[go: up one dir, main page]

MX9203803A - Proceso novedoso para la preparacion de microparticulas de lipido. - Google Patents

Proceso novedoso para la preparacion de microparticulas de lipido.

Info

Publication number
MX9203803A
MX9203803A MX9203803A MX9203803A MX9203803A MX 9203803 A MX9203803 A MX 9203803A MX 9203803 A MX9203803 A MX 9203803A MX 9203803 A MX9203803 A MX 9203803A MX 9203803 A MX9203803 A MX 9203803A
Authority
MX
Mexico
Prior art keywords
microparticles
phospholipid
substance
preparation
aqueous solution
Prior art date
Application number
MX9203803A
Other languages
English (en)
Inventor
Brigitte Leclef
Patrick Cerfontaine
Jean-Marie Nicolas
Henri Wainter
Andre Trouet
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9385466&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9203803(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Publication of MX9203803A publication Critical patent/MX9203803A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
MX9203803A 1989-09-14 1992-06-29 Proceso novedoso para la preparacion de microparticulas de lipido. MX9203803A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8912038A FR2651680B1 (fr) 1989-09-14 1989-09-14 Nouveau procede de preparation de microparticules lipidiques.

Publications (1)

Publication Number Publication Date
MX9203803A true MX9203803A (es) 1992-08-01

Family

ID=9385466

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9203803A MX9203803A (es) 1989-09-14 1992-06-29 Proceso novedoso para la preparacion de microparticulas de lipido.

Country Status (11)

Country Link
US (1) US5100591A (es)
EP (1) EP0418153B2 (es)
JP (1) JP2831455B2 (es)
AT (1) ATE93385T1 (es)
CA (1) CA2025298C (es)
DE (1) DE69002905T2 (es)
DK (1) DK0418153T4 (es)
ES (1) ES2060107T5 (es)
FR (1) FR2651680B1 (es)
GR (1) GR3020068T3 (es)
MX (1) MX9203803A (es)

