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MX2021014771A - Tratamiento combinado con un agonista de tlr7 y un inhibidor de montaje de capsida de hbv. - Google Patents

Tratamiento combinado con un agonista de tlr7 y un inhibidor de montaje de capsida de hbv.

Info

Publication number
MX2021014771A
MX2021014771A MX2021014771A MX2021014771A MX2021014771A MX 2021014771 A MX2021014771 A MX 2021014771A MX 2021014771 A MX2021014771 A MX 2021014771A MX 2021014771 A MX2021014771 A MX 2021014771A MX 2021014771 A MX2021014771 A MX 2021014771A
Authority
MX
Mexico
Prior art keywords
tlr7 agonist
capsid assembly
hbv capsid
combined treatment
assembly inhibitor
Prior art date
Application number
MX2021014771A
Other languages
English (en)
Inventor
Lu Gao
Lue Dai
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2021014771A publication Critical patent/MX2021014771A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se dirige a composiciones y métodos para tratar infección de virus de hepatitis B virus. En particular, la presente invención se dirige a una terapia de combinación que comprende administración de un agonista de TLR7 y un inhibidor de montaje de cápsida de HBV para el uso en el tratamiento de paciente con hepatitis B crónica.
MX2021014771A 2016-09-13 2019-03-07 Tratamiento combinado con un agonista de tlr7 y un inhibidor de montaje de capsida de hbv. MX2021014771A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2016098892 2016-09-13

Publications (1)

Publication Number Publication Date
MX2021014771A true MX2021014771A (es) 2022-01-18

Family

ID=59859071

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2019002678A MX2019002678A (es) 2016-09-13 2017-09-11 Tratamiento combinado con un agonista de tlr7 y un inhibidor de montaje de capsida de hbv.
MX2021014771A MX2021014771A (es) 2016-09-13 2019-03-07 Tratamiento combinado con un agonista de tlr7 y un inhibidor de montaje de capsida de hbv.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2019002678A MX2019002678A (es) 2016-09-13 2017-09-11 Tratamiento combinado con un agonista de tlr7 y un inhibidor de montaje de capsida de hbv.

Country Status (14)

Country Link
US (1) US11337982B2 (es)
EP (2) EP3512556B1 (es)
JP (2) JP7101663B2 (es)
KR (1) KR102497701B1 (es)
CN (1) CN109715214B (es)
AU (1) AU2017326400B2 (es)
BR (1) BR112019004560A2 (es)
CA (1) CA3034185A1 (es)
ES (1) ES2894605T3 (es)
IL (2) IL264926B (es)
MX (2) MX2019002678A (es)
PL (1) PL3512556T3 (es)
TW (1) TWI720250B (es)
WO (1) WO2018050571A1 (es)

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LT3114128T (lt) * 2014-03-07 2019-03-25 F. Hoffmann-La Roche Ag Nauji 6 padėtyje kondensuoti heteroarildihidropirimidinai, skirti hepatito b virusinės infekcijos gydymui ir profilaktikai
CN107427514B (zh) 2015-03-16 2021-07-13 豪夫迈·罗氏有限公司 使用tlr7激动剂和hbv衣壳装配抑制剂的组合治疗
EP3645516A4 (en) 2017-06-27 2021-07-07 Janssen Pharmaceutica NV HETEROARYLDIHYDROPYRIMIDE DERIVATIVES AND METHODS OF TREATMENT OF HEPATITIS B INFECTIONS
JP7328977B2 (ja) 2018-02-12 2023-08-17 エフ． ホフマン－ラ ロシュ アーゲー ウイルス感染の処置および予防のための新規のスルホン化合物および誘導体
BR112020016509A2 (pt) * 2018-02-28 2020-12-15 F. Hoffmann-La Roche Ag Composto, composto para uso no tratamento ou profilaxia do câncer de fígado, composição farmacêutica ou medicamento, uso e método para o tratamento ou profilaxia do câncer de fígado
US11554120B2 (en) * 2018-08-03 2023-01-17 Bristol-Myers Squibb Company 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor
US11053235B2 (en) 2018-08-09 2021-07-06 Janssen Sciences Ireland Unlimited Company Substituted 1,4-dihydropyrimidines for the treatment of HBV infection or HBV-induced diseases
US20220048919A1 (en) 2018-12-20 2022-02-17 Janssen Phrmaceutica NV Heteroaryldihydropyrimidine derivatives and methods of treating hepatitis b infections
KR102732006B1 (ko) 2019-03-25 2024-11-20 에프. 호프만-라 로슈 아게 Hbv 코어 단백질 알로스테릭 조절제 화합물의 고체 형태
CA3146992A1 (en) * 2019-07-31 2021-02-04 Janssen Sciences Ireland Unlimited Company Dihydropyrimidine derivatives and uses thereof in the treatment of hbv infection or of hbv-induced diseases
TW202126304A (zh) * 2019-09-20 2021-07-16 瑞士商赫孚孟拉羅股份公司 使用核心蛋白異位調節劑治療hbv感染之方法

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CN107427514B (zh) * 2015-03-16 2021-07-13 豪夫迈·罗氏有限公司 使用tlr7激动剂和hbv衣壳装配抑制剂的组合治疗
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Also Published As

Publication number Publication date
TW201811371A (zh) 2018-04-01
IL287545B2 (en) 2023-02-01
AU2017326400B2 (en) 2023-03-30
IL264926B (en) 2021-12-01
CN109715214A (zh) 2019-05-03
KR102497701B1 (ko) 2023-02-09
JP2019526610A (ja) 2019-09-19
TWI720250B (zh) 2021-03-01
WO2018050571A1 (en) 2018-03-22
AU2017326400A1 (en) 2019-02-21
ES2894605T3 (es) 2022-02-15
IL287545B (en) 2022-10-01
KR20190053219A (ko) 2019-05-17
JP7101663B2 (ja) 2022-07-15
US20190298726A1 (en) 2019-10-03
US11337982B2 (en) 2022-05-24
PL3512556T3 (pl) 2021-12-27
EP3512556B1 (en) 2021-08-18
JP2022130672A (ja) 2022-09-06
CN109715214B (zh) 2022-03-04
EP3970750A1 (en) 2022-03-23
IL287545A (en) 2021-12-01
BR112019004560A2 (pt) 2019-07-02
EP3512556A1 (en) 2019-07-24
MX2019002678A (es) 2019-05-20
CA3034185A1 (en) 2018-03-22

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