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MX367541B - Inhibidores de papd5 y papd7 para tratar la infeccion por hepatitis b. - Google Patents

Inhibidores de papd5 y papd7 para tratar la infeccion por hepatitis b.

Info

Publication number
MX367541B
MX367541B MX2018015516A MX2018015516A MX367541B MX 367541 B MX367541 B MX 367541B MX 2018015516 A MX2018015516 A MX 2018015516A MX 2018015516 A MX2018015516 A MX 2018015516A MX 367541 B MX367541 B MX 367541B
Authority
MX
Mexico
Prior art keywords
papd7
papd5
infection
hbv
hbv infection
Prior art date
Application number
MX2018015516A
Other languages
English (en)
Other versions
MX2018015516A (es
Inventor
Javanbakht Hassan
Han Xingchun
Wang Yongguang
Yang Song
Mueller Henrik
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2018015516A publication Critical patent/MX2018015516A/es
Publication of MX367541B publication Critical patent/MX367541B/es

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
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    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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Abstract

La presente invención se relaciona con un método para identificar un compuesto que previene, mejora y/o inhibe una infección por virus de hepatitis B (VHB), donde un compuesto que (i) reduce la expresión y/o actividad dominio asociado de PAP que contiene 5 (PAPD5) y/o dominio asociado de PAP que contiene 7 (PAPD7); y/o (ii) se une a PAPD5 y/o PAPD7 e inhibe la propagación de VHB; es identificado como compuesto que previene, mejora y/o inhibe una infección por VHB. La invención también proporciona un inhibidor de PAPD5 y/o PAPD7 para usarse en el tratamiento y/o prevención de una infección por VHB; así como una preparación combinada que comprende un inhibidor de PAPD5 y un inhibidor de PAPD7 para el uso simultáneo o secuencial en el tratamiento o prevención de una infección por VHB. La presente invención también comprende una composición farmacéutica para usarse en el tratamiento y/o prevención de una infección por VHB, y un método para verificar el éxito terapéutico durante el tratamiento de una infección por VHB.
MX2018015516A 2016-06-17 2017-06-19 Inhibidores de papd5 y papd7 para tratar la infeccion por hepatitis b. MX367541B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16175045 2016-06-17
PCT/EP2017/064981 WO2017216391A1 (en) 2016-06-17 2017-06-19 Papd5 and papd7 inhibitors for treating a hepatitis b infection

Publications (2)

Publication Number Publication Date
MX2018015516A MX2018015516A (es) 2019-03-18
MX367541B true MX367541B (es) 2019-08-22

Family

ID=56321739

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018015521A MX367543B (es) 2016-06-17 2017-06-19 MOLÉCULAS DE ÁCIDO NUCLEICO PARA LA REDUCCIÓN DE ARNm DE PAPD5 O PAPD7 PARA TRATAR LA INFECCIÓN POR HEPATITIS B.
MX2018015516A MX367541B (es) 2016-06-17 2017-06-19 Inhibidores de papd5 y papd7 para tratar la infeccion por hepatitis b.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2018015521A MX367543B (es) 2016-06-17 2017-06-19 MOLÉCULAS DE ÁCIDO NUCLEICO PARA LA REDUCCIÓN DE ARNm DE PAPD5 O PAPD7 PARA TRATAR LA INFECCIÓN POR HEPATITIS B.

Country Status (19)

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