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MX2017010698A - Metodos y composiciones para chlamydia atenuada como vacuna y vector. - Google Patents

Metodos y composiciones para chlamydia atenuada como vacuna y vector.

Info

Publication number
MX2017010698A
MX2017010698A MX2017010698A MX2017010698A MX2017010698A MX 2017010698 A MX2017010698 A MX 2017010698A MX 2017010698 A MX2017010698 A MX 2017010698A MX 2017010698 A MX2017010698 A MX 2017010698A MX 2017010698 A MX2017010698 A MX 2017010698A
Authority
MX
Mexico
Prior art keywords
substitution
compositions
methods
vaccine
vector
Prior art date
Application number
MX2017010698A
Other languages
English (en)
Inventor
Zhong Guangming
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Publication of MX2017010698A publication Critical patent/MX2017010698A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/118—Chlamydiaceae, e.g. Chlamydia trachomatis or Chlamydia psittaci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/295—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Chlamydiales (O)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/36—Adaptation or attenuation of cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Mycology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención provee organismos de Chlamydia y composiciones y métodos de uso en el tratamiento/prevención de infección por Chlamydia en un sujeto, para producer una respuesta inmune en un sujeto y para uso como vectores; en un aspecto, la presente invención provee una célula de Chlamydia trachomatis aislada que comprende una sustitución de aminoácido en Q117, por ejemplo, Q117E, en un marco de lectura abierto de CT849; y una mutación de G216* incorporada en la secuencia de nucléotidos; y/o una sustitución en G322, por ejemplo, G322R, en un marco de lectura abierto de CT389, en donde dicha célula de Chlamydia trachomatis tiene un fenotipo debido a dicha sustitución en Q117 y dicha mutación y/o sustitución en G216 o G322 de patogenicidad atenuada.
MX2017010698A 2015-02-20 2016-02-19 Metodos y composiciones para chlamydia atenuada como vacuna y vector. MX2017010698A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562118961P 2015-02-20 2015-02-20
PCT/US2016/018746 WO2016134300A1 (en) 2015-02-20 2016-02-19 Methods and compositions for attenuated chlamydia as vaccine and vector

Publications (1)

Publication Number Publication Date
MX2017010698A true MX2017010698A (es) 2018-04-30

Family

ID=56689210

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017010698A MX2017010698A (es) 2015-02-20 2016-02-19 Metodos y composiciones para chlamydia atenuada como vacuna y vector.
MX2023009696A MX2023009696A (es) 2015-02-20 2017-08-18 Metodos y composiciones para chlamydia atenuada como vacuna y vector.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2023009696A MX2023009696A (es) 2015-02-20 2017-08-18 Metodos y composiciones para chlamydia atenuada como vacuna y vector.

Country Status (6)

Country Link
US (1) US10596247B2 (es)
EP (1) EP3258961A4 (es)
CA (1) CA2977071A1 (es)
HK (1) HK1248554A1 (es)
MX (2) MX2017010698A (es)
WO (1) WO2016134300A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240156938A1 (en) * 2022-11-10 2024-05-16 Board Of Regents, The University Of Texas System Compositions and methods for treating and preventing human chlamydial infections and diseases using attenuated animal chlamydia

Family Cites Families (28)

* Cited by examiner, † Cited by third party
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US4968603A (en) 1986-12-31 1990-11-06 The Regents Of The University Of California Determination of status in neoplastic disease
EP0442926A1 (en) 1988-11-10 1991-08-28 Imperial Cancer Research Technology Limited Polypeptides
DK0761231T3 (da) 1992-06-25 2000-05-08 Smithkline Beecham Biolog Vaccinepræparat indeholdende adjuvanser
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
US5869248A (en) 1994-03-07 1999-02-09 Yale University Targeted cleavage of RNA using ribonuclease P targeting and cleavage sequences
US5599706A (en) 1994-09-23 1997-02-04 Stinchcomb; Dan T. Ribozymes targeted to apo(a) mRNA
UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
CA2240494C (en) 1995-12-15 2007-03-13 Lloyd G. Mitchell Therapeutic molecules generated by trans-splicing
US6083702A (en) 1995-12-15 2000-07-04 Intronn Holdings Llc Methods and compositions for use in spliceosome mediated RNA trans-splicing
US6822071B1 (en) 1998-11-12 2004-11-23 The Regents Of The University Of California Polypeptides from Chlamydia pneumoniae and their use in the diagnosis, prevention and treatment of disease
EP1286703B1 (en) 2000-06-01 2009-08-05 University Of North Carolina At Chapel Hill Methods and compounds for controlled release of recombinant parvovirus vectors
GB0103169D0 (en) * 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
US6623729B2 (en) 2001-07-09 2003-09-23 Korea Advanced Institute Of Science And Technology Process for preparing sustained release micelle employing conjugate of anticancer drug and biodegradable polymer
NZ546711A (en) * 2001-12-12 2008-06-30 Chiron Srl Immunisation against chlamydia trachomatis
AU2003223766A1 (en) 2002-04-30 2003-11-17 University Of North Carolina At Chapel Hill Secretion signal vectors
ITRM20020253A1 (it) 2002-05-08 2003-11-10 Univ Roma Molecole chimeriche di snrna con sequenze antisenso per le giunzioni di splicing del gene della distrofina e applicazioni terapeutiche.
WO2005002619A2 (en) * 2003-06-26 2005-01-13 Chiron Corporation Immunogenic compositions for chlamydia trachomatis
FR2874384B1 (fr) 2004-08-17 2010-07-30 Genethon Vecteur viral adeno-associe pour realiser du saut d'exons dans un gene codant une proteine a domaines dispensables
EP1791432A4 (en) 2004-09-09 2010-07-07 Gen Hospital Corp MODULATION OF PHOSPHATASE ACTIVITY IN HERZCELLS
JP4798663B2 (ja) 2005-01-05 2011-10-19 塩野義製薬株式会社 新規血管新生抑制因子
AU2006242371A1 (en) 2005-04-29 2006-11-09 The University Of North Carolina At Chapel Hill Methods and compositions for regulated expression of nucleic acid at post-transcriptional level
EP2441770A1 (en) 2006-02-10 2012-04-18 The University of Cincinnati Phosphatase inhibitor protein-1 as a regulator of cardiac function
JP5575486B2 (ja) 2007-01-18 2014-08-20 ユニヴァーシティ オブ ミズーリー−コロンビア 筋鞘にｎＮＯＳを回復させる合成ミニ／ミクロジストロフィン遺伝子
WO2010042206A1 (en) * 2008-10-09 2010-04-15 Board Of Regents, University Of Texas System Methods and compositions for chlamydial antigens for diagnosis and treatment of chlamydial infection and disease
US20130095487A1 (en) * 2011-10-18 2013-04-18 University Of South Florida Interferon-Gamma Response as a Diagnostic Test for Persistent Chlamydial Infections

Also Published As

Publication number Publication date
WO2016134300A1 (en) 2016-08-25
US20180021423A1 (en) 2018-01-25
EP3258961A1 (en) 2017-12-27
MX2023009696A (es) 2023-08-28
CA2977071A1 (en) 2016-08-25
HK1248554A1 (zh) 2018-10-19
EP3258961A4 (en) 2018-08-22
US10596247B2 (en) 2020-03-24

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