Families Citing this family (137)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6406713B1 (en) 1987-03-05 2002-06-18 The Liposome Company, Inc. Methods of preparing low-toxicity drug-lipid complexes
US5091188A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
EP0556392A4 (en) * 1990-11-06 1994-03-17 Nippon Shinyaku Co Ltd PROCESS FOR PRODUCING A FATTY EMULSION.
JP2653246B2 (ja) * 1990-11-06 1997-09-17 日本新薬株式会社 脂肪乳剤の製法
US5534502A (en) * 1990-11-06 1996-07-09 Nippon Shinyaku Co. Ltd. Process for producing fat emulsion
DE4131562A1 (de) * 1991-09-18 1993-03-25 Medac Klinische Spezialpraep Arzneistofftraeger aus festen lipidteilchen-feste lipidnanosphaeren (sln)
US5319116A (en) * 1992-02-12 1994-06-07 Gary Viole Lecithin fractions and dilutions, methods for their preparation and pharmacological uses thereof
US5336507A (en) * 1992-12-11 1994-08-09 Sterling Winthrop Inc. Use of charged phospholipids to reduce nanoparticle aggregation
DE4244466C2 (de) * 1992-12-24 1995-02-23 Pharmatech Gmbh Verfahren zur Herstellung von Pseudolatices und Mikro- oder Nanopartikeln und deren Verwendung zur Herstellung von pharmazeutischen Präparaten
US5393527A (en) * 1993-01-04 1995-02-28 Becton, Dickinson And Company Stabilized microspheres and methods of preparation
ES2219646T5 (es) * 1993-02-22 2008-11-01 Abraxis Bioscience, Inc. Metodos para la administracion in vivo de compuestos biologicos y composiciones utiles para los mismos.
US5439686A (en) * 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US5916596A (en) * 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US6528067B1 (en) 1993-02-22 2003-03-04 American Bioscience, Inc. Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof
US5665382A (en) * 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of pharmaceutically active agents for in vivo delivery
US5650156A (en) * 1993-02-22 1997-07-22 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of nutriceuticals and compositions useful therefor
US6753006B1 (en) 1993-02-22 2004-06-22 American Bioscience, Inc. Paclitaxel-containing formulations
US5997904A (en) * 1993-02-22 1999-12-07 American Bioscience, Inc. Total nutrient admixtures as stable multicomponent liquids or dry powders and methods for the preparation thereof
US5919466A (en) * 1993-10-01 1999-07-06 Gerbu Biotechnik Gmbh Method for improving the yield of immunoantibodies in the vaccination of animals and humans
US5716526A (en) * 1994-01-14 1998-02-10 The Liposome Company, Inc. Method of separating materials from liposomes or lipid complexes
EP0855906B1 (en) 1995-10-17 2008-02-20 Jagotec AG Insoluble drug delivery
US6465016B2 (en) 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
US7255877B2 (en) 1996-08-22 2007-08-14 Jagotec Ag Fenofibrate microparticles
US20060165606A1 (en) * 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6565885B1 (en) * 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
ES2384094T3 (es) * 1997-11-14 2012-06-29 Pacira Pharmaceuticals, Inc. Producción de liposomas multivesiculares
IL136342A0 (en) * 1997-12-01 2001-05-20 Yissum Res Dev Co Formulation for topical treatment of skin infections
AU762246B2 (en) * 1998-02-11 2003-06-19 Rtp Pharma Corporation Method and composition for treatment of inflammatory conditions
US6979456B1 (en) 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
HK1039458B (zh) 1998-05-29 2006-09-01 Skyepharma Canada Inc. 熱保護微粒組合物及其最終蒸汽滅菌的方法
HK1040195B (zh) 1998-08-19 2006-06-02 Skyepharma Canada Inc. 普鲁泊福的可注射水分散体
WO2000030615A1 (en) * 1998-11-20 2000-06-02 Rtp Pharma Inc. Method of preparing stable suspensions of insoluble microparticles
AU767154B2 (en) 1998-11-20 2003-10-30 Skyepharma Canada Inc. Dispersible phospholipid stabilized microparticles
WO2000047187A1 (en) * 1999-02-11 2000-08-17 Kinetana Inc. Serum albumin-based parenteral formulations of polyene macrolides
EP1074248A1 (en) * 1999-07-08 2001-02-07 Arnold Hilgers Delivery system for biological material
CN1174741C (zh) * 1999-09-21 2004-11-10 Rtp药品公司 生物活性物质的表面改性微粒组合物
EP1276465B1 (en) 2000-04-20 2014-03-12 Jagotec AG Improved water-insoluble drug particle process
US8404217B2 (en) * 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
EP1280520B2 (en) 2000-05-10 2018-03-21 Novartis AG Phospholipid-based powders for drug delivery
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
US6634576B2 (en) 2000-08-31 2003-10-21 Rtp Pharma Inc. Milled particles
ES2372746T3 (es) * 2000-09-20 2012-01-26 Jagotec Ag Micropartículas de fibrato estabilizadas.
US8586094B2 (en) * 2000-09-20 2013-11-19 Jagotec Ag Coated tablets
WO2002028367A1 (fr) * 2000-10-04 2002-04-11 Kyowa Hakko Kogyo Co., Ltd. Procede de revetement de particules fines avec un film de lipides
JP2004517127A (ja) 2000-12-21 2004-06-10 ネクター セラピューティックス ポリエン抗真菌剤の肺送達
