DK0580817T3 - Farmaceutisk præparat og fremgangsmåde til fremstilling deraf - Google Patents

Farmaceutisk præparat og fremgangsmåde til fremstilling deraf

Info

Publication number: DK0580817T3
Authority: DK; Denmark
Prior art keywords: preparation; pharmaceutical composition; solid phase; cyclosporin; solution
Prior art date: 1991-04-19

Application number

DK92922779.1T

Other languages

English (en)

Inventor

Jill P Adler-Moore

William A Ernst

Original Assignee

Nexstar Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-04-19

Filing date

1992-04-20

Publication date

1996-08-05

1992-04-20 Application filed by Nexstar Pharmaceuticals Inc filed Critical Nexstar Pharmaceuticals Inc

1996-08-05 Application granted granted Critical

1996-08-05 Publication of DK0580817T3 publication Critical patent/DK0580817T3/da

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 2
229930105110 Cyclosporin A Natural products 0.000 abstract 2
108010036949 Cyclosporine Proteins 0.000 abstract 2
229960001265 ciclosporin Drugs 0.000 abstract 2
229930182912 cyclosporin Natural products 0.000 abstract 2
239000007790 solid phase Substances 0.000 abstract 2
239000007864 aqueous solution Substances 0.000 abstract 1
238000001035 drying Methods 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
230000000887 hydrating effect Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000007935 neutral effect Effects 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
150000003904 phospholipids Chemical class 0.000 abstract 1
239000000243 solution Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Dispersion Chemistry (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK92922779.1T 1991-04-19 1992-04-20 Farmaceutisk præparat og fremgangsmåde til fremstilling deraf DK0580817T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US68781291A	1991-04-19	1991-04-19

Publications (1)

Publication Number	Publication Date
DK0580817T3 true DK0580817T3 (da)	1996-08-05

Family

ID=24761958

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92922779.1T DK0580817T3 (da)	1991-04-19	1992-04-20	Farmaceutisk præparat og fremgangsmåde til fremstilling deraf

Country Status (11)

Country	Link
US (3)	US5688525A (da)
EP (1)	EP0580817B1 (da)
JP (1)	JP2721041B2 (da)
AT (1)	ATE139439T1 (da)
AU (1)	AU657961B2 (da)
CA (1)	CA2108288C (da)
DE (1)	DE69211691T2 (da)
DK (1)	DK0580817T3 (da)
ES (1)	ES2088160T3 (da)
GR (1)	GR3020396T3 (da)
WO (1)	WO1992018104A1 (da)

Families Citing this family (41)

