MX2016007921A - Composiciones de acido hialuronico que comprenden mepivacaina. - Google Patents
Composiciones de acido hialuronico que comprenden mepivacaina.Info
- Publication number
- MX2016007921A MX2016007921A MX2016007921A MX2016007921A MX2016007921A MX 2016007921 A MX2016007921 A MX 2016007921A MX 2016007921 A MX2016007921 A MX 2016007921A MX 2016007921 A MX2016007921 A MX 2016007921A MX 2016007921 A MX2016007921 A MX 2016007921A
- Authority
- MX
- Mexico
- Prior art keywords
- hyaluronic acid
- mepivacaine
- mepi
- compositions including
- acid compositions
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 8
- 229920002674 hyaluronan Polymers 0.000 title abstract 8
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 8
- 229960002409 mepivacaine Drugs 0.000 title abstract 7
- INWLQCZOYSRPNW-UHFFFAOYSA-N mepivacaine Chemical compound CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C INWLQCZOYSRPNW-UHFFFAOYSA-N 0.000 title abstract 7
- 239000000203 mixture Substances 0.000 title abstract 4
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 abstract 2
- 229960004194 lidocaine Drugs 0.000 abstract 2
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
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- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
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- A61L2400/00—Materials characterised by their function or physical properties
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente invención se refiere a una composición acuosa esterilizada, que comprende al menos un ácido hialurónico y al menos la mepivacaína y eventualmente uno o varios compuestos adicionales, la relación másica entre la concentración del ácido hialurónico [HA] y la concentración de la mepivacaína [MEPI] : [HA] / [MEPI] es mayor que o igual a 0.1; [HA] / [MEPI] = 0.1. La invención se refiere igualmente al uso de la mepivacaína en substitución de la lidocaína en una cantidad equivalente para obtener una composición de ácido hialurónico que comprende un anestésico local cuyas propiedades reológicas después de la esterilización con calor son superiores a las propiedades reológicas de una misma composición de ácido hialurónico que comprende la lidocaína.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1363505A FR3015290B1 (fr) | 2013-12-23 | 2013-12-23 | Compositions d'acide hyaluronique compreant de la mepivacaine |
| PCT/EP2014/079270 WO2015097261A1 (fr) | 2013-12-23 | 2014-12-23 | Compositions d'acide hyaluronique comprenant de la mepivacaïne |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2016007921A true MX2016007921A (es) | 2016-10-07 |
| MX362530B MX362530B (es) | 2019-01-23 |
Family
ID=50624705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2016007921A MX362530B (es) | 2013-12-23 | 2014-12-23 | Composiciones de acido hialuronico que comprenden mepivacaina. |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20160346433A1 (es) |
| EP (3) | EP3049091B1 (es) |
| JP (1) | JP6446462B2 (es) |
| KR (1) | KR102343660B1 (es) |
| CN (2) | CN105916512B (es) |
| AU (1) | AU2014372513B2 (es) |
| BR (1) | BR112016014247A2 (es) |
| CA (1) | CA2932967C (es) |
| EA (3) | EA036502B1 (es) |
| ES (2) | ES2625841T3 (es) |
| FR (2) | FR3015290B1 (es) |
| IL (2) | IL246062B (es) |
| MX (1) | MX362530B (es) |
| PL (2) | PL3173086T3 (es) |
| PT (1) | PT3049091T (es) |
| SG (2) | SG11201604862XA (es) |
| WO (1) | WO2015097261A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3613423T3 (pl) | 2013-07-10 | 2023-02-13 | Matrix Biology Institute | Kompozycje hialuronanu o dużej sprężystości i ich zastosowanie |
| US9421198B2 (en) | 2013-07-30 | 2016-08-23 | Teoxane | Composition comprising hyaluronic acid and mepivacaine |
| US10004824B2 (en) | 2015-05-11 | 2018-06-26 | Laboratoires Vivacy | Compositions comprising at least one polyol and at least one anesthetic |
| PL3352766T3 (pl) * | 2015-09-24 | 2021-08-02 | Matrix Biology Institute | Kompozycie z hialuronanem o dużej elastyczności i sposoby ich użycia |
| FR3058064B1 (fr) | 2016-10-28 | 2020-08-07 | Lab Vivacy | Composition a base d'acide hyaluronique comprenant de la mepivacaine |