US6977085B2 (en) * 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US6884436B2 (en) * 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US7193084B2 (en) * 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US8067032B2 (en) * 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US20040022862A1 (en) * 2000-12-22 2004-02-05 Kipp James E. Method for preparing small particles
US20050048126A1 (en) * 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
US6869617B2 (en) * 2000-12-22 2005-03-22 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US6951656B2 (en) * 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US20040256749A1 (en) * 2000-12-22 2004-12-23 Mahesh Chaubal Process for production of essentially solvent-free small particles
US20030096013A1 (en) * 2000-12-22 2003-05-22 Jane Werling Preparation of submicron sized particles with polymorph control
US9700866B2 (en) * 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US20030072807A1 (en) * 2000-12-22 2003-04-17 Wong Joseph Chung-Tak Solid particulate antifungal compositions for pharmaceutical use
AU2001259099B2 (en) * 2001-02-22 2005-12-22 Skyepharma Canada Inc. Fibrate-statin combinations with reduced fed-fasted effects
IN188924B (es) * 2001-03-01 2002-11-23 Bharat Serums & Vaccines Ltd
WO2003013472A1 (en) 2001-08-06 2003-02-20 Astrazeneca Ab Aqueous dispersion comprising stable nanoparticles of a water-insoluble active and an excipient like middle chain triglycerides (mct)
US20030054042A1 (en) * 2001-09-14 2003-03-20 Elaine Liversidge Stabilization of chemical compounds using nanoparticulate formulations
US20060003012A9 (en) * 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
JP2005504090A (ja) * 2001-09-26 2005-02-10 バクスター・インターナショナル・インコーポレイテッド 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製
US8663687B2 (en) * 2001-10-12 2014-03-04 Monosol Rx, Llc Film compositions for delivery of actives
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US20190328679A1 (en) 2001-10-12 2019-10-31 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
US11207805B2 (en) 2001-10-12 2021-12-28 Aquestive Therapeutics, Inc. Process for manufacturing a resulting pharmaceutical film
US20070281003A1 (en) 2001-10-12 2007-12-06 Fuisz Richard C Polymer-Based Films and Drug Delivery Systems Made Therefrom
US7112340B2 (en) * 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
DE60132094T3 (de) * 2001-10-26 2012-02-02 Octoplus Polyactive Sciences B.V. Verfahren zur Herstellung von gereinigten Partikeln
WO2003072118A1 (de) 2002-02-28 2003-09-04 Gerold Lukowski Mikro-/nanopartikel aus lipidhaltigen marinen organismen für pharmazie und kosmetik
US20050152980A1 (en) 2002-03-13 2005-07-14 Michael Ausborn Pharmeutical microparticles
CA2479665C (en) * 2002-03-20 2011-08-30 Elan Pharma International Ltd. Nanoparticulate compositions of angiogenesis inhibitors
US20080220075A1 (en) * 2002-03-20 2008-09-11 Elan Pharma International Ltd. Nanoparticulate compositions of angiogenesis inhibitors
GB0230088D0 (en) * 2002-12-24 2003-01-29 Astrazeneca Ab Therapeutic agents
GB0302671D0 (en) * 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
GB0302672D0 (en) * 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
GB0302673D0 (en) * 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
WO2004091572A2 (en) * 2003-04-09 2004-10-28 Biodelivery Sciences International, Inc. Cochleate compositions directed against expression of proteins
US20050013854A1 (en) * 2003-04-09 2005-01-20 Mannino Raphael J. Novel encochleation methods, cochleates and methods of use
CN1791386A (zh) * 2003-05-19 2006-06-21 巴克斯特国际公司 抗癫痫和抗痴呆药物以及免疫抑制剂的小－颗粒药物制剂
EP1641779A1 (en) * 2003-06-18 2006-04-05 AstraZeneca AB 2-substitued 5, 6-diaryl-pyrazine derivatives as cb1 modulator.
GB0314057D0 (en) * 2003-06-18 2003-07-23 Astrazeneca Ab Therapeutic agents
GB0314261D0 (en) * 2003-06-19 2003-07-23 Astrazeneca Ab Therapeutic agents
CA2540695A1 (en) * 2003-06-24 2004-12-29 Baxter International Inc. Specific delivery of drugs to the brain
US8986736B2 (en) * 2003-06-24 2015-03-24 Baxter International Inc. Method for delivering particulate drugs to tissues
CN1905905B (zh) 2003-09-22 2011-06-08 巴克斯特国际公司 用于药物制剂和医药产品最终灭菌的高压灭菌
RU2006130958A (ru) * 2004-01-29 2008-03-10 Бакстер Интернэшнл Инк. (Us) Наносуспензии антиретровирусных агентов для улучшенной доставки в центральную нервную систему
US20050196416A1 (en) * 2004-02-05 2005-09-08 Kipp James E. Dispersions prepared by use of self-stabilizing agents
EP1728550A4 (en) * 2004-03-23 2007-09-05 Kyowa Hakko Kogyo Kk Method for producing coated fine particles
AU2005255039A1 (en) * 2004-06-15 2005-12-29 Baxter Healthcare S.A. Ex-vivo application of solid microparticulate therapeutic agents
KR20070102686A (ko) * 2005-01-28 2007-10-19 교와 핫꼬 고교 가부시끼가이샤 피복 미립자의 제조 방법
US20060280787A1 (en) * 2005-06-14 2006-12-14 Baxter International Inc. Pharmaceutical formulation of the tubulin inhibitor indibulin for oral administration with improved pharmacokinetic properties, and process for the manufacture thereof
WO2006138202A2 (en) * 2005-06-14 2006-12-28 Baxter International Inc. Pharmaceutical formulations for minimizing drug-drug interactions
