution Substances 0.000 claims 1
- 208000024693 gingival disease Diseases 0.000 claims 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000001245 periodontitis Diseases 0.000 claims 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims 1
- UUOCDFGUEXAVIL-UHFFFAOYSA-N Sanguinarin Natural products CNc1c(ccc2cc3OCOc3cc12)c4ccc5OCOc5c4C=O UUOCDFGUEXAVIL-UHFFFAOYSA-N 0.000 description 34
- 206010028980 Neoplasm Diseases 0.000 description 21
- 241001465754 Metazoa Species 0.000 description 11
- 239000003814 drug Substances 0.000 description 11
- 241000282472 Canis lupus familiaris Species 0.000 description 10
- 239000002585 base Substances 0.000 description 10
- 238000001727 in vivo Methods 0.000 description 10
- 229940079593 drug Drugs 0.000 description 9
- 210000001519 tissue Anatomy 0.000 description 9
- 208000002064 Dental Plaque Diseases 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 239000000835 fiber Substances 0.000 description 8
- 241000282412 Homo Species 0.000 description 7
- 238000000338 in vitro Methods 0.000 description 7
- 244000005700 microbiome Species 0.000 description 7
- 241000283073 Equus caballus Species 0.000 description 6
- 150000008622 benzophenanthridines Chemical class 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- 206010004146 Basal cell carcinoma Diseases 0.000 description 5
- 229920000742 Cotton Polymers 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 230000003239 periodontal effect Effects 0.000 description 5
- 241000283690 Bos taurus Species 0.000 description 4
- 230000035876 healing Effects 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 201000008808 Fibrosarcoma Diseases 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- 244000001385 Sanguinaria canadensis Species 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 239000000969 carrier Substances 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 230000002262 irrigation Effects 0.000 description 3
- 238000003973 irrigation Methods 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- 239000006072 paste Substances 0.000 description 3
- 210000004261 periodontium Anatomy 0.000 description 3
- 239000000344 soap Substances 0.000 description 3
- 206010041823 squamous cell carcinoma Diseases 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000000699 topical effect Effects 0.000 description 3
- MADYLZJCRKUBIK-RYGJVYDSSA-N (+/-)-Homochelidonine Chemical compound C([C@@H]1O)C2=CC=3OCOC=3C=C2[C@@H]2[C@H]1C1=CC=C(OC)C(OC)=C1CN2C MADYLZJCRKUBIK-RYGJVYDSSA-N 0.000 description 2
- 240000008025 Alternanthera ficoidea Species 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 2
- 241000283086 Equidae Species 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 241000194019 Streptococcus mutans Species 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- XQNZLTZMXPNJQY-UHFFFAOYSA-L [Cl-].[Cl-].[Zn+2].OCC(O)CO Chemical compound [Cl-].[Cl-].[Zn+2].OCC(O)CO XQNZLTZMXPNJQY-UHFFFAOYSA-L 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 150000001340 alkali metals Chemical class 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 230000002500 effect on skin Effects 0.000 description 2
- 150000002222 fluorine compounds Chemical class 0.000 description 2
- 229910001385 heavy metal Inorganic materials 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000002787 reinforcement Effects 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 235000013479 Amaranthus retroflexus Nutrition 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 244000157790 Buglossoides arvense Species 0.000 description 1
- 235000004256 Buglossoides arvense Nutrition 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 235000014224 Ceanothus americanus Nutrition 0.000 description 1
- 235000001904 Ceanothus herbaceus Nutrition 0.000 description 1
- 208000009043 Chemical Burns Diseases 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 208000009738 Connective Tissue Neoplasms Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 241000194032 Enterococcus faecalis Species 0.000 description 1
- 241000588722 Escherichia Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010015548 Euthanasia Diseases 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 208000004898 Herpes Labialis Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000588747 Klebsiella pneumoniae Species 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 206010067152 Oral herpes Diseases 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 235000016551 Potentilla erecta Nutrition 0.000 description 1
- 241000588767 Proteus vulgaris Species 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical compound OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 description 1
- 208000008312 Tooth Loss Diseases 0.000 description 1
- 208000009596 Tooth Mobility Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 150000008043 acidic salts Chemical class 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229910001515 alkali metal fluoride Inorganic materials 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- MADYLZJCRKUBIK-UHFFFAOYSA-N alpha-homochelidonine Natural products OC1CC2=CC=3OCOC=3C=C2C2C1C1=CC=C(OC)C(OC)=C1CN2C MADYLZJCRKUBIK-UHFFFAOYSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 230000000721 bacterilogical effect Effects 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004061 bleaching Methods 0.000 description 1
- 208000002352 blister Diseases 0.000 description 1
- 150000003842 bromide salts Chemical class 0.000 description 1
- 239000004075 cariostatic agent Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 150000001991 dicarboxylic acids Chemical class 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 229960003072 epinephrine hydrochloride Drugs 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000009408 flooring Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 238000010562 histological examination Methods 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- 230000000415 inactivating effect Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 229940124508 injectable medicine Drugs 0.000 description 1
- 229910001506 inorganic fluoride Inorganic materials 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 150000004694 iodide salts Chemical class 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 229910001509 metal bromide Inorganic materials 0.000 description 1
- 229910001510 metal chloride Inorganic materials 0.000 description 1
- 229910001511 metal iodide Inorganic materials 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 150000002763 monocarboxylic acids Chemical class 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- NQCBIMOYRRMVNA-UHFFFAOYSA-N propane-1,2,3-triol;hydrochloride Chemical compound Cl.OCC(O)CO NQCBIMOYRRMVNA-UHFFFAOYSA-N 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 229940007042 proteus vulgaris Drugs 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000011833 salt mixture Substances 0.000 description 1
- 235000012420 sanguinaria Nutrition 0.000 description 1
- 201000000306 sarcoidosis Diseases 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical class [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15170680A | 1980-05-20 | 1980-05-20 | |
| US15170680 | 1980-05-20 | ||
| US22608881A | 1981-01-19 | 1981-01-19 | |
| US22608881 | 1981-01-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8102369A true NL8102369A (nl) | 1981-12-16 |
Family
ID=26848887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8102369A NL8102369A (nl) | 1980-05-20 | 1981-05-14 | Preparaat van een antimicrobisch middel en werkwijze ter bereiding daarvan. |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPH0686380B2 (de) |
| AU (1) | AU548560B2 (de) |
| CA (1) | CA1177407A (de) |
| CH (1) | CH645268A5 (de) |
| DE (1) | DE3119746A1 (de) |
| FR (1) | FR2482860B1 (de) |
| GB (1) | GB2078109B (de) |
| IT (1) | IT1136620B (de) |
| NL (1) | NL8102369A (de) |
| SE (1) | SE8103152L (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4517172A (en) * | 1983-12-29 | 1985-05-14 | Vipont Laboratories, Inc. | Plaque disclosing agent |
| US4818533A (en) * | 1985-07-09 | 1989-04-04 | Vipont Pharmaceutical, Inc. | Production of high purity alkaloids |
| US4767861A (en) * | 1986-01-28 | 1988-08-30 | Vipont Laboratories | Recovery of benzo-c-phenanthridine alkaloids |
| US4769452A (en) * | 1986-02-07 | 1988-09-06 | Vipont Laboratories, Inc. | Production of purity benzo-c-phenanthridine alkaloid salts |
| EP0326627A1 (de) * | 1988-02-01 | 1989-08-09 | Vipont Pharmaceutical, Inc. | Methode zur Verhinderung der Knochenresorption und der Kollagenasefreisetzung |
| IL86802A0 (en) * | 1987-06-30 | 1988-11-30 | Vipont Pharma | Drug delivery devices |
| US4975271A (en) * | 1988-12-19 | 1990-12-04 | Vipont Pharmaceutical, Inc. | Muscosal delivery systems for treatment of periodontal disease |
| JPH0539764U (ja) * | 1991-10-28 | 1993-05-28 | 日鐵建材工業株式会社 | 合成床板におけるデツキプレ−トと梁との接合用金具 |
| AT403873B (de) * | 1992-02-21 | 1998-06-25 | Neufeld Klaus Dr | Tierfutter zur leistungssteigerung |
| US7404967B2 (en) | 1994-12-21 | 2008-07-29 | Cosmederm, Inc. | Topical product formulations containing strontium for reducing skin irritation |
| CA2208078C (en) * | 1994-12-21 | 2009-06-23 | Cosmederm Technologies | Formulations and methods for reducing skin irritation |
| IL140095A (en) * | 1998-06-09 | 2005-11-20 | Embro William J | Composition for the treatment of epidermal irritations and infections |
| AT500455B1 (de) * | 2000-09-15 | 2007-08-15 | Roth Hermann Dr | Verwendung von benzophenanthridinalkaloiden als futteradditiv |
| JP5677936B2 (ja) * | 2008-04-24 | 2015-02-25 | インデナ エッセ ピ ア | 慢性炎症を有する膣感染治療の組成物 |
| CN110934870A (zh) * | 2019-12-20 | 2020-03-31 | 陕西科技大学 | 血根碱在抑制多重耐药雷氏普罗威登斯菌生长中的应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4145412A (en) * | 1977-02-14 | 1979-03-20 | Vipont Chemical Company | Composition for application to oral cavity and method for preparation thereof |
| US4335110A (en) * | 1979-08-23 | 1982-06-15 | Orewa Inc. | Pharmaceutical compositions of sanguinaria galangal and zinc chloride |
-
1981
- 1981-05-05 AU AU70156/81A patent/AU548560B2/en not_active Ceased
- 1981-05-14 NL NL8102369A patent/NL8102369A/nl not_active Application Discontinuation
- 1981-05-18 DE DE19813119746 patent/DE3119746A1/de active Granted
- 1981-05-18 GB GB8115186A patent/GB2078109B/en not_active Expired
- 1981-05-19 CA CA000377816A patent/CA1177407A/en not_active Expired
- 1981-05-19 FR FR8110379A patent/FR2482860B1/fr not_active Expired
- 1981-05-19 SE SE8103152A patent/SE8103152L/ not_active Application Discontinuation
- 1981-05-20 JP JP56076408A patent/JPH0686380B2/ja not_active Expired - Lifetime
- 1981-05-20 IT IT21849/81A patent/IT1136620B/it active
- 1981-05-20 CH CH327981A patent/CH645268A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0686380B2 (ja) | 1994-11-02 |
| GB2078109A (en) | 1982-01-06 |
| CA1177407A (en) | 1984-11-06 |
| AU548560B2 (en) | 1985-12-19 |
| IT8121849A0 (it) | 1981-05-20 |
| CH645268A5 (de) | 1984-09-28 |
| DE3119746A1 (de) | 1982-03-04 |
| IT1136620B (it) | 1986-09-03 |
| SE8103152L (sv) | 1981-11-21 |
| FR2482860B1 (fr) | 1987-04-17 |
| AU7015681A (en) | 1981-11-26 |
| FR2482860A1 (fr) | 1981-11-27 |
| JPS5756428A (en) | 1982-04-05 |
| GB2078109B (en) | 1984-03-07 |
| DE3119746C2 (de) | 1991-09-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4406881A (en) | Antimicrobial agent | |
| US4599228A (en) | Antimicrobial agent | |
| DE69033994T2 (de) | Flüssige Polymerzusammensetzung und Verfahren zu ihrer Verwendung | |
| US12059466B2 (en) | Hypertonic antimicrobial therapeutic compositions | |
| US7115252B2 (en) | Therapeutic compositions and methods of use thereof | |
| DE69430903T2 (de) | Behandlung von periodontitis mit misoprostol | |
| NL8102369A (nl) | Preparaat van een antimicrobisch middel en werkwijze ter bereiding daarvan. | |
| US8303938B2 (en) | Anti-calculus dental composition | |
| US20120189710A1 (en) | Antibacterial compositions | |
| DE2709121C2 (de) | ||
| EP1115385B1 (de) | Verwendung einer zusammensetzung zur herstellung eines arzneimittels zur vorbeugung und behandlung von parodontitis | |
| Wilson et al. | Effect of phenoxyethanol, chlorhexidine and their combination on subgingival plaque bacteria | |
| US20070020200A1 (en) | Therapeutic compositions and methods of use thereof | |
| DE68914451T2 (de) | Mundversorgungsmittel. | |
| BE888843A (fr) | Procede de preparation d'un agent antimicrobien, composition antimicrobienne, medicament comprenant cette composition | |
| CA3225800A1 (en) | Oral pharmaceutical composition for preventing and/or treating diseases of the soft and hard tissues surrounding the tooth in the oral cavity | |
| JPS62273910A (ja) | 口腔用組成物 | |
| EP2470175B1 (de) | Fulvinsäurezusammensetzungen und ihre verwendung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A85 | Still pending on 85-01-01 | ||
| BA | A request for search or an international-type search has been filed | ||
| BB | A search report has been drawn up | ||
| BC | A request for examination has been filed | ||
| BV | The patent application has lapsed |