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EP0697214A1 (en) *	1994-07-19	1996-02-21	Vestar, Inc.	Liposomal cyclosporin pharmaceutical formulations
ES2163530T3 (es) *	1994-11-04	2002-02-01	Polymun Scient Immunbio Forsch	Aplicacion de superoxido dismutasa (sod) en liposomas.
US5693336A (en) *	1995-06-07	1997-12-02	Nexstar Pharmaceuticals, Inc.	Blood stable liposomal cyclosporin formulations
WO1996040064A1 (en) *	1995-06-07	1996-12-19	Nexstar Pharmaceuticals, Inc.	Liposomal cyclosporin formulations as agents for immunosuppression and multiple drug resistant indications
CA2202103C (en) *	1996-04-11	2007-01-09	Toshiaki Tagawa	Method for preparing closed vesicles
US6979456B1 (en)	1998-04-01	2005-12-27	Jagotec Ag	Anticancer compositions
US7026290B1 (en)	1998-12-30	2006-04-11	Dexcel Ltd.	Dispersible concentrate for the delivery of cyclosprin
US6613352B2 (en)	1999-04-13	2003-09-02	Universite De Montreal	Low-rigidity liposomal formulation
US7732404B2 (en)	1999-12-30	2010-06-08	Dexcel Ltd	Pro-nanodispersion for the delivery of cyclosporin
CN1406124A (zh) *	2000-01-20	2003-03-26	巴斯利尔药物股份公司	鼻给药的环肽组合物
US7125568B2 (en) *	2001-08-23	2006-10-24	Sung Michael T	Lipophilic drug compositions
AU2002333098B2 (en)	2001-10-19	2006-03-16	Isotechnika Pharma Inc.	Novel cyclosporin analog microemulsion preconcentrates
EP1585504A4 (en) *	2002-11-06	2009-07-15	Azaya Therapeutics Inc	LIPOSOMAL PREPARATIONS OF PHARMACEUTICAL AGENTS STABILIZED BY PROTEINS
JP4758915B2 (ja) *	2004-08-06	2011-08-31	バイオスペクトラム，インコーポレイテッド	多重層リポソームおよびその製造方法
US20060165641A1 (en) *	2005-01-18	2006-07-27	Kumar Pillai	Cosmetic compositions containing combinations of hydroxamate derivatives and antioxidants in a liposomal delivery system
US20070026061A1 (en) *	2005-05-25	2007-02-01	Nahid Ali	Liposomal formulation and use thereof
US20070225217A1 (en)	2005-11-09	2007-09-27	Combinatorx, Incorporated	Methods, compositions, and kits for the treatment of medical conditions
EP2457589A1 (en) *	2006-08-31	2012-05-30	Astellas Pharma Inc.	Reverse targeting lipid vesicle
EP3246034A1 (en)	2008-03-06	2017-11-22	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules as anti-inflammatory agents
US8218847B2 (en)	2008-06-06	2012-07-10	Superdimension, Ltd.	Hybrid registration method
JP6205133B2 (ja)	2009-07-10	2017-09-27	プレジデントアンドフェローズオブハーバードカレッジ	抗炎症剤としての恒久的に荷電したナトリウムおよびカルシウムチャンネルブロッカー
JP6200648B2 (ja)	2009-12-18	2017-09-20	アケリオスセラピューティクス，インコーポレーテッド	三叉神経・自律神経性頭痛、片頭痛、および血管症状の治療および予防のための組成物
US8716478B2 (en)	2010-01-27	2014-05-06	Anacor Pharmaceuticals, Inc.	Boron-containing small molecules
EP3191135B1 (en)	2014-09-12	2020-08-19	Genentech, Inc.	Anti-her2 antibodies and immunoconjugates
EP3226972A4 (en)	2014-12-01	2018-08-08	Achelios Therapeutics, Inc.	Methods and compositions for treating migraine and conditions associated with pain
WO2017024037A1 (en)	2015-08-03	2017-02-09	President And Fellows Of Harvard College	Charged ion channel blockers and methods for use
CN110023321A (zh)	2016-08-17	2019-07-16	索尔斯蒂斯生物有限公司	多核苷酸构建体
EP3645546A4 (en)	2017-06-30	2021-12-01	Solstice Biologics, Ltd.	CHIRAL PHOSPHORAMIDITIS AUXILIARIES AND THEIR METHODS OF USE
US20210244664A1 (en)	2018-06-27	2021-08-12	Breath Therapeutics Gmbh	Pharmaceutical compositions in lyophilized form
JP7630439B2 (ja)	2019-03-11	2025-02-17	ノシオンセラピューティクス，インコーポレイテッド	エステル置換イオンチャンネル遮断薬および使用方法
US10780083B1 (en)	2019-03-11	2020-09-22	Nocion Therapeutics, Inc.	Charged ion channel blockers and methods for use
US10968179B2 (en)	2019-03-11	2021-04-06	Nocion Therapeutics, Inc.	Charged ion channel blockers and methods for use
US10786485B1 (en)	2019-03-11	2020-09-29	Nocion Therapeutics, Inc.	Charged ion channel blockers and methods for use
CN113811305A (zh)	2019-03-11	2021-12-17	诺西恩医疗公司	带电的离子通道阻滞剂及其使用方法
US12089902B2 (en)	2019-07-30	2024-09-17	Coviden Lp	Cone beam and 3D fluoroscope lung navigation
EP4021934A4 (en)	2019-08-30	2024-02-14	The Regents of the University of California	Gene fragment overexpression screening methodologies, and uses thereof
MX2022005335A (es)	2019-11-06	2022-08-17	Nocion Therapeutics Inc	Bloqueadores de canales ionicos cargados y metodos de uso.
US10933055B1 (en)	2019-11-06	2021-03-02	Nocion Therapeutics, Inc.	Charged ion channel blockers and methods for use
WO2021183639A1 (en)	2020-03-11	2021-09-16	Nocion Therapeutics, Inc.	Charged ion channel blockers and methods for use
US12162851B2 (en)	2020-03-11	2024-12-10	Nocion Therapeutics, Inc.	Charged ion channel blockers and methods for use
WO2022243866A1 (en) *	2021-05-17	2022-11-24	Mahmoud Reza Jaafari	Method for producing liposomes entrapping cyclosporine a

