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MX2021007296A - Grupo de moléculas biológicamente activas. - Google Patents

Grupo de moléculas biológicamente activas.

Info

Publication number
MX2021007296A
MX2021007296A MX2021007296A MX2021007296A MX2021007296A MX 2021007296 A MX2021007296 A MX 2021007296A MX 2021007296 A MX2021007296 A MX 2021007296A MX 2021007296 A MX2021007296 A MX 2021007296A MX 2021007296 A MX2021007296 A MX 2021007296A
Authority
MX
Mexico
Prior art keywords
biologically active
scaffold
molecule
molecules
active molecule
Prior art date
Application number
MX2021007296A
Other languages
English (en)
Inventor
Ruben Postel
Hendrik Fuchs
Original Assignee
Sapreme Tech Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sapreme Tech Bv filed Critical Sapreme Tech Bv
Publication of MX2021007296A publication Critical patent/MX2021007296A/es

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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
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    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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Abstract

La invención se refiere a un armazón molecular adecuado para unir covalentemente al menos una molécula biológicamente activa a una molécula portadora, el armazón comprende una estructura polimérica y las moléculas biológicamente activas unidas covalentemente a dicha estructura polimérica, y en el que el armazón comprende adicionalmente un grupo químico para acoplamiento covalente del armazón a la molécula portadora. La molécula biológicamente activa tiene un peso molecular de 3.000 Dalton o menos, tal como 1.700 Dalton - 1.950 Dalton. La molécula biológicamente activa es una molécula anfifílica en algunas realizaciones. La molécula biológicamente activa es una única molécula específica o es una mezcla de diferentes tipos de moléculas, cuando más de una molécula biológicamente activa está unida covalentemente a la estructura polimérica (u oligomérica). En particular, la invención se refiere a conjugados anticuerpo-fármaco basados en anticuerpos monoclonales con una ventana terapéutica mejorada del fármaco debido al enlace covalente de (un grupo de) moléculas potenciadoras, por ejemplo, una carga útil tal como una toxina proteica u oligonucleótido para el ADC, o alternativamente, debido a la coadministración de un ADC y un conjugado de direccionamiento celular que comprende (un grupo de) moléculas potenciadoras a un paciente que lo necesita. La invención también se refiere a un procedimiento de producción de un armazón adecuado para unir covalentemente una molécula biológicamente activa a una molécula portadora, proporcionando un grupo de moléculas potenciadoras. Adicionalmente, la invención se refiere a un procedimiento para producir un armazón unido covalentemente a una molécula portadora, el armazón comprende una molécula biológicamente activa unida covalentemente, la molécula portadora comprende un anticuerpo y una carga útil.
MX2021007296A 2018-12-21 2019-12-09 Grupo de moléculas biológicamente activas. MX2021007296A (es)

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NL2022283 2018-12-21
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PCT/EP2019/084290 WO2020126626A1 (en) 2018-12-21 2019-12-09 Biologically active cluster of molecules

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