MX347176B - Procedimiento para la preparacion de pleuromutilinas. - Google Patents
Procedimiento para la preparacion de pleuromutilinas.Info
- Publication number
- MX347176B MX347176B MX2012013645A MX2012013645A MX347176B MX 347176 B MX347176 B MX 347176B MX 2012013645 A MX2012013645 A MX 2012013645A MX 2012013645 A MX2012013645 A MX 2012013645A MX 347176 B MX347176 B MX 347176B
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- compound
- preparation
- pleuromutilins
- intermediates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/43—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/08—Acetic acid
- C07C53/10—Salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/145—Maleic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
- C07C59/08—Lactic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/76—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members
- C07C2603/80—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings
- C07C2603/82—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings having three condensed rings with in total fourteen carbon atoms and having a having a [5.4.3.0(1,8)] ring structure, e.g. pleuromutiline
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un procedimiento para la preparación de un compuesto de la fórmula I (Ver Formula) en forma de un estereoisómero individual en forma cristalina, que comprende desproteger el grupo amina en un compuesto de la fórmula lla (Ver Formula) o en una mezcla de un compuesto de la fórmula ha con un compuesto de la fórmula lIb (Ver Formula) y aislar un compuesto de la fórmula I de la mezcla de reacción; compuestos y sales de compuestos de la fórmula I en forma cristalina; composiciones farmacéuticas que comprenden dichas sales; procedimientos para la preparación de intermediarios e intermediarios en un procedimiento para la preparación de un compuesto de la fórmula I.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20100450092 EP2399904A1 (en) | 2010-05-26 | 2010-05-26 | Process for the preparation of pleuromutilins |
| PCT/AT2011/000237 WO2011146954A1 (en) | 2010-05-26 | 2011-05-23 | Process for the preparation of pleuromutilins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2012013645A MX2012013645A (es) | 2013-05-01 |
| MX347176B true MX347176B (es) | 2017-04-17 |
Family
ID=42937801
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2012013645A MX347176B (es) | 2010-05-26 | 2011-05-23 | Procedimiento para la preparacion de pleuromutilinas. |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US9120727B2 (es) |
| EP (3) | EP2399904A1 (es) |
| JP (2) | JP6038021B2 (es) |
| KR (1) | KR101935333B1 (es) |
| CN (2) | CN103080083B (es) |
| AU (1) | AU2011257938B2 (es) |
| BR (1) | BR112012029982A2 (es) |
| CA (1) | CA2799029C (es) |
| DK (2) | DK2576505T3 (es) |
| EA (1) | EA023273B1 (es) |
| ES (2) | ES2659729T3 (es) |
| HK (1) | HK1253006A1 (es) |
| HR (1) | HRP20220201T1 (es) |
| HU (2) | HUE035861T2 (es) |
| IL (1) | IL222999A (es) |
| MA (1) | MA34332B1 (es) |
| MX (1) | MX347176B (es) |
| MY (1) | MY164666A (es) |
| NZ (1) | NZ603804A (es) |
