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MX2017011651A - Inhibidores de kv1.3 y su aplicacion medica. - Google Patents

Inhibidores de kv1.3 y su aplicacion medica.

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Publication number
MX2017011651A
MX2017011651A MX2017011651A MX2017011651A MX2017011651A MX 2017011651 A MX2017011651 A MX 2017011651A MX 2017011651 A MX2017011651 A MX 2017011651A MX 2017011651 A MX2017011651 A MX 2017011651A MX 2017011651 A MX2017011651 A MX 2017011651A
Authority
MX
Mexico
Prior art keywords
group
alkyl
hydrogen
nr4r5
heterocycloalkyl
Prior art date
Application number
MX2017011651A
Other languages
English (en)
Other versions
MX378039B (es
Inventor
Tasler Stefan
KRIMMELBEIN Ilga
Original Assignee
4Sc Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4Sc Ag filed Critical 4Sc Ag
Publication of MX2017011651A publication Critical patent/MX2017011651A/es
Publication of MX378039B publication Critical patent/MX378039B/es

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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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Abstract

La presente invención se refiere a un compuesto de la fórmula general (III) o una sal, solvato o profármaco del mismo, así como a usos médicos que implican los mismos, en donde (ver Fórmula) en donde A1 se selecciona del grupo que consiste en N y C-R8; A2 se selecciona del grupo que consiste en N y C-R3; A3 se selecciona del grupo que consiste en N y C-R9; A4 y A5 y A6 se seleccionan independientemente del grupo que consiste en N y C-R1; R1 se selecciona del grupo que consiste en hidrógeno, alquilo (C1-C3), halógeno, alcoxi (C1-C3) y haloalquilo (C1-C3); R2 se selecciona del grupo que consiste en hidrógeno, halógeno y alquilo (C1-C3); R3 se selecciona del grupo que consiste en hidrógeno, alquilo (C1-C3), NR4R5, alquil (C1-C3)-NR4R5 y ciano; en donde R4 y R5 se seleccionan independientemente del grupo que consiste en hidrógeno, cicloalquilo (C3-C5), heterocicloalquilo (C3-C5), alquilo (C1-C3), o R4 y R5, junto con el átomo de nitrógeno al que están unidos, forman un anillo heterocíclico de 5 a 7 miembros, que comprende opcionalmente, además del átomo de nitrógeno antes mencionado, un grupo heteroátomo adicional seleccionado del grupo que consiste en O y NR6, en donde R6 se selecciona del grupo que consiste en hidrógeno, metilo, acetilo y formilo; Y se selecciona del grupo que consiste en O y S; R7 se selecciona del grupo que consiste en hidrógeno y alquilo (C1-C3); R8 se selecciona del grupo que consiste en alquilo (C1-C4), cicloalquilo (C3-C5) y heterocicloalquilo (C3-C5); y R9 se selecciona del grupo que consiste en hidrógeno, alquilo (C1-C3), alcoxi (C1-C3), y a métodos para producir este tipo de compuestos.
MX2017011651A 2015-03-13 2016-03-14 Inhibidores de kv1.3 y su aplicación médica. MX378039B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15159083 2015-03-13
PCT/EP2016/055441 WO2016146575A1 (en) 2015-03-13 2016-03-14 Kv1.3 inhibitors and their medical application

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MX2017011651A true MX2017011651A (es) 2018-02-09
MX378039B MX378039B (es) 2025-03-10

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EP (1) EP3268372B9 (es)
JP (1) JP6506410B2 (es)
KR (1) KR20170137055A (es)
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KR20220079575A (ko) * 2019-10-07 2022-06-13 디.이. 쇼우 리서치, 엘엘씨 Kv1.3 칼륨 셰이커 채널 차단제로서의 아릴 헤테로비시클릭 화합물

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