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MX2013011327A - Combinaciones de compuestos inhibidores de akta y agentes quimioterapeuticos y metodos de uso de los mismos. - Google Patents

Combinaciones de compuestos inhibidores de akta y agentes quimioterapeuticos y metodos de uso de los mismos.

Info

Publication number
MX2013011327A
MX2013011327A MX2013011327A MX2013011327A MX2013011327A MX 2013011327 A MX2013011327 A MX 2013011327A MX 2013011327 A MX2013011327 A MX 2013011327A MX 2013011327 A MX2013011327 A MX 2013011327A MX 2013011327 A MX2013011327 A MX 2013011327A
Authority
MX
Mexico
Prior art keywords
combinations
methods
chemotherapeutic agents
inhibitor compounds
akt inhibitor
Prior art date
Application number
MX2013011327A
Other languages
English (en)
Inventor
Elizabeth Punnoose
Premal Patel
Kui Link
Michelle Nannini
Deepak Sampath
Jeffrey Wallin
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46931958&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2013011327(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2013011327A publication Critical patent/MX2013011327A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

La invención provee combinaciones que comprenden a) un compuesto de fórmula I: (ver Fórmula) o una sal aceptable farmaceúticamente del mismo, en donde R1, R2, R5, R10 y A tienen cualquiera de los valores definidos en la especificación y b) uno o más agentes seleccionados de 5-FU, un agente de platino, leucovorina, irinotecana, docetaxel, doxorubicina, gemcitabina, SN-38, capecitabina, temozolomida, paclitaxel, bevacizumab, pertuzumab, tamoxifeno, rapamicina y lapatinib. Las combinaciones son particularmente útiles para el tratamiento de alteraciones hiperproliferativas, tales como cáncer.
MX2013011327A 2011-04-01 2012-03-30 Combinaciones de compuestos inhibidores de akta y agentes quimioterapeuticos y metodos de uso de los mismos. MX2013011327A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161470803P 2011-04-01 2011-04-01
US201161470624P 2011-04-01 2011-04-01
PCT/US2012/031720 WO2012135781A1 (en) 2011-04-01 2012-03-30 Combinations of akt inhibitor compounds and chemotherapeutic agents, and methods of use

Publications (1)

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MX2013011327A true MX2013011327A (es) 2014-03-05

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ID=46931958

Family Applications (4)

Application Number Title Priority Date Filing Date
MX2013011327A MX2013011327A (es) 2011-04-01 2012-03-30 Combinaciones de compuestos inhibidores de akta y agentes quimioterapeuticos y metodos de uso de los mismos.
MX2013011332A MX354509B (es) 2011-04-01 2012-03-30 Combinaciones de compuestos inhibidores de akt y vemurafenib y metodos de uso de los mismos.
MX2013011330A MX351892B (es) 2011-04-01 2012-03-30 Combinaciones de compuestos inhibidores de akt y abiraterona y metodos de uso.
MX2013011329A MX2013011329A (es) 2011-04-01 2012-03-30 Combinaciones de compuestos inhibidores de akt y erlotinib y metodos de uso.

Family Applications After (3)

Application Number Title Priority Date Filing Date
MX2013011332A MX354509B (es) 2011-04-01 2012-03-30 Combinaciones de compuestos inhibidores de akt y vemurafenib y metodos de uso de los mismos.
MX2013011330A MX351892B (es) 2011-04-01 2012-03-30 Combinaciones de compuestos inhibidores de akt y abiraterona y metodos de uso.
MX2013011329A MX2013011329A (es) 2011-04-01 2012-03-30 Combinaciones de compuestos inhibidores de akt y erlotinib y metodos de uso.

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