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MX381987B - El uso de un agente inhibidor de masp-2 para tratar condiciones asociadas con la activacion del complemento dependiente de masp-2 - Google Patents

El uso de un agente inhibidor de masp-2 para tratar condiciones asociadas con la activacion del complemento dependiente de masp-2

Info

Publication number
MX381987B
MX381987B MX2018005314A MX2018005314A MX381987B MX 381987 B MX381987 B MX 381987B MX 2018005314 A MX2018005314 A MX 2018005314A MX 2018005314 A MX2018005314 A MX 2018005314A MX 381987 B MX381987 B MX 381987B
Authority
MX
Mexico
Prior art keywords
masp
complement activation
dependent complement
methods
dependent
Prior art date
Application number
MX2018005314A
Other languages
English (en)
Inventor
Gregory A Demopulos
Hans-Wilhelm Schwaeble
Tom Dudler
Original Assignee
Univ Of Leicester
Omeros Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Of Leicester, Omeros Corp filed Critical Univ Of Leicester
Publication of MX381987B publication Critical patent/MX381987B/es

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    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K—PEPTIDES
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    • C07K2317/54—F(ab')2
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
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Abstract

En un aspecto, la invención proporciona métodos para inhibir los efectos de la activación de complemento dependiente de MASP-2 en un sujeto vivo. Los métodos comprenden los pasos de administrar, a un sujeto en necesidad del mismo, una cantidad eficaz de un agente inhibidor de MASP-2 para inhibir la activación del complemento dependiente de MASP-2. En algunas modalidades, el agente inhibidor de MASP-2 inhibe la lesión celular asociada con la activación de la vía del complemento alternativa mediada por MASP-2, mientras deja al componente de la vía clásica (dependiente de C1q) intacta. En otro aspecto, la invención proporciona composiciones para inhibir los efectos de la activación de complemento dependiente de lectina, comprendiendo una cantidad terapéuticamente eficaz de un agente inhibidor de MASP-2 y un vehículo farmacéuticamente aceptable.
MX2018005314A 2011-04-08 2012-04-06 El uso de un agente inhibidor de masp-2 para tratar condiciones asociadas con la activacion del complemento dependiente de masp-2 MX381987B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161473698P 2011-04-08 2011-04-08
PCT/US2012/032650 WO2012139081A2 (en) 2011-04-08 2012-04-06 Methods for treating conditions associated with masp-2 dependent complement activation

Publications (1)

Publication Number Publication Date
MX381987B true MX381987B (es) 2025-03-13

Family

ID=46966283

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2016006039A MX355648B (es) 2011-04-08 2012-04-06 El uso de un agente inhibidor de masp-2 para tratar condiciones asociadas con la activacion del complemento dependiente de masp-2.
MX2018005314A MX381987B (es) 2011-04-08 2012-04-06 El uso de un agente inhibidor de masp-2 para tratar condiciones asociadas con la activacion del complemento dependiente de masp-2
MX2013011721A MX339002B (es) 2011-04-08 2012-04-06 El uso de un agente inhibidor de masp-2 para tratar condiciones asociadas con la activacion del complemento dependiente de masp-2.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2016006039A MX355648B (es) 2011-04-08 2012-04-06 El uso de un agente inhibidor de masp-2 para tratar condiciones asociadas con la activacion del complemento dependiente de masp-2.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2013011721A MX339002B (es) 2011-04-08 2012-04-06 El uso de un agente inhibidor de masp-2 para tratar condiciones asociadas con la activacion del complemento dependiente de masp-2.

Country Status (18)

Country Link
US (5) US8951522B2 (es)
EP (3) EP2694108B1 (es)
JP (4) JP5937197B2 (es)
KR (6) KR101720562B1 (es)
CN (3) CN107638565B (es)
AU (1) AU2012239889B2 (es)
BR (1) BR112013025917A2 (es)
CA (4) CA2977009C (es)
CL (1) CL2013002874A1 (es)
DK (2) DK3287142T3 (es)
ES (2) ES2894342T3 (es)
HK (1) HK1250342A1 (es)
IL (3) IL228758B (es)
MX (3) MX355648B (es)
NZ (5) NZ617298A (es)
PL (1) PL3287142T3 (es)
RU (2) RU2662563C2 (es)
WO (1) WO2012139081A2 (es)

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MX355648B (es) 2011-04-08 2018-04-26 Univ Leicester El uso de un agente inhibidor de masp-2 para tratar condiciones asociadas con la activacion del complemento dependiente de masp-2.
EP2794656B1 (en) 2011-12-21 2019-02-27 Novartis AG Compositions comprising antibodies targeting factor p and c5
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PL3628680T3 (pl) 2014-06-12 2022-01-10 Ra Pharmaceuticals, Inc. Modulowanie aktywności dopełniacza
SMT202100688T1 (it) 2015-01-28 2022-01-10 Ra Pharmaceuticals Inc Modulatori di attività del complemento
ES2938359T3 (es) 2015-04-06 2023-04-10 Bioverativ Usa Inc Anticuerpos humanizados anti-C1s y métodos de uso de los mismos
BR112018009311A8 (pt) 2015-11-09 2019-02-26 Omeros Corporation E Univ Of Leicester ?método para tratar um sujeito humano sofrendo de tma persistente associada com transplante de célula tronco hematopoiética?
KR20180094913A (ko) 2015-12-16 2018-08-24 라 파마슈티컬스 인코포레이티드 보체 활성의 조절인자
AU2016375183B2 (en) 2015-12-23 2021-01-21 eleva GmbH Polypeptides for inhibiting complement activation
KR102564616B1 (ko) * 2016-01-05 2023-08-08 유니버시티 오브 레스터 필요로 하는 대상체에서 섬유증의 억제 방법
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UY37376A (es) * 2016-08-26 2018-03-23 Amgen Inc Construcciones de arni para inhibir expresión de asgr1 y métodos para su uso
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