WO2007021228A1 (en) * 2005-08-12 2007-02-22 Astrazeneca Ab Process
BRPI0618661A2 (pt) * 2005-11-15 2011-09-06 Baxter Int composições de inibidores de lipoxigenase
WO2007092088A1 (en) * 2005-12-28 2007-08-16 Nektar Therapeutics Compositions comprising amphotericin b
JP5089887B2 (ja) * 2006-01-23 2012-12-05 日本精化株式会社 生理活性物質含有複合体
WO2008013785A2 (en) 2006-07-24 2008-01-31 Singh-Broemer And Company, Inc. Solid nanoparticle formulation of water insoluble pharmaceutical substances with reduced ostwald ripening
WO2008080047A2 (en) * 2006-12-23 2008-07-03 Baxter International Inc. Magnetic separation of fine particles from compositions
EP2109443A4 (en) * 2007-02-09 2012-08-22 Astrazeneca Ab METHOD FOR PRODUCING A STABLE DISPERSION FROM SOLID AMORPHIC SUBMICRON PARTICLES IN AN AQUEOUS MEDIUM
TW200848039A (en) * 2007-02-09 2008-12-16 Astrazeneca Ab Pharmaceutical compositions
JP2010526822A (ja) * 2007-05-07 2010-08-05 クエスター ファーマシューティカルズ，インク． ベンゾジアゼピン類の経鼻投与
US8530463B2 (en) * 2007-05-07 2013-09-10 Hale Biopharma Ventures Llc Multimodal particulate formulations
US8722736B2 (en) * 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
US20080293814A1 (en) * 2007-05-22 2008-11-27 Deepak Tiwari Concentrate esmolol
US8426467B2 (en) * 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
RU2496482C2 (ru) 2008-03-05 2013-10-27 Бакстер Интернэшнл Инк. Композиции и способы для доставки лекарственных средств
DK2271347T3 (en) 2008-03-28 2016-08-15 Hale Biopharma Ventures Llc Administration of benzodiazepine compositions
US8895546B2 (en) 2009-03-27 2014-11-25 Hale Biopharma Ventures, Llc Administration of benzodiazepine compositions
DE102008035442A1 (de) 2008-07-26 2010-01-28 Ernst-Moritz-Arndt-Universität Greifswald Zubereitungen aus Artemisia Annua, ihre Umwandlung in Mikro- und Nanopartikel und ihre Verwendung
US10952965B2 (en) * 2009-05-15 2021-03-23 Baxter International Inc. Compositions and methods for drug delivery
TWI540319B (zh) 2010-03-29 2016-07-01 中央研究院 以細胞質譜分析定量細胞所攝入之奈米/微米粒子
US9149959B2 (en) 2010-10-22 2015-10-06 Monosol Rx, Llc Manufacturing of small film strips
US10702604B2 (en) 2012-06-01 2020-07-07 Galderma Research & Development Lipid nanocapsules comprising a retinoid, nanodispersion and composition containing the same, process for preparing the same and use thereof in dermatology
EP3076944A1 (fr) * 2013-12-04 2016-10-12 Galderma Research & Development Microcapsules lipidiques comprenant de preference un actif lipophile et composition les contenant, leur procede de preparation et leur utilisation en dermatologie et en cosmetique
WO2016193588A1 (fr) * 2015-05-29 2016-12-08 Galderma Research & Development Compositions comprenant au moins un principe actif disperse et des microcapsules lipidiques
EP3452023A1 (en) 2016-05-05 2019-03-13 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
US12427121B2 (en) 2016-05-05 2025-09-30 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions
US12433850B2 (en) 2016-05-05 2025-10-07 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine and prodrug compositions
RU2657767C1 (ru) * 2017-08-07 2018-06-15 Александр Александрович Кролевец Способ получения нанокапсул стрептоцида в каппа-каррагинане
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12151024B2 (en) 2021-01-22 2024-11-26 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12285419B2 (en) 2021-10-14 2025-04-29 Pacira Pharmaceuticals, Inc. Bupivacaine multivesicular liposome formulations and uses thereof
US12465564B2 (en) 2021-10-25 2025-11-11 Aquestive Therapeutics, Inc. Oral and nasal compositions and methods of treatment
US12156940B1 (en) 2024-05-20 2024-12-03 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12280149B1 (en) 2024-05-20 2025-04-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12251472B1 (en) 2024-05-20 2025-03-18 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0158441B2 (en) * 1984-03-08 2001-04-04 Phares Pharmaceutical Research N.V. Liposome-forming composition
DE3515335C2 (de) * 1985-04-27 1995-01-26 Bayer Ag Arzneizubereitung enthaltend Dihydropyridine und Verfahren zu ihrer Herstellung
US4766046A (en) * 1985-09-27 1988-08-23 Liposome Technology, Inc. Stabilized liposome/amphotericin composition and method
CA1338736C (fr) * 1986-12-05 1996-11-26 Roger Baurain Microcristaux comportant une substance active presentant une affinite pour les phospholipides, et au moins un phospholipide, procede de preparation
US4839111A (en) * 1987-02-02 1989-06-13 The University Of Tennessee Research Corporation Preparation of solid core liposomes
US4950432A (en) * 1987-10-16 1990-08-21 Board Of Regents, The University Of Texas System Polyene microlide pre-liposomal powders
US5000887A (en) * 1988-05-17 1991-03-19 Liposome Technology, Inc. Preparation of uniform-size liposomes
US4994213A (en) * 1988-05-17 1991-02-19 Liposome Technology, Inc. Method of preparing lipid structures