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4663167A (en) *	1984-04-16	1987-05-05	The Board Of Regents Of The University Of Texas System	Composition and method for treatment of disseminated fungal infections in mammals
US4797285A (en) *	1985-12-06	1989-01-10	Yissum Research And Development Company Of The Hebrew University Of Jerusalem	Lipsome/anthraquinone drug composition and method
US5023087A (en) *	1986-02-10	1991-06-11	Liposome Technology, Inc.	Efficient method for preparation of prolonged release liposome-based drug delivery system
US4963362A (en) *	1987-08-07	1990-10-16	Regents Of The University Of Minnesota	Freeze-dried liposome mixture containing cyclosporin
US5000887A (en) *	1988-05-17	1991-03-19	Liposome Technology, Inc.	Preparation of uniform-size liposomes
US4952405A (en) *	1988-10-20	1990-08-28	Liposome Technology, Inc.	Method of treating M. avium infection
WO1991004019A1 (en) *	1989-09-12	1991-04-04	The Regents Of The University Of California	Therapeutic peptides and proteins

1992
- 1992-04-20 DE DE69211691T patent/DE69211691T2/de not_active Expired - Lifetime
- 1992-04-20 AU AU17977/92A patent/AU657961B2/en not_active Expired
- 1992-04-20 EP EP92922779A patent/EP0580817B1/en not_active Expired - Lifetime
- 1992-04-20 WO PCT/US1992/003234 patent/WO1992018104A1/en active IP Right Grant
- 1992-04-20 ES ES92922779T patent/ES2088160T3/es not_active Expired - Lifetime
- 1992-04-20 JP JP4510313A patent/JP2721041B2/ja not_active Expired - Lifetime
- 1992-04-20 DK DK92922779.1T patent/DK0580817T3/da active
- 1992-04-20 AT AT92922779T patent/ATE139439T1/de active
- 1992-04-20 CA CA002108288A patent/CA2108288C/en not_active Expired - Lifetime
1993
- 1993-06-30 US US08/085,673 patent/US5688525A/en not_active Expired - Lifetime
1995
- 1995-05-05 US US08/435,909 patent/US5660856A/en not_active Expired - Lifetime
- 1995-06-06 US US08/468,956 patent/US5670166A/en not_active Expired - Lifetime
1996
- 1996-06-28 GR GR960401773T patent/GR3020396T3/el unknown

Also Published As

Publication number	Publication date
US5670166A (en)	1997-09-23
AU1797792A (en)	1992-11-17
AU657961B2 (en)	1995-03-30
JPH06510024A (ja)	1994-11-10
CA2108288C (en)	2003-09-16
ES2088160T3 (es)	1996-08-01
US5688525A (en)	1997-11-18
EP0580817A1 (en)	1994-02-02
US5660856A (en)	1997-08-26
DE69211691D1 (de)	1996-07-25
WO1992018104A1 (en)	1992-10-29
CA2108288A1 (en)	1992-10-20
JP2721041B2 (ja)	1998-03-04
EP0580817B1 (en)	1996-06-19
GR3020396T3 (en)	1996-09-30
ATE139439T1 (de)	1996-07-15
DE69211691T2 (de)	1997-01-16

