[go: up one dir, main page]

MA34332B1 - Procédé pour la préparation de pleuromutilines - Google Patents

Procédé pour la préparation de pleuromutilines

Info

Publication number
MA34332B1
MA34332B1 MA35484A MA35484A MA34332B1 MA 34332 B1 MA34332 B1 MA 34332B1 MA 35484 A MA35484 A MA 35484A MA 35484 A MA35484 A MA 35484A MA 34332 B1 MA34332 B1 MA 34332B1
Authority
MA
Morocco
Prior art keywords
formula
compound
preparation
pleuromutilines
intermediates
Prior art date
Application number
MA35484A
Other languages
English (en)
Inventor
Rosemarie Riedl
Werner Heilmayer
Lee Spence
Original Assignee
Nabriva Therapeutics Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nabriva Therapeutics Ag filed Critical Nabriva Therapeutics Ag
Publication of MA34332B1 publication Critical patent/MA34332B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/08—Acetic acid
    • C07C53/10—Salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/01—Saturated compounds having only one carboxyl group and containing hydroxy or O-metal groups
    • C07C59/08—Lactic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/76—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members
    • C07C2603/80—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings
    • C07C2603/82—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings having three condensed rings with in total fourteen carbon atoms and having a having a [5.4.3.0(1,8)] ring structure, e.g. pleuromutiline
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte sur un procédé pour la préparation d'un composé de formule I sous la forme d'un seul stéréoisomère sous forme cristalline, comprenant la déprotection du groupe amine dans un composé de formule IIa ou dans un mélange d'un composé de formule IIa avec un composé de formule IIb et la séparation d'un composé de formule I du mélange réactionnel ; sur des composés et sels de composés de formule I sous forme cristalline ; sur des compositions pharmaceutiques comprenant de tels sels ; sur des procédés pour la préparation d'intermédiaires ; et sur des intermédiaires dans un procédé pour la préparation d'un composé de formule I.
MA35484A 2010-05-26 2011-05-23 Procédé pour la préparation de pleuromutilines MA34332B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20100450092 EP2399904A1 (fr) 2010-05-26 2010-05-26 Procédé de préparation de pleuromutilines
PCT/AT2011/000237 WO2011146954A1 (fr) 2010-05-26 2011-05-23 Procédé pour la préparation de pleuromutilines

Publications (1)

Publication Number Publication Date
MA34332B1 true MA34332B1 (fr) 2013-06-01

Family

ID=42937801

Family Applications (1)

Application Number Title Priority Date Filing Date
MA35484A MA34332B1 (fr) 2010-05-26 2011-05-23 Procédé pour la préparation de pleuromutilines

Country Status (30)

Country Link
US (1) US9120727B2 (fr)
EP (3) EP2399904A1 (fr)
JP (2) JP6038021B2 (fr)
KR (1) KR101935333B1 (fr)
CN (2) CN103080083B (fr)
AU (1) AU2011257938B2 (fr)
BR (1) BR112012029982A2 (fr)
CA (1) CA2799029C (fr)
DK (2) DK2576505T3 (fr)
EA (1) EA023273B1 (fr)
ES (2) ES2659729T3 (fr)
HK (1) HK1253006A1 (fr)
HR (1) HRP20220201T1 (fr)
HU (2) HUE035861T2 (fr)
IL (1) IL222999A (fr)
MA (1) MA34332B1 (fr)
MX (1) MX347176B (fr)
MY (1) MY164666A (fr)
NZ (1) NZ603804A (fr)
PH (1) PH12012502321A1 (fr)
PL (2) PL3299356T3 (fr)
PT (2) PT3299356T (fr)
SG (1) SG185104A1 (fr)
SI (1) SI3299356T1 (fr)
TN (1) TN2012000506A1 (fr)
TR (1) TR201802636T4 (fr)
TW (1) TWI585073B (fr)
UA (1) UA108378C2 (fr)
WO (1) WO2011146954A1 (fr)
ZA (1) ZA201208056B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104447294A (zh) * 2014-11-24 2015-03-25 苏州乔纳森新材料科技有限公司 一种3-环己烯-1-甲酸的手性拆分方法
AU2016278774C1 (en) * 2015-06-17 2021-11-18 Nabriva Therapeutics GmbH Injectable pharmaceutical formulations of lefamulin
PE20180398A1 (es) 2015-06-18 2018-02-28 Mithra Pharmaceuticals S A Unidad de dosificacion orodispersable que contiene un componente estetrol
SI3310333T1 (sl) 2015-06-18 2020-08-31 Estetra Sprl Orodisperzibilna enota odmerka, ki vsebuje komponento estetrola
TWI762573B (zh) * 2017-02-10 2022-05-01 奧地利商納畢瓦治療有限責任公司 截短側耳素之純化
CN107417586A (zh) * 2017-06-21 2017-12-01 华南农业大学 一种截短侧耳素类抗生素及其制备方法和应用
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
TWI755055B (zh) 2019-09-18 2022-02-11 台灣神隆股份有限公司 用於製備惡拉戈利鈉及其中間體的方法
CN111170893B (zh) * 2020-01-19 2022-04-26 郑州依米花手性药物研究有限公司 Lefamulin的中间体化合物及其在Lefamulin制备中的应用
US20230218558A1 (en) * 2020-04-17 2023-07-13 Nabriva Therapeutics GmbH Novel therapeutic use of pleuromutilins
TW202203908A (zh) 2020-04-17 2022-02-01 奧地利商納畢瓦治療有限責任公司 截短側耳素類之醫療用途
EP4475834A1 (fr) 2022-02-09 2024-12-18 Nabriva Therapeutics GMBH Léfamuline et ses dérivés pour utilisation dans le traitement contre une bactérie en forme de spirale
EP4338732A1 (fr) 2022-09-16 2024-03-20 Nabriva Therapeutics GMBH Lefamulin et ses dérivés pour leur utilisation dans le traitement de la tularémie