Also Published As

Publication number Publication date
JP2831455B2 (ja) 1998-12-02
EP0418153A1 (fr) 1991-03-20
FR2651680A1 (fr) 1991-03-15
CA2025298C (fr) 2005-05-10
DK0418153T4 (da) 1996-08-12
EP0418153B2 (fr) 1996-03-27
EP0418153B1 (fr) 1993-08-25
CA2025298A1 (fr) 1991-03-15
ATE93385T1 (de) 1993-09-15
ES2060107T3 (es) 1994-11-16
DE69002905T2 (de) 1993-12-23
GR3020068T3 (en) 1996-08-31
JPH03169808A (ja) 1991-07-23
ES2060107T5 (es) 1996-06-16
DE69002905D1 (de) 1993-09-30
FR2651680B1 (fr) 1991-12-27
US5100591A (en) 1992-03-31

Similar Documents

Publication Publication Date Title
MX9203803A (es) Proceso novedoso para la preparacion de microparticulas de lipido.
Mongar et al. The effect of phospholipids on anaphylactic histamine release
DE3751258D1 (de) Mikrokristalle, die eine aktive Substanz mit phospholipidischer Affinität enthalten und mindestens ein Phospholipid, Verfahren zur Herstellung.
DE2430357C2 (de) Verfahren zur qualitativen oder quantitativen Feststellung von Immunoglobulin der IgG-Klasse
DE68927669D1 (de) Verfahren zur herstellung von in lösungsmitteln verdünnbaren mikroträgern
GR900100481A (el) Μέ?οδος παρακευής υδατικού αιωρήματος για ουσιαστικά αδιάλυτους στο νερό ενεργούς παράγοντες.
NO982364L (no) FremgangsmÕte for fremstilling av morfologisk anhetlige mikrokapsler, samt mikrokapsler fremstilt ved fremgangsmÕten
DK157730C (da) Fremgangsmaade til fremstilling af et farmaceutisk mikrokapselpraeparat og praeparat fremstillet ved fremgangsmaaden
DK0580817T3 (da) Farmaceutisk præparat og fremgangsmåde til fremstilling deraf
PL342473A1 (en) Method of obtaining a mixture of lipides and suspension of phopholipides containing such mixture
DE3367517D1 (en) Microcapsules with walls formed of a mixture of reticulated polyholosides and proteins, and process for producing them
BRPI0507742A (pt) processo de preparação de um isolado de proteìna de canola, e composição alimentìcia para aquacultura
Shapiro Limited proteolysis of some egg surface components is an early event following fertilization of the sea urchin, Strongylocentrotus purpuratus
ES2087151T3 (es) Preparacion de composiciones complejas de liposomas y lipidos.
DK0629128T3 (da) Vandig phospholipidvesikeldispersion, fremgangsmåde til fremstilling deraf samt anvendelse deraf
KR880012753A (ko) 활성적인 형태의 단백질 제조방법
ATE66684T1 (de) Verfahren zur herstellung einer polysaccharid-in- oel-dispersion und so hergestellte dispersion.
DE3110610A1 (de) Chemokinesine und chemotaxine der leukozyten und des entzuendungsgewebes: natuerliche mediatoren zur selektiven reversiblen motilitaetsbeinflussung (chemokinesis) und chemische anlockung (chemotaxis) bei der ansammlung von leukozyten
Kersken et al. The secretory contents of Paramecium tetraurelia trichocysts: ultrastructural--cytochemical characterization.
Simpkins et al. Studies on the characterization of the sodium—potassium transport adenosinetriphosphatase: XIII. On the organization and role of phospholipids in the purified enzyme
Dadosh et al. Impairment of red cell membrane cytoskeleton by protoporphyrin‐IX: light and dark effects
Moldt et al. Dimethyl sulfoxide decreases the fluorescence yield of the reaction between histamine and ortho-phthalaldehyde and may influence histamine release
MA21807A1 (fr) Procede de preparation de la proteine activee et solution de proteine c activee ainsi obtenue .
Deffner Chemical investigations of the giant nerve fibers of the squid V. quaternary ammonium ions in axoplasm
PT99146A (pt) Processo para a preparacao de complexos de inclusao com silibinina e de composicoes farmaceuticas que os contem