| PH (1) | PH12012502321A1 (es) |
| PL (2) | PL3299356T3 (es) |
| PT (2) | PT3299356T (es) |
| SG (1) | SG185104A1 (es) |
| SI (1) | SI3299356T1 (es) |
| TN (1) | TN2012000506A1 (es) |
| TR (1) | TR201802636T4 (es) |
| TW (1) | TWI585073B (es) |
| UA (1) | UA108378C2 (es) |
| WO (1) | WO2011146954A1 (es) |
| ZA (1) | ZA201208056B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104447294A (zh) * | 2014-11-24 | 2015-03-25 | 苏州乔纳森新材料科技有限公司 | 一种3-环己烯-1-甲酸的手性拆分方法 |
| AU2016278774C1 (en) * | 2015-06-17 | 2021-11-18 | Nabriva Therapeutics GmbH | Injectable pharmaceutical formulations of lefamulin |
| PE20180398A1 (es) | 2015-06-18 | 2018-02-28 | Mithra Pharmaceuticals S A | Unidad de dosificacion orodispersable que contiene un componente estetrol |
| SI3310333T1 (sl) | 2015-06-18 | 2020-08-31 | Estetra Sprl | Orodisperzibilna enota odmerka, ki vsebuje komponento estetrola |
| TWI762573B (zh) * | 2017-02-10 | 2022-05-01 | 奧地利商納畢瓦治療有限責任公司 | 截短側耳素之純化 |
| CN107417586A (zh) * | 2017-06-21 | 2017-12-01 | 华南农业大学 | 一种截短侧耳素类抗生素及其制备方法和应用 |
| JOP20200260A1 (ar) | 2018-04-19 | 2019-10-19 | Estetra Sprl | مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث |
| TWI801561B (zh) | 2018-04-19 | 2023-05-11 | 比利時商依思特拉私人有限責任公司 | 化合物及其用於緩解絕經相關症狀的用途 |
| TWI755055B (zh) | 2019-09-18 | 2022-02-11 | 台灣神隆股份有限公司 | 用於製備惡拉戈利鈉及其中間體的方法 |
| CN111170893B (zh) * | 2020-01-19 | 2022-04-26 | 郑州依米花手性药物研究有限公司 | Lefamulin的中间体化合物及其在Lefamulin制备中的应用 |
| US20230218558A1 (en) * | 2020-04-17 | 2023-07-13 | Nabriva Therapeutics GmbH | Novel therapeutic use of pleuromutilins |
| TW202203908A (zh) | 2020-04-17 | 2022-02-01 | 奧地利商納畢瓦治療有限責任公司 | 截短側耳素類之醫療用途 |
| EP4475834A1 (en) | 2022-02-09 | 2024-12-18 | Nabriva Therapeutics GMBH | Lefamulin and its derivatives for use in the treatment of a spiral shaped bacteria |
| EP4338732A1 (en) | 2022-09-16 | 2024-03-20 | Nabriva Therapeutics GMBH | Lefamulin and its derivatives for use in the treatment of tularemia |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61207370A (ja) * | 1985-03-11 | 1986-09-13 | Seitetsu Kagaku Co Ltd | ４−（メタンスルホニルオキシ）チオフエノ−ルの製法 |
| GB0017031D0 (en) * | 2000-07-11 | 2000-08-30 | Biochemie Gmbh | Antimicrobials |
| BRPI0312882B8 (pt) * | 2002-07-24 | 2021-05-25 | Nabriva Therapeutics Ag | derivados de pleuromutilina e composição farmacêutica |
| GB0308114D0 (en) * | 2003-04-08 | 2003-05-14 | Glaxo Group Ltd | Novel compounds |
| JP4634380B2 (ja) * | 2003-08-04 | 2011-02-16 | “ジョイント ストック カンパニー グリンデクス” | メルドニウム（Ｍｅｌｄｏｎｉｕｍ）塩、メルドニウム塩の調製方法、およびメルドニウム塩を主成分とする薬学的組成物 |
| EP1658276B1 (en) * | 2003-08-18 | 2012-10-10 | H. Lundbeck A/S | Trans-1(6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine |
| DE602004024417D1 (de) * | 2003-09-03 | 2010-01-14 | Glaxo Group Ltd | Neues verfahren zur herstellung von pleuromutilinderivaten |
| JP2009544354A (ja) | 2006-07-20 | 2009-12-17 | ダブリューエムエス・ゲイミング・インコーポレーテッド | 受動的ゲームプレイに基づく特別イベント資格機能（ｆｅａｔｕｒｅ）を有する賭け事ゲーム |
| EP1908750A1 (en) * | 2006-10-05 | 2008-04-09 | Nabriva Therapeutics Forschungs GmbH | Process for the preparation of pleuromutilins |