Publication	Publication Date	Title
DK0580817T3 (da)	1996-08-05	Farmaceutisk præparat og fremgangsmåde til fremstilling deraf
RU94040170A (ru)	1996-10-10	Изохинолины
SE8201351L (sv)	1982-03-04	Sett att framstella liposomberedningar
ATE101340T1 (de)	1994-02-15	Neue arzneimittelformulierung sowie verfahren zu deren herstellung.
NO884989L (no)	1989-05-16	Fremgangsmaate for opploeseliggjoering av amfifile medisinske preparater/forbindelser.
DK1073415T3 (da)	2006-03-06	Gelerbare farmaceutiske sammensætninger
FI963424A0 (fi)	1996-09-02	Menetelmä terapeuttisesti aktiivisten tiofeenisulfonamidien valmistamiseksi
FI98460B (fi)	1997-03-14	Menetelmä terapeuttisesti käyttökelpoisen 4H-1-bentsopyran-4-onijohdoksen tai sen suolan valmistamiseksi ja menetelmässä käyttökelpoinen välituote
DK653688D0 (da)	1988-11-23	Stabiliserede laegemiddelaktive forbindelser, fremgangsmaade til deres frmstilling samt stabile laegemiddelpraeparater
DE10199004I1 (de)	2001-03-29	Liposomen-Formulierungen mit hohem antineoplastischem Wirkstoff/Lipid-Verhaeltnis
HUT38263A (en)	1986-05-28	Process for rendering active substances soluble and production of therapeutic compositions comprising these substances
DE69517048D1 (de)	2000-06-21	Hilfsmittel zum löschmachen von hydrophylen makromolekülen
ATE63220T1 (de)	1991-05-15	Transdermal resorbierbare, wasserhaltige zubereitungen von arylpropionsaeurederivaten und verfahren zur herstellung derselben.
HUT54144A (en)	1991-01-28	Process for producing 3-desmethylmevalonic acid derivatives and pharmaceutical compositions comprising same as active ingredient
ES2091019T3 (es)	1996-10-16	Formulaciones liposomicas de itraconazol.
PT95697A (pt)	1991-09-13	Processo para a preparacao de composicoes farmaceuticas contendo substancias antiandrogenicamente activas
ATE67406T1 (de)	1991-10-15	Nicorandil enthaltende zubereitung zum einspritzen.
MX9302327A (es)	1993-10-01	Aminoacidos ciclicos novedosos y derivados de los mismos.
BG60101B2 (bg)	1993-10-29	Метод за получаване на 4-флуор-2-(((4-метокси-2- пиридинил)метил)тионил)-1н-бензимидазол
NO172537C (no)	1993-08-04	Analogifremgangsmaate til fremstilling av terapeutisk aktive 3-desmetyl-4-fluor-mevalonsyrederivater
KR900701300A (ko)	1990-12-01	생물학적 활성 펩티드 및 특정음이온을 갖는 조성물 및 이것을 사용하는 방법
ES2133928T3 (es)	1999-09-16	Agente para el tratamiento del cabello en 2 fases.
ATE136783T1 (de)	1996-05-15	Arzneimittel mit antineoplastischer wirkung enthaltend als wirkstoff octadecyl-(2-(n- methylpiperidino)-ethyl>-phosphat und verfahren zu dessen herstellung
MY101266A (en)	1991-08-17	Pharmaceutical formulations
DE3851842D1 (de)	1994-11-17	Wässrige bereitung von liposomenzusammensetzungen.