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61207370A (ja) * 1985-03-11 1986-09-13 Seitetsu Kagaku Co Ltd ４−（メタンスルホニルオキシ）チオフエノ−ルの製法
GB0017031D0 (en) * 2000-07-11 2000-08-30 Biochemie Gmbh Antimicrobials
BRPI0312882B8 (pt) * 2002-07-24 2021-05-25 Nabriva Therapeutics Ag derivados de pleuromutilina e composição farmacêutica
GB0308114D0 (en) * 2003-04-08 2003-05-14 Glaxo Group Ltd Novel compounds
JP4634380B2 (ja) * 2003-08-04 2011-02-16 “ジョイント ストック カンパニー グリンデクス” メルドニウム（Ｍｅｌｄｏｎｉｕｍ）塩、メルドニウム塩の調製方法、およびメルドニウム塩を主成分とする薬学的組成物
EP1658276B1 (fr) * 2003-08-18 2012-10-10 H. Lundbeck A/S Trans-1(6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine
DE602004024417D1 (de) * 2003-09-03 2010-01-14 Glaxo Group Ltd Neues verfahren zur herstellung von pleuromutilinderivaten
JP2009544354A (ja) 2006-07-20 2009-12-17 ダブリューエムエス・ゲイミング・インコーポレーテッド 受動的ゲームプレイに基づく特別イベント資格機能（ｆｅａｔｕｒｅ）を有する賭け事ゲーム
EP1908750A1 (fr) * 2006-10-05 2008-04-09 Nabriva Therapeutics Forschungs GmbH Procédé de préparation des pleuromutilines
PL1961735T3 (pl) * 2007-02-22 2010-04-30 Indena Spa Sposób wytwarzania octanu metylowego estru (2r,3s)-3-fenyloizoseryny
EP1972618A1 (fr) 2007-03-20 2008-09-24 Nabriva Therapeutics AG Dérivés de pleuromutilin pour le traitement des maladies médiées par des microbes
EP2014645A1 (fr) * 2007-07-13 2009-01-14 Nabriva Therapeutics AG Dérivés de pleuromutiline et leur application comme agents antimicrobiens
EP2159220A1 (fr) * 2008-09-02 2010-03-03 Nabriva Therapeutics AG Composés organiques

