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CY1121599T1 - Νεο παραγωγο αμινης ή αλας αυτου ως παρεμποδιστες tnf αλφα - Google Patents

Νεο παραγωγο αμινης ή αλας αυτου ως παρεμποδιστες tnf αλφα

Info

Publication number
CY1121599T1
CY1121599T1 CY20191100396T CY191100396T CY1121599T1 CY 1121599 T1 CY1121599 T1 CY 1121599T1 CY 20191100396 T CY20191100396 T CY 20191100396T CY 191100396 T CY191100396 T CY 191100396T CY 1121599 T1 CY1121599 T1 CY 1121599T1
Authority
CY
Cyprus
Prior art keywords
salt
amine
new product
tnf alpha
formula
Prior art date
Application number
CY20191100396T
Other languages
English (en)
Inventor
Tadashi Tanaka
Yoshitake Konishi
Daisuke Kubo
Masataka Fujino
Issei Doi
Daisuke Nakagawa
Tatsuya Murakami
Takayuki Yamakawa
Original Assignee
Fujifilm Toyama Chemical Co., Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujifilm Toyama Chemical Co., Ltd filed Critical Fujifilm Toyama Chemical Co., Ltd
Publication of CY1121599T1 publication Critical patent/CY1121599T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/4164—1,3-Diazoles
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    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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Abstract

Ένα νέο παράγωγο αμίνης που εκφράζεται με το γενικό τύπο (1) (στον τύπο: G1, G2 και G3 είναι τα ίδια ή διαφορετικά και αντιπροσωπεύουν CH ή άτομο αζώτου· R1 αντιπροσωπεύει άτομο χλωρίου, προαιρετικώς υποκατεστημένη C3-8 κυκλοαλκύλ ομάδα, ή τα παρόμοια· R2 αντιπροσωπεύει -COOR5 (στον τύπο, R5 αντιπροσωπεύει άτομο υδρογόνου ή καρβοξύλ προστατευτική ομάδα) ή τα παρόμοια· R3 αντιπροσωπεύει άτομο υδρογόνου ή τα παρόμοια· και R4 αντιπροσωπεύει προαιρετικώς υποκατεστημένη συμπυκνωμένου δικυκλικού υδρογονάνθρακα ομάδα, προαιρετικώς υποκατεστημένη δικυκλική ετεροκυκλική ομάδα ή τα παρόμοια), ή άλας αυτού, είναι χρήσιμο σε πορείες όπως τη θεραπεία ή την αποτροπή καταστάσεων που σχετίζονται προς εκτεταμένο πολλαπλασιασμό κερατινοκυττάρου.
CY20191100396T 2012-10-31 2019-04-09 Νεο παραγωγο αμινης ή αλας αυτου ως παρεμποδιστες tnf αλφα CY1121599T1 (el)

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