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NL192986C - Werkwijze voor het bereiden van 1,4-dihydro-4-oxo-naftyridinederivaten. - Google Patents

Werkwijze voor het bereiden van 1,4-dihydro-4-oxo-naftyridinederivaten. Download PDF

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Publication number
NL192986C
NL192986C NL8600138A NL8600138A NL192986C NL 192986 C NL192986 C NL 192986C NL 8600138 A NL8600138 A NL 8600138A NL 8600138 A NL8600138 A NL 8600138A NL 192986 C NL192986 C NL 192986C
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NL
Netherlands
Prior art keywords
group
formula
compound
compounds
added
Prior art date
Application number
NL8600138A
Other languages
English (en)
Dutch (nl)
Other versions
NL8600138A (nl
NL192986B (nl
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP60009191A external-priority patent/JPH0629247B2/ja
Priority claimed from JP60028397A external-priority patent/JPH0629246B2/ja
Priority claimed from JP60043644A external-priority patent/JPH0665670B2/ja
Priority claimed from JP60069061A external-priority patent/JPH0665671B2/ja
Priority claimed from JP60097065A external-priority patent/JPH0662619B2/ja
Priority claimed from JP60129323A external-priority patent/JPH0665672B2/ja
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of NL8600138A publication Critical patent/NL8600138A/xx
Priority to NL9700011A priority Critical patent/NL193540C/nl
Publication of NL192986B publication Critical patent/NL192986B/xx
Application granted granted Critical
Publication of NL192986C publication Critical patent/NL192986C/nl

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/74Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79Acids; Esters
    • C07D213/80Acids; Esters in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
NL8600138A 1985-01-23 1986-01-22 Werkwijze voor het bereiden van 1,4-dihydro-4-oxo-naftyridinederivaten. NL192986C (nl)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL9700011A NL193540C (nl) 1985-01-23 1997-11-06 Werkwijze voor het bereiden van nicotinezuurderivaten.

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
JP60009191A JPH0629247B2 (ja) 1985-01-23 1985-01-23 5−フルオロニコチン酸誘導体およびその塩
JP919185 1985-01-23
JP60028397A JPH0629246B2 (ja) 1985-02-18 1985-02-18 2−(5−フルオロニコチノイル)酢酸誘導体およびその塩
JP2839785 1985-02-18
JP4364485 1985-03-07
JP60043644A JPH0665670B2 (ja) 1985-03-07 1985-03-07 1,4−ジヒドロ−4−オキソナフチリジン誘導体およびその塩
JP60069061A JPH0665671B2 (ja) 1985-04-03 1985-04-03 1−置換アリ−ル−1,4−ジヒドロ−4−オキソナフチリジン誘導体またはその塩の新規製造法
JP6906185 1985-04-03
JP9706585 1985-05-08
JP60097065A JPH0662619B2 (ja) 1985-05-08 1985-05-08 1,4−ジヒドロ−4−オキソナフチリジン誘導体またはその塩の新規製造法
JP12932385 1985-06-14
JP60129323A JPH0665672B2 (ja) 1985-06-14 1985-06-14 1,4−ジヒドロ−4−オキソナフチリジン誘導体またはその塩の新規製造法

Publications (3)

Publication Number Publication Date
NL8600138A NL8600138A (nl) 1986-08-18
NL192986B NL192986B (nl) 1998-03-02
NL192986C true NL192986C (nl) 1998-07-03

Family

ID=27548185

Family Applications (1)

Application Number Title Priority Date Filing Date
NL8600138A NL192986C (nl) 1985-01-23 1986-01-22 Werkwijze voor het bereiden van 1,4-dihydro-4-oxo-naftyridinederivaten.

Country Status (20)

Country Link
US (1) US4704459A (it)
KR (1) KR880001078B1 (it)
AT (1) AT392789B (it)
BE (1) BE904086A (it)
CA (2) CA1340706C (it)
CH (2) CH671957A5 (it)
DE (2) DE3601517A1 (it)
DK (3) DK169570B1 (it)
FI (2) FI83313C (it)
FR (1) FR2576305B1 (it)
GB (2) GB2170804B (it)
IL (1) IL77688A (it)
IT (1) IT1190193B (it)
LU (1) LU86264A1 (it)
NL (1) NL192986C (it)
NO (1) NO163227C (it)
NZ (1) NZ214901A (it)
PH (2) PH22956A (it)
PT (1) PT81889B (it)
SE (3) SE462164B (it)

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US4920120A (en) 1988-01-25 1990-04-24 Warner-Lambert Company Antibacterial agents
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DE3934082A1 (de) * 1989-10-12 1991-04-18 Bayer Ag Chinoloncarbonsaeurederivate, verfahren zu ihrer herstellung sowie ihre verwendung als antivirale mittel
EP0449445A3 (en) * 1990-03-27 1993-08-25 Pfizer Inc. Preparation of beta-ketoesters useful in preparing quinolone antibiotics
EP0571400A1 (en) * 1991-01-14 1993-12-01 Hanmi Pharmaceutical Co.,Ltd. Novel quinolone compounds and processes for preparation thereof
US5532239A (en) * 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
CN1041202C (zh) * 1993-08-13 1998-12-16 同和药品工业株式会社 一种具有药物活性的喹诺酮羧酸衍生物
WO1996002275A1 (fr) * 1994-07-20 1996-02-01 Toyama Chemical Co., Ltd. Onguent buccal a liberation prolongee
US6313299B1 (en) 1997-06-26 2001-11-06 Dong Wha Pharmaceutical Industrial Co., Ltd. Quinolone carboxylic acid derivatives
CA2353557A1 (en) 1998-12-04 2000-06-08 Influx, Inc. Inhibitors of multidrug transporters
TWI258471B (en) 1999-09-16 2006-07-21 Tanabe Seiyaku Co Aromatic nitrogen-containing 6-membered cyclic compounds and pharmaceutical composition having phosphodiesterase V inhibitory activity
MXPA02010693A (es) * 2000-04-28 2003-03-10 Tanabe Seiyaku Co Compuestos ciclicos.
US7273868B2 (en) * 2000-04-28 2007-09-25 Tanabe Seiyaku Co., Ltd. Pyrazine derivatives
US20080027037A1 (en) * 2000-04-28 2008-01-31 Tanabe Seiyaku Co., Ltd. Cyclic compounds
EP1364950A4 (en) * 2001-02-26 2005-03-09 Tanabe Seiyaku Co PYRIDOPYRIMIDINE OR NAPHTHYRIDINE DERIVATIVE
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US7732616B2 (en) * 2003-11-19 2010-06-08 Array Biopharma Inc. Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
US7517994B2 (en) * 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
CN1905873A (zh) * 2003-11-19 2007-01-31 阵列生物制药公司 Mek的杂环抑制剂及其使用方法
DE102005055385A1 (de) * 2004-12-09 2006-06-14 Bayer Healthcare Ag Arzneimittel zur hygienischen Applikation im Ohr
EP2364973B1 (en) * 2005-05-18 2014-07-09 Array Biopharma, Inc. Heterocyclic inhibitors of mek and methods of use thereof
US20070197548A1 (en) * 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions
US20070196398A1 (en) * 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone fatty acid salt compositions
US7973022B2 (en) * 2006-02-17 2011-07-05 Idexx Laboratories, Inc. Fluoroquinolone carboxylic acid salt compositions
DE102006010643A1 (de) 2006-03-08 2007-09-13 Bayer Healthcare Aktiengesellschaft Arzneimittel enthaltend Fluorchinolone
DE102006010642A1 (de) * 2006-03-08 2007-09-27 Bayer Healthcare Aktiengesellschaft Arzneimittelformulierungen, enthaltend Fluorchinolone
WO2007123939A2 (en) * 2006-04-19 2007-11-01 Laboratoires Serono S.A. Novel arylamino n-heteraryls as mek inhibitors
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MD4291C1 (ro) * 2013-12-27 2015-02-28 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Preparat medicamentos pentru tratamentul otitelor
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US4350817A (en) * 1980-02-28 1982-09-21 American Home Products Corporation 4-Cl, Br or I-3-Carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives
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JPS60228479A (ja) * 1984-04-26 1985-11-13 Toyama Chem Co Ltd 1,4−ジヒドロ−4−オキソナフチリジン誘導体およびその塩

Also Published As

Publication number Publication date
SE8902264L (sv) 1989-06-21
NZ214901A (en) 1989-01-27
PT81889A (en) 1986-02-01
DE3601517A1 (de) 1986-08-21
DK285290A (da) 1990-11-30
FI860250A0 (fi) 1986-01-20
DK285290D0 (da) 1990-11-30
FI83313C (fi) 1991-06-25
SE469984B (sv) 1993-10-18
SE8902265D0 (sv) 1989-06-21
GB2170804A (en) 1986-08-13
SE8902264D0 (sv) 1989-06-21
ATA7286A (de) 1990-11-15
DK285190A (da) 1990-11-30
DK169570B1 (da) 1994-12-05
IL77688A (en) 1991-01-31
CA1340706C (en) 1999-08-17
DE3637679C1 (de) 1992-08-27
FR2576305A1 (fr) 1986-07-25
US4704459A (en) 1987-11-03
DK32286D0 (da) 1986-01-22
NO163227B (no) 1990-01-15
GB8811645D0 (en) 1988-06-22
BE904086A (fr) 1986-07-22
AT392789B (de) 1991-06-10
SE8600274D0 (sv) 1986-01-22
FI893075A0 (fi) 1989-06-22
FR2576305B1 (fr) 1991-04-19
SE462164B (sv) 1990-05-14
CH671957A5 (it) 1989-10-13
IT1190193B (it) 1988-02-16
NO860226L (no) 1986-07-24
NO163227C (no) 1990-04-25
KR880001078B1 (ko) 1988-06-22
SE8902265L (sv) 1989-06-21
SE469983B (sv) 1993-10-18
CA1340783C (en) 1999-10-12
DK170857B1 (da) 1996-02-12
DK32286A (da) 1986-07-24
FI893075A (fi) 1989-06-22
DK285190D0 (da) 1990-11-30
PH22956A (en) 1989-02-03
CH667456A5 (de) 1988-10-14
FI83313B (fi) 1991-03-15
GB2204040B (en) 1989-09-20
GB2170804B (en) 1989-09-20
FI860250A (fi) 1986-07-24
IT8647562A0 (it) 1986-01-22
GB2204040A (en) 1988-11-02
DE3601517C2 (it) 1989-11-16
PT81889B (pt) 1988-05-27
SE8600274L (sv) 1986-09-10
LU86264A1 (fr) 1986-08-04
FI87647C (fi) 1993-02-10
NL8600138A (nl) 1986-08-18
FI87647B (fi) 1992-10-30
GB8601045D0 (en) 1986-02-19
NL192986B (nl) 1998-03-02
PH23202A (en) 1989-06-06
DK170532B1 (da) 1995-10-16
KR860005817A (ko) 1986-08-13

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Free format text: IN THE PAMPHLET OF PATENT 192986, ISSUED 01.09.98, SHOULD THE FOLLOWING ALTERATIONS BE MADE IN PAGE37; IN LINE 8 SHOULD THE WORD "DIALOXIFOSFONYLOXI" BE MODIFIED INTO: DIALKOXIFOSFONYLOXI AND IN LINE 33 SHOULD THE WORD "N,N-DISGESUBSTITUEERD" BE MODIFIED INTO: N,N-DIGESUBSTITUEERD.

BK Erratum

Free format text: IN THE PAMPHLET OF PATENT 192986, ISSUED 01.09.98, SHOULD THE FOLLOWING ALTERATION BE MADE IN PAGE 37; IN LINE 8 SHOULD THE WORD "DIALKOXIFOSFONYLOXI" BE MODIFIED INTO: DIALKOXIFOSFINYLOXI.

V4 Discontinued because of reaching the maximum lifetime of a patent

Effective date: 20060122