Also Published As

Publication number Publication date
IL222999A0 (en) 2013-02-03
KR101935333B1 (ko) 2019-01-04
PL3299356T3 (pl) 2022-04-04
JP2013528162A (ja) 2013-07-08
WO2011146954A1 (fr) 2011-12-01
TW201209026A (en) 2012-03-01
US20130079400A1 (en) 2013-03-28
PT3299356T (pt) 2022-02-21
ES2659729T3 (es) 2018-03-19
MY164666A (en) 2018-01-30
SG185104A1 (en) 2012-12-28
SI3299356T1 (sl) 2022-05-31
CN105111117A (zh) 2015-12-02
EP3299356B1 (fr) 2021-11-24
AU2011257938B2 (en) 2016-06-23
ES2909198T3 (es) 2022-05-05
PL2576505T3 (pl) 2018-05-30
JP2016210804A (ja) 2016-12-15
HUE057587T2 (hu) 2022-05-28
KR20130079406A (ko) 2013-07-10
DK3299356T3 (da) 2022-01-31
PT2576505T (pt) 2018-03-05
TR201802636T4 (tr) 2018-03-21
MX347176B (es) 2017-04-17
EP2576505A1 (fr) 2013-04-10
DK2576505T3 (en) 2018-03-05
CN103080083B (zh) 2016-03-02
HRP20220201T1 (hr) 2022-04-29
EP2576505B1 (fr) 2017-11-29
ZA201208056B (en) 2014-01-29
HK1253006A1 (zh) 2019-06-06
US9120727B2 (en) 2015-09-01
PH12012502321A1 (en) 2013-02-11
EA201291370A1 (ru) 2013-09-30
TN2012000506A1 (en) 2014-04-01
JP6038021B2 (ja) 2016-12-07
CN103080083A (zh) 2013-05-01
MX2012013645A (es) 2013-05-01
CA2799029A1 (fr) 2011-12-01
EA023273B1 (ru) 2016-05-31
UA108378C2 (uk) 2015-04-27
EP3299356A1 (fr) 2018-03-28
EP2399904A1 (fr) 2011-12-28
HUE035861T2 (hu) 2018-06-28
CA2799029C (fr) 2019-01-29
NZ603804A (en) 2014-03-28
JP6501742B2 (ja) 2019-04-17
TWI585073B (zh) 2017-06-01
IL222999A (en) 2016-02-29
BR112012029982A2 (pt) 2020-09-01

Similar Documents

Publication Publication Date Title
MA34332B1 (fr) Procédé pour la préparation de pleuromutilines
MA35128B1 (fr) Nouveaux dérivés d'imidazole utiles pour le traitement de l'arthrite
MX2009013733A (es) Nuevos derivados de acido dicarboxilico como agonistas de los receptores de s1p1.
MA31311B1 (fr) Dérivés d'indazole substitués par oxadiazole, destinés à être utilisés comme agonistes de la sphingosine 1-phosphate (s1p)
MA32965B1 (fr) Derives de sulfonamides
MA32104B1 (fr) Dérivés d'oxime en tant qu'inhibiteurs de hsp90
TN2009000450A1 (fr) Derives de pyridine
MA33642B1 (fr) Composés chimiques
MX2011011156A (es) COMPUESTOS DIAMIDA QUE TIENE ACTIVIDAD COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS Y COMO AGONISTAS DE LOS RECEPTORES ANDRENERGICOS ß2.
MA34767B1 (fr) Compositions et procédés pour la modulation de fxr
MA33662B1 (fr) Composés de spiropipéridine et leur utilisation pharmaceutique pour le traitement du diabète
MA31593B1 (fr) Derives de 2-aza-bicyclo[3.3.0]octane
EA201001585A1 (ru) Производные тиенопиридона в качестве активаторов амр-активированной протеинкиназы (амрк)
MA34308B1 (fr) Triazolopyridines substituées
MX2010002171A (es) Compuestos 8-azabiciclo[3.2.1] octil-2 hidroxibenzamida como antagonistas de los receptores opioides mu.
WO2010024930A3 (fr) Analogues de cortistatine et leurs synthèses
MA29839B1 (fr) Derives de carboxamides servant d'antagonistes des recepteurs muscariniques
MA34957B1 (fr) Derives heteroaryle a titre modulateurs des nachr alpha 7
MX2009008324A (es) Compuestos 6´-sustituidos que tienen afinidad con el receptor de 5-hidroxitriptamina-6.
MA34982B1 (fr) Synthese de derives de 2-carboxamidocycloaminouree
MA31863B1 (fr) Dérivés de pyrazole comme inhibiteurs de 5-lo
WO2009076408A3 (fr) Dérivés de 3-carboxypropyl-aminotétraline et composés associés en tant qu'antagonistes du récepteurs mu-opioïde
MA30540B1 (fr) Derives de quinolines et compositions pharmaceutiques de ces derives.
UA94579C2 (ru) Анетолдитиолтион и другие дитиолтионы для лечения состояний, связанных с дисфункцией нейротрансмисии моноамина
TW200833371A (en) Process for solid formulations