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MXPA02012660A - 1,3-(fenilo-substituido-bis)-2-propen-1-onas y su uso para el tratamiento de padecimientos transmitidos por el vcam-1. - Google Patents

1,3-(fenilo-substituido-bis)-2-propen-1-onas y su uso para el tratamiento de padecimientos transmitidos por el vcam-1.

Info

Publication number
MXPA02012660A
MXPA02012660A MXPA02012660A MXPA02012660A MXPA02012660A MX PA02012660 A MXPA02012660 A MX PA02012660A MX PA02012660 A MXPA02012660 A MX PA02012660A MX PA02012660 A MXPA02012660 A MX PA02012660A MX PA02012660 A MXPA02012660 A MX PA02012660A
Authority
MX
Mexico
Prior art keywords
vcam
propen
bis
ones
phenyl
Prior art date
Application number
MXPA02012660A
Other languages
English (en)
Inventor
James A Sikorski
Original Assignee
Atherogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Atherogenics Inc filed Critical Atherogenics Inc
Publication of MXPA02012660A publication Critical patent/MXPA02012660A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/794—Ketones containing a keto group bound to a six-membered aromatic ring having unsaturation outside an aromatic ring
    • C07C49/796—Ketones containing a keto group bound to a six-membered aromatic ring having unsaturation outside an aromatic ring polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
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    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
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    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
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    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants

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  • Chemical & Material Sciences (AREA)
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  • Urology & Nephrology (AREA)
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Abstract

Se ha descubierto que ciertas 1,3-bis-(fenilo-substituidas)-2-propen-1-onas, que incluyen compuestos de la formula (I) inhiben la expresion del VCAM-1, y por lo tanto, pueden ser usadas para tratar a un paciente con un padecimiento transmitido por el VCAM-1. Los ejemplos de las enfermedades inflamatorias que son transmitidas por el VCAM-1, incluyen, pero no estan limitadas a, artritis, asma, dermatitis, fibrosis quistica, rechazo de organos solidos cronico y tardio posterior al trasplante, esclerosis multiple, lupus eritematoso sistemico, enfermedades inflamatorias del intestino, diabetes autoinmune, retinopatia diabetica, rinitis, lesion por reperfusion isquemica, restenosis posterior a la angioplastia, enfermedad obstruyente pulmonar cronica (COPD), glomerulonefritis, enfermedad de Graves, alergias gastrointestinales, conjuntivitis, aterosclerosis, enfermedad de la arteria coronaria, angina y enfermedad de arterias pequenas.
MXPA02012660A 2000-06-20 2001-06-20 1,3-(fenilo-substituido-bis)-2-propen-1-onas y su uso para el tratamiento de padecimientos transmitidos por el vcam-1. MXPA02012660A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21276900P 2000-06-20 2000-06-20
US25593400P 2000-12-15 2000-12-15
PCT/US2001/019720 WO2001098291A2 (en) 2000-06-20 2001-06-20 1,3-bis-(substituted-phenyl)-2-propen-1-ones and their use to treat vcam-1 mediated disorders

Publications (1)

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MXPA02012660A true MXPA02012660A (es) 2004-05-14

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MXPA02012660A MXPA02012660A (es) 2000-06-20 2001-06-20 1,3-(fenilo-substituido-bis)-2-propen-1-onas y su uso para el tratamiento de padecimientos transmitidos por el vcam-1.

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US (2) US6608101B1 (es)
EP (1) EP1330448A2 (es)
JP (1) JP2004501147A (es)
KR (1) KR20030031500A (es)
CN (1) CN1447804A (es)
AU (1) AU6861001A (es)
BR (1) BR0111889A (es)
CA (1) CA2413878A1 (es)
IL (1) IL153565A0 (es)
MX (1) MXPA02012660A (es)
NZ (1) NZ523443A (es)
WO (1) WO2001098291A2 (es)
ZA (1) ZA200300134B (es)

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WO2003013548A1 (fr) * 2001-08-09 2003-02-20 Sekisui Chemical Co., Ltd. Composition medicale a usage externe destinee au traitement des dermatoses
EP1465854A4 (en) * 2001-12-19 2005-06-08 Atherogenics Inc CHALCONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASES
FR2841900B1 (fr) 2002-07-08 2007-03-02 Genfit S A Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations
FR2841784B1 (fr) 2002-07-08 2007-03-02 Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations
DE10239531A1 (de) * 2002-08-23 2004-03-04 Gulbins, Erich, Prof. Dr. Prophylaxe und Therapie von Infektionserkrankungen
US20040181075A1 (en) * 2002-12-19 2004-09-16 Weingarten M. David Process of making chalcone derivatives
AU2004232858B2 (en) 2003-04-23 2009-07-09 Mannkind Corporation Hydraulically actuated pump for long duration medicament administration
US20070092551A1 (en) * 2003-05-02 2007-04-26 Takara Bio Inc. Therapeutic agent
US7173129B2 (en) * 2003-06-06 2007-02-06 Athero Genics, Inc. Sulfonamide-substituted chalcone derivatives and their use to treat diseases
EP2289504A3 (en) 2003-07-01 2012-05-23 President and Fellows of Harvard College SIRT1 modulators for manipulating cell/organism lifespan/stress response
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