| PL1961735T3 (pl) * | 2007-02-22 | 2010-04-30 | Indena Spa | Sposób wytwarzania octanu metylowego estru (2r,3s)-3-fenyloizoseryny |
| EP1972618A1 (en) | 2007-03-20 | 2008-09-24 | Nabriva Therapeutics AG | Pleuromutilin derivatives for the treatment of diseases mediated by microbes |
| EP2014645A1 (en) * | 2007-07-13 | 2009-01-14 | Nabriva Therapeutics AG | Pleuromutilin derivatives and their use as antimicrobials |
| EP2159220A1 (en) * | 2008-09-02 | 2010-03-03 | Nabriva Therapeutics AG | Organic compounds |
-
2010
- 2010-05-26 EP EP20100450092 patent/EP2399904A1/en not_active Withdrawn
-
2011
- 2011-05-23 TW TW100117950A patent/TWI585073B/zh active
- 2011-05-23 UA UAA201214910A patent/UA108378C2/ru unknown
- 2011-05-23 PT PT171973506T patent/PT3299356T/pt unknown
- 2011-05-23 MX MX2012013645A patent/MX347176B/es active IP Right Grant
- 2011-05-23 MA MA35484A patent/MA34332B1/fr unknown
- 2011-05-23 KR KR1020127030731A patent/KR101935333B1/ko active IP Right Grant
- 2011-05-23 BR BR112012029982-4A patent/BR112012029982A2/pt not_active Application Discontinuation
- 2011-05-23 DK DK11724938.3T patent/DK2576505T3/en active
- 2011-05-23 EA EA201291370A patent/EA023273B1/ru unknown
- 2011-05-23 WO PCT/AT2011/000237 patent/WO2011146954A1/en active Application Filing
- 2011-05-23 PL PL17197350T patent/PL3299356T3/pl unknown
- 2011-05-23 EP EP17197350.6A patent/EP3299356B1/en active Active
- 2011-05-23 SI SI201132039T patent/SI3299356T1/sl unknown
- 2011-05-23 JP JP2013511476A patent/JP6038021B2/ja active Active
- 2011-05-23 HU HUE11724938A patent/HUE035861T2/hu unknown
- 2011-05-23 HR HRP20220201TT patent/HRP20220201T1/hr unknown
- 2011-05-23 EP EP11724938.3A patent/EP2576505B1/en active Active
- 2011-05-23 HU HUE17197350A patent/HUE057587T2/hu unknown
- 2011-05-23 DK DK17197350.6T patent/DK3299356T3/da active
- 2011-05-23 SG SG2012080339A patent/SG185104A1/en unknown
- 2011-05-23 NZ NZ603804A patent/NZ603804A/en unknown
- 2011-05-23 PT PT117249383T patent/PT2576505T/pt unknown
- 2011-05-23 CN CN201180036554.1A patent/CN103080083B/zh active Active
- 2011-05-23 PL PL11724938T patent/PL2576505T3/pl unknown
- 2011-05-23 CA CA2799029A patent/CA2799029C/en active Active
- 2011-05-23 PH PH1/2012/502321A patent/PH12012502321A1/en unknown
- 2011-05-23 AU AU2011257938A patent/AU2011257938B2/en active Active
- 2011-05-23 ES ES11724938.3T patent/ES2659729T3/es active Active
- 2011-05-23 TR TR2018/02636T patent/TR201802636T4/tr unknown
- 2011-05-23 US US13/699,589 patent/US9120727B2/en active Active
- 2011-05-23 ES ES17197350T patent/ES2909198T3/es active Active
- 2011-05-23 MY MYPI2012700960A patent/MY164666A/en unknown
- 2011-05-23 CN CN201510488095.0A patent/CN105111117A/zh active Pending
-
2012
- 2012-10-23 TN TNP2012000506A patent/TN2012000506A1/en unknown
- 2012-10-25 ZA ZA2012/08056A patent/ZA201208056B/en unknown
- 2012-11-12 IL IL222999A patent/IL222999A/en active IP Right Grant
-
2016
- 2016-09-08 JP JP2016175859A patent/JP6501742B2/ja active Active
-
2018
- 2018-09-27 HK HK18112372.3A patent/HK1253006A1/zh unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |