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CY1123797T1 - Αναστολεις kv1.3 και η ιατρικη εφαρμογη τους - Google Patents

Αναστολεις kv1.3 και η ιατρικη εφαρμογη τους

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Publication number
CY1123797T1
CY1123797T1 CY20201100815T CY201100815T CY1123797T1 CY 1123797 T1 CY1123797 T1 CY 1123797T1 CY 20201100815 T CY20201100815 T CY 20201100815T CY 201100815 T CY201100815 T CY 201100815T CY 1123797 T1 CY1123797 T1 CY 1123797T1
Authority
CY
Cyprus
Prior art keywords
group
alkyl
hydrogen
nr4r5
heterocycloalkyl
Prior art date
Application number
CY20201100815T
Other languages
English (en)
Inventor
Stefan Tasler
Ilga KRIMMELBEIN
Original Assignee
4Sc Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4Sc Ag filed Critical 4Sc Ag
Publication of CY1123797T1 publication Critical patent/CY1123797T1/el

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    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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Abstract

Η παρούσα εφεύρεση αφορά σε μια ένωση του γενικού τύπου (III) ή ένα άλας, ουσία διάλυσης ή προφάρμακό της, καθώς επίσης και στις ιατρικές χρήσεις στις οποίες αυτές συμμετέχουν, όπου (III) το Α1 επιλέγεται από την ομάδα που αποτελείται από Ν και C-R8, το Α2 επιλέγεται από την ομάδα που αποτελείται από Ν και C-R3, το Α3 επιλέγεται από την ομάδα που αποτελείται από Ν και C-R9, το Α4 και το Α5 και το Α6 επιλέγονται ανεξάρτητα από την ομάδα που αποτελείται από Ν και C-R1, το R1 επιλέγεται από την ομάδα που αποτελείται από υδρογόνο, (C1-C3)αλκύλιο, αλογόνο, (C1-C3)αλκόξυ, και (C1-C3)αλοαλκύλιο, το R2 επιλέγεται από την ομάδα που αποτελείται από υδρογόνο, αλογόνο, και (C1-C3)αλκύλιο, το R3 επιλέγεται από την ομάδα που αποτελείται από υδρογόνο, (C1-C3)αλκύλιο, NR4R5, (C1-C3)αλκύλιο-NR4R5 και κύανο, όπου το R4 και το R5 επιλέγονται ανεξάρτητα από την ομάδα που αποτελείται από υδρογόνο, (C3-C5)κυκλοαλκύλιο, (C3-C5)ετεροκυκλοαλκύλιο, (C1-C3)αλκύλιο, ή το R4 και το R5 μαζί με το άτομο αζώτου στο οποίο είναι προσαρτημένα σχηματίζουν έναν ετεροκυκλικό δακτύλιο με 5 έως 7 μέλη, ο οποίος περιλαμβάνει προαιρετικά, εκτός από το προαναφερθέν άτομο αζώτου, μια περαιτέρω ομάδα ετεροατόμου που επιλέγεται από την ομάδα που αποτελείται από Ο and NR6, όπου το R6 επιλέγεται από την ομάδα που αποτελείται από υδρογόνο, μεθύλιο, ακετύλιο και φορμύλιο, το Υ επιλέγεται από την ομάδα που αποτελείται από Ο and S, το R7 επιλέγεται από την ομάδα που αποτελείται από υδρογόνο, και (C1-C3)αλκύλιο, τo R8 επιλέγεται από την ομάδα που αποτελείται από (C1-C4)αλκύλιο, (C3-C5)κυκλοαλκύλιο και (C3-C5)ετεροκυκλοαλκύλιο, το R9 επιλέγεται από την ομάδα που αποτελείται από υδρογόνο,(C1-C3)αλκύλιο και (C1-C3)αλκόξυ, καθώς και σε μεθόδους για παραγωγή αυτών των ενώσεων.
CY20201100815T 2015-03-13 2020-09-01 Αναστολεις kv1.3 και η ιατρικη εφαρμογη τους CY1123797T1 (el)

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EP15159083 2015-03-13
PCT/EP2016/055441 WO2016146575A1 (en) 2015-03-13 2016-03-14 Kv1.3 inhibitors and their medical application

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CY1123797T1 true CY1123797T1 (el) 2022-03-24

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