| JP2020516695A (ja) * | 2017-04-12 | 2020-06-11 | ウリゲン ファーマシューティカルズ、インコーポレイテッド | 改善された安定性を備えた注射器中に局所麻酔薬、緩衝液、およびグルコサミノグリカンを含む製品 |
| KR102091452B1 (ko) * | 2017-12-19 | 2020-03-20 | 대화제약 주식회사 | 국소 마취제 및 히알루론산 하이드로겔을 포함하는 사전충전형 주사기의 제조방법 |
| WO2020232539A1 (en) | 2019-05-17 | 2020-11-26 | The Governing Council Of The University Of Toronto | Sustained release local anesthetic hydrogel composition |
| KR102566288B1 (ko) * | 2019-12-24 | 2023-08-11 | 주식회사 엘지화학 | 마취제, 완충 용액 및 히알루론산 하이드로겔을 포함하는 주사용 조성물 및 이의 제조방법 |
| AR126276A1 (es) * | 2021-07-01 | 2023-10-04 | Biopolimeri S R L | Composición de ácido hialurónico reticulado con anestésicos locales |
| KR102493003B1 (ko) * | 2022-05-09 | 2023-01-27 | 구태훈 | 히알루론산과 리도카인을 포함하는 관절활액 보충재용 조성물 |
| WO2025133721A1 (en) | 2023-12-19 | 2025-06-26 | Universidade Nova De Lisboa | Injectable composition of nonsteroidal anti-inflammatory drugs, methods and uses thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1352971A (fr) | 1963-01-09 | 1964-02-21 | Siemens Ag | Montage pour mesurer l'éloignement des défauts sur des lignes |
| SE442820B (sv) | 1984-06-08 | 1986-02-03 | Pharmacia Ab | Gel av tverbunden hyaluronsyra for anvendning som glaskroppssubstitut |
| JPH02215707A (ja) * | 1989-02-15 | 1990-08-28 | Chisso Corp | 皮膚化粧料 |
| GB9902412D0 (en) | 1999-02-03 | 1999-03-24 | Fermentech Med Ltd | Process |
| FR2861734B1 (fr) | 2003-04-10 | 2006-04-14 | Corneal Ind | Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus |
| US8124120B2 (en) | 2003-12-22 | 2012-02-28 | Anika Therapeutics, Inc. | Crosslinked hyaluronic acid compositions for tissue augmentation |
| CA2567532C (en) | 2004-05-20 | 2013-10-01 | Mentor Corporation | Methods for making injectable polymer hydrogels |
| FR2924615B1 (fr) | 2007-12-07 | 2010-01-22 | Vivacy Lab | Hydrogel cohesif biodegradable. |
| US8357795B2 (en) | 2008-08-04 | 2013-01-22 | Allergan, Inc. | Hyaluronic acid-based gels including lidocaine |
| FR2938187B1 (fr) | 2008-11-07 | 2012-08-17 | Anteis Sa | Composition injectable a base d'acide hyaluronique ou l'un de ses sels, de polyols et de lidocaine, sterilisee a la chaleur |
| EP2484387A1 (en) * | 2011-02-03 | 2012-08-08 | Q-Med AB | Hyaluronic acid composition |
| FR2979539B1 (fr) * | 2011-09-05 | 2013-09-27 | Teoxane | Composition sterile dermo-injectable |
| EP2581079B1 (en) | 2011-10-11 | 2016-12-07 | BioPolymer GmbH & Co. KG | Combination of hyaluronic acid and prilocaine |
| FR2983483B1 (fr) | 2011-12-02 | 2014-11-14 | Vivacy Lab | Procede de substitution et reticulation simultanees d'un polysaccharide via ses fonctions hydroxyles |
| FR2991876B1 (fr) * | 2012-06-13 | 2014-11-21 | Vivacy Lab | Composition, en milieu aqueux, comprenant au moins un acide hyaluronique et au moins un sel hydrosoluble de sucrose octasulfate |
| KR20140025117A (ko) * | 2012-08-21 | 2014-03-04 | 김종서 | 하이알루론산을 포함하는 마취제 조성물 |
| CN102805882B (zh) * | 2012-08-28 | 2014-04-23 | 华熙福瑞达生物医药有限公司 | 一种软组织填充剂在使用前与麻醉剂注射液混合的方法 |
| FR2994846B1 (fr) * | 2012-08-29 | 2014-12-26 | Vivacy Lab | Composition, sterilisee, comprenant au moins un acide hyaluronique et de l'ascorbyl phosphate de magnesium |
| US9421198B2 (en) * | 2013-07-30 | 2016-08-23 | Teoxane | Composition comprising hyaluronic acid and mepivacaine |
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2013
- 2013-12-23 FR FR1363505A patent/FR3015290B1/fr not_active Expired - Fee Related
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2014
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- 2014-12-23 WO PCT/EP2014/079270 patent/WO2015097261A1/fr active Application Filing
- 2014-12-23 MX MX2016007921A patent/MX362530B/es active IP Right Grant
- 2014-12-23 JP JP2016542172A patent/JP6446462B2/ja active Active
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- 2014-12-23 EP EP17150080.4A patent/EP3173086B1/fr active Active
- 2014-12-23 EP EP19209272.4A patent/EP3799875A1/fr not_active Withdrawn
- 2014-12-23 CN CN201910795056.3A patent/CN110623954A/zh active Pending
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2016
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2019
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2020
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