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MX9704880A - Derivados de quinuclidina novedosos y composicion medicinal de los mismos. - Google Patents

Derivados de quinuclidina novedosos y composicion medicinal de los mismos.

Info

Publication number
MX9704880A
MX9704880A MX9704880A MX9704880A MX9704880A MX 9704880 A MX9704880 A MX 9704880A MX 9704880 A MX9704880 A MX 9704880A MX 9704880 A MX9704880 A MX 9704880A MX 9704880 A MX9704880 A MX 9704880A
Authority
MX
Mexico
Prior art keywords
amino
carbamoyl
mono
lower alkyl
diseases
Prior art date
Application number
MX9704880A
Other languages
English (en)
Inventor
Makoto Takeuchi
Ryo Naito
Masahiko Hayakawa
Yoshinori Okamoto
Yasuhiro Yonetoku
Ken Ikeda
Yasuo Isomura
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18194699&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9704880(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Publication of MX9704880A publication Critical patent/MX9704880A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K19/00—Liquid crystal materials
    • C09K19/04—Liquid crystal materials characterised by the chemical structure of the liquid crystal components, e.g. by a specific unit
    • C09K19/06—Non-steroidal liquid crystal compounds
    • C09K19/34—Non-steroidal liquid crystal compounds containing at least one heterocyclic ring
    • C09K19/3441—Non-steroidal liquid crystal compounds containing at least one heterocyclic ring having nitrogen as hetero atom
    • C09K19/3444—Non-steroidal liquid crystal compounds containing at least one heterocyclic ring having nitrogen as hetero atom the heterocyclic ring being a six-membered aromatic ring containing one nitrogen atom, e.g. pyridine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • External Artificial Organs (AREA)
  • Tea And Coffee (AREA)

Abstract

Derivados de quinuclidina representados por la formula general (I), sales, N-oxidos, o sales de amonio cuaternario de los mismos, y composiciones medicinales que contienen los mismos, en donde el anillo A representa aril opcionalmente sustituido, cicloalquilo, cicloalquenilo, heteroarilo que contiene de 1 a 4 heteroátomos seleccionados a partir de oxígeno, nitrogeno, y azufre, o heterociclo saturado de 5 a 7 miembros; X representa un enlace sencillo o metileno; R representa halogeno, hidroxilo, sulfinilo, alquilo inferior-sulfinilo, sulfonamido, alcano inferior-sulfonamido, carbamoílo, tiocarbamoílo, mono-o di-(alquilo inferior) carba-moílo, nitro, ciano, amino, mono- o di-(alquilo inferior) amino, metilendioxi, etilendioxi, o alquilo inferior opcionalmente sustituido por halogeno, hidroxilo, alcoxi inferior, amino, o mono- o di-(alquilo inferior)amino; l es 0 o 1; m es un entero de 1 a 3; y n es un entero de 1 o 2. El compuesto tiene un efecto antagonista sobre los receptores muscarínicos M3, y es util para prevenir o remediar enfermedades urologicas, enfermedades respiratorias, o enfermedades digestivas.
MX9704880A 1994-12-28 1995-12-27 Derivados de quinuclidina novedosos y composicion medicinal de los mismos. MX9704880A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP32704594 1994-12-28
PCT/JP1995/002713 WO1996020194A1 (fr) 1994-12-28 1995-12-27 Nouveaux derives de quinuclidine et composition pharmaceutique les contenant

Publications (1)

Publication Number Publication Date
MX9704880A true MX9704880A (es) 1997-10-31

Family

ID=18194699

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9704880A MX9704880A (es) 1994-12-28 1995-12-27 Derivados de quinuclidina novedosos y composicion medicinal de los mismos.

Country Status (24)

Country Link
US (2) US6017927A (es)
EP (1) EP0801067B1 (es)
JP (1) JP3014457B2 (es)
KR (1) KR100386487B1 (es)
CN (1) CN1045601C (es)
AT (1) ATE233761T1 (es)
AU (1) AU695616B2 (es)
CA (1) CA2208839C (es)
DE (2) DE69529844T2 (es)
DK (1) DK0801067T3 (es)
ES (1) ES2193208T3 (es)
FI (1) FI115631B (es)
FR (1) FR04C0032I2 (es)
HU (1) HU223778B1 (es)
LU (1) LU91133I9 (es)
MX (1) MX9704880A (es)
NL (1) NL300141I1 (es)
NO (4) NO2005012I1 (es)
NZ (1) NZ298144A (es)
PL (1) PL182344B1 (es)
PT (1) PT801067E (es)
RU (1) RU2143432C1 (es)
TW (1) TW305842B (es)
WO (1) WO1996020194A1 (es)

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NO2005016I1 (no) 2005-08-29
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RU2143432C1 (ru) 1999-12-27
DE122004000048I1 (de) 2005-04-21
AU4355396A (en) 1996-07-19
NO318026B1 (no) 2005-01-24
KR100386487B1 (ko) 2003-09-26
WO1996020194A1 (fr) 1996-07-04
DK0801067T3 (da) 2003-06-30
DE122004000048I2 (de) 2006-02-02
JPH09508401A (ja) 1997-08-26
PL182344B1 (pl) 2001-12-31
NO973027L (no) 1997-08-28
KR987000303A (ko) 1998-03-30
NO973027D0 (no) 1997-06-27
EP0801067A1 (en) 1997-10-15
NO2017055I2 (no) 2017-11-06
ES2193208T3 (es) 2003-11-01
EP0801067B1 (en) 2003-03-05
LU91133I9 (en) 2018-08-01
AU695616B2 (en) 1998-08-20
EP0801067A4 (en) 1998-03-11
NZ298144A (en) 1998-04-27
ATE233761T1 (de) 2003-03-15
LU91133I2 (fr) 2005-03-29
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US6017927A (en) 